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Found 3793 with Last Name = 'yuan' and Initial = 'j'
TargetD(1A) dopamine receptor(BOVINE)
Research Biochemicals

Curated by ChEMBL
LigandPNGBDBM82247(8-Chloro-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-b...)
Affinity DataKi:  0.100nMAssay Description:Ability to inhibit the dopamine-stimulated adenylate-cyclase activity in dispersed cells of bovine parathyroid glandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Research Biochemicals

Curated by ChEMBL
LigandPNGBDBM82247(8-Chloro-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-b...)
Affinity DataKi:  0.150nMAssay Description:Ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(BOVINE)
Research Biochemicals

Curated by ChEMBL
LigandPNGBDBM82247(8-Chloro-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-b...)
Affinity DataKi:  0.160nMAssay Description:Ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50260806(CHEMBL497557 | N-(1-(6-(3-chloropyridin-4-yl)-5-(4...)
Affinity DataKi:  0.240nMAssay Description:Antagonist activity at human CB1 receptor expressed in SF9 cells assessed as inhibition of CP-55940-stimulated GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Neurogen

Curated by ChEMBL
LigandPNGBDBM21278(5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl...)
Affinity DataKi:  0.310nMAssay Description:Antagonist activity at rat CB1 receptor in SF9 cells assessed as inhibition of CP-55940-stimulated GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50433038(CHEMBL2375957 | US8633204, 299)
Affinity DataKi:  0.312nMAssay Description:Inhibition of mouse PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50433032(CHEMBL2376096)
Affinity DataKi:  0.350nMAssay Description:Inhibition of mouse PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50260806(CHEMBL497557 | N-(1-(6-(3-chloropyridin-4-yl)-5-(4...)
Affinity DataKi:  0.410nMAssay Description:Antagonist activity at rat CB1 receptor in SF9 cells assessed as inhibition of CP-55940-stimulated GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM21278(5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl...)
Affinity DataKi:  0.430nMAssay Description:Antagonist activity at human CB1 receptor expressed in SF9 cells assessed as inhibition of CP-55940-stimulated GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

LigandPNGBDBM50380313(CHEMBL1234354 | US8633204, 286)
Affinity DataKi:  0.570nMAssay Description:Inhibition of mouse PI3KalphaMore data for this Ligand-Target Pair
LigandPNGBDBM50433050(CHEMBL2375968)
Affinity DataKi:  0.654nMAssay Description:Inhibition of mouse PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50260767(1-(5-(4-chlorophenyl)-6-(2-chloropyridin-4-yl)pyra...)
Affinity DataKi:  0.670nMAssay Description:Antagonist activity at human CB1 receptor expressed in SF9 cells assessed as inhibition of CP-55940-stimulated GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Cercopithecus aethiops)
Neurogen

Curated by ChEMBL
LigandPNGBDBM50048233(1-(2-Methoxy-phenyl)-4-(1-phenyl-1H-pyrrol-3-ylmet...)
Affinity DataKi:  0.700nMAssay Description:Displacement of [3H]-YM 09151 from african green monkey Dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50433044(CHEMBL2375963 | US8633204, 304)
Affinity DataKi:  0.700nMAssay Description:Inhibition of mouse PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50327904(2-amino-4-methyl-6-(1H-pyrazol-3-yl)-8-(tetrahydro...)
Affinity DataKi:  0.800nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50260805(CHEMBL524804 | N-(1-(6-(3-chloropyridin-4-yl)-5-(4...)
Affinity DataKi:  0.800nMAssay Description:Antagonist activity at human CB1 receptor expressed in SF9 cells assessed as inhibition of CP-55940-stimulated GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50048240(1-(2-Methoxy-phenyl)-4-(1-methyl-5-phenyl-1H-pyrro...)
Affinity DataKi:  0.800nMAssay Description:Binding affinity towards Dopamine receptor D2 of rat using [3H]spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50260681(4-[6-(3-Chloro-pyridin-4-yl)-5-(4-trifluoromethyl-...)
Affinity DataKi:  0.830nMAssay Description:Antagonist activity at rat CB1 receptor in SF9 cells assessed as inhibition of CP-55940-stimulated GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50260681(4-[6-(3-Chloro-pyridin-4-yl)-5-(4-trifluoromethyl-...)
Affinity DataKi:  0.830nMAssay Description:Antagonist activity at human CB1 receptor expressed in SF9 cells assessed as inhibition of CP-55940-stimulated GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50327907(CHEMBL1257295 | trans-2-amino-8-(4-hydroxycyclohex...)
Affinity DataKi:  0.850nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50260768(1-(6-(2-chloropyridin-4-yl)-5-(4-(trifluoromethyl)...)
Affinity DataKi:  0.870nMAssay Description:Antagonist activity at human CB1 receptor expressed in SF9 cells assessed as inhibition of CP-55940-stimulated GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50071958(Biphenylene-2-carboxylic acid {4-[4-(2,3-dichloro-...)
Affinity DataKi:  0.900nMAssay Description:Compound was evaluated for binding affinity against human Dopamine receptor D3 transfected in CHO cell membranes to stimulate [3H]-thymidine uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50260682(1-(5-(4-chlorophenyl)-6-(2,4-dichlorophenyl)pyrazi...)
Affinity DataKi:  0.910nMAssay Description:Antagonist activity at human CB1 receptor expressed in SF9 cells assessed as inhibition of CP-55940-stimulated GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50116112(CHEMBL67484 | [1,5-Dimethyl-3-(2,4,6-trimethyl-phe...)
Affinity DataKi:  1nMAssay Description:Displacement of [125I]-sauvagine from Corticotropin releasing factor receptor 1 endogenously expressed in IMR-32 human neuroblastoma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50433049(CHEMBL2375365)
Affinity DataKi:  1nMAssay Description:Inhibition of mouse PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50260803(1-(6-(2-chloropyridin-4-yl)-5-(4-(trifluoromethyl)...)
Affinity DataKi:  1.20nMAssay Description:Antagonist activity at human CB1 receptor expressed in SF9 cells assessed as inhibition of CP-55940-stimulated GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50433031(CHEMBL2376094)
Affinity DataKi:  1.20nMAssay Description:Inhibition of mouse PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50048233(1-(2-Methoxy-phenyl)-4-(1-phenyl-1H-pyrrol-3-ylmet...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]-YM 09151 from human Dopamine receptor D4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50071959(9H-Fluorene-2-carboxylic acid {4-[4-(2,3-dichloro-...)
Affinity DataKi:  1.40nMAssay Description:Compound was evaluated for binding affinity against human Dopamine receptor D3 transfected in CHO cell membranes to stimulate [3H]-thymidine uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM16047((4S)-4-[(2S)-2-[(2R,4S,5S)-5-[(2S)-2-[(2S)-2-[(4S)...)
Affinity DataKi:  1.60nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
TargetD(4) dopamine receptor(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50048230(1-(1-Phenyl-1H-pyrrol-3-ylmethyl)-4-pyridin-2-yl-p...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]-YM 09151 from human Dopamine receptor D4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50260718(1-(6-(2-chlorophenyl)-5-(4-chlorophenyl)pyrazin-2-...)
Affinity DataKi:  1.66nMAssay Description:Antagonist activity at human CB1 receptor expressed in SF9 cells assessed as inhibition of CP-55940-stimulated GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50433045(CHEMBL2375964 | US8633204, 303)
Affinity DataKi:  1.70nMAssay Description:Inhibition of mouse PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50260717(1-(6-(2,4-dichlorophenyl)-5-(4-fluorophenyl)pyrazi...)
Affinity DataKi:  1.75nMAssay Description:Antagonist activity at human CB1 receptor expressed in SF9 cells assessed as inhibition of CP-55940-stimulated GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50433043(CHEMBL2375961 | US8633204, 307)
Affinity DataKi:  1.80nMAssay Description:Inhibition of mouse PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50433037(CHEMBL2375956 | US8633204, 311)
Affinity DataKi:  1.80nMAssay Description:Inhibition of mouse PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50433039(CHEMBL2375958 | US8633204, 309)
Affinity DataKi:  1.90nMAssay Description:Inhibition of mouse PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50260804(CHEMBL497556 | N-(1-(6-(3-chloropyridin-4-yl)-5-(4...)
Affinity DataKi:  1.97nMAssay Description:Antagonist activity at human CB1 receptor expressed in SF9 cells assessed as inhibition of CP-55940-stimulated GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50116095(CHEMBL293228 | [3-(2,4-Dichloro-phenyl)-2,5-dimeth...)
Affinity DataKi:  2nMAssay Description:Displacement of [125I]-sauvagine from Corticotropin releasing factor receptor 1 endogenously expressed in IMR-32 human neuroblastoma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50116123(Butyl-[3-(2,4-dichloro-phenyl)-2,5-dimethyl-2H-pyr...)
Affinity DataKi:  2nMAssay Description:Displacement of [125I]-sauvagine from Corticotropin releasing factor receptor 1 endogenously expressed in IMR-32 human neuroblastoma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50260803(1-(6-(2-chloropyridin-4-yl)-5-(4-(trifluoromethyl)...)
Affinity DataKi:  2.06nMAssay Description:Antagonist activity at rat CB1 receptor in SF9 cells assessed as inhibition of CP-55940-stimulated GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50433048(CHEMBL2375967)
Affinity DataKi:  2.20nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50433030(CHEMBL2376093)
Affinity DataKi:  2.40nMAssay Description:Inhibition of mouse PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50433045(CHEMBL2375964 | US8633204, 303)
Affinity DataKi:  2.5nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50058163(Butyl-[2,5-dimethyl-7-(2,4,6-trimethyl-phenyl)-7H-...)
Affinity DataKi:  2.70nMAssay Description:Displacement of [125I]-sauvagine from Corticotropin releasing factor receptor 1 endogenously expressed in IMR-32 human neuroblastoma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50260720(1-(5,6-bis(4-ethoxyphenyl)pyrazin-2-yl)-4-(ethylam...)
Affinity DataKi:  2.84nMAssay Description:Antagonist activity at human CB1 receptor expressed in SF9 cells assessed as inhibition of CP-55940-stimulated GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50116093(CHEMBL304335 | [3-(2,4-Dichloro-phenyl)-2,5-dimeth...)
Affinity DataKi:  3nMAssay Description:Displacement of [125I]-sauvagine from Corticotropin releasing factor receptor 1 endogenously expressed in IMR-32 human neuroblastoma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50116092(CHEMBL66054 | [2-Ethyl-5-methyl-3-(2,4,6-trimethyl...)
Affinity DataKi:  3nMAssay Description:Displacement of [125I]-sauvagine from Corticotropin releasing factor receptor 1 endogenously expressed in IMR-32 human neuroblastoma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Chlorocebus aethiops)
Neurogen

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]-YM 09151 from african moonkey Dopamine receptor D3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50116118(CHEMBL304272 | [3-(2,4-Dichloro-phenyl)-2,5-dimeth...)
Affinity DataKi:  3nMAssay Description:Displacement of [125I]-sauvagine from Corticotropin releasing factor receptor 1 endogenously expressed in IMR-32 human neuroblastoma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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