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142 similar compounds to monomer 121882

Compile data set for download or QSAR
Wt: 390.4
BDBM121975
Wt: 347.4
BDBM122284
Wt: 365.4
BDBM122285
Wt: 348.4
BDBM122290
Wt: 405.4
BDBM121784
Wt: 405.4
BDBM121788
Wt: 434.5
BDBM121789
Wt: 407.5
BDBM121790
Wt: 403.5
BDBM121791
Wt: 405.5
BDBM121792
Wt: 389.4
BDBM121793
Wt: 391.5
BDBM121794
Wt: 393.4
BDBM121795
Wt: 395.4
BDBM121796
Wt: 432.5
BDBM121797
Displayed 1 to 15 (of 142 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 121975,122284,122285,122290,121784,121788,121789,121790,121791,121792,121793,121794,121795,121796,121797   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM121784
PNG
(US8722692, 223)
Show SMILES CN1CCC(CC1)Nc1ccc(cn1)-c1cc2ncn(C)c(=O)c2c(NC2CC2)n1
Show InChI InChI=1S/C22H27N7O/c1-28-9-7-16(8-10-28)25-19-6-3-14(12-23-19)17-11-18-20(22(30)29(2)13-24-18)21(27-17)26-15-4-5-15/h3,6,11-13,15-16H,4-5,7-10H2,1-2H3,(H,23,25)(H,26,27)
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n/an/a 232n/an/an/an/an/an/a



TBA

US Patent


Assay Description
Compounds of the examples provided herein were assessed for their ability to inhibit Syk kinase by utilizing Caliper Life Sciences' proprietary L...


US Patent US8722692 (2014)


BindingDB Entry DOI: 10.7270/Q24Q7SNS
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM122290
PNG
(US8722692, 730)
Show SMILES Cn1cnc2cc(nc(NC3CC3)c2c1=O)-c1ccc(nc1)C1(N)CC1
Show InChI InChI=1S/C19H20N6O/c1-25-10-22-14-8-13(11-2-5-15(21-9-11)19(20)6-7-19)24-17(16(14)18(25)26)23-12-3-4-12/h2,5,8-10,12H,3-4,6-7,20H2,1H3,(H,23,24)
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n/an/a 219n/an/an/an/an/an/a



TBA

US Patent


Assay Description
Compounds of the examples provided herein were assessed for their ability to inhibit Syk kinase by utilizing Caliper Life Sciences' proprietary L...


US Patent US8722692 (2014)


BindingDB Entry DOI: 10.7270/Q24Q7SNS
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM121789
PNG
(US8722692, 228)
Show SMILES CCN1CCN(CCc2ccc(cc2)-c2cc3ncn(C)c(=O)c3c(NC(C)C)n2)CC1
Show InChI InChI=1S/C25H34N6O/c1-5-30-12-14-31(15-13-30)11-10-19-6-8-20(9-7-19)21-16-22-23(24(28-21)27-18(2)3)25(32)29(4)17-26-22/h6-9,16-18H,5,10-15H2,1-4H3,(H,27,28)
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n/an/a 269n/an/an/an/an/an/a



TBA

US Patent


Assay Description
Compounds of the examples provided herein were assessed for their ability to inhibit Syk kinase by utilizing Caliper Life Sciences' proprietary L...


US Patent US8722692 (2014)


BindingDB Entry DOI: 10.7270/Q24Q7SNS
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM121790
PNG
(US8722692, 229)
Show SMILES CC(C)Nc1nc(cc2ncn(C)c(=O)c12)-c1ccc(CCN2CCOCC2)cc1
Show InChI InChI=1S/C23H29N5O2/c1-16(2)25-22-21-20(24-15-27(3)23(21)29)14-19(26-22)18-6-4-17(5-7-18)8-9-28-10-12-30-13-11-28/h4-7,14-16H,8-13H2,1-3H3,(H,25,26)
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n/an/a 380n/an/an/an/an/an/a



TBA

US Patent


Assay Description
Compounds of the examples provided herein were assessed for their ability to inhibit Syk kinase by utilizing Caliper Life Sciences' proprietary L...


US Patent US8722692 (2014)


BindingDB Entry DOI: 10.7270/Q24Q7SNS
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM121791
PNG
(US8722692, 230)
Show SMILES Cn1cnc2cc(nc(NC3CC3)c2c1=O)-c1ccc(CCN2CCCCC2)cc1
Show InChI InChI=1S/C24H29N5O/c1-28-16-25-21-15-20(27-23(22(21)24(28)30)26-19-9-10-19)18-7-5-17(6-8-18)11-14-29-12-3-2-4-13-29/h5-8,15-16,19H,2-4,9-14H2,1H3,(H,26,27)
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n/an/a 141n/an/an/an/an/an/a



TBA

US Patent


Assay Description
Compounds of the examples provided herein were assessed for their ability to inhibit Syk kinase by utilizing Caliper Life Sciences' proprietary L...


US Patent US8722692 (2014)


BindingDB Entry DOI: 10.7270/Q24Q7SNS
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM121792
PNG
(US8722692, 231)
Show SMILES CC(C)Nc1nc(cc2ncn(C)c(=O)c12)-c1ccc(CCN2CCCCC2)cc1
Show InChI InChI=1S/C24H31N5O/c1-17(2)26-23-22-21(25-16-28(3)24(22)30)15-20(27-23)19-9-7-18(8-10-19)11-14-29-12-5-4-6-13-29/h7-10,15-17H,4-6,11-14H2,1-3H3,(H,26,27)
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n/an/a 143n/an/an/an/an/an/a



TBA

US Patent


Assay Description
Compounds of the examples provided herein were assessed for their ability to inhibit Syk kinase by utilizing Caliper Life Sciences' proprietary L...


US Patent US8722692 (2014)


BindingDB Entry DOI: 10.7270/Q24Q7SNS
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM121793
PNG
(US8722692, 232)
Show SMILES Cn1cnc2cc(nc(NC3CC3)c2c1=O)-c1ccc(CCN2CCCC2)cc1
Show InChI InChI=1S/C23H27N5O/c1-27-15-24-20-14-19(26-22(21(20)23(27)29)25-18-8-9-18)17-6-4-16(5-7-17)10-13-28-11-2-3-12-28/h4-7,14-15,18H,2-3,8-13H2,1H3,(H,25,26)
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n/an/a 139n/an/an/an/an/an/a



TBA

US Patent


Assay Description
Compounds of the examples provided herein were assessed for their ability to inhibit Syk kinase by utilizing Caliper Life Sciences' proprietary L...


US Patent US8722692 (2014)


BindingDB Entry DOI: 10.7270/Q24Q7SNS
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM121794
PNG
(US8722692, 233)
Show SMILES CC(C)Nc1nc(cc2ncn(C)c(=O)c12)-c1ccc(CCN2CCCC2)cc1
Show InChI InChI=1S/C23H29N5O/c1-16(2)25-22-21-20(24-15-27(3)23(21)29)14-19(26-22)18-8-6-17(7-9-18)10-13-28-11-4-5-12-28/h6-9,14-16H,4-5,10-13H2,1-3H3,(H,25,26)
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n/an/a 101n/an/an/an/an/an/a



TBA

US Patent


Assay Description
Compounds of the examples provided herein were assessed for their ability to inhibit Syk kinase by utilizing Caliper Life Sciences' proprietary L...


US Patent US8722692 (2014)


BindingDB Entry DOI: 10.7270/Q24Q7SNS
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM121795
PNG
(US8722692, 234)
Show SMILES COCCNCCc1ccc(cc1)-c1cc2ncn(C)c(=O)c2c(NC2CC2)n1
Show InChI InChI=1S/C22H27N5O2/c1-27-14-24-19-13-18(26-21(20(19)22(27)28)25-17-7-8-17)16-5-3-15(4-6-16)9-10-23-11-12-29-2/h3-6,13-14,17,23H,7-12H2,1-2H3,(H,25,26)
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n/an/a 156n/an/an/an/an/an/a



TBA

US Patent


Assay Description
Compounds of the examples provided herein were assessed for their ability to inhibit Syk kinase by utilizing Caliper Life Sciences' proprietary L...


US Patent US8722692 (2014)


BindingDB Entry DOI: 10.7270/Q24Q7SNS
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM121796
PNG
(US8722692, 235)
Show SMILES COCCNCCc1ccc(cc1)-c1cc2ncn(C)c(=O)c2c(NC(C)C)n1
Show InChI InChI=1S/C22H29N5O2/c1-15(2)25-21-20-19(24-14-27(3)22(20)28)13-18(26-21)17-7-5-16(6-8-17)9-10-23-11-12-29-4/h5-8,13-15,23H,9-12H2,1-4H3,(H,25,26)
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n/an/a 135n/an/an/an/an/an/a



TBA

US Patent


Assay Description
Compounds of the examples provided herein were assessed for their ability to inhibit Syk kinase by utilizing Caliper Life Sciences' proprietary L...


US Patent US8722692 (2014)


BindingDB Entry DOI: 10.7270/Q24Q7SNS
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM121797
PNG
(US8722692, 236)
Show SMILES CN1CCC(CC1)NCCc1ccc(cc1)-c1cc2ncn(C)c(=O)c2c(NC2CC2)n1
Show InChI InChI=1S/C25H32N6O/c1-30-13-10-19(11-14-30)26-12-9-17-3-5-18(6-4-17)21-15-22-23(25(32)31(2)16-27-22)24(29-21)28-20-7-8-20/h3-6,15-16,19-20,26H,7-14H2,1-2H3,(H,28,29)
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n/an/a 146n/an/an/an/an/an/a



TBA

US Patent


Assay Description
Compounds of the examples provided herein were assessed for their ability to inhibit Syk kinase by utilizing Caliper Life Sciences' proprietary L...


US Patent US8722692 (2014)


BindingDB Entry DOI: 10.7270/Q24Q7SNS
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM121975
PNG
(US8722692, 414)
Show SMILES Cn1cnc2cc(nc(NCCC#N)c2c1=O)-c1ccc(cc1)N1CCOCC1
Show InChI InChI=1S/C21H22N6O2/c1-26-14-24-18-13-17(25-20(19(18)21(26)28)23-8-2-7-22)15-3-5-16(6-4-15)27-9-11-29-12-10-27/h3-6,13-14H,2,8-12H2,1H3,(H,23,25)
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n/an/a 133n/an/an/an/an/an/a



TBA

US Patent


Assay Description
Compounds of the examples provided herein were assessed for their ability to inhibit Syk kinase by utilizing Caliper Life Sciences' proprietary L...


US Patent US8722692 (2014)


BindingDB Entry DOI: 10.7270/Q24Q7SNS
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM122284
PNG
(US8722692, 724)
Show SMILES Cn1cnc2cc(nc(NC3CC3)c2c1=O)-c1ccc(cc1)C1(N)CC1
Show InChI InChI=1S/C20H21N5O/c1-25-11-22-16-10-15(12-2-4-13(5-3-12)20(21)8-9-20)24-18(17(16)19(25)26)23-14-6-7-14/h2-5,10-11,14H,6-9,21H2,1H3,(H,23,24)
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n/an/a 1.15E+3n/an/an/an/an/an/a



TBA

US Patent


Assay Description
Compounds of the examples provided herein were assessed for their ability to inhibit Syk kinase by utilizing Caliper Life Sciences' proprietary L...


US Patent US8722692 (2014)


BindingDB Entry DOI: 10.7270/Q24Q7SNS
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM122285
PNG
(US8722692, 725)
Show SMILES Cn1cnc2cc(nc(NCCCO)c2c1=O)-c1ccc(cc1)C1(N)CC1
Show InChI InChI=1S/C20H23N5O2/c1-25-12-23-16-11-15(13-3-5-14(6-4-13)20(21)7-8-20)24-18(17(16)19(25)27)22-9-2-10-26/h3-6,11-12,26H,2,7-10,21H2,1H3,(H,22,24)
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n/an/a 884n/an/an/an/an/an/a



TBA

US Patent


Assay Description
Compounds of the examples provided herein were assessed for their ability to inhibit Syk kinase by utilizing Caliper Life Sciences' proprietary L...


US Patent US8722692 (2014)


BindingDB Entry DOI: 10.7270/Q24Q7SNS
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM121788
PNG
(US8722692, 227)
Show SMILES Cn1cnc2cc(nc(NC3CC3)c2c1=O)-c1ccc(CCN2CCOCC2)cc1
Show InChI InChI=1S/C23H27N5O2/c1-27-15-24-20-14-19(26-22(21(20)23(27)29)25-18-6-7-18)17-4-2-16(3-5-17)8-9-28-10-12-30-13-11-28/h2-5,14-15,18H,6-13H2,1H3,(H,25,26)
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n/an/a 230n/an/an/an/an/an/a



TBA

US Patent


Assay Description
Compounds of the examples provided herein were assessed for their ability to inhibit Syk kinase by utilizing Caliper Life Sciences' proprietary L...


US Patent US8722692 (2014)


BindingDB Entry DOI: 10.7270/Q24Q7SNS
More data for this
Ligand-Target Pair