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Found 3099 with Last Name = 'winum' and Initial = 'jy'
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50153970(4-(4,6-Diethoxy-[1,3,5]triazin-2-ylamino)-benzenes...)
Affinity DataKi:  0.120nMAssay Description:Inhibitory activity against human carbonic anhydrase IX expressed in Escherichia coli BL21More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50153971(4-(4,6-Dichloro-[1,3,5]triazin-2-ylamino)-benzenes...)
Affinity DataKi:  0.150nMAssay Description:Inhibitory activity against human carbonic anhydrase IX expressed in Escherichia coli BL21More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
University Of Montpellier

Curated by ChEMBL
LigandPNGBDBM11625(2-N-(4-amino-3-chloro-5-fluorobenzene)-1,3,4-thiad...)
Affinity DataKi:  0.300nMpH: 7.5Assay Description:Inhibition of human carbonic anhydrase II by spectrophotometry at pH 7.5More data for this Ligand-Target Pair
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50153964(4-((4,6-diethoxy-1,3,5-triazin-2-ylamino)methyl)be...)
Affinity DataKi:  0.340nMAssay Description:Inhibitory activity against human carbonic anhydrase IX expressed in Escherichia coli BL21More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50395391(CHEMBL2164737)
Affinity DataKi:  0.400nMAssay Description:Inhibition of human recombinant CA9 catalytic domain preincubated for 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 12(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr

Curated by ChEMBL
LigandPNGBDBM50395391(CHEMBL2164737)
Affinity DataKi:  0.5nMAssay Description:Inhibition of human recombinant CA12 catalytic domain preincubated for 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
University Of Montpellier

Curated by ChEMBL
LigandPNGBDBM50155543(5-{4-[3-(2-Fluoro-phenyl)-thioureido]-benzenesulfo...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity towards human cloned carbonic anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 6(Homo sapiens (Human))
Institut Des BiomolÉCules Max Mousseron (Ibmm)

LigandPNGBDBM50137675(4-(3,4,5-Trihydroxy-tetrahydro-pyran-2-ylamino)-be...)
Affinity DataKi:  0.560nM ΔG°:  -51.9kJ/molepH: 7.5 T: 2°CAssay Description:Inhibition assay using carbonic anhydrases with an SX.18MV-R, a stopped-flow instrument from Applied Photophysics was used for assaying the CA cataly...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
University Of Montpellier

Curated by ChEMBL
LigandPNGBDBM50155547(5-(4-{3-[1,2-Dihydroxy-2-(4-nitro-phenyl)-ethyl]-t...)
Affinity DataKi:  0.600nMAssay Description:Binding affinity towards human cloned carbonic anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
University Of Montpellier

Curated by ChEMBL
LigandPNGBDBM50155546(CHEMBL445650 | N-[4-({[5-(aminosulfonyl)-1,3,4-thi...)
Affinity DataKi:  0.600nMAssay Description:Binding affinity towards human cloned carbonic anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50155547(5-(4-{3-[1,2-Dihydroxy-2-(4-nitro-phenyl)-ethyl]-t...)
Affinity DataKi:  0.600nMAssay Description:Binding affinity towards human cloned carbonic anhydrase IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50155545(5-{4-[3-(4-Methyl-piperazin-1-yl)-thioureido]-benz...)
Affinity DataKi:  0.600nMAssay Description:Binding affinity towards human cloned carbonic anhydrase IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
University Of Montpellier

Curated by ChEMBL
LigandPNGBDBM50395391(CHEMBL2164737)
Affinity DataKi:  0.600nMAssay Description:Inhibition of full length human CA2 cytosolic isoform preincubated for 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50155542(5-{4-[3-(2-Dimethylamino-ethyl)-thioureido]-benzen...)
Affinity DataKi:  0.600nMAssay Description:Binding affinity towards human cloned carbonic anhydrase IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 6(Homo sapiens (Human))
Institut Des BiomolÉCules Max Mousseron (Ibmm)

LigandPNGBDBM50137677(4-(3,4,5-Trihydroxy-6-hydroxymethyl-tetrahydro-pyr...)
Affinity DataKi:  0.640nM ΔG°:  -51.6kJ/molepH: 7.5 T: 2°CAssay Description:Inhibition assay using carbonic anhydrases with an SX.18MV-R, a stopped-flow instrument from Applied Photophysics was used for assaying the CA cataly...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
University Of Montpellier

Curated by ChEMBL
LigandPNGBDBM33280(CHEMBL153094 | aliphatic sulfamate, 2)
Affinity DataKi:  0.700nM ΔG°:  -51.9kJ/molepH: 7.5 T: 2°CAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50155546(CHEMBL445650 | N-[4-({[5-(aminosulfonyl)-1,3,4-thi...)
Affinity DataKi:  0.700nMAssay Description:Binding affinity towards human cloned carbonic anhydrase IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
University Of Montpellier

Curated by ChEMBL
LigandPNGBDBM33280(CHEMBL153094 | aliphatic sulfamate, 2)
Affinity DataKi:  0.700nMAssay Description:Inhibitory activity against human carbonic anhydrase II.More data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
University Of Montpellier

Curated by ChEMBL
LigandPNGBDBM50155545(5-{4-[3-(4-Methyl-piperazin-1-yl)-thioureido]-benz...)
Affinity DataKi:  0.700nMAssay Description:Binding affinity towards human cloned carbonic anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50155543(5-{4-[3-(2-Fluoro-phenyl)-thioureido]-benzenesulfo...)
Affinity DataKi:  0.700nMAssay Description:Binding affinity towards human cloned carbonic anhydrase IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
University Of Montpellier

Curated by ChEMBL
LigandPNGBDBM50228328(([2-(Carboxymethyl-{[2-(4-sulfamoyl-phenyl)-ethylc...)
Affinity DataKi:  0.770nMAssay Description:Inhibition of human recombinant CA2 by CO2 hydration stopped flow assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 6(Homo sapiens (Human))
Institut Des BiomolÉCules Max Mousseron (Ibmm)

LigandPNGBDBM11638(CHEMBL26 | Compound 7 | N-[(1-ethylpyrrolidin-2-yl...)
Affinity DataKi:  0.800nM ΔG°:  -51.1kJ/molepH: 7.5 T: 2°CAssay Description:Inhibition assay using carbonic anhydrases with an SX.18MV-R, a stopped-flow instrument from Applied Photophysics was used for assaying the CA cataly...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
University Of Montpellier

Curated by ChEMBL
LigandPNGBDBM50155548(5-{4-[3-(2-Morpholin-4-yl-ethyl)-thioureido]-benze...)
Affinity DataKi:  0.800nMAssay Description:Binding affinity towards human cloned carbonic anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 7(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr

Curated by ChEMBL
LigandPNGBDBM10882(6-ethoxy-1,3-benzothiazole-2-sulfonamide | CHEMBL1...)
Affinity DataKi:  0.800nMAssay Description:Inhibition of full length human carbonic anhydrase 7 preincubated for 15 mins by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 7(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr

Curated by ChEMBL
LigandPNGBDBM10882(6-ethoxy-1,3-benzothiazole-2-sulfonamide | CHEMBL1...)
Affinity DataKi:  0.800nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
University Of Montpellier

Curated by ChEMBL
LigandPNGBDBM50228326(CHEMBL1795055 | CHEMBL285436 | {(2-{Carboxymethyl-...)
Affinity DataKi:  0.890nMAssay Description:Inhibition of human recombinant CA2 by CO2 hydration stopped flow assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 7(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr

Curated by ChEMBL
LigandPNGBDBM10887(Sulfamate 7 | Topiramate (TPM) | US11535599, Examp...)
Affinity DataKi:  0.900nMAssay Description:Inhibition of human recombinant CA7 after 15 mins by CO2 hydration stopped flow assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 7(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr

Curated by ChEMBL
LigandPNGBDBM10887(Sulfamate 7 | Topiramate (TPM) | US11535599, Examp...)
Affinity DataKi:  0.900nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
University Of Montpellier

Curated by ChEMBL
LigandPNGBDBM50155542(5-{4-[3-(2-Dimethylamino-ethyl)-thioureido]-benzen...)
Affinity DataKi:  0.900nMAssay Description:Binding affinity towards human cloned carbonic anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 7(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr

Curated by ChEMBL
LigandPNGBDBM10887(Sulfamate 7 | Topiramate (TPM) | US11535599, Examp...)
Affinity DataKi:  0.900nMAssay Description:Inhibition of full length human carbonic anhydrase 7 preincubated for 15 mins by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
University Of Montpellier

Curated by ChEMBL
LigandPNGBDBM50155541(Aminobenzolamide derivative | CHEMBL435094)
Affinity DataKi:  0.900nMAssay Description:Binding affinity towards human cloned carbonic anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 6(Homo sapiens (Human))
Institut Des BiomolÉCules Max Mousseron (Ibmm)

LigandPNGBDBM82123(Brinzolamide, BRZ)
Affinity DataKi:  0.900nM ΔG°:  -50.8kJ/molepH: 7.5 T: 2°CAssay Description:Inhibition assay using carbonic anhydrases with an SX.18MV-R, a stopped-flow instrument from Applied Photophysics was used for assaying the CA cataly...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
University Of Montpellier

Curated by ChEMBL
LigandPNGBDBM50155540(5-{4-[3-(2-Piperazin-1-yl-ethyl)-thioureido]-benze...)
Affinity DataKi:  0.900nMAssay Description:Binding affinity towards human cloned carbonic anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
University Of Montpellier

Curated by ChEMBL
LigandPNGBDBM50155544(5-[4-(3-Morpholin-4-yl-thioureido)-benzenesulfonyl...)
Affinity DataKi:  0.900nMAssay Description:Binding affinity towards human cloned carbonic anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
University Of Montpellier

Curated by ChEMBL
LigandPNGBDBM50112638(CHEMBL3609431)
Affinity DataKi:  1nMAssay Description:Inhibition of full length human carbonic anhydrase-2 by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 12(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr

Curated by ChEMBL
LigandPNGBDBM50387125(4-ureidophenyl sulfamate ring derivative 3j | CHEM...)
Affinity DataKi:  1nMAssay Description:Inhibition of human recombinant transmembrane CA12 preincubated for 15 mins by stopped-flow CO2 hydration methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 12(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr

Curated by ChEMBL
LigandPNGBDBM50387125(4-ureidophenyl sulfamate ring derivative 3j | CHEM...)
Affinity DataKi:  1nMAssay Description:Inhibition of human carbonic anhydrase 12 preincubated for 15 mins measured for 10 to 100 sec using phenol red indicator-based stopped flow assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50167353(4-[2-(4,6-Diamino-[1,3,5]triazin-2-ylamino)-ethyl]...)
Affinity DataKi:  1nMAssay Description:Inhibitory constant against human Carbonic anhydrase IXMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50167355(CHEMBL189526 | {4-Chloro-6-[2-(4-sulfamoyl-phenyl)...)
Affinity DataKi:  1nMAssay Description:Inhibitory constant against human Carbonic anhydrase IXMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
University Of Montpellier

Curated by ChEMBL
LigandPNGBDBM50136078(CHEMBL436261 | Sulfamic acid phenethyl ester)
Affinity DataKi:  1.10nMAssay Description:Inhibitory activity against human carbonic anhydrase II.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
University Of Montpellier

Curated by ChEMBL
LigandPNGBDBM50098102(CHEMBL23350 | Sulfamic acid 4-chloro-phenyl ester)
Affinity DataKi:  1.10nMAssay Description:Inhibition of human carbonic anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
University Of Montpellier

Curated by ChEMBL
LigandPNGBDBM50098102(CHEMBL23350 | Sulfamic acid 4-chloro-phenyl ester)
Affinity DataKi:  1.10nMpH: 7.5Assay Description:Inhibition of human carbonic anhydrase II by spectrophotometry at pH 7.5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50153969(4-[2-(4,6-Bis-methylamino-[1,3,5]triazin-2-ylamino...)
Affinity DataKi:  1.10nMAssay Description:Inhibitory activity against human carbonic anhydrase IX expressed in Escherichia coli BL21More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50167337(3-{4-Chloro-6-[2-(4-sulfamoyl-phenyl)-ethylamino]-...)
Affinity DataKi:  1.20nMAssay Description:Inhibitory constant against human Carbonic anhydrase IXMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50167361(4-[(4,6-Diamino-[1,3,5]triazin-2-ylamino)-methyl]-...)
Affinity DataKi:  1.20nMAssay Description:Inhibitory constant against human Carbonic anhydrase IXMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
University Of Montpellier

Curated by ChEMBL
LigandPNGBDBM50098106(CHEMBL24259 | PHENYLSULFAMATE | Sulfamic acid phen...)
Affinity DataKi:  1.30nMAssay Description:Inhibition of human carbonic anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50167350(4-[(4,6-Bis-dimethylamino-[1,3,5]triazin-2-ylamino...)
Affinity DataKi:  1.30nMAssay Description:Inhibitory constant against human Carbonic anhydrase IXMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50153976(4-[(4,6-Bis-methylamino-[1,3,5]triazin-2-ylamino)-...)
Affinity DataKi:  1.30nMAssay Description:Inhibitory activity against human carbonic anhydrase IX expressed in Escherichia coli BL21More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50167341(4-[2-(4,6-Dihydrazino-[1,3,5]triazin-2-ylamino)-et...)
Affinity DataKi:  1.30nMAssay Description:Inhibitory constant against human Carbonic anhydrase IXMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50167357(4-[(4,6-Dihydrazino-[1,3,5]triazin-2-ylamino)-meth...)
Affinity DataKi:  1.40nMAssay Description:Inhibitory constant against human Carbonic anhydrase IXMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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