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Found 262 with Last Name = 'zrada' and Initial = 'mm'
TargetB1 bradykinin receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50156449(2-[(R)-7-Chloro-1-(naphthalene-2-sulfonyl)-3-oxo-1...)
Affinity DataKi:  0.0100nMAssay Description:Binding affinity to human Bradykinin receptor B1 over-expressed in transgenic rats was determined by ex vivo receptor occupancy assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50385312(CHEMBL2035984)
Affinity DataKi:  0.0140nMAssay Description:Displacement of [125I]CGRP from human recombinant CALCRL/RAMP1 receptor expressed in HEK293 cells after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50184069(CHEMBL207197 | N-((R)-1-((S)-6-amino-1-oxo-1-(4-(p...)
Affinity DataKi:  0.0140nMAssay Description:Displacement of [125I]CGRP from CGRP receptor in human SK-N-MC cells after 3 hrsMore data for this Ligand-Target Pair
TargetCalcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50385311(CHEMBL2035985)
Affinity DataKi:  0.0160nMAssay Description:Displacement of [125I]CGRP from human recombinant CALCRL/RAMP1 receptor expressed in HEK293 cells after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50156451(2-[(R)-7-Chloro-1-(naphthalene-2-sulfonyl)-3-oxo-1...)
Affinity DataKi:  0.0200nMAssay Description:Binding affinity to human Bradykinin receptor B1 over-expressed in transgenic rats was determined by ex vivo receptor occupancy assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50156446(CHEMBL359553 | N-{2-[4-(4,5-Dihydro-1H-imidazol-2-...)
Affinity DataKi:  0.0200nMAssay Description:Binding affinity of the [35S]- radiolabelled compound to rhesus monkey Bradykinin receptor B1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50156446(CHEMBL359553 | N-{2-[4-(4,5-Dihydro-1H-imidazol-2-...)
Affinity DataKi:  0.0200nMAssay Description:Binding affinity of the [35S]- radiolabelled compound to human Bradykinin receptor B1 over-expressed in transgenic rats was determined by ex vivo rec...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50356282(CHEMBL1910936)
Affinity DataKi:  0.0220nMAssay Description:Displacement of [125I]CGRP from human recombinant CALCRL/RAMP1 receptor expressed in HEK293 cells after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50385313(CHEMBL2035982)
Affinity DataKi:  0.0280nMAssay Description:Displacement of [125I]CGRP from human recombinant CALCRL/RAMP1 receptor expressed in HEK293 cells after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50156455((R)-N-(4-(4,5-dihydro-1H-imidazol-2-yl)phenethyl)-...)
Affinity DataKi:  0.0300nMAssay Description:Binding affinity to human Bradykinin receptor B1 over-expressed in transgenic rats was determined by ex vivo receptor occupancy assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50385314(CHEMBL2035981)
Affinity DataKi:  0.0400nMAssay Description:Displacement of [125I]CGRP from human recombinant CALCRL/RAMP1 receptor expressed in HEK293 cells after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50385309(CHEMBL2035983)
Affinity DataKi:  0.0470nMAssay Description:Displacement of [125I]CGRP from human recombinant CALCRL/RAMP1 receptor expressed in HEK293 cells after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Oryctolagus cuniculus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50156446(CHEMBL359553 | N-{2-[4-(4,5-Dihydro-1H-imidazol-2-...)
Affinity DataKi:  0.0500nMAssay Description:Binding affinity of the [35S]- radiolabelled compound to rabbit Bradykinin receptor B1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50385309(CHEMBL2035983)
Affinity DataKi:  0.0520nMAssay Description:Displacement of [125I]CGRP from CGRP receptor in human SK-N-MC cells after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50156450(2-[(R)-7-Chloro-1-(naphthalene-2-sulfonyl)-3-oxo-1...)
Affinity DataKi:  0.0700nMAssay Description:Binding affinity to human Bradykinin receptor B1 over-expressed in transgenic rats was determined by ex vivo receptor occupancy assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50156448(CHEMBL185811 | N-{2-[4-(1H-Imidazol-2-yl)-phenyl]-...)
Affinity DataKi:  0.0700nMAssay Description:Binding affinity to human Bradykinin receptor B1 over-expressed in transgenic rats was determined by ex vivo receptor occupancy assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50385310(CHEMBL2035986)
Affinity DataKi:  0.25nMAssay Description:Displacement of [125I]CGRP from human recombinant CALCRL/RAMP1 receptor expressed in HEK293 cells after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164264((S)-1-(9-Hydroxy-9H-fluorene-9-carbonyl)-pyrrolidi...)
Affinity DataKi:  0.490nMAssay Description:Inhibition of coagulation factor II (thrombin) of humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Canis familiaris)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50156446(CHEMBL359553 | N-{2-[4-(4,5-Dihydro-1H-imidazol-2-...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity of the [35S]- radiolabelled compound to dog Bradykinin receptor B1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164256((S)-1-(2-Hydroxy-2,2-diphenyl-acetyl)-pyrrolidine-...)
Affinity DataKi:  0.550nMAssay Description:Inhibition of coagulation factor II (thrombin) of humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIsoform 1 of Calcitonin receptor (1)/Receptor activity-modifying protein 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50385309(CHEMBL2035983)
Affinity DataKi:  0.640nMAssay Description:Displacement of [125I]amylin from human AMY1 receptor expressed in COS7 cells after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50156452(2-[(R)-1-(3,4-Dichloro-benzenesulfonyl)-3-oxo-1,2,...)
Affinity DataKi:  1.09nMAssay Description:Binding affinity to human Bradykinin receptor B1 over-expressed in transgenic rats was determined by ex vivo receptor occupancy assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164260((S)-1-(7-Chloro-5-hydroxy-5H-indeno[1,2-b]pyridine...)
Affinity DataKi:  1.10nMAssay Description:Inhibition of coagulation factor II (thrombin) of humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164260((S)-1-(7-Chloro-5-hydroxy-5H-indeno[1,2-b]pyridine...)
Affinity DataKi:  1.10nMAssay Description:Inhibition of coagulation factor II (thrombin) of humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164269((S)-1-(5-Hydroxy-5H-indeno[1,2-b]pyridine-5-carbon...)
Affinity DataKi:  1.40nMAssay Description:Inhibition of coagulation factor II (thrombin) of humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164269((S)-1-(5-Hydroxy-5H-indeno[1,2-b]pyridine-5-carbon...)
Affinity DataKi:  1.40nMAssay Description:Inhibition of coagulation factor II (thrombin) of humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164268((S)-1-(9-Hydroxy-9H-fluorene-9-carbonyl)-pyrrolidi...)
Affinity DataKi:  1.5nMAssay Description:Inhibition of coagulation factor II (thrombin) of humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164263((S)-1-(9-Hydroxy-9H-3-aza-fluorene-9-carbonyl)-pyr...)
Affinity DataKi:  2nMAssay Description:Inhibition of coagulation factor II (thrombin) of humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164263((S)-1-(9-Hydroxy-9H-3-aza-fluorene-9-carbonyl)-pyr...)
Affinity DataKi:  2nMAssay Description:Inhibition of coagulation factor II (thrombin) of humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164266((S)-1-(9-Hydroxy-9H-fluorene-9-carbonyl)-pyrrolidi...)
Affinity DataKi:  3.10nMAssay Description:Inhibition of coagulation factor II (thrombin) of humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164257((S)-1-(9-Hydroxy-9H-indeno[2,1-c]pyridine-9-carbon...)
Affinity DataKi:  3.20nMAssay Description:Inhibition of coagulation factor II (thrombin) of humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164257((S)-1-(9-Hydroxy-9H-indeno[2,1-c]pyridine-9-carbon...)
Affinity DataKi:  3.20nMAssay Description:Inhibition of coagulation factor II (thrombin) of humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164259((S)-1-(9-Hydroxy-9H-indeno[2,1-b]pyridine-9-carbon...)
Affinity DataKi:  3.30nMAssay Description:Inhibition of coagulation factor II (thrombin) of humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164259((S)-1-(9-Hydroxy-9H-indeno[2,1-b]pyridine-9-carbon...)
Affinity DataKi:  3.30nMAssay Description:Inhibition of coagulation factor II (thrombin) of humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164258((S)-1-(5-Hydroxy-1-oxy-5H-indeno[1,2-b]pyridine-5-...)
Affinity DataKi:  3.30nMAssay Description:Inhibition of coagulation factor II (thrombin) of humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164258((S)-1-(5-Hydroxy-1-oxy-5H-indeno[1,2-b]pyridine-5-...)
Affinity DataKi:  3.30nMAssay Description:Inhibition of coagulation factor II (thrombin) of humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50184069(CHEMBL207197 | N-((R)-1-((S)-6-amino-1-oxo-1-(4-(p...)
Affinity DataKi:  3.40nMAssay Description:Displacement of [125I]CGRP from CGRP receptor in rat spleen homogenate after 180 mins by gamma countingMore data for this Ligand-Target Pair
TargetCalcitonin gene-related peptide type 1 receptor(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50385314(CHEMBL2035981)
Affinity DataKi:  3.40nMAssay Description:Displacement of [125I]CGRP from CGRP receptor in rat brain membrane after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50156453(2-[(R)-1-(3,4-Dichloro-benzenesulfonyl)-3-oxo-1,2,...)
Affinity DataKi:  3.73nMAssay Description:Binding affinity to human Bradykinin receptor B1 over-expressed in transgenic rats was determined by ex vivo receptor occupancy assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(BOVINE)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50018739(1,3,4,5,6,11b-Hexahydro-2H-11-thia-4a-aza-benzo[a]...)
Affinity DataKi:  4.30nMAssay Description:Affinity to alpha-2 adrenergic receptor by the displacement of [3H]-clonidine from calf cerebral cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(BOVINE)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50018739(1,3,4,5,6,11b-Hexahydro-2H-11-thia-4a-aza-benzo[a]...)
Affinity DataKi:  4.30nMAssay Description:Affinity to alpha-2 adrenergic receptor by the displacement of [3H]-clonidine from calf cerebral cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164267((S)-1-(9-Hydroxy-3-oxy-9H-3-aza-fluorene-9-carbony...)
Affinity DataKi:  4.40nMAssay Description:Inhibition of coagulation factor II (thrombin) of humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164267((S)-1-(9-Hydroxy-3-oxy-9H-3-aza-fluorene-9-carbony...)
Affinity DataKi:  4.40nMAssay Description:Inhibition of coagulation factor II (thrombin) of humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50356282(CHEMBL1910936)
Affinity DataKi:  10nMAssay Description:Displacement of [125I]CGRP from CGRP receptor in rat brain membrane after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50385311(CHEMBL2035985)
Affinity DataKi:  13nMAssay Description:Displacement of [125I]CGRP from CGRP receptor in rat brain membrane after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(BOVINE)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50002151(8-Piperazin-1-yl-imidazo[1,2-a]pyrazine | CHEMBL33...)
Affinity DataKi:  15nMAssay Description:Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(BOVINE)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50018736(1,3,4,5,6,11b-Hexahydro-2H-11-oxa-4a-aza-benzo[a]f...)
Affinity DataKi:  16nMAssay Description:Affinity to alpha-1 adrenergic receptor by the displacement of [3H]-prazosin from calf cerebral cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(CALF)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50018739(1,3,4,5,6,11b-Hexahydro-2H-11-thia-4a-aza-benzo[a]...)
Affinity DataKi:  16nMAssay Description:Compound was evaluated for log 1/Ki at alpha-2 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(BOVINE)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50018736(1,3,4,5,6,11b-Hexahydro-2H-11-oxa-4a-aza-benzo[a]f...)
Affinity DataKi:  16nMAssay Description:Affinity to alpha-2 adrenergic receptor by the displacement of [3H]-clonidine from calf cerebral cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(CALF)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50018739(1,3,4,5,6,11b-Hexahydro-2H-11-thia-4a-aza-benzo[a]...)
Affinity DataKi:  16nMAssay Description:Affinity to alpha-1 adrenergic receptor by the displacement of [3H]-prazosin from calf cerebral cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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