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42 similar compounds to monomer 189080

Compile data set for download or QSAR
Wt: 366.8
BDBM153656
Wt: 357.3
BDBM153657
Wt: 347.3
BDBM116319
Wt: 430.4
BDBM188768
Wt: 373.4
BDBM188816
Wt: 473.5
BDBM188833
Wt: 426.4
BDBM188834
Wt: 452.4
BDBM188835
Wt: 501.5
BDBM189084
Wt: 410.4
BDBM189086
Wt: 395.4
BDBM188857
Wt: 395.4
BDBM188859
Wt: 399.3
BDBM188860
Wt: 411.4
BDBM188861
Wt: 413.4
BDBM188862
Displayed 1 to 15 (of 42 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 26 hits for monomerid = 153656,153657,116319,188768,188816,188833,188834,188835,189084,189086,188857,188859,188860,188861,188862   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM116319
PNG
(US8637526, 343)
Show SMILES Cc1cc(NC(=O)c2cnn3ccc(N)nc23)n(n1)-c1ccccc1C
Show InChI InChI=1S/C18H17N7O/c1-11-5-3-4-6-14(11)25-16(9-12(2)23-25)22-18(26)13-10-20-24-8-7-15(19)21-17(13)24/h3-10H,1-2H3,(H2,19,21)(H,22,26)
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US Patent
4.20 -11.3n/an/an/an/an/a7.222



Genentech Inc

US Patent


Assay Description
To determine the inhibition constants (Ki), compounds were diluted serially in DMSO and added to 50 kinase reactions containing 0.2 nM purified JAK2 ...


US Patent US8637526 (2014)


BindingDB Entry DOI: 10.7270/Q25719Q3
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM153656
PNG
(US8999998, 6)
Show SMILES Cc1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1cc(Cl)ccc1C
Show InChI InChI=1S/C18H15ClN6O/c1-11-4-5-13(19)9-15(11)25-16(8-12(2)23-25)22-18(26)14-10-21-24-7-3-6-20-17(14)24/h3-10H,1-2H3,(H,22,26)
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US Patent
4.90n/an/an/an/an/an/a7.2n/a



Genentech Inc

US Patent


Assay Description
The activity of the isolated JAK1, JAK2 or TYK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-Ala-Leu-...


US Patent US8999998 (2015)


BindingDB Entry DOI: 10.7270/Q2J67FN6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM153657
PNG
(US8999998, 38)
Show SMILES Cc1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1cc(ccc1C)C#N
Show InChI InChI=1S/C19H15N7O/c1-12-4-5-14(10-20)9-16(12)26-17(8-13(2)24-26)23-19(27)15-11-22-25-7-3-6-21-18(15)25/h3-9,11H,1-2H3,(H,23,27)
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US Patent
5.70n/an/an/an/an/an/a7.2n/a



Genentech Inc

US Patent


Assay Description
The activity of the isolated JAK1, JAK2 or TYK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-Ala-Leu-...


US Patent US8999998 (2015)


BindingDB Entry DOI: 10.7270/Q2J67FN6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM116319
PNG
(US8637526, 343)
Show SMILES Cc1cc(NC(=O)c2cnn3ccc(N)nc23)n(n1)-c1ccccc1C
Show InChI InChI=1S/C18H17N7O/c1-11-5-3-4-6-14(11)25-16(9-12(2)23-25)22-18(26)13-10-20-24-8-7-15(19)21-17(13)24/h3-10H,1-2H3,(H2,19,21)(H,22,26)
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28.6 -10.2n/an/an/an/an/a7.222



Genentech Inc

US Patent


Assay Description
To determine inhibition constants (Ki), compounds were diluted serially in DMSO and added to 50 uL kinase reactions containing 5 nM purified JAK3 enz...


US Patent US8637526 (2014)


BindingDB Entry DOI: 10.7270/Q25719Q3
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM116319
PNG
(US8637526, 343)
Show SMILES Cc1cc(NC(=O)c2cnn3ccc(N)nc23)n(n1)-c1ccccc1C
Show InChI InChI=1S/C18H17N7O/c1-11-5-3-4-6-14(11)25-16(9-12(2)23-25)22-18(26)13-10-20-24-8-7-15(19)21-17(13)24/h3-10H,1-2H3,(H2,19,21)(H,22,26)
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US Patent
29.9n/an/an/an/an/an/a7.2n/a



Genentech Inc

US Patent


Assay Description
To determine inhibition constants (Ki), compounds were diluted serially in DMSO and added to 50 uL kinase reactions containing 1.5 nM JAK1, 0.2 nM pu...


US Patent US8637526 (2014)


BindingDB Entry DOI: 10.7270/Q25719Q3
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM153657
PNG
(US8999998, 38)
Show SMILES Cc1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1cc(ccc1C)C#N
Show InChI InChI=1S/C19H15N7O/c1-12-4-5-14(10-20)9-16(12)26-17(8-13(2)24-26)23-19(27)15-11-22-25-7-3-6-21-18(15)25/h3-9,11H,1-2H3,(H,23,27)
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US Patent
40.3n/an/an/an/an/an/a7.2n/a



Genentech Inc

US Patent


Assay Description
The activity of the isolated JAK1, JAK2 or TYK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-Ala-Leu-...


US Patent US8999998 (2015)


BindingDB Entry DOI: 10.7270/Q2J67FN6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM153656
PNG
(US8999998, 6)
Show SMILES Cc1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1cc(Cl)ccc1C
Show InChI InChI=1S/C18H15ClN6O/c1-11-4-5-13(19)9-15(11)25-16(8-12(2)23-25)22-18(26)14-10-21-24-7-3-6-20-17(14)24/h3-10H,1-2H3,(H,22,26)
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US Patent
46.2n/an/an/an/an/an/a7.2n/a



Genentech Inc

US Patent


Assay Description
The activity of the isolated JAK1, JAK2 or TYK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-Ala-Leu-...


US Patent US8999998 (2015)


BindingDB Entry DOI: 10.7270/Q2J67FN6
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM116319
PNG
(US8637526, 343)
Show SMILES Cc1cc(NC(=O)c2cnn3ccc(N)nc23)n(n1)-c1ccccc1C
Show InChI InChI=1S/C18H17N7O/c1-11-5-3-4-6-14(11)25-16(9-12(2)23-25)22-18(26)13-10-20-24-8-7-15(19)21-17(13)24/h3-10H,1-2H3,(H2,19,21)(H,22,26)
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US Patent
97.6n/an/an/an/an/an/a7.2n/a



Genentech Inc

US Patent


Assay Description
To determine inhibition constants (Ki), compounds were diluted serially in DMSO and added to 50 uL kinase reactions containing 1.5 nM JAK1, 0.2 nM pu...


US Patent US8637526 (2014)


BindingDB Entry DOI: 10.7270/Q25719Q3
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM153656
PNG
(US8999998, 6)
Show SMILES Cc1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1cc(Cl)ccc1C
Show InChI InChI=1S/C18H15ClN6O/c1-11-4-5-13(19)9-15(11)25-16(8-12(2)23-25)22-18(26)14-10-21-24-7-3-6-20-17(14)24/h3-10H,1-2H3,(H,22,26)
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US Patent
99.6n/an/an/an/an/an/a7.2n/a



Genentech Inc

US Patent


Assay Description
The activity of the isolated JAK1, JAK2 or TYK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-Ala-Leu-...


US Patent US8999998 (2015)


BindingDB Entry DOI: 10.7270/Q2J67FN6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM153657
PNG
(US8999998, 38)
Show SMILES Cc1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1cc(ccc1C)C#N
Show InChI InChI=1S/C19H15N7O/c1-12-4-5-14(10-20)9-16(12)26-17(8-13(2)24-26)23-19(27)15-11-22-25-7-3-6-21-18(15)25/h3-9,11H,1-2H3,(H,23,27)
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US Patent
102n/an/an/an/an/an/a7.2n/a



Genentech Inc

US Patent


Assay Description
The activity of the isolated JAK3 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Leu-Pro-Leu-Asp-Lys-Asp-Ty...


US Patent US8999998 (2015)


BindingDB Entry DOI: 10.7270/Q2J67FN6
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM153657
PNG
(US8999998, 38)
Show SMILES Cc1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1cc(ccc1C)C#N
Show InChI InChI=1S/C19H15N7O/c1-12-4-5-14(10-20)9-16(12)26-17(8-13(2)24-26)23-19(27)15-11-22-25-7-3-6-21-18(15)25/h3-9,11H,1-2H3,(H,23,27)
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US Patent
131n/an/an/an/an/an/a7.2n/a



Genentech Inc

US Patent


Assay Description
The activity of the isolated JAK1, JAK2 or TYK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-Ala-Leu-...


US Patent US8999998 (2015)


BindingDB Entry DOI: 10.7270/Q2J67FN6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM153656
PNG
(US8999998, 6)
Show SMILES Cc1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1cc(Cl)ccc1C
Show InChI InChI=1S/C18H15ClN6O/c1-11-4-5-13(19)9-15(11)25-16(8-12(2)23-25)22-18(26)14-10-21-24-7-3-6-20-17(14)24/h3-10H,1-2H3,(H,22,26)
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US Patent
152n/an/an/an/an/an/a7.2n/a



Genentech Inc

US Patent


Assay Description
The activity of the isolated JAK3 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Leu-Pro-Leu-Asp-Lys-Asp-Ty...


US Patent US8999998 (2015)


BindingDB Entry DOI: 10.7270/Q2J67FN6
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM188859
PNG
(US9169260, 125)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)-c1ccncc1
Show InChI InChI=1S/C22H17N7O/c1-15-3-5-17(6-4-15)29-20(13-19(27-29)16-7-10-23-11-8-16)26-22(30)18-14-25-28-12-2-9-24-21(18)28/h2-14H,1H3,(H,26,30)
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Article
PubMed
n/an/a 61n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of recombinant N-terminal GST-tagged full length human IRAK4 expressed in baculovirus-infected insect Sf9 cells using 5FAM-RKRQGSVRRRVH-CO...


ACS Med Chem Lett 6: 677-82 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00106
BindingDB Entry DOI: 10.7270/Q2G73GGK
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM189086
PNG
(US9169260, 355)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)-c1ccnc(N)c1
Show InChI InChI=1S/C22H18N8O/c1-14-3-5-16(6-4-14)30-20(12-18(28-30)15-7-9-24-19(23)11-15)27-22(31)17-13-26-29-10-2-8-25-21(17)29/h2-13H,1H3,(H2,23,24)(H,27,31)
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n/an/a<100n/an/an/an/a7.2n/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...


US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM189084
PNG
(US9169260, 353)
Show SMILES CN(C)S(=O)(=O)c1ccc(cc1)-c1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1ccc(C)cc1
Show InChI InChI=1S/C25H23N7O3S/c1-17-5-9-19(10-6-17)32-23(28-25(33)21-16-27-31-14-4-13-26-24(21)31)15-22(29-32)18-7-11-20(12-8-18)36(34,35)30(2)3/h4-16H,1-3H3,(H,28,33)
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n/an/a<100n/an/an/an/a7.2n/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...


US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM188862
PNG
(US9169260, 128)
Show SMILES Cc1ccc(cc1F)-n1nc(cc1NC(=O)c1cnn2cccnc12)-c1ccncc1
Show InChI InChI=1S/C22H16FN7O/c1-14-3-4-16(11-18(14)23)30-20(12-19(28-30)15-5-8-24-9-6-15)27-22(31)17-13-26-29-10-2-7-25-21(17)29/h2-13H,1H3,(H,27,31)
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n/an/a<1.00E+3n/an/an/an/a7.2n/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...


US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM188861
PNG
(US9169260, 127)
Show SMILES COc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)-c1ccncc1
Show InChI InChI=1S/C22H17N7O2/c1-31-17-5-3-16(4-6-17)29-20(13-19(27-29)15-7-10-23-11-8-15)26-22(30)18-14-25-28-12-2-9-24-21(18)28/h2-14H,1H3,(H,26,30)
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n/an/a<1.00E+3n/an/an/an/a7.2n/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...


US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM188860
PNG
(US9169260, 126)
Show SMILES Fc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)-c1ccncc1
Show InChI InChI=1S/C21H14FN7O/c22-15-2-4-16(5-3-15)29-19(12-18(27-29)14-6-9-23-10-7-14)26-21(30)17-13-25-28-11-1-8-24-20(17)28/h1-13H,(H,26,30)
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n/an/a<1.00E+3n/an/an/an/a7.2n/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...


US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM188859
PNG
(US9169260, 125)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)-c1ccncc1
Show InChI InChI=1S/C22H17N7O/c1-15-3-5-17(6-4-15)29-20(13-19(27-29)16-7-10-23-11-8-16)26-22(30)18-14-25-28-12-2-9-24-21(18)28/h2-14H,1H3,(H,26,30)
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n/an/a<100n/an/an/an/a7.2n/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...


US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM188857
PNG
(US9169260, 123)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)-c1cccnc1
Show InChI InChI=1S/C22H17N7O/c1-15-5-7-17(8-6-15)29-20(12-19(27-29)16-4-2-9-23-13-16)26-22(30)18-14-25-28-11-3-10-24-21(18)28/h2-14H,1H3,(H,26,30)
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US Patent
n/an/a<100n/an/an/an/a7.2n/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...


US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM188835
PNG
(US9169260, 101)
Show SMILES Cc1ccc(cc1)-c1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1ccc(cc1F)C1CC1
Show InChI InChI=1S/C26H21FN6O/c1-16-3-5-18(6-4-16)22-14-24(30-26(34)20-15-29-32-12-2-11-28-25(20)32)33(31-22)23-10-9-19(13-21(23)27)17-7-8-17/h2-6,9-15,17H,7-8H2,1H3,(H,30,34)
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US Patent
n/an/a<100n/an/an/an/a7.2n/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...


US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM188834
PNG
(US9169260, 100)
Show SMILES Cc1ccc(cc1)-c1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1ccc(C)cc1F
Show InChI InChI=1S/C24H19FN6O/c1-15-4-7-17(8-5-15)20-13-22(31(29-20)21-9-6-16(2)12-19(21)25)28-24(32)18-14-27-30-11-3-10-26-23(18)30/h3-14H,1-2H3,(H,28,32)
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US Patent
n/an/a<100n/an/an/an/a7.2n/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...


US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM188833
PNG
(US9169260, 99)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)-c1ccc(NS(=O)=O)cc1
Show InChI InChI=1S/C23H19N7O3S/c1-15-3-9-18(10-4-15)30-21(26-23(31)19-14-25-29-12-2-11-24-22(19)29)13-20(27-30)16-5-7-17(8-6-16)28-34(32)33/h2-14,34H,1H3,(H,26,31)(H,28,32,33)
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US Patent
n/an/a<100n/an/an/an/a7.2n/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...


US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM188816
PNG
(US9169260, 82)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CNC1
Show InChI InChI=1S/C20H19N7O/c1-13-3-5-15(6-4-13)27-18(9-17(25-27)14-10-21-11-14)24-20(28)16-12-23-26-8-2-7-22-19(16)26/h2-9,12,14,21H,10-11H2,1H3,(H,24,28)
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US Patent
n/an/a>1.00E+3n/an/an/an/a7.2n/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...


US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM188857
PNG
(US9169260, 123)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)-c1cccnc1
Show InChI InChI=1S/C22H17N7O/c1-15-5-7-17(8-6-15)29-20(12-19(27-29)16-4-2-9-23-13-16)26-22(30)18-14-25-28-11-3-10-24-21(18)28/h2-14H,1H3,(H,26,30)
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Article
PubMed
n/an/a 99n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of recombinant N-terminal GST-tagged full length human IRAK4 expressed in baculovirus-infected insect Sf9 cells using 5FAM-RKRQGSVRRRVH-CO...


ACS Med Chem Lett 6: 677-82 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00106
BindingDB Entry DOI: 10.7270/Q2G73GGK
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM188768
PNG
(US9169260, 34)
Show SMILES Cc1ccc(cc1)-c1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1ccc(F)cc1F
Show InChI InChI=1S/C23H16F2N6O/c1-14-3-5-15(6-4-14)19-12-21(31(29-19)20-8-7-16(24)11-18(20)25)28-23(32)17-13-27-30-10-2-9-26-22(17)30/h2-13H,1H3,(H,28,32)
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US Patent
n/an/a<100n/an/an/an/a7.2n/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...


US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair