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82 molecules are shown

Compile data set for download or QSAR
Wt: 471.4
BDBM119322
Wt: 471.4
BDBM119323
Wt: 453.5
BDBM119324
Wt: 485.5
BDBM119325
Wt: 515.5
BDBM119326
Wt: 541.5
BDBM119327
Wt: 471.4
BDBM119328
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 119322,119323,119324,119325,119326,119327,119328   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM119322
PNG
(US8673906, 9.01 | US9718800, 9.01)
Show SMILES CC(Nc1cc(F)cc(F)c1)c1cc(cc2c1oc(cc2=O)N1CCO[C@H](C)C1)C(=O)N(C)C
Show InChI InChI=1S/C25H27F2N3O4/c1-14-13-30(5-6-33-14)23-12-22(31)21-8-16(25(32)29(3)4)7-20(24(21)34-23)15(2)28-19-10-17(26)9-18(27)11-19/h7-12,14-15,28H,5-6,13H2,1-4H3/t14-,15?/m1/s1
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n/an/a 4n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
The inhibition of PI3Kβ, PI3Kα, PI3Kγ and PI3Kδ was evaluated in a Kinase Glo based enzyme activity assay using human recombinant...


US Patent US8673906 (2014)


BindingDB Entry DOI: 10.7270/Q2280682
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM119323
PNG
(US8673906, 9.02 | US9718800, 9.02)
Show SMILES CC(Nc1cc(F)cc(F)c1)c1cc(cc2c1oc(cc2=O)N1CCO[C@@H](C)C1)C(=O)N(C)C
Show InChI InChI=1S/C25H27F2N3O4/c1-14-13-30(5-6-33-14)23-12-22(31)21-8-16(25(32)29(3)4)7-20(24(21)34-23)15(2)28-19-10-17(26)9-18(27)11-19/h7-12,14-15,28H,5-6,13H2,1-4H3/t14-,15?/m0/s1
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n/an/a 11n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
The inhibition of PI3Kβ, PI3Kα, PI3Kγ and PI3Kδ was evaluated in a Kinase Glo based enzyme activity assay using human recombinant...


US Patent US8673906 (2014)


BindingDB Entry DOI: 10.7270/Q2280682
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM119324
PNG
(US8673906, 9.03 | US9718800, 9.03)
Show SMILES CC(Nc1ccc(F)cc1)c1cc(cc2c1oc(cc2=O)N1CCO[C@@H](C)C1)C(=O)N(C)C
Show InChI InChI=1S/C25H28FN3O4/c1-15-14-29(9-10-32-15)23-13-22(30)21-12-17(25(31)28(3)4)11-20(24(21)33-23)16(2)27-19-7-5-18(26)6-8-19/h5-8,11-13,15-16,27H,9-10,14H2,1-4H3/t15-,16?/m0/s1
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n/an/a 64n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
The inhibition of PI3Kβ, PI3Kα, PI3Kγ and PI3Kδ was evaluated in a Kinase Glo based enzyme activity assay using human recombinant...


US Patent US8673906 (2014)


BindingDB Entry DOI: 10.7270/Q2280682
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM119325
PNG
(US8673906, 10.01 | US9718800, 10.01)
Show SMILES CC(N(C)c1cc(F)cc(F)c1)c1cc(cc2c1oc(cc2=O)N1CCO[C@H](C)C1)C(=O)N(C)C
Show InChI InChI=1S/C26H29F2N3O4/c1-15-14-31(6-7-34-15)24-13-23(32)22-9-17(26(33)29(3)4)8-21(25(22)35-24)16(2)30(5)20-11-18(27)10-19(28)12-20/h8-13,15-16H,6-7,14H2,1-5H3/t15-,16?/m1/s1
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n/an/a 12n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
The inhibition of PI3Kβ, PI3Kα, PI3Kγ and PI3Kδ was evaluated in a Kinase Glo based enzyme activity assay using human recombinant...


US Patent US8673906 (2014)


BindingDB Entry DOI: 10.7270/Q2280682
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM119326
PNG
(US8673906, 10.02 | US9718800, 10.02)
Show SMILES CC(N(C)c1cc(F)cc(F)c1)c1cc(cc2c1oc(cc2=O)N1CCO[C@H](C)C1)C(=O)N(C)CCO
Show InChI InChI=1S/C27H31F2N3O5/c1-16-15-32(6-8-36-16)25-14-24(34)23-10-18(27(35)30(3)5-7-33)9-22(26(23)37-25)17(2)31(4)21-12-19(28)11-20(29)13-21/h9-14,16-17,33H,5-8,15H2,1-4H3/t16-,17?/m1/s1
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n/an/a 11n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
The inhibition of PI3Kβ, PI3Kα, PI3Kγ and PI3Kδ was evaluated in a Kinase Glo based enzyme activity assay using human recombinant...


US Patent US8673906 (2014)


BindingDB Entry DOI: 10.7270/Q2280682
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM119327
PNG
(US8673906, 10.03 | US9718800, 10.03)
Show SMILES CC(N(C)c1cc(F)cc(F)c1)c1cc(cc2c1oc(cc2=O)N1CCO[C@H](C)C1)C(=O)N1CCC(O)CC1
Show InChI InChI=1S/C29H33F2N3O5/c1-17-16-34(8-9-38-17)27-15-26(36)25-11-19(29(37)33-6-4-23(35)5-7-33)10-24(28(25)39-27)18(2)32(3)22-13-20(30)12-21(31)14-22/h10-15,17-18,23,35H,4-9,16H2,1-3H3/t17-,18?/m1/s1
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n/an/a 9n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
The inhibition of PI3Kβ, PI3Kα, PI3Kγ and PI3Kδ was evaluated in a Kinase Glo based enzyme activity assay using human recombinant...


US Patent US8673906 (2014)


BindingDB Entry DOI: 10.7270/Q2280682
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM119328
PNG
(US8673906, 11 | US9718800, 11)
Show SMILES CC(Nc1cc(F)cc(F)c1)c1cc(cc2c1oc(cc2=O)N1CCOC[C@@H]1C)C(=O)N(C)C
Show InChI InChI=1S/C25H27F2N3O4/c1-14-13-33-6-5-30(14)23-12-22(31)21-8-16(25(32)29(3)4)7-20(24(21)34-23)15(2)28-19-10-17(26)9-18(27)11-19/h7-12,14-15,28H,5-6,13H2,1-4H3/t14-,15?/m0/s1
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n/an/a 21n/an/an/an/an/a25



ASTRAZENECA AB

US Patent


Assay Description
Compounds in 100% DMSO were added to assay plates by acoustic dispensing. PI3Kβ was added in a Tris buffer (50 mM Tris pH7.4, 0.05% CHAPS, 2.1 m...


US Patent US9718800 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM119322
PNG
(US8673906, 9.01 | US9718800, 9.01)
Show SMILES CC(Nc1cc(F)cc(F)c1)c1cc(cc2c1oc(cc2=O)N1CCO[C@H](C)C1)C(=O)N(C)C
Show InChI InChI=1S/C25H27F2N3O4/c1-14-13-30(5-6-33-14)23-12-22(31)21-8-16(25(32)29(3)4)7-20(24(21)34-23)15(2)28-19-10-17(26)9-18(27)11-19/h7-12,14-15,28H,5-6,13H2,1-4H3/t14-,15?/m1/s1
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n/an/a 4n/an/an/an/an/a25



ASTRAZENECA AB

US Patent


Assay Description
Compounds in 100% DMSO were added to assay plates by acoustic dispensing. PI3Kβ was added in a Tris buffer (50 mM Tris pH7.4, 0.05% CHAPS, 2.1 m...


US Patent US9718800 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM119323
PNG
(US8673906, 9.02 | US9718800, 9.02)
Show SMILES CC(Nc1cc(F)cc(F)c1)c1cc(cc2c1oc(cc2=O)N1CCO[C@@H](C)C1)C(=O)N(C)C
Show InChI InChI=1S/C25H27F2N3O4/c1-14-13-30(5-6-33-14)23-12-22(31)21-8-16(25(32)29(3)4)7-20(24(21)34-23)15(2)28-19-10-17(26)9-18(27)11-19/h7-12,14-15,28H,5-6,13H2,1-4H3/t14-,15?/m0/s1
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n/an/a 11n/an/an/an/an/a25



ASTRAZENECA AB

US Patent


Assay Description
Compounds in 100% DMSO were added to assay plates by acoustic dispensing. PI3Kβ was added in a Tris buffer (50 mM Tris pH7.4, 0.05% CHAPS, 2.1 m...


US Patent US9718800 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM119324
PNG
(US8673906, 9.03 | US9718800, 9.03)
Show SMILES CC(Nc1ccc(F)cc1)c1cc(cc2c1oc(cc2=O)N1CCO[C@@H](C)C1)C(=O)N(C)C
Show InChI InChI=1S/C25H28FN3O4/c1-15-14-29(9-10-32-15)23-13-22(30)21-12-17(25(31)28(3)4)11-20(24(21)33-23)16(2)27-19-7-5-18(26)6-8-19/h5-8,11-13,15-16,27H,9-10,14H2,1-4H3/t15-,16?/m0/s1
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n/an/a 64n/an/an/an/an/a25



ASTRAZENECA AB

US Patent


Assay Description
Compounds in 100% DMSO were added to assay plates by acoustic dispensing. PI3Kβ was added in a Tris buffer (50 mM Tris pH7.4, 0.05% CHAPS, 2.1 m...


US Patent US9718800 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM119325
PNG
(US8673906, 10.01 | US9718800, 10.01)
Show SMILES CC(N(C)c1cc(F)cc(F)c1)c1cc(cc2c1oc(cc2=O)N1CCO[C@H](C)C1)C(=O)N(C)C
Show InChI InChI=1S/C26H29F2N3O4/c1-15-14-31(6-7-34-15)24-13-23(32)22-9-17(26(33)29(3)4)8-21(25(22)35-24)16(2)30(5)20-11-18(27)10-19(28)12-20/h8-13,15-16H,6-7,14H2,1-5H3/t15-,16?/m1/s1
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n/an/a 12n/an/an/an/an/a25



ASTRAZENECA AB

US Patent


Assay Description
Compounds in 100% DMSO were added to assay plates by acoustic dispensing. PI3Kβ was added in a Tris buffer (50 mM Tris pH7.4, 0.05% CHAPS, 2.1 m...


US Patent US9718800 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM119326
PNG
(US8673906, 10.02 | US9718800, 10.02)
Show SMILES CC(N(C)c1cc(F)cc(F)c1)c1cc(cc2c1oc(cc2=O)N1CCO[C@H](C)C1)C(=O)N(C)CCO
Show InChI InChI=1S/C27H31F2N3O5/c1-16-15-32(6-8-36-16)25-14-24(34)23-10-18(27(35)30(3)5-7-33)9-22(26(23)37-25)17(2)31(4)21-12-19(28)11-20(29)13-21/h9-14,16-17,33H,5-8,15H2,1-4H3/t16-,17?/m1/s1
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n/an/a 11n/an/an/an/an/a25



ASTRAZENECA AB

US Patent


Assay Description
Compounds in 100% DMSO were added to assay plates by acoustic dispensing. PI3Kβ was added in a Tris buffer (50 mM Tris pH7.4, 0.05% CHAPS, 2.1 m...


US Patent US9718800 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM119327
PNG
(US8673906, 10.03 | US9718800, 10.03)
Show SMILES CC(N(C)c1cc(F)cc(F)c1)c1cc(cc2c1oc(cc2=O)N1CCO[C@H](C)C1)C(=O)N1CCC(O)CC1
Show InChI InChI=1S/C29H33F2N3O5/c1-17-16-34(8-9-38-17)27-15-26(36)25-11-19(29(37)33-6-4-23(35)5-7-33)10-24(28(25)39-27)18(2)32(3)22-13-20(30)12-21(31)14-22/h10-15,17-18,23,35H,4-9,16H2,1-3H3/t17-,18?/m1/s1
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n/an/a 9n/an/an/an/an/a25



ASTRAZENECA AB

US Patent


Assay Description
Compounds in 100% DMSO were added to assay plates by acoustic dispensing. PI3Kβ was added in a Tris buffer (50 mM Tris pH7.4, 0.05% CHAPS, 2.1 m...


US Patent US9718800 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM119328
PNG
(US8673906, 11 | US9718800, 11)
Show SMILES CC(Nc1cc(F)cc(F)c1)c1cc(cc2c1oc(cc2=O)N1CCOC[C@@H]1C)C(=O)N(C)C
Show InChI InChI=1S/C25H27F2N3O4/c1-14-13-33-6-5-30(14)23-12-22(31)21-8-16(25(32)29(3)4)7-20(24(21)34-23)15(2)28-19-10-17(26)9-18(27)11-19/h7-12,14-15,28H,5-6,13H2,1-4H3/t14-,15?/m0/s1
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n/an/a 21n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
The inhibition of PI3Kβ, PI3Kα, PI3Kγ and PI3Kδ was evaluated in a Kinase Glo based enzyme activity assay using human recombinant...


US Patent US8673906 (2014)


BindingDB Entry DOI: 10.7270/Q2280682
More data for this
Ligand-Target Pair