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Found 390 with Last Name = 'yokoyama' and Initial = 'k'
TargetCoagulation factor X(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50273137((3-{[(3-Carbamimidoyl-phenyl)-({4-[1-(1-imino-ethy...)
Affinity DataKi:  1.73nMAssay Description:Inhibition of human factor 10a by Dixon-plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50273136(CHEMBL455932 | CHEMBL463179 | {4-[2-(5-Carbamimido...)
Affinity DataKi:  5nMAssay Description:Inhibition of human factor 10a by Dixon-plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50273299(CHEMBL455933 | {4-[2-(5-Carbamimidoyl-2-hydroxy-be...)
Affinity DataKi:  5.70nMAssay Description:Inhibition of human factor 10a by Dixon-plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50273297(CHEMBL459136 | N-{2-[2-(5-Carbamimidoyl-2-hydroxy-...)
Affinity DataKi:  9.70nMAssay Description:Inhibition of human factor 10a by Dixon-plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50273229(CHEMBL455916 | {(5-Carbamimidoyl-2-hydroxy-benzene...)
Affinity DataKi:  14nMAssay Description:Inhibition of human factor 10a by Dixon-plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50273188(3-[2-(4-tert-Butyl-phenyl)-ethylsulfamoyl]-4-hydro...)
Affinity DataKi:  27nMAssay Description:Inhibition of human factor 10a by Dixon-plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50273138(4-Hydroxy-3-[2-(4-isopropyl-phenyl)-ethylsulfamoyl...)
Affinity DataKi:  29nMAssay Description:Inhibition of human factor 10a by Dixon-plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM17283((2S)-3-(7-carbamimidoylnaphthalen-2-yl)-2-(4-{[(3S...)
Affinity DataKi:  41nMAssay Description:Inhibition of factor 10a in human plasmaMore data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50273262(CHEMBL458067 | {2-[2-(5-Carbamimidoyl-2-hydroxy-be...)
Affinity DataKi:  51nMAssay Description:Inhibition of human factor 10a by Dixon-plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50273227(4-Hydroxy-3-{[2-(4-isopropyl-phenyl)-ethyl]-methyl...)
Affinity DataKi:  59nMAssay Description:Inhibition of human factor 10a by Dixon-plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50273265(CHEMBL457633 | {2-[2-(5-Carbamimidoyl-2-hydroxy-be...)
Affinity DataKi:  62nMAssay Description:Inhibition of human factor 10a by Dixon-plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50273187(4-Hydroxy-3-[2-(4-isopropoxy-phenyl)-ethylsulfamoy...)
Affinity DataKi:  100nMAssay Description:Inhibition of human factor 10a by Dixon-plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50273136(CHEMBL455932 | CHEMBL463179 | {4-[2-(5-Carbamimido...)
Affinity DataKi:  500nMAssay Description:Inhibition of human factor 10a by Dixon-plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50273189(3-[2-(4-Isopropyl-phenyl)-ethylsulfamoyl]-benzamid...)
Affinity DataKi:  2.10E+3nMAssay Description:Inhibition of human factor 10a by Dixon-plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50273190(4-Chloro-3-[2-(4-isopropyl-phenyl)-ethylsulfamoyl]...)
Affinity DataKi:  3.00E+3nMAssay Description:Inhibition of human factor 10a by Dixon-plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50273264(CHEMBL457632 | ethyl 2-(2-(2-(2-hydroxy-5-(N'-hydr...)
Affinity DataKi:  3.50E+3nMAssay Description:Inhibition of human factor 10a by Dixon-plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50273231(CHEMBL455919 | ethyl 2-(N-(4-isopropylphenethyl)-2...)
Affinity DataKi:  3.70E+3nMAssay Description:Inhibition of human factor 10a by Dixon-plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50273230(CHEMBL509493 | {[2-Hydroxy-5-(N-hydroxycarbamimido...)
Affinity DataKi:  7.00E+3nMAssay Description:Inhibition of human factor 10a by Dixon-plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50273228(4,N-Dihydroxy-3-[2-(4-isopropyl-phenyl)-ethylsulfa...)
Affinity DataKi:  7.30E+3nMAssay Description:Inhibition of human factor 10a by Dixon-plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50273263(2-(2-(2-(2-hydroxy-5-(N'-hydroxycarbamimidoyl)phen...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human factor 10a by Dixon-plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50273138(4-Hydroxy-3-[2-(4-isopropyl-phenyl)-ethylsulfamoyl...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human thrombin by Dixon-plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50273187(4-Hydroxy-3-[2-(4-isopropoxy-phenyl)-ethylsulfamoy...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human thrombin by Dixon-plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50273189(3-[2-(4-Isopropyl-phenyl)-ethylsulfamoyl]-benzamid...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human thrombin by Dixon-plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50273191(3-[2-(4-Isopropyl-phenyl)-ethylsulfamoyl]-4-methox...)
Affinity DataKi:  1.40E+4nMAssay Description:Inhibition of human factor 10a by Dixon-plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50273137((3-{[(3-Carbamimidoyl-phenyl)-({4-[1-(1-imino-ethy...)
Affinity DataKi:  2.60E+4nMAssay Description:Inhibition of human thrombin by Dixon-plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50273136(CHEMBL455932 | CHEMBL463179 | {4-[2-(5-Carbamimido...)
Affinity DataKi:  5.78E+4nMAssay Description:Inhibition of human thrombin by Dixon-plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM17283((2S)-3-(7-carbamimidoylnaphthalen-2-yl)-2-(4-{[(3S...)
Affinity DataKi: >2.00E+6nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50451011(CHEMBL4216889)
Affinity DataIC50:  0.160nMAssay Description:Displacement of [125I]-PYY from human neuropeptide Y2 receptor expressed in CHO cell membranes incubated for 60 mins by TopCount based methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50451012(CHEMBL4208191)
Affinity DataIC50:  0.270nMAssay Description:Displacement of [125I]-PYY from human neuropeptide Y2 receptor expressed in CHO cell membranes incubated for 60 mins by TopCount based methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50451003(CHEMBL4207076)
Affinity DataIC50:  0.300nMAssay Description:Displacement of [125I]-PYY from human neuropeptide Y2 receptor expressed in CHO cell membranes incubated for 60 mins by TopCount based methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50450993(CHEMBL4210786)
Affinity DataIC50:  0.310nMAssay Description:Displacement of [125I]-PYY from human neuropeptide Y2 receptor expressed in CHO cell membranes incubated for 60 mins by TopCount based methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetATP-dependent RNA helicase RhlE(Plasmodium falciparum (malaria parasite P. falcipa...)
University Of Washington At Seattle

LigandPNGBDBM13321(1-Methyl-1H-imidazole-4-sulfonic Acid (2-Bromoally...)
Affinity DataIC50:  0.400nMpH: 7.5 T: 2°CAssay Description:Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50450996(CHEMBL4212927)
Affinity DataIC50:  0.400nMAssay Description:Displacement of [125I]-PYY from human neuropeptide Y2 receptor expressed in CHO cell membranes incubated for 60 mins by TopCount based methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50451008(CHEMBL4211953)
Affinity DataIC50:  0.410nMAssay Description:Displacement of [125I]-PYY from human neuropeptide Y2 receptor expressed in CHO cell membranes incubated for 60 mins by TopCount based methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50451027(CHEMBL4211310)
Affinity DataIC50:  0.440nMAssay Description:Displacement of [125I]-PYY from human neuropeptide Y2 receptor expressed in CHO cell membranes incubated for 60 mins by TopCount based methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50451025(CHEMBL4204797)
Affinity DataIC50:  0.450nMAssay Description:Displacement of [125I]-PYY from human neuropeptide Y2 receptor expressed in CHO cell membranes incubated for 60 mins by TopCount based methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50451030(CHEMBL4216864)
Affinity DataIC50:  0.460nMAssay Description:Displacement of [125I]-PYY from human neuropeptide Y2 receptor expressed in CHO cell membranes incubated for 60 mins by TopCount based methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50269185(CHEMBL4069788)
Affinity DataIC50:  0.490nMAssay Description:Displacement of [125I]peptide YY from human Y2 receptor expressed in CHO cell membranes after 60 mins by TopCount scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50067584((S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-bip...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of mammalian FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50067584((S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-bip...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of mammalian protein farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent RNA helicase RhlE(Plasmodium falciparum (malaria parasite P. falcipa...)
University Of Washington At Seattle

LigandPNGBDBM13307(1-Methyl-1H-imidazole-4-sulfonic Acid Benzyl-{2-[(...)
Affinity DataIC50:  0.5nMpH: 7.5 T: 2°CAssay Description:Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50450998(CHEMBL4207590)
Affinity DataIC50:  0.510nMAssay Description:Displacement of [125I]-PYY from human neuropeptide Y2 receptor expressed in CHO cell membranes incubated for 60 mins by TopCount based methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50269166(CHEMBL4063306)
Affinity DataIC50:  0.550nMAssay Description:Displacement of [125I]peptide YY from human Y2 receptor expressed in CHO cell membranes after 60 mins by TopCount scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50450997(CHEMBL4202723)
Affinity DataIC50:  0.570nMAssay Description:Displacement of [125I]-PYY from human neuropeptide Y2 receptor expressed in CHO cell membranes incubated for 60 mins by TopCount based methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50254346(CHEMBL4069932)
Affinity DataIC50:  0.570nMAssay Description:Displacement of [125I]-PYY from human Y2R expressed in CHO cell membranes after 60 mins by liquid scintillation methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50197025(CHEMBL439904 | PYY(3-36))
Affinity DataIC50:  0.570nMAssay Description:Displacement of [125I]-PYY from human neuropeptide Y2 receptor expressed in CHO cell membranes incubated for 60 mins by TopCount based methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50197025(CHEMBL439904 | PYY(3-36))
Affinity DataIC50:  0.570nMAssay Description:Displacement of [125I]peptide YY from human Y2 receptor expressed in CHO cell membranes after 60 mins by TopCount scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50450994(CHEMBL4206938)
Affinity DataIC50:  0.580nMAssay Description:Displacement of [125I]-PYY from human neuropeptide Y2 receptor expressed in CHO cell membranes incubated for 60 mins by TopCount based methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50269168(CHEMBL4069205)
Affinity DataIC50:  0.600nMAssay Description:Displacement of [125I]peptide YY from human Y2 receptor expressed in CHO cell membranes after 60 mins by TopCount scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetATP-dependent RNA helicase RhlE(Plasmodium falciparum (malaria parasite P. falcipa...)
University Of Washington At Seattle

LigandPNGBDBM13323(1-Methyl-1H-imidazole-4-sulfonic Acid Benzyl-[6-cy...)
Affinity DataIC50:  0.600nMpH: 7.5 T: 2°CAssay Description:Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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