Affinity DataKi: <1nMAssay Description:Displacement of [3H]UR-3189 from integrin alpha2b beta3 receptor in resting human plateletMore data for this Ligand-Target Pair
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
The Netherlands Institute
Curated by ChEMBL
The Netherlands Institute
Curated by ChEMBL
Affinity DataKi: 6nMAssay Description:Competitive inhibition of human ATX expressed in HEK293 Flp-In cells assessed as decrease in LPC hydrolysis measured every 30 secs for 90 mins by Lin...More data for this Ligand-Target Pair
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
The Netherlands Institute
Curated by ChEMBL
The Netherlands Institute
Curated by ChEMBL
Affinity DataKi: 270nMAssay Description:Mixed-type inhibition of human recombinant ATX using FS3 as substrate assessed as enzyme-inhibitor complex incubated for 2 hrs by Michaelis-Menten eq...More data for this Ligand-Target Pair
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
The Netherlands Institute
Curated by ChEMBL
The Netherlands Institute
Curated by ChEMBL
Affinity DataKi: 280nMAssay Description:Mixed-type inhibition of human recombinant ATX using FS3 as substrate assessed as enzyme-substrate-inhibitor complex incubated for 2 hrs by Michaelis...More data for this Ligand-Target Pair
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
The Netherlands Institute
Curated by ChEMBL
The Netherlands Institute
Curated by ChEMBL
Affinity DataKi: 390nMAssay Description:Inhibition of recombinant human C-terminal V5/His6-tagged ATX expressed in HEK293 cells assessed as choline release at 0.5 uM using oleoyl-lysophosph...More data for this Ligand-Target Pair
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
The Netherlands Institute
Curated by ChEMBL
The Netherlands Institute
Curated by ChEMBL
Affinity DataKi: 1.30E+3nMAssay Description:Inhibition of recombinant human C-terminal V5/His6-tagged ATX expressed in HEK293 cells assessed as choline release at 0.5 uM using oleoyl-lysophosph...More data for this Ligand-Target Pair
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
The Netherlands Institute
Curated by ChEMBL
The Netherlands Institute
Curated by ChEMBL
Affinity DataIC50: 0.0100nMAssay Description:Inhibition of human ATX using FS3 as substrate preincubated for 30 mins followed by substrate addition measured after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
University Of Manchester
Curated by ChEMBL
University Of Manchester
Curated by ChEMBL
Affinity DataIC50: 0.410nMAssay Description:Inhibition of human RET cytoplasmic domain (658 to 1114 residues) expressed in baculovirus system preincubated for 15 mins followed by substrate addi...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
University Of Manchester
Curated by ChEMBL
University Of Manchester
Curated by ChEMBL
Affinity DataIC50: 0.75nMAssay Description:Inhibition of human RET cytoplasmic domain (658 to 1114 residues) expressed in baculovirus system preincubated for 15 mins followed by substrate addi...More data for this Ligand-Target Pair
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
The Netherlands Institute
Curated by ChEMBL
The Netherlands Institute
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant human C-terminal His-tagged ATX expressed in HEK293E cells using lysophosphatidylcholine as substrate preincubated with enz...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
University Of Manchester
Curated by ChEMBL
University Of Manchester
Curated by ChEMBL
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human RET cytoplasmic domain (658 to 1114 residues) expressed in baculovirus system preincubated for 15 mins followed by substrate addi...More data for this Ligand-Target Pair
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
The Netherlands Institute
Curated by ChEMBL
The Netherlands Institute
Curated by ChEMBL
Affinity DataIC50: <1.70nMAssay Description:Inhibition of recombinant human C-terminal His-tagged ATX expressed in HEK293E cells using lysophosphatidylcholine as substrate preincubated with enz...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
University Of Manchester
Curated by ChEMBL
University Of Manchester
Curated by ChEMBL
Affinity DataIC50: 1.70nMAssay Description:Inhibition of human RET cytoplasmic domain (658 to 1114 residues) expressed in baculovirus system preincubated for 15 mins followed by substrate addi...More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsMore data for this Ligand-Target Pair
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
The Netherlands Institute
Curated by ChEMBL
The Netherlands Institute
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant ATX expressed in HEK cells using oleoyl-lysophosphatidylcholine as substrate preincubated for 20 mins followed by sub...More data for this Ligand-Target Pair
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
The Netherlands Institute
Curated by ChEMBL
The Netherlands Institute
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of ATX (unknown origin) using lysophosphatidyl choline as substrateMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
University Of Manchester
Curated by ChEMBL
University Of Manchester
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of human RET cytoplasmic domain (658 to 1114 residues) expressed in baculovirus system preincubated for 15 mins followed by substrate addi...More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Antagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of MIP-1alpha induced chemotaxis after 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University Of Manchester
Curated by ChEMBL
University Of Manchester
Curated by ChEMBL
Affinity DataIC50: 2.30nMAssay Description:Inhibition of recombinant His-tagged human KDR expressed in insect Sf21 cells preincubated for 15 mins followed by substrate addition measured after ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.5nMAssay Description:Inhibition of full length BRPF1 in human HUT78 cell nuclear/chromatin extract after 45 mins by chemoproteomic competition binding assayMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
University Of Manchester
Curated by ChEMBL
University Of Manchester
Curated by ChEMBL
Affinity DataIC50: 2.60nMAssay Description:Inhibition of human RET cytoplasmic domain (658 to 1114 residues) expressed in baculovirus system preincubated for 15 mins followed by substrate addi...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
University Of Manchester
Curated by ChEMBL
University Of Manchester
Curated by ChEMBL
Affinity DataIC50: 2.60nMAssay Description:Inhibition of human RET cytoplasmic domain (658 to 1114 residues) expressed in baculovirus system preincubated for 15 mins followed by substrate addi...More data for this Ligand-Target Pair
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
The Netherlands Institute
Curated by ChEMBL
The Netherlands Institute
Curated by ChEMBL
Affinity DataIC50: 2.60nMAssay Description:Inhibition of human recombinant ATX using FS3 as substrate incubated for 30 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
The Netherlands Institute
Curated by ChEMBL
The Netherlands Institute
Curated by ChEMBL
Affinity DataIC50: 2.80nMAssay Description:Inhibition of human ATX expressed in HEK293 cells using FS-3 as substrate preincubated for 15 mins followed by substrate addition measured after 30 m...More data for this Ligand-Target Pair
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
The Netherlands Institute
Curated by ChEMBL
The Netherlands Institute
Curated by ChEMBL
Affinity DataIC50: 2.80nMAssay Description:Inhibition of human recombinant ATX using FS3 as substrate incubated for 30 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Antagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of MIP-1alpha induced chemotaxis after 60 minsMore data for this Ligand-Target Pair
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
The Netherlands Institute
Curated by ChEMBL
The Netherlands Institute
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of human ATX expressed in HEK293 cells using FS-3 as substrate after 15 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 3.20nMAssay Description:Antagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of HCC4-induced chemotaxis after 60 minsMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
University Of Manchester
Curated by ChEMBL
University Of Manchester
Curated by ChEMBL
Affinity DataIC50: 3.20nMAssay Description:Inhibition of human RET cytoplasmic domain (658 to 1114 residues) expressed in baculovirus system preincubated for 15 mins followed by substrate addi...More data for this Ligand-Target Pair
Affinity DataIC50: 3.30nMAssay Description:Antagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of RANTES-induced chemotaxis after 60 minsMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
University Of Manchester
Curated by ChEMBL
University Of Manchester
Curated by ChEMBL
Affinity DataIC50: 3.90nMAssay Description:Inhibition of human RET cytoplasmic domain (658 to 1114 residues) expressed in baculovirus system preincubated for 15 mins followed by substrate addi...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
University Of Manchester
Curated by ChEMBL
University Of Manchester
Curated by ChEMBL
Affinity DataIC50: 3.90nMAssay Description:Inhibition of human RET cytoplasmic domain (658 to 1114 residues) expressed in baculovirus system preincubated for 15 mins followed by substrate addi...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Antagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of MIP-1alpha induced chemotaxis after 60 minsMore data for this Ligand-Target Pair
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
The Netherlands Institute
Curated by ChEMBL
The Netherlands Institute
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant human ATX using bisP-nitrophenyl phosphate as substrate measured after 30 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 4.20nMAssay Description:Displacement of [125I]hMIP-1alpha from CCR1 in human PBMCMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
University Of Manchester
Curated by ChEMBL
University Of Manchester
Curated by ChEMBL
Affinity DataIC50: 4.5nMAssay Description:Inhibition of human RET cytoplasmic domain (658 to 1114 residues) expressed in baculovirus system preincubated for 15 mins followed by substrate addi...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
University Of Manchester
Curated by ChEMBL
University Of Manchester
Curated by ChEMBL
Affinity DataIC50: 4.60nMAssay Description:Inhibition of human RET cytoplasmic domain (658 to 1114 residues) expressed in baculovirus system preincubated for 15 mins followed by substrate addi...More data for this Ligand-Target Pair