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82 molecules are shown

Compile data set for download or QSAR
Wt: 473.9
BDBM119245
Wt: 457.4
BDBM119246
Wt: 487.9
BDBM119248
Wt: 455.9
BDBM119249
Wt: 457.4
BDBM119250
Wt: 475.4
BDBM119251
Wt: 439.4
BDBM119252
Wt: 475.4
BDBM119253
Wt: 473.9
BDBM119254
Wt: 457.4
BDBM119255
Wt: 453.5
BDBM119256
Wt: 464.4
BDBM119257
Wt: 446.4
BDBM119258
Wt: 453.5
BDBM119262
Wt: 469.5
BDBM119264
<<  First   |  Previous   |  Displayed 16 to 30 (of 82 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 67 hits for monomerid = 119245,119246,119248,119249,119250,119251,119252,119253,119254,119255,119256,119257,119258,119262,119264   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM119245
PNG
(US8673906, 3.05 | US9718800, 3.05)
Show SMILES CC(Nc1ccc(F)c(Cl)c1)c1cc(cc2c1oc(cc2=O)N1CCOCC1)C(=O)N(C)C
Show InChI InChI=1S/C24H25ClFN3O4/c1-14(27-16-4-5-20(26)19(25)12-16)17-10-15(24(31)28(2)3)11-18-21(30)13-22(33-23(17)18)29-6-8-32-9-7-29/h4-5,10-14,27H,6-9H2,1-3H3
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n/an/a 6n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
The inhibition of PI3Kβ, PI3Kα, PI3Kγ and PI3Kδ was evaluated in a Kinase Glo based enzyme activity assay using human recombinant...


US Patent US8673906 (2014)


BindingDB Entry DOI: 10.7270/Q2280682
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM119246
PNG
(US8673906, 3.06 | US9718800, 3.06)
Show SMILES CC(Nc1cc(F)cc(F)c1)c1cc(cc2c1oc(cc2=O)N1CCOCC1)C(=O)N(C)C
Show InChI InChI=1S/C24H25F2N3O4/c1-14(27-18-11-16(25)10-17(26)12-18)19-8-15(24(31)28(2)3)9-20-21(30)13-22(33-23(19)20)29-4-6-32-7-5-29/h8-14,27H,4-7H2,1-3H3
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AstraZeneca AB

US Patent


Assay Description
The inhibition of PI3Kβ, PI3Kα, PI3Kγ and PI3Kδ was evaluated in a Kinase Glo based enzyme activity assay using human recombinant...


US Patent US8673906 (2014)


BindingDB Entry DOI: 10.7270/Q2280682
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM119248
PNG
(US8673906, 3.08 | US9718800, 3.08)
Show SMILES CC(N(C)c1ccc(F)c(Cl)c1)c1cc(cc2c1oc(cc2=O)N1CCOCC1)C(=O)N(C)C
Show InChI InChI=1S/C25H27ClFN3O4/c1-15(29(4)17-5-6-21(27)20(26)13-17)18-11-16(25(32)28(2)3)12-19-22(31)14-23(34-24(18)19)30-7-9-33-10-8-30/h5-6,11-15H,7-10H2,1-4H3
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AstraZeneca AB

US Patent


Assay Description
The inhibition of PI3Kβ, PI3Kα, PI3Kγ and PI3Kδ was evaluated in a Kinase Glo based enzyme activity assay using human recombinant...


US Patent US8673906 (2014)


BindingDB Entry DOI: 10.7270/Q2280682
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM119249
PNG
(US8673906, 3.09 | US9718800, 3.09)
Show SMILES CC(Nc1cccc(Cl)c1)c1cc(cc2c1oc(cc2=O)N1CCOCC1)C(=O)N(C)C
Show InChI InChI=1S/C24H26ClN3O4/c1-15(26-18-6-4-5-17(25)13-18)19-11-16(24(30)27(2)3)12-20-21(29)14-22(32-23(19)20)28-7-9-31-10-8-28/h4-6,11-15,26H,7-10H2,1-3H3
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n/an/a 4n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
The inhibition of PI3Kβ, PI3Kα, PI3Kγ and PI3Kδ was evaluated in a Kinase Glo based enzyme activity assay using human recombinant...


US Patent US8673906 (2014)


BindingDB Entry DOI: 10.7270/Q2280682
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM119250
PNG
(US8673906, 3.1 | US9718800, 3.10)
Show SMILES CC(Nc1cccc(F)c1F)c1cc(cc2c1oc(cc2=O)N1CCOCC1)C(=O)N(C)C
Show InChI InChI=1S/C24H25F2N3O4/c1-14(27-19-6-4-5-18(25)22(19)26)16-11-15(24(31)28(2)3)12-17-20(30)13-21(33-23(16)17)29-7-9-32-10-8-29/h4-6,11-14,27H,7-10H2,1-3H3
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AstraZeneca AB

US Patent


Assay Description
The inhibition of PI3Kβ, PI3Kα, PI3Kγ and PI3Kδ was evaluated in a Kinase Glo based enzyme activity assay using human recombinant...


US Patent US8673906 (2014)


BindingDB Entry DOI: 10.7270/Q2280682
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM119251
PNG
(US8673906, 3.11 | US8673906, 8.02 | US9718800, 8.0...)
Show SMILES CC(Nc1cc(F)c(F)c(F)c1)c1cc(cc2c1oc(cc2=O)N1CCOCC1)C(=O)N(C)C
Show InChI InChI=1S/C24H24F3N3O4/c1-13(28-15-10-18(25)22(27)19(26)11-15)16-8-14(24(32)29(2)3)9-17-20(31)12-21(34-23(16)17)30-4-6-33-7-5-30/h8-13,28H,4-7H2,1-3H3
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n/an/a 4n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
The inhibition of PI3Kβ, PI3Kα, PI3Kγ and PI3Kδ was evaluated in a Kinase Glo based enzyme activity assay using human recombinant...


US Patent US8673906 (2014)


BindingDB Entry DOI: 10.7270/Q2280682
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM119252
PNG
(US8673906, 3.12 | US9718800, 3.12)
Show SMILES CC(Nc1cccc(F)c1)c1cc(cc2c1oc(cc2=O)N1CCOCC1)C(=O)N(C)C
Show InChI InChI=1S/C24H26FN3O4/c1-15(26-18-6-4-5-17(25)13-18)19-11-16(24(30)27(2)3)12-20-21(29)14-22(32-23(19)20)28-7-9-31-10-8-28/h4-6,11-15,26H,7-10H2,1-3H3
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n/an/a 7n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
The inhibition of PI3Kβ, PI3Kα, PI3Kγ and PI3Kδ was evaluated in a Kinase Glo based enzyme activity assay using human recombinant...


US Patent US8673906 (2014)


BindingDB Entry DOI: 10.7270/Q2280682
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM119252
PNG
(US8673906, 3.12 | US9718800, 3.12)
Show SMILES CC(Nc1cccc(F)c1)c1cc(cc2c1oc(cc2=O)N1CCOCC1)C(=O)N(C)C
Show InChI InChI=1S/C24H26FN3O4/c1-15(26-18-6-4-5-17(25)13-18)19-11-16(24(30)27(2)3)12-20-21(29)14-22(32-23(19)20)28-7-9-31-10-8-28/h4-6,11-15,26H,7-10H2,1-3H3
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AstraZeneca AB

US Patent


Assay Description
The inhibition of PI3Kβ, PI3Kα, PI3Kγ and PI3Kδ was evaluated in a Kinase Glo based enzyme activity assay using human recombinant...


US Patent US8673906 (2014)


BindingDB Entry DOI: 10.7270/Q2280682
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM119253
PNG
(US8673906, 3.13 | US9718800, 3.13)
Show SMILES CC(Nc1cc(F)cc(F)c1F)c1cc(cc2c1oc(cc2=O)N1CCOCC1)C(=O)N(C)C
Show InChI InChI=1S/C24H24F3N3O4/c1-13(28-19-11-15(25)10-18(26)22(19)27)16-8-14(24(32)29(2)3)9-17-20(31)12-21(34-23(16)17)30-4-6-33-7-5-30/h8-13,28H,4-7H2,1-3H3
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n/an/a 6n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
The inhibition of PI3Kβ, PI3Kα, PI3Kγ and PI3Kδ was evaluated in a Kinase Glo based enzyme activity assay using human recombinant...


US Patent US8673906 (2014)


BindingDB Entry DOI: 10.7270/Q2280682
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM119254
PNG
(US8673906, 3.14 | US8673906, 8 | US9718800, 8.0)
Show SMILES CC(Nc1cc(F)cc(Cl)c1)c1cc(cc2c1oc(cc2=O)N1CCOCC1)C(=O)N(C)C
Show InChI InChI=1S/C24H25ClFN3O4/c1-14(27-18-11-16(25)10-17(26)12-18)19-8-15(24(31)28(2)3)9-20-21(30)13-22(33-23(19)20)29-4-6-32-7-5-29/h8-14,27H,4-7H2,1-3H3
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n/an/a 4n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
The inhibition of PI3Kβ, PI3Kα, PI3Kγ and PI3Kδ was evaluated in a Kinase Glo based enzyme activity assay using human recombinant...


US Patent US8673906 (2014)


BindingDB Entry DOI: 10.7270/Q2280682
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM119255
PNG
(US8673906, 3.15 | US9718800, 3.15)
Show SMILES CC(Nc1cc(F)ccc1F)c1cc(cc2c1oc(cc2=O)N1CCOCC1)C(=O)N(C)C
Show InChI InChI=1S/C24H25F2N3O4/c1-14(27-20-12-16(25)4-5-19(20)26)17-10-15(24(31)28(2)3)11-18-21(30)13-22(33-23(17)18)29-6-8-32-9-7-29/h4-5,10-14,27H,6-9H2,1-3H3
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n/an/a 10n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
The inhibition of PI3Kβ, PI3Kα, PI3Kγ and PI3Kδ was evaluated in a Kinase Glo based enzyme activity assay using human recombinant...


US Patent US8673906 (2014)


BindingDB Entry DOI: 10.7270/Q2280682
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM119256
PNG
(US8673906, 3.16 | US9718800, 3.16)
Show SMILES CC(Nc1cc(C)cc(F)c1)c1cc(cc2c1oc(cc2=O)N1CCOCC1)C(=O)N(C)C
Show InChI InChI=1S/C25H28FN3O4/c1-15-9-18(26)13-19(10-15)27-16(2)20-11-17(25(31)28(3)4)12-21-22(30)14-23(33-24(20)21)29-5-7-32-8-6-29/h9-14,16,27H,5-8H2,1-4H3
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n/an/a 5n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
The inhibition of PI3Kβ, PI3Kα, PI3Kγ and PI3Kδ was evaluated in a Kinase Glo based enzyme activity assay using human recombinant...


US Patent US8673906 (2014)


BindingDB Entry DOI: 10.7270/Q2280682
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM119257
PNG
(US8673906, 3.17 | US8673906, 8.01 | US9718800, 8.0...)
Show SMILES CC(Nc1cc(F)cc(c1)C#N)c1cc(cc2c1oc(cc2=O)N1CCOCC1)C(=O)N(C)C
Show InChI InChI=1S/C25H25FN4O4/c1-15(28-19-9-16(14-27)8-18(26)12-19)20-10-17(25(32)29(2)3)11-21-22(31)13-23(34-24(20)21)30-4-6-33-7-5-30/h8-13,15,28H,4-7H2,1-3H3
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AstraZeneca AB

US Patent


Assay Description
The inhibition of PI3Kβ, PI3Kα, PI3Kγ and PI3Kδ was evaluated in a Kinase Glo based enzyme activity assay using human recombinant...


US Patent US8673906 (2014)


BindingDB Entry DOI: 10.7270/Q2280682
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM119258
PNG
(US8673906, 3.18 | US9718800, 3.18)
Show SMILES CC(Nc1cccc(c1)C#N)c1cc(cc2c1oc(cc2=O)N1CCOCC1)C(=O)N(C)C
Show InChI InChI=1S/C25H26N4O4/c1-16(27-19-6-4-5-17(11-19)15-26)20-12-18(25(31)28(2)3)13-21-22(30)14-23(33-24(20)21)29-7-9-32-10-8-29/h4-6,11-14,16,27H,7-10H2,1-3H3
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n/an/a 10n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
The inhibition of PI3Kβ, PI3Kα, PI3Kγ and PI3Kδ was evaluated in a Kinase Glo based enzyme activity assay using human recombinant...


US Patent US8673906 (2014)


BindingDB Entry DOI: 10.7270/Q2280682
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM119262
PNG
(US8673906, 3.22 | US9718800, 3.22)
Show SMILES CC(Nc1cc(F)ccc1C)c1cc(cc2c1oc(cc2=O)N1CCOCC1)C(=O)N(C)C
Show InChI InChI=1S/C25H28FN3O4/c1-15-5-6-18(26)13-21(15)27-16(2)19-11-17(25(31)28(3)4)12-20-22(30)14-23(33-24(19)20)29-7-9-32-10-8-29/h5-6,11-14,16,27H,7-10H2,1-4H3
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AstraZeneca AB

US Patent


Assay Description
The inhibition of PI3Kβ, PI3Kα, PI3Kγ and PI3Kδ was evaluated in a Kinase Glo based enzyme activity assay using human recombinant...


US Patent US8673906 (2014)


BindingDB Entry DOI: 10.7270/Q2280682
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM119264
PNG
(US8673906, 3.24 | US9718800, 3.24)
Show SMILES COc1ccc(F)cc1NC(C)c1cc(cc2c1oc(cc2=O)N1CCOCC1)C(=O)N(C)C
Show InChI InChI=1S/C25H28FN3O5/c1-15(27-20-13-17(26)5-6-22(20)32-4)18-11-16(25(31)28(2)3)12-19-21(30)14-23(34-24(18)19)29-7-9-33-10-8-29/h5-6,11-15,27H,7-10H2,1-4H3
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AstraZeneca AB

US Patent


Assay Description
The inhibition of PI3Kβ, PI3Kα, PI3Kγ and PI3Kδ was evaluated in a Kinase Glo based enzyme activity assay using human recombinant...


US Patent US8673906 (2014)


BindingDB Entry DOI: 10.7270/Q2280682
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM119254
PNG
(US8673906, 3.14 | US8673906, 8 | US9718800, 8.0)
Show SMILES CC(Nc1cc(F)cc(Cl)c1)c1cc(cc2c1oc(cc2=O)N1CCOCC1)C(=O)N(C)C
Show InChI InChI=1S/C24H25ClFN3O4/c1-14(27-18-11-16(25)10-17(26)12-18)19-8-15(24(31)28(2)3)9-20-21(30)13-22(33-23(19)20)29-4-6-32-7-5-29/h8-14,27H,4-7H2,1-3H3
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n/an/a 3n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
The inhibition of PI3Kβ, PI3Kα, PI3Kγ and PI3Kδ was evaluated in a Kinase Glo based enzyme activity assay using human recombinant...


US Patent US8673906 (2014)


BindingDB Entry DOI: 10.7270/Q2280682
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM119257
PNG
(US8673906, 3.17 | US8673906, 8.01 | US9718800, 8.0...)
Show SMILES CC(Nc1cc(F)cc(c1)C#N)c1cc(cc2c1oc(cc2=O)N1CCOCC1)C(=O)N(C)C
Show InChI InChI=1S/C25H25FN4O4/c1-15(28-19-9-16(14-27)8-18(26)12-19)20-10-17(25(32)29(2)3)11-21-22(31)13-23(34-24(20)21)30-4-6-33-7-5-30/h8-13,15,28H,4-7H2,1-3H3
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n/an/a 5n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
The inhibition of PI3Kβ, PI3Kα, PI3Kγ and PI3Kδ was evaluated in a Kinase Glo based enzyme activity assay using human recombinant...


US Patent US8673906 (2014)


BindingDB Entry DOI: 10.7270/Q2280682
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM119251
PNG
(US8673906, 3.11 | US8673906, 8.02 | US9718800, 8.0...)
Show SMILES CC(Nc1cc(F)c(F)c(F)c1)c1cc(cc2c1oc(cc2=O)N1CCOCC1)C(=O)N(C)C
Show InChI InChI=1S/C24H24F3N3O4/c1-13(28-15-10-18(25)22(27)19(26)11-15)16-8-14(24(32)29(2)3)9-17-20(31)12-21(34-23(16)17)30-4-6-33-7-5-30/h8-13,28H,4-7H2,1-3H3
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n/an/a 2n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
The inhibition of PI3Kβ, PI3Kα, PI3Kγ and PI3Kδ was evaluated in a Kinase Glo based enzyme activity assay using human recombinant...


US Patent US8673906 (2014)


BindingDB Entry DOI: 10.7270/Q2280682
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM119252
PNG
(US8673906, 3.12 | US9718800, 3.12)
Show SMILES CC(Nc1cccc(F)c1)c1cc(cc2c1oc(cc2=O)N1CCOCC1)C(=O)N(C)C
Show InChI InChI=1S/C24H26FN3O4/c1-15(26-18-6-4-5-17(25)13-18)19-11-16(24(30)27(2)3)12-20-21(29)14-22(32-23(19)20)28-7-9-31-10-8-28/h4-6,11-15,26H,7-10H2,1-3H3
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n/an/a 2.60E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PI3Kgamma using PIP2 by Kinase-Glo Plus assay


J Med Chem 58: 943-62 (2015)


Article DOI: 10.1021/jm501629p
BindingDB Entry DOI: 10.7270/Q2VT1TS8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM119249
PNG
(US8673906, 3.09 | US9718800, 3.09)
Show SMILES CC(Nc1cccc(Cl)c1)c1cc(cc2c1oc(cc2=O)N1CCOCC1)C(=O)N(C)C
Show InChI InChI=1S/C24H26ClN3O4/c1-15(26-18-6-4-5-17(25)13-18)19-11-16(24(30)27(2)3)12-20-21(29)14-22(32-23(19)20)28-7-9-31-10-8-28/h4-6,11-15,26H,7-10H2,1-3H3
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n/an/a 700n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PI3Kgamma using PIP2 by Kinase-Glo Plus assay


J Med Chem 58: 943-62 (2015)


Article DOI: 10.1021/jm501629p
BindingDB Entry DOI: 10.7270/Q2VT1TS8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM119250
PNG
(US8673906, 3.1 | US9718800, 3.10)
Show SMILES CC(Nc1cccc(F)c1F)c1cc(cc2c1oc(cc2=O)N1CCOCC1)C(=O)N(C)C
Show InChI InChI=1S/C24H25F2N3O4/c1-14(27-19-6-4-5-18(25)22(19)26)16-11-15(24(31)28(2)3)12-17-20(30)13-21(33-23(16)17)29-7-9-32-10-8-29/h4-6,11-14,27H,7-10H2,1-3H3
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n/an/a 4.20E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PI3Kgamma using PIP2 by Kinase-Glo Plus assay


J Med Chem 58: 943-62 (2015)


Article DOI: 10.1021/jm501629p
BindingDB Entry DOI: 10.7270/Q2VT1TS8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM119255
PNG
(US8673906, 3.15 | US9718800, 3.15)
Show SMILES CC(Nc1cc(F)ccc1F)c1cc(cc2c1oc(cc2=O)N1CCOCC1)C(=O)N(C)C
Show InChI InChI=1S/C24H25F2N3O4/c1-14(27-20-12-16(25)4-5-19(20)26)17-10-15(24(31)28(2)3)11-18-21(30)13-22(33-23(17)18)29-6-8-32-9-7-29/h4-5,10-14,27H,6-9H2,1-3H3
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n/an/a 6.00E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PI3Kgamma using PIP2 by Kinase-Glo Plus assay


J Med Chem 58: 943-62 (2015)


Article DOI: 10.1021/jm501629p
BindingDB Entry DOI: 10.7270/Q2VT1TS8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM119245
PNG
(US8673906, 3.05 | US9718800, 3.05)
Show SMILES CC(Nc1ccc(F)c(Cl)c1)c1cc(cc2c1oc(cc2=O)N1CCOCC1)C(=O)N(C)C
Show InChI InChI=1S/C24H25ClFN3O4/c1-14(27-16-4-5-20(26)19(25)12-16)17-10-15(24(31)28(2)3)11-18-21(30)13-22(33-23(17)18)29-6-8-32-9-7-29/h4-5,10-14,27H,6-9H2,1-3H3
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n/an/a 1.80E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PI3Kgamma using PIP2 by Kinase-Glo Plus assay


J Med Chem 58: 943-62 (2015)


Article DOI: 10.1021/jm501629p
BindingDB Entry DOI: 10.7270/Q2VT1TS8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM119256
PNG
(US8673906, 3.16 | US9718800, 3.16)
Show SMILES CC(Nc1cc(C)cc(F)c1)c1cc(cc2c1oc(cc2=O)N1CCOCC1)C(=O)N(C)C
Show InChI InChI=1S/C25H28FN3O4/c1-15-9-18(26)13-19(10-15)27-16(2)20-11-17(25(31)28(3)4)12-21-22(30)14-23(33-24(20)21)29-5-7-32-8-6-29/h9-14,16,27H,5-8H2,1-4H3
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n/an/a 2.20E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PI3Kgamma using PIP2 by Kinase-Glo Plus assay


J Med Chem 58: 943-62 (2015)


Article DOI: 10.1021/jm501629p
BindingDB Entry DOI: 10.7270/Q2VT1TS8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM119252
PNG
(US8673906, 3.12 | US9718800, 3.12)
Show SMILES CC(Nc1cccc(F)c1)c1cc(cc2c1oc(cc2=O)N1CCOCC1)C(=O)N(C)C
Show InChI InChI=1S/C24H26FN3O4/c1-15(26-18-6-4-5-17(25)13-18)19-11-16(24(30)27(2)3)12-20-21(29)14-22(32-23(19)20)28-7-9-31-10-8-28/h4-6,11-15,26H,7-10H2,1-3H3
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n/an/a 73n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PI3Kdelta using PIP2 by Kinase-Glo Plus assay


J Med Chem 58: 943-62 (2015)


Article DOI: 10.1021/jm501629p
BindingDB Entry DOI: 10.7270/Q2VT1TS8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM119249
PNG
(US8673906, 3.09 | US9718800, 3.09)
Show SMILES CC(Nc1cccc(Cl)c1)c1cc(cc2c1oc(cc2=O)N1CCOCC1)C(=O)N(C)C
Show InChI InChI=1S/C24H26ClN3O4/c1-15(26-18-6-4-5-17(25)13-18)19-11-16(24(30)27(2)3)12-20-21(29)14-22(32-23(19)20)28-7-9-31-10-8-28/h4-6,11-15,26H,7-10H2,1-3H3
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n/an/a 73n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PI3Kdelta using PIP2 by Kinase-Glo Plus assay


J Med Chem 58: 943-62 (2015)


Article DOI: 10.1021/jm501629p
BindingDB Entry DOI: 10.7270/Q2VT1TS8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM119250
PNG
(US8673906, 3.1 | US9718800, 3.10)
Show SMILES CC(Nc1cccc(F)c1F)c1cc(cc2c1oc(cc2=O)N1CCOCC1)C(=O)N(C)C
Show InChI InChI=1S/C24H25F2N3O4/c1-14(27-19-6-4-5-18(25)22(19)26)16-11-15(24(31)28(2)3)12-17-20(30)13-21(33-23(16)17)29-7-9-32-10-8-29/h4-6,11-14,27H,7-10H2,1-3H3
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n/an/a 76n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PI3Kdelta using PIP2 by Kinase-Glo Plus assay


J Med Chem 58: 943-62 (2015)


Article DOI: 10.1021/jm501629p
BindingDB Entry DOI: 10.7270/Q2VT1TS8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM119255
PNG
(US8673906, 3.15 | US9718800, 3.15)
Show SMILES CC(Nc1cc(F)ccc1F)c1cc(cc2c1oc(cc2=O)N1CCOCC1)C(=O)N(C)C
Show InChI InChI=1S/C24H25F2N3O4/c1-14(27-20-12-16(25)4-5-19(20)26)17-10-15(24(31)28(2)3)11-18-21(30)13-22(33-23(17)18)29-6-8-32-9-7-29/h4-5,10-14,27H,6-9H2,1-3H3
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n/an/a 150n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PI3Kdelta using PIP2 by Kinase-Glo Plus assay


J Med Chem 58: 943-62 (2015)


Article DOI: 10.1021/jm501629p
BindingDB Entry DOI: 10.7270/Q2VT1TS8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM119245
PNG
(US8673906, 3.05 | US9718800, 3.05)
Show SMILES CC(Nc1ccc(F)c(Cl)c1)c1cc(cc2c1oc(cc2=O)N1CCOCC1)C(=O)N(C)C
Show InChI InChI=1S/C24H25ClFN3O4/c1-14(27-16-4-5-20(26)19(25)12-16)17-10-15(24(31)28(2)3)11-18-21(30)13-22(33-23(17)18)29-6-8-32-9-7-29/h4-5,10-14,27H,6-9H2,1-3H3
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n/an/a 64n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PI3Kdelta using PIP2 by Kinase-Glo Plus assay


J Med Chem 58: 943-62 (2015)


Article DOI: 10.1021/jm501629p
BindingDB Entry DOI: 10.7270/Q2VT1TS8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM119256
PNG
(US8673906, 3.16 | US9718800, 3.16)
Show SMILES CC(Nc1cc(C)cc(F)c1)c1cc(cc2c1oc(cc2=O)N1CCOCC1)C(=O)N(C)C
Show InChI InChI=1S/C25H28FN3O4/c1-15-9-18(26)13-19(10-15)27-16(2)20-11-17(25(31)28(3)4)12-21-22(30)14-23(33-24(20)21)29-5-7-32-8-6-29/h9-14,16,27H,5-8H2,1-4H3
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n/an/a 110n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PI3Kdelta using PIP2 by Kinase-Glo Plus assay


J Med Chem 58: 943-62 (2015)


Article DOI: 10.1021/jm501629p
BindingDB Entry DOI: 10.7270/Q2VT1TS8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM119252
PNG
(US8673906, 3.12 | US9718800, 3.12)
Show SMILES CC(Nc1cccc(F)c1)c1cc(cc2c1oc(cc2=O)N1CCOCC1)C(=O)N(C)C
Show InChI InChI=1S/C24H26FN3O4/c1-15(26-18-6-4-5-17(25)13-18)19-11-16(24(30)27(2)3)12-20-21(29)14-22(32-23(19)20)28-7-9-31-10-8-28/h4-6,11-15,26H,7-10H2,1-3H3
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n/an/a 32n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PI3Kbeta in PTEN-null human MDA-MB-468 cells assessed as inhibition of Akt phosphorylation after 2 hrs


J Med Chem 58: 943-62 (2015)


Article DOI: 10.1021/jm501629p
BindingDB Entry DOI: 10.7270/Q2VT1TS8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM119249
PNG
(US8673906, 3.09 | US9718800, 3.09)
Show SMILES CC(Nc1cccc(Cl)c1)c1cc(cc2c1oc(cc2=O)N1CCOCC1)C(=O)N(C)C
Show InChI InChI=1S/C24H26ClN3O4/c1-15(26-18-6-4-5-17(25)13-18)19-11-16(24(30)27(2)3)12-20-21(29)14-22(32-23(19)20)28-7-9-31-10-8-28/h4-6,11-15,26H,7-10H2,1-3H3
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n/an/a 9n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PI3Kbeta in PTEN-null human MDA-MB-468 cells assessed as inhibition of Akt phosphorylation after 2 hrs


J Med Chem 58: 943-62 (2015)


Article DOI: 10.1021/jm501629p
BindingDB Entry DOI: 10.7270/Q2VT1TS8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM119250
PNG
(US8673906, 3.1 | US9718800, 3.10)
Show SMILES CC(Nc1cccc(F)c1F)c1cc(cc2c1oc(cc2=O)N1CCOCC1)C(=O)N(C)C
Show InChI InChI=1S/C24H25F2N3O4/c1-14(27-19-6-4-5-18(25)22(19)26)16-11-15(24(31)28(2)3)12-17-20(30)13-21(33-23(16)17)29-7-9-32-10-8-29/h4-6,11-14,27H,7-10H2,1-3H3
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n/an/a 24n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PI3Kbeta in PTEN-null human MDA-MB-468 cells assessed as inhibition of Akt phosphorylation after 2 hrs


J Med Chem 58: 943-62 (2015)


Article DOI: 10.1021/jm501629p
BindingDB Entry DOI: 10.7270/Q2VT1TS8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM119255
PNG
(US8673906, 3.15 | US9718800, 3.15)
Show SMILES CC(Nc1cc(F)ccc1F)c1cc(cc2c1oc(cc2=O)N1CCOCC1)C(=O)N(C)C
Show InChI InChI=1S/C24H25F2N3O4/c1-14(27-20-12-16(25)4-5-19(20)26)17-10-15(24(31)28(2)3)11-18-21(30)13-22(33-23(17)18)29-6-8-32-9-7-29/h4-5,10-14,27H,6-9H2,1-3H3
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n/an/a 60n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PI3Kbeta in PTEN-null human MDA-MB-468 cells assessed as inhibition of Akt phosphorylation after 2 hrs


J Med Chem 58: 943-62 (2015)


Article DOI: 10.1021/jm501629p
BindingDB Entry DOI: 10.7270/Q2VT1TS8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM119245
PNG
(US8673906, 3.05 | US9718800, 3.05)
Show SMILES CC(Nc1ccc(F)c(Cl)c1)c1cc(cc2c1oc(cc2=O)N1CCOCC1)C(=O)N(C)C
Show InChI InChI=1S/C24H25ClFN3O4/c1-14(27-16-4-5-20(26)19(25)12-16)17-10-15(24(31)28(2)3)11-18-21(30)13-22(33-23(17)18)29-6-8-32-9-7-29/h4-5,10-14,27H,6-9H2,1-3H3
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n/an/a 16n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PI3Kbeta in PTEN-null human MDA-MB-468 cells assessed as inhibition of Akt phosphorylation after 2 hrs


J Med Chem 58: 943-62 (2015)


Article DOI: 10.1021/jm501629p
BindingDB Entry DOI: 10.7270/Q2VT1TS8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM119256
PNG
(US8673906, 3.16 | US9718800, 3.16)
Show SMILES CC(Nc1cc(C)cc(F)c1)c1cc(cc2c1oc(cc2=O)N1CCOCC1)C(=O)N(C)C
Show InChI InChI=1S/C25H28FN3O4/c1-15-9-18(26)13-19(10-15)27-16(2)20-11-17(25(31)28(3)4)12-21-22(30)14-23(33-24(20)21)29-5-7-32-8-6-29/h9-14,16,27H,5-8H2,1-4H3
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n/an/a 49n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PI3Kbeta in PTEN-null human MDA-MB-468 cells assessed as inhibition of Akt phosphorylation after 2 hrs


J Med Chem 58: 943-62 (2015)


Article DOI: 10.1021/jm501629p
BindingDB Entry DOI: 10.7270/Q2VT1TS8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM119252
PNG
(US8673906, 3.12 | US9718800, 3.12)
Show SMILES CC(Nc1cccc(F)c1)c1cc(cc2c1oc(cc2=O)N1CCOCC1)C(=O)N(C)C
Show InChI InChI=1S/C24H26FN3O4/c1-15(26-18-6-4-5-17(25)13-18)19-11-16(24(30)27(2)3)12-20-21(29)14-22(32-23(19)20)28-7-9-31-10-8-28/h4-6,11-15,26H,7-10H2,1-3H3
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n/an/a 12n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PI3Kbeta using PIP2 by Kinase-Glo Plus assay


J Med Chem 58: 943-62 (2015)


Article DOI: 10.1021/jm501629p
BindingDB Entry DOI: 10.7270/Q2VT1TS8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM119249
PNG
(US8673906, 3.09 | US9718800, 3.09)
Show SMILES CC(Nc1cccc(Cl)c1)c1cc(cc2c1oc(cc2=O)N1CCOCC1)C(=O)N(C)C
Show InChI InChI=1S/C24H26ClN3O4/c1-15(26-18-6-4-5-17(25)13-18)19-11-16(24(30)27(2)3)12-20-21(29)14-22(32-23(19)20)28-7-9-31-10-8-28/h4-6,11-15,26H,7-10H2,1-3H3
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n/an/a 10n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PI3Kbeta using PIP2 by Kinase-Glo Plus assay


J Med Chem 58: 943-62 (2015)


Article DOI: 10.1021/jm501629p
BindingDB Entry DOI: 10.7270/Q2VT1TS8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM119250
PNG
(US8673906, 3.1 | US9718800, 3.10)
Show SMILES CC(Nc1cccc(F)c1F)c1cc(cc2c1oc(cc2=O)N1CCOCC1)C(=O)N(C)C
Show InChI InChI=1S/C24H25F2N3O4/c1-14(27-19-6-4-5-18(25)22(19)26)16-11-15(24(31)28(2)3)12-17-20(30)13-21(33-23(16)17)29-7-9-32-10-8-29/h4-6,11-14,27H,7-10H2,1-3H3
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n/an/a 13n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PI3Kbeta using PIP2 by Kinase-Glo Plus assay


J Med Chem 58: 943-62 (2015)


Article DOI: 10.1021/jm501629p
BindingDB Entry DOI: 10.7270/Q2VT1TS8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM119255
PNG
(US8673906, 3.15 | US9718800, 3.15)
Show SMILES CC(Nc1cc(F)ccc1F)c1cc(cc2c1oc(cc2=O)N1CCOCC1)C(=O)N(C)C
Show InChI InChI=1S/C24H25F2N3O4/c1-14(27-20-12-16(25)4-5-19(20)26)17-10-15(24(31)28(2)3)11-18-21(30)13-22(33-23(17)18)29-6-8-32-9-7-29/h4-5,10-14,27H,6-9H2,1-3H3
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n/an/a 19n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PI3Kbeta using PIP2 by Kinase-Glo Plus assay


J Med Chem 58: 943-62 (2015)


Article DOI: 10.1021/jm501629p
BindingDB Entry DOI: 10.7270/Q2VT1TS8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM119245
PNG
(US8673906, 3.05 | US9718800, 3.05)
Show SMILES CC(Nc1ccc(F)c(Cl)c1)c1cc(cc2c1oc(cc2=O)N1CCOCC1)C(=O)N(C)C
Show InChI InChI=1S/C24H25ClFN3O4/c1-14(27-16-4-5-20(26)19(25)12-16)17-10-15(24(31)28(2)3)11-18-21(30)13-22(33-23(17)18)29-6-8-32-9-7-29/h4-5,10-14,27H,6-9H2,1-3H3
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n/an/a 12n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PI3Kbeta using PIP2 by Kinase-Glo Plus assay


J Med Chem 58: 943-62 (2015)


Article DOI: 10.1021/jm501629p
BindingDB Entry DOI: 10.7270/Q2VT1TS8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM119256
PNG
(US8673906, 3.16 | US9718800, 3.16)
Show SMILES CC(Nc1cc(C)cc(F)c1)c1cc(cc2c1oc(cc2=O)N1CCOCC1)C(=O)N(C)C
Show InChI InChI=1S/C25H28FN3O4/c1-15-9-18(26)13-19(10-15)27-16(2)20-11-17(25(31)28(3)4)12-21-22(30)14-23(33-24(20)21)29-5-7-32-8-6-29/h9-14,16,27H,5-8H2,1-4H3
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n/an/a 15n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PI3Kbeta using PIP2 by Kinase-Glo Plus assay


J Med Chem 58: 943-62 (2015)


Article DOI: 10.1021/jm501629p
BindingDB Entry DOI: 10.7270/Q2VT1TS8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM119256
PNG
(US8673906, 3.16 | US9718800, 3.16)
Show SMILES CC(Nc1cc(C)cc(F)c1)c1cc(cc2c1oc(cc2=O)N1CCOCC1)C(=O)N(C)C
Show InChI InChI=1S/C25H28FN3O4/c1-15-9-18(26)13-19(10-15)27-16(2)20-11-17(25(31)28(3)4)12-21-22(30)14-23(33-24(20)21)29-5-7-32-8-6-29/h9-14,16,27H,5-8H2,1-4H3
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n/an/a 130n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PI3Kalpha using PIP2 by Kinase-Glo Plus assay


J Med Chem 58: 943-62 (2015)


Article DOI: 10.1021/jm501629p
BindingDB Entry DOI: 10.7270/Q2VT1TS8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM119245
PNG
(US8673906, 3.05 | US9718800, 3.05)
Show SMILES CC(Nc1ccc(F)c(Cl)c1)c1cc(cc2c1oc(cc2=O)N1CCOCC1)C(=O)N(C)C
Show InChI InChI=1S/C24H25ClFN3O4/c1-14(27-16-4-5-20(26)19(25)12-16)17-10-15(24(31)28(2)3)11-18-21(30)13-22(33-23(17)18)29-6-8-32-9-7-29/h4-5,10-14,27H,6-9H2,1-3H3
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n/an/a 170n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PI3Kalpha using PIP2 by Kinase-Glo Plus assay


J Med Chem 58: 943-62 (2015)


Article DOI: 10.1021/jm501629p
BindingDB Entry DOI: 10.7270/Q2VT1TS8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM119255
PNG
(US8673906, 3.15 | US9718800, 3.15)
Show SMILES CC(Nc1cc(F)ccc1F)c1cc(cc2c1oc(cc2=O)N1CCOCC1)C(=O)N(C)C
Show InChI InChI=1S/C24H25F2N3O4/c1-14(27-20-12-16(25)4-5-19(20)26)17-10-15(24(31)28(2)3)11-18-21(30)13-22(33-23(17)18)29-6-8-32-9-7-29/h4-5,10-14,27H,6-9H2,1-3H3
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n/an/a 450n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PI3Kalpha using PIP2 by Kinase-Glo Plus assay


J Med Chem 58: 943-62 (2015)


Article DOI: 10.1021/jm501629p
BindingDB Entry DOI: 10.7270/Q2VT1TS8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM119250
PNG
(US8673906, 3.1 | US9718800, 3.10)
Show SMILES CC(Nc1cccc(F)c1F)c1cc(cc2c1oc(cc2=O)N1CCOCC1)C(=O)N(C)C
Show InChI InChI=1S/C24H25F2N3O4/c1-14(27-19-6-4-5-18(25)22(19)26)16-11-15(24(31)28(2)3)12-17-20(30)13-21(33-23(16)17)29-7-9-32-10-8-29/h4-6,11-14,27H,7-10H2,1-3H3
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n/an/a 370n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PI3Kalpha using PIP2 by Kinase-Glo Plus assay


J Med Chem 58: 943-62 (2015)


Article DOI: 10.1021/jm501629p
BindingDB Entry DOI: 10.7270/Q2VT1TS8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM119249
PNG
(US8673906, 3.09 | US9718800, 3.09)
Show SMILES CC(Nc1cccc(Cl)c1)c1cc(cc2c1oc(cc2=O)N1CCOCC1)C(=O)N(C)C
Show InChI InChI=1S/C24H26ClN3O4/c1-15(26-18-6-4-5-17(25)13-18)19-11-16(24(30)27(2)3)12-20-21(29)14-22(32-23(19)20)28-7-9-31-10-8-28/h4-6,11-15,26H,7-10H2,1-3H3
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n/an/a 85n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PI3Kalpha using PIP2 by Kinase-Glo Plus assay


J Med Chem 58: 943-62 (2015)


Article DOI: 10.1021/jm501629p
BindingDB Entry DOI: 10.7270/Q2VT1TS8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM119252
PNG
(US8673906, 3.12 | US9718800, 3.12)
Show SMILES CC(Nc1cccc(F)c1)c1cc(cc2c1oc(cc2=O)N1CCOCC1)C(=O)N(C)C
Show InChI InChI=1S/C24H26FN3O4/c1-15(26-18-6-4-5-17(25)13-18)19-11-16(24(30)27(2)3)12-20-21(29)14-22(32-23(19)20)28-7-9-31-10-8-28/h4-6,11-15,26H,7-10H2,1-3H3
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n/an/a 220n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PI3Kalpha using PIP2 by Kinase-Glo Plus assay


J Med Chem 58: 943-62 (2015)


Article DOI: 10.1021/jm501629p
BindingDB Entry DOI: 10.7270/Q2VT1TS8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM119245
PNG
(US8673906, 3.05 | US9718800, 3.05)
Show SMILES CC(Nc1ccc(F)c(Cl)c1)c1cc(cc2c1oc(cc2=O)N1CCOCC1)C(=O)N(C)C
Show InChI InChI=1S/C24H25ClFN3O4/c1-14(27-16-4-5-20(26)19(25)12-16)17-10-15(24(31)28(2)3)11-18-21(30)13-22(33-23(17)18)29-6-8-32-9-7-29/h4-5,10-14,27H,6-9H2,1-3H3
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US Patent
n/an/a 6n/an/an/an/an/a25



ASTRAZENECA AB

US Patent


Assay Description
Compounds in 100% DMSO were added to assay plates by acoustic dispensing. PI3Kβ was added in a Tris buffer (50 mM Tris pH7.4, 0.05% CHAPS, 2.1 m...


US Patent US9718800 (2017)

More data for this
Ligand-Target Pair
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