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Found 170 with Last Name = 'wolfe' and Initial = 'ms'
TargetPresenilin-1(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50575178(CHEMBL4853450)
Affinity DataKi:  0.420nMAssay Description:Noncompetitive inhibition of gamma secretase (unknown origin) expressed in HEK293 cells assessed as reduction of A-beta40 levels using varying level ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50575197(CHEMBL4868549)
Affinity DataKi:  0.650nMAssay Description:Noncompetitive inhibition of gamma secretase (unknown origin) expressed in HEK293 cells assessed as reduction of A-beta40 levels using varying level ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50575187(CHEMBL4848116)
Affinity DataKi:  1.20nMAssay Description:Noncompetitive inhibition of gamma secretase (unknown origin) expressed in HEK293 cells assessed as reduction of A-beta40 levels using varying level ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50575179(CHEMBL4851959)
Affinity DataKi:  2.60nMAssay Description:Noncompetitive inhibition of gamma secretase (unknown origin) expressed in HEK293 cells assessed as reduction of A-beta40 levels using varying level ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50006222((1S,2R,5R)-5-(6-Amino-purin-9-yl)-3-hydroxymethyl-...)
Affinity DataKi:  3.80nMAssay Description:Inhibitory activity of the compound against bovine liver S-adenosyl-L-homocysteine hydrolase (AdoHcy) rate of inactivation by NpcAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50100439(4-[2-(5-{2-[2-(2-Amino-3-carboxy-propionylamino)-3...)
Affinity DataKi:  10nMAssay Description:Inhibition of human recombinant beta-secretaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50006218((1R,2S,3R)-3-(6-amino-9H-purin-9-yl)cyclopentane-1...)
Affinity DataKi:  12nMAssay Description:Inhibitory activity of the compound against bovine liver S-adenosyl-L-homocysteine hydrolase (AdoHcy).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50006220(3-(6-Amino-purin-9-yl)-5-vinyl-cyclopentane-1,2-di...)
Affinity DataKi:  22nMAssay Description:Inhibitory activity of the compound against bovine liver S-adenosyl-L-homocysteine hydrolase (AdoHcy).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50006221(3-(6-Amino-purin-9-yl)-5-methyl-cyclopentane-1,2-d...)
Affinity DataKi:  27nMAssay Description:Inhibitory activity of the compound against bovine liver S-adenosyl-L-homocysteine hydrolase (AdoHcy).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50280299((2R,3R,4S)-2-(6-Amino-purin-9-yl)-5-[1-fluoro-meth...)
Affinity DataKi:  39nMAssay Description:Compound was tested for its inhibitory activity against recombinant rat liver S-adenosylhomocysteine hydrolaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAdenosylhomocysteinase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50280301((2R,3R,4S)-2-(6-Amino-purin-9-yl)-5-[1-fluoro-meth...)
Affinity DataKi:  40nMAssay Description:Compound was tested for its inhibitory activity against recombinant rat liver S-adenosylhomocysteine hydrolaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAdenosylhomocysteinase(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50006215((1'R,2'S,3'R)-9-(2',3'-dihydroxycyclopent-4'-enyl)...)
Affinity DataKi:  49nMAssay Description:Inhibitory activity of the compound against bovine liver S-adenosyl-L-homocysteine hydrolase (AdoHcy).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50100440(4-(2-{5-[2-(2-Amino-3-methyl-butyrylamino)-3-carba...)
Affinity DataKi:  68nMAssay Description:Inhibition of human recombinant beta-secretaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50280300((1R,2S,3R)-3-(6-Amino-purin-9-yl)-5-[1-fluoro-meth...)
Affinity DataKi:  87nMAssay Description:Compound was tested for its inhibitory activity against recombinant rat liver S-adenosylhomocysteine hydrolaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAdenosylhomocysteinase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50280298((1R,2S,3R)-3-(6-Amino-purin-9-yl)-5-[1-fluoro-meth...)
Affinity DataKi:  112nMAssay Description:Compound was tested for its inhibitory activity against recombinant rat liver S-adenosylhomocysteine hydrolaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAdenosylhomocysteinase(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50006217(3-(6-Amino-purin-9-yl)-5-ethyl-cyclopentane-1,2-di...)
Affinity DataKi:  586nMAssay Description:Inhibitory activity of the compound against bovine liver S-adenosyl-L-homocysteine hydrolase (AdoHcy).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50018205(4-(6-Amino-purin-9-yl)-5-hydroxy-2-hydroxymethyl-c...)
Affinity DataKi:  800nMAssay Description:Binding affinity towards S-adenosylhomocysteine hydrolase was determined using [3H]-AdoHcy as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50006219(3-(6-Amino-purin-9-yl)-5-methyl-cyclopentane-1,2-d...)
Affinity DataKi:  5.02E+3nMAssay Description:Inhibitory activity of the compound against bovine liver S-adenosyl-L-homocysteine hydrolase (AdoHcy).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50006223(5-(6-Amino-purin-9-yl)-3-methyl-cyclopent-3-ene-1,...)
Affinity DataKi:  9.15E+3nMAssay Description:Inhibitory activity of the compound against bovine liver S-adenosyl-L-homocysteine hydrolase (AdoHcy).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50006216(3-(6-Amino-purin-9-yl)-5-phenyl-cyclopentane-1,2-d...)
Affinity DataKi:  6.76E+4nMAssay Description:Inhibitory activity of the compound against bovine liver S-adenosyl-L-homocysteine hydrolase (AdoHcy).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50410179(CHEMBL2096800)
Affinity DataIC50:  0.140nMAssay Description:Inhibitory activity against Gamma-secretase in HeLa cells expressing APP-reporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50575197(CHEMBL4868549)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of gamma secretase (unknown origin) expressed in HEK293 cells assessed as reduction of A-beta40 levels using C100-FLAG as substrate incuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50575178(CHEMBL4853450)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of gamma secretase (unknown origin) expressed in HEK293 cells assessed as reduction of A-beta40 levels using C100-FLAG as substrate incuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50575198(CHEMBL4848394)
Affinity DataIC50:  0.870nMAssay Description:Inhibition of gamma secretase (unknown origin) expressed in HEK293 cells assessed as reduction of A-beta40 levels using C100-FLAG as substrate incuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50575196(CHEMBL4862085)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of gamma secretase (unknown origin) expressed in HEK293 cells assessed as reduction of A-beta40 levels using C100-FLAG as substrate incuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50575195(CHEMBL4874185)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of gamma secretase (unknown origin) expressed in HEK293 cells assessed as reduction of A-beta40 levels using C100-FLAG as substrate incuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50575180(CHEMBL4874349)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of gamma secretase (unknown origin) expressed in HEK293 cells assessed as reduction of A-beta40 levels using C100-FLAG as substrate incuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50575187(CHEMBL4848116)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of gamma secretase (unknown origin) expressed in HEK293 cells assessed as reduction of A-beta40 levels using C100-FLAG as substrate incuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50575194(CHEMBL4863759)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of gamma secretase (unknown origin) expressed in HEK293 cells assessed as reduction of A-beta40 levels using C100-FLAG as substrate incuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50575179(CHEMBL4851959)
Affinity DataIC50:  4.40nMAssay Description:Inhibition of gamma secretase (unknown origin) expressed in HEK293 cells assessed as reduction of A-beta40 levels using C100-FLAG as substrate incuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50575188(CHEMBL4866068)
Affinity DataIC50:  5.70nMAssay Description:Inhibition of gamma secretase (unknown origin) expressed in HEK293 cells assessed as reduction of A-beta40 levels using C100-FLAG as substrate incuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50575193(CHEMBL4854028)
Affinity DataIC50:  6nMAssay Description:Inhibition of gamma secretase (unknown origin) expressed in HEK293 cells assessed as reduction of A-beta40 levels using C100-FLAG as substrate incuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50575192(CHEMBL4870824)
Affinity DataIC50:  7.5nMAssay Description:Inhibition of gamma secretase (unknown origin) expressed in HEK293 cells assessed as reduction of A-beta40 levels using C100-FLAG as substrate incuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50575189(CHEMBL4865718)
Affinity DataIC50:  7.70nMAssay Description:Inhibition of gamma secretase (unknown origin) expressed in HEK293 cells assessed as reduction of A-beta40 levels using C100-FLAG as substrate incuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50575190(CHEMBL4850432)
Affinity DataIC50:  8.30nMAssay Description:Inhibition of gamma secretase (unknown origin) expressed in HEK293 cells assessed as reduction of A-beta40 levels using C100-FLAG as substrate incuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50410179(CHEMBL2096800)
Affinity DataIC50:  9nMAssay Description:Inhibitory activity against Gamma-secretase from APP-transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50157581((S)-methyl 2-((S)-2-(3-benzyl-3-((2R,3R)-3-(tert-b...)
Affinity DataIC50:  10nMAssay Description:Inhibition of gamma secretase isolated from HeLa cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50143457((R)-methyl 2-((R)-2-(3-benzyl-3-((2S,3R)-3-(tert-b...)
Affinity DataIC50:  10nMAssay Description:Inhibition of gamma secretase isolated from HeLa cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50410182(CHEMBL2096799)
Affinity DataIC50:  12nMAssay Description:Inhibitory activity against Gamma-secretase in HeLa cells expressing APP-reporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50410183(CHEMBL2096801)
Affinity DataIC50:  14nMAssay Description:Inhibitory activity against Gamma-secretase in HeLa cells expressing APP-reporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50150691(311951 | CHEMBL437635)
Affinity DataIC50:  16nMAssay Description:Inhibitory activity against Gamma-secretase in HeLa cells expressing APP-reporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50150696(CHEMBL436787 | methyl 2-[(2R,3R)-2-[(2R)-2-{2-[(2R...)
Affinity DataIC50:  25nMAssay Description:Inhibitory activity against Gamma-secretase in HeLa cells expressing APP-reporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50150689(311952 | CHEMBL411599)
Affinity DataIC50:  26nMAssay Description:Inhibitory activity against Gamma-secretase in HeLa cells expressing APP-reporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50410178(CHEMBL2096802)
Affinity DataIC50:  28nMAssay Description:Inhibitory activity against Gamma-secretase in HeLa cells expressing APP-reporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1/2(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50100436(CHEMBL412768 | NH2-Lys-Thr-Glu-Glu-Ile-Ser-Glu-Val...)
Affinity DataIC50:  30nMAssay Description:In vitro inhibition of beta-secretase was evaluatedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50157595((R)-methyl 2-((R)-2-(3-benzyl-3-((2R,3S)-3-(tert-b...)
Affinity DataIC50:  30nMAssay Description:Inhibition of gamma secretase isolated from HeLa cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50143453((R)-methyl 2-((R)-2-(3-benzyl-3-((2S,3R)-3-(tert-b...)
Affinity DataIC50:  30nMAssay Description:Inhibition of gamma secretase isolated from HeLa cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50575191(CHEMBL4846563)
Affinity DataIC50:  35nMAssay Description:Inhibition of gamma secretase (unknown origin) expressed in HEK293 cells assessed as reduction of A-beta40 levels using C100-FLAG as substrate incuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50575176(CHEMBL4869215)
Affinity DataIC50:  41nMAssay Description:Inhibition of gamma secretase (unknown origin) expressed in HEK293 cells assessed as reduction of A-beta40 levels using C100-FLAG as substrate incuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50575184(CHEMBL4856827)
Affinity DataIC50:  42nMAssay Description:Inhibition of gamma secretase (unknown origin) expressed in HEK293 cells assessed as reduction of A-beta40 levels using C100-FLAG as substrate incuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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