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29 similar compounds to monomer 50439644

Compile data set for download or QSAR
Wt: 432.5
BDBM152821
Wt: 432.5
BDBM152822
Wt: 451.9
BDBM152823
Wt: 451.9
BDBM152824
Wt: 406.4
BDBM152874
Wt: 446.5
BDBM152888
Wt: 432.5
BDBM152878
Wt: 432.5
BDBM152879
Wt: 432.5
BDBM152890
Wt: 446.5
BDBM152891
Wt: 435.5
BDBM152893
Wt: 421.4
BDBM152894
Wt: 417.5
BDBM152883
Wt: 432.5
BDBM152906
Wt: 446.5
BDBM152907
Displayed 1 to 15 (of 29 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 30 hits for monomerid = 152821,152822,152823,152824,152874,152888,152878,152879,152890,152891,152893,152894,152883,152906,152907   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Acetyl-CoA carboxylase 1 (ACC1)


(Homo sapiens (Human))
BDBM152874
PNG
(US8993586, 52)
Show SMILES CC(C)(C)n1cc2CC3(CCN(CC3)C(=O)c3ccc4cn[nH]c4c3)NC(=O)c2n1
Show InChI InChI=1S/C22H26N6O2/c1-21(2,3)28-13-16-11-22(24-19(29)18(16)26-28)6-8-27(9-7-22)20(30)14-4-5-15-12-23-25-17(15)10-14/h4-5,10,12-13H,6-9,11H2,1-3H3,(H,23,25)(H,24,29)
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n/an/a 88n/an/an/an/a7.5n/a



Pfizer Inc

US Patent


Assay Description
Preparation of rhACC1. Two liters of SF9 cells, infected with recombinant baculovirus containing full length human ACC1 cDNA, were suspended in ice-c...


US Patent US8993586 (2015)


BindingDB Entry DOI: 10.7270/Q2N58K43
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM152824
PNG
(US8993586, 104)
Show SMILES CC(C)(C)n1cc2CC3(CCN(CC3)C(=O)c3ccc4ccc(Cl)nc4c3)NC(=O)c2n1
Show InChI InChI=1S/C24H26ClN5O2/c1-23(2,3)30-14-17-13-24(27-21(31)20(17)28-30)8-10-29(11-9-24)22(32)16-5-4-15-6-7-19(25)26-18(15)12-16/h4-7,12,14H,8-11,13H2,1-3H3,(H,27,31)
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n/an/a 16n/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
Preparation of rhACC2. Human ACC2 inhibition was measured using purified recombinant human ACC2 (hrACC2). Briefly, a full length Cytomax clone of ACC...


US Patent US8993586 (2015)


BindingDB Entry DOI: 10.7270/Q2N58K43
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Homo sapiens (Human))
BDBM152879
PNG
(US8993586, 59)
Show SMILES CC(C)(C)n1cc2CC3(CCN(CC3)C(=O)c3ccc4cnc(N)cc4c3)NC(=O)c2n1
Show InChI InChI=1S/C24H28N6O2/c1-23(2,3)30-14-18-12-24(27-21(31)20(18)28-30)6-8-29(9-7-24)22(32)15-4-5-16-13-26-19(25)11-17(16)10-15/h4-5,10-11,13-14H,6-9,12H2,1-3H3,(H2,25,26)(H,27,31)
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n/an/a 123n/an/an/an/a7.5n/a



Pfizer Inc

US Patent


Assay Description
Preparation of rhACC1. Two liters of SF9 cells, infected with recombinant baculovirus containing full length human ACC1 cDNA, were suspended in ice-c...


US Patent US8993586 (2015)


BindingDB Entry DOI: 10.7270/Q2N58K43
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Homo sapiens (Human))
BDBM152883
PNG
(US8993586, 63)
Show SMILES CC(C)(C)n1cc2CC3(CCN(CC3)C(=O)c3ccc4ncccc4c3)NC(=O)c2n1
Show InChI InChI=1S/C24H27N5O2/c1-23(2,3)29-15-18-14-24(26-21(30)20(18)27-29)8-11-28(12-9-24)22(31)17-6-7-19-16(13-17)5-4-10-25-19/h4-7,10,13,15H,8-9,11-12,14H2,1-3H3,(H,26,30)
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n/an/a 160n/an/an/an/a7.5n/a



Pfizer Inc

US Patent


Assay Description
Preparation of rhACC1. Two liters of SF9 cells, infected with recombinant baculovirus containing full length human ACC1 cDNA, were suspended in ice-c...


US Patent US8993586 (2015)


BindingDB Entry DOI: 10.7270/Q2N58K43
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Homo sapiens (Human))
BDBM152888
PNG
(US8993586, 69)
Show SMILES CNc1ccc2cc(ccc2n1)C(=O)N1CCC2(CC1)Cc1cn(nc1C(=O)N2)C(C)(C)C
Show InChI InChI=1S/C25H30N6O2/c1-24(2,3)31-15-18-14-25(28-22(32)21(18)29-31)9-11-30(12-10-25)23(33)17-5-7-19-16(13-17)6-8-20(26-4)27-19/h5-8,13,15H,9-12,14H2,1-4H3,(H,26,27)(H,28,32)
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n/an/a 185n/an/an/an/a7.5n/a



Pfizer Inc

US Patent


Assay Description
Preparation of rhACC1. Two liters of SF9 cells, infected with recombinant baculovirus containing full length human ACC1 cDNA, were suspended in ice-c...


US Patent US8993586 (2015)


BindingDB Entry DOI: 10.7270/Q2N58K43
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Homo sapiens (Human))
BDBM152890
PNG
(US8993586, 72)
Show SMILES CC(C)(C)n1cc2CC3(CCN(CC3)C(=O)c3ccc4ccc(N)nc4c3)NC(=O)c2n1
Show InChI InChI=1S/C24H28N6O2/c1-23(2,3)30-14-17-13-24(27-21(31)20(17)28-30)8-10-29(11-9-24)22(32)16-5-4-15-6-7-19(25)26-18(15)12-16/h4-7,12,14H,8-11,13H2,1-3H3,(H2,25,26)(H,27,31)
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n/an/a 28n/an/an/an/a7.5n/a



Pfizer Inc

US Patent


Assay Description
Preparation of rhACC1. Two liters of SF9 cells, infected with recombinant baculovirus containing full length human ACC1 cDNA, were suspended in ice-c...


US Patent US8993586 (2015)


BindingDB Entry DOI: 10.7270/Q2N58K43
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Homo sapiens (Human))
BDBM152891
PNG
(US8993586, 73)
Show SMILES CNc1cc2cc(ccc2cn1)C(=O)N1CCC2(CC1)Cc1cn(nc1C(=O)N2)C(C)(C)C
Show InChI InChI=1S/C25H30N6O2/c1-24(2,3)31-15-19-13-25(28-22(32)21(19)29-31)7-9-30(10-8-25)23(33)16-5-6-17-14-27-20(26-4)12-18(17)11-16/h5-6,11-12,14-15H,7-10,13H2,1-4H3,(H,26,27)(H,28,32)
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n/an/a 48n/an/an/an/a7.5n/a



Pfizer Inc

US Patent


Assay Description
Preparation of rhACC1. Two liters of SF9 cells, infected with recombinant baculovirus containing full length human ACC1 cDNA, were suspended in ice-c...


US Patent US8993586 (2015)


BindingDB Entry DOI: 10.7270/Q2N58K43
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Homo sapiens (Human))
BDBM152893
PNG
(US8993586, 75)
Show SMILES CNc1nc2cc(ccc2[nH]1)C(=O)N1CCC2(CC1)Cc1cn(nc1C(=O)N2)C(C)(C)C
Show InChI InChI=1S/C23H29N7O2/c1-22(2,3)30-13-15-12-23(27-19(31)18(15)28-30)7-9-29(10-8-23)20(32)14-5-6-16-17(11-14)26-21(24-4)25-16/h5-6,11,13H,7-10,12H2,1-4H3,(H,27,31)(H2,24,25,26)
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n/an/a 79n/an/an/an/a7.5n/a



Pfizer Inc

US Patent


Assay Description
Preparation of rhACC1. Two liters of SF9 cells, infected with recombinant baculovirus containing full length human ACC1 cDNA, were suspended in ice-c...


US Patent US8993586 (2015)


BindingDB Entry DOI: 10.7270/Q2N58K43
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Homo sapiens (Human))
BDBM152894
PNG
(US8993586, 77)
Show SMILES CC(C)(C)n1cc2CC3(CCN(CC3)C(=O)c3ccc4[nH]c(N)nc4c3)NC(=O)c2n1
Show InChI InChI=1S/C22H27N7O2/c1-21(2,3)29-12-14-11-22(26-18(30)17(14)27-29)6-8-28(9-7-22)19(31)13-4-5-15-16(10-13)25-20(23)24-15/h4-5,10,12H,6-9,11H2,1-3H3,(H,26,30)(H3,23,24,25)
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n/an/a 80n/an/an/an/a7.5n/a



Pfizer Inc

US Patent


Assay Description
Preparation of rhACC1. Two liters of SF9 cells, infected with recombinant baculovirus containing full length human ACC1 cDNA, were suspended in ice-c...


US Patent US8993586 (2015)


BindingDB Entry DOI: 10.7270/Q2N58K43
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Homo sapiens (Human))
BDBM152906
PNG
(US8993586, 94)
Show SMILES CC(C)(C)n1cc2CC3(CCN(CC3)C(=O)c3ccc4cc(N)ncc4c3)NC(=O)c2n1
Show InChI InChI=1S/C24H28N6O2/c1-23(2,3)30-14-18-12-24(27-21(31)20(18)28-30)6-8-29(9-7-24)22(32)16-5-4-15-11-19(25)26-13-17(15)10-16/h4-5,10-11,13-14H,6-9,12H2,1-3H3,(H2,25,26)(H,27,31)
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n/an/a 130n/an/an/an/a7.5n/a



Pfizer Inc

US Patent


Assay Description
Preparation of rhACC1. Two liters of SF9 cells, infected with recombinant baculovirus containing full length human ACC1 cDNA, were suspended in ice-c...


US Patent US8993586 (2015)


BindingDB Entry DOI: 10.7270/Q2N58K43
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Homo sapiens (Human))
BDBM152907
PNG
(US8993586, 95)
Show SMILES CNc1cc2ccc(cc2cn1)C(=O)N1CCC2(CC1)Cc1cn(nc1C(=O)N2)C(C)(C)C
Show InChI InChI=1S/C25H30N6O2/c1-24(2,3)31-15-19-13-25(28-22(32)21(19)29-31)7-9-30(10-8-25)23(33)17-6-5-16-12-20(26-4)27-14-18(16)11-17/h5-6,11-12,14-15H,7-10,13H2,1-4H3,(H,26,27)(H,28,32)
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n/an/a 105n/an/an/an/a7.5n/a



Pfizer Inc

US Patent


Assay Description
Preparation of rhACC1. Two liters of SF9 cells, infected with recombinant baculovirus containing full length human ACC1 cDNA, were suspended in ice-c...


US Patent US8993586 (2015)


BindingDB Entry DOI: 10.7270/Q2N58K43
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Homo sapiens (Human))
BDBM152821
PNG
(US8993586, 100)
Show SMILES CC(C)(C)n1cc2CC3(CCN(CC3)C(=O)c3ccc4ccnc(N)c4c3)NC(=O)c2n1
Show InChI InChI=1S/C24H28N6O2/c1-23(2,3)30-14-17-13-24(27-21(31)19(17)28-30)7-10-29(11-8-24)22(32)16-5-4-15-6-9-26-20(25)18(15)12-16/h4-6,9,12,14H,7-8,10-11,13H2,1-3H3,(H2,25,26)(H,27,31)
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n/an/a 62n/an/an/an/a7.5n/a



Pfizer Inc

US Patent


Assay Description
Preparation of rhACC1. Two liters of SF9 cells, infected with recombinant baculovirus containing full length human ACC1 cDNA, were suspended in ice-c...


US Patent US8993586 (2015)


BindingDB Entry DOI: 10.7270/Q2N58K43
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Homo sapiens (Human))
BDBM152822
PNG
(US8993586, 101)
Show SMILES CC(C)(C)n1cc2CC3(CCN(CC3)C(=O)c3ccc4c(N)nccc4c3)NC(=O)c2n1
Show InChI InChI=1S/C24H28N6O2/c1-23(2,3)30-14-17-13-24(27-21(31)19(17)28-30)7-10-29(11-8-24)22(32)16-4-5-18-15(12-16)6-9-26-20(18)25/h4-6,9,12,14H,7-8,10-11,13H2,1-3H3,(H2,25,26)(H,27,31)
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n/an/a 160n/an/an/an/a7.5n/a



Pfizer Inc

US Patent


Assay Description
Preparation of rhACC1. Two liters of SF9 cells, infected with recombinant baculovirus containing full length human ACC1 cDNA, were suspended in ice-c...


US Patent US8993586 (2015)


BindingDB Entry DOI: 10.7270/Q2N58K43
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Homo sapiens (Human))
BDBM152823
PNG
(US8993586, 103)
Show SMILES CC(C)(C)n1cc2CC3(CCN(CC3)C(=O)c3ccc4ccnc(Cl)c4c3)NC(=O)c2n1
Show InChI InChI=1S/C24H26ClN5O2/c1-23(2,3)30-14-17-13-24(27-21(31)19(17)28-30)7-10-29(11-8-24)22(32)16-5-4-15-6-9-26-20(25)18(15)12-16/h4-6,9,12,14H,7-8,10-11,13H2,1-3H3,(H,27,31)
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n/an/a 73n/an/an/an/a7.5n/a



Pfizer Inc

US Patent


Assay Description
Preparation of rhACC1. Two liters of SF9 cells, infected with recombinant baculovirus containing full length human ACC1 cDNA, were suspended in ice-c...


US Patent US8993586 (2015)


BindingDB Entry DOI: 10.7270/Q2N58K43
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Homo sapiens (Human))
BDBM152824
PNG
(US8993586, 104)
Show SMILES CC(C)(C)n1cc2CC3(CCN(CC3)C(=O)c3ccc4ccc(Cl)nc4c3)NC(=O)c2n1
Show InChI InChI=1S/C24H26ClN5O2/c1-23(2,3)30-14-17-13-24(27-21(31)20(17)28-30)8-10-29(11-9-24)22(32)16-5-4-15-6-7-19(25)26-18(15)12-16/h4-7,12,14H,8-11,13H2,1-3H3,(H,27,31)
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n/an/a 89n/an/an/an/a7.5n/a



Pfizer Inc

US Patent


Assay Description
Preparation of rhACC1. Two liters of SF9 cells, infected with recombinant baculovirus containing full length human ACC1 cDNA, were suspended in ice-c...


US Patent US8993586 (2015)


BindingDB Entry DOI: 10.7270/Q2N58K43
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM152874
PNG
(US8993586, 52)
Show SMILES CC(C)(C)n1cc2CC3(CCN(CC3)C(=O)c3ccc4cn[nH]c4c3)NC(=O)c2n1
Show InChI InChI=1S/C22H26N6O2/c1-21(2,3)28-13-16-11-22(24-19(29)18(16)26-28)6-8-27(9-7-22)20(30)14-4-5-15-12-23-25-17(15)10-14/h4-5,10,12-13H,6-9,11H2,1-3H3,(H,23,25)(H,24,29)
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n/an/a 17n/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
Preparation of rhACC2. Human ACC2 inhibition was measured using purified recombinant human ACC2 (hrACC2). Briefly, a full length Cytomax clone of ACC...


US Patent US8993586 (2015)


BindingDB Entry DOI: 10.7270/Q2N58K43
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM152878
PNG
(US8993586, 58)
Show SMILES CC(C)(C)n1cc2CC3(CCN(CC3)C(=O)c3ccc4nc(N)ccc4c3)NC(=O)c2n1
Show InChI InChI=1S/C24H28N6O2/c1-23(2,3)30-14-17-13-24(27-21(31)20(17)28-30)8-10-29(11-9-24)22(32)16-4-6-18-15(12-16)5-7-19(25)26-18/h4-7,12,14H,8-11,13H2,1-3H3,(H2,25,26)(H,27,31)
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n/an/a 12n/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
Preparation of rhACC2. Human ACC2 inhibition was measured using purified recombinant human ACC2 (hrACC2). Briefly, a full length Cytomax clone of ACC...


US Patent US8993586 (2015)


BindingDB Entry DOI: 10.7270/Q2N58K43
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM152879
PNG
(US8993586, 59)
Show SMILES CC(C)(C)n1cc2CC3(CCN(CC3)C(=O)c3ccc4cnc(N)cc4c3)NC(=O)c2n1
Show InChI InChI=1S/C24H28N6O2/c1-23(2,3)30-14-18-12-24(27-21(31)20(18)28-30)6-8-29(9-7-24)22(32)15-4-5-16-13-26-19(25)11-17(16)10-15/h4-5,10-11,13-14H,6-9,12H2,1-3H3,(H2,25,26)(H,27,31)
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n/an/a 14n/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
Preparation of rhACC2. Human ACC2 inhibition was measured using purified recombinant human ACC2 (hrACC2). Briefly, a full length Cytomax clone of ACC...


US Patent US8993586 (2015)


BindingDB Entry DOI: 10.7270/Q2N58K43
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM152883
PNG
(US8993586, 63)
Show SMILES CC(C)(C)n1cc2CC3(CCN(CC3)C(=O)c3ccc4ncccc4c3)NC(=O)c2n1
Show InChI InChI=1S/C24H27N5O2/c1-23(2,3)29-15-18-14-24(26-21(30)20(18)27-29)8-11-28(12-9-24)22(31)17-6-7-19-16(13-17)5-4-10-25-19/h4-7,10,13,15H,8-9,11-12,14H2,1-3H3,(H,26,30)
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n/an/a 28n/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
Preparation of rhACC2. Human ACC2 inhibition was measured using purified recombinant human ACC2 (hrACC2). Briefly, a full length Cytomax clone of ACC...


US Patent US8993586 (2015)


BindingDB Entry DOI: 10.7270/Q2N58K43
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM152888
PNG
(US8993586, 69)
Show SMILES CNc1ccc2cc(ccc2n1)C(=O)N1CCC2(CC1)Cc1cn(nc1C(=O)N2)C(C)(C)C
Show InChI InChI=1S/C25H30N6O2/c1-24(2,3)31-15-18-14-25(28-22(32)21(18)29-31)9-11-30(12-10-25)23(33)17-5-7-19-16(13-17)6-8-20(26-4)27-19/h5-8,13,15H,9-12,14H2,1-4H3,(H,26,27)(H,28,32)
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n/an/a 28n/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
Preparation of rhACC2. Human ACC2 inhibition was measured using purified recombinant human ACC2 (hrACC2). Briefly, a full length Cytomax clone of ACC...


US Patent US8993586 (2015)


BindingDB Entry DOI: 10.7270/Q2N58K43
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM152890
PNG
(US8993586, 72)
Show SMILES CC(C)(C)n1cc2CC3(CCN(CC3)C(=O)c3ccc4ccc(N)nc4c3)NC(=O)c2n1
Show InChI InChI=1S/C24H28N6O2/c1-23(2,3)30-14-17-13-24(27-21(31)20(17)28-30)8-10-29(11-9-24)22(32)16-5-4-15-6-7-19(25)26-18(15)12-16/h4-7,12,14H,8-11,13H2,1-3H3,(H2,25,26)(H,27,31)
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n/an/a 5.90n/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
Preparation of rhACC2. Human ACC2 inhibition was measured using purified recombinant human ACC2 (hrACC2). Briefly, a full length Cytomax clone of ACC...


US Patent US8993586 (2015)


BindingDB Entry DOI: 10.7270/Q2N58K43
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM152891
PNG
(US8993586, 73)
Show SMILES CNc1cc2cc(ccc2cn1)C(=O)N1CCC2(CC1)Cc1cn(nc1C(=O)N2)C(C)(C)C
Show InChI InChI=1S/C25H30N6O2/c1-24(2,3)31-15-19-13-25(28-22(32)21(19)29-31)7-9-30(10-8-25)23(33)16-5-6-17-14-27-20(26-4)12-18(17)11-16/h5-6,11-12,14-15H,7-10,13H2,1-4H3,(H,26,27)(H,28,32)
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n/an/a 5.5n/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
Preparation of rhACC2. Human ACC2 inhibition was measured using purified recombinant human ACC2 (hrACC2). Briefly, a full length Cytomax clone of ACC...


US Patent US8993586 (2015)


BindingDB Entry DOI: 10.7270/Q2N58K43
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM152893
PNG
(US8993586, 75)
Show SMILES CNc1nc2cc(ccc2[nH]1)C(=O)N1CCC2(CC1)Cc1cn(nc1C(=O)N2)C(C)(C)C
Show InChI InChI=1S/C23H29N7O2/c1-22(2,3)30-13-15-12-23(27-19(31)18(15)28-30)7-9-29(10-8-23)20(32)14-5-6-16-17(11-14)26-21(24-4)25-16/h5-6,11,13H,7-10,12H2,1-4H3,(H,27,31)(H2,24,25,26)
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n/an/a 11n/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
Preparation of rhACC2. Human ACC2 inhibition was measured using purified recombinant human ACC2 (hrACC2). Briefly, a full length Cytomax clone of ACC...


US Patent US8993586 (2015)


BindingDB Entry DOI: 10.7270/Q2N58K43
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM152894
PNG
(US8993586, 77)
Show SMILES CC(C)(C)n1cc2CC3(CCN(CC3)C(=O)c3ccc4[nH]c(N)nc4c3)NC(=O)c2n1
Show InChI InChI=1S/C22H27N7O2/c1-21(2,3)29-12-14-11-22(26-18(30)17(14)27-29)6-8-28(9-7-22)19(31)13-4-5-15-16(10-13)25-20(23)24-15/h4-5,10,12H,6-9,11H2,1-3H3,(H,26,30)(H3,23,24,25)
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n/an/a 8.40n/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
Preparation of rhACC2. Human ACC2 inhibition was measured using purified recombinant human ACC2 (hrACC2). Briefly, a full length Cytomax clone of ACC...


US Patent US8993586 (2015)


BindingDB Entry DOI: 10.7270/Q2N58K43
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM152906
PNG
(US8993586, 94)
Show SMILES CC(C)(C)n1cc2CC3(CCN(CC3)C(=O)c3ccc4cc(N)ncc4c3)NC(=O)c2n1
Show InChI InChI=1S/C24H28N6O2/c1-23(2,3)30-14-18-12-24(27-21(31)20(18)28-30)6-8-29(9-7-24)22(32)16-5-4-15-11-19(25)26-13-17(15)10-16/h4-5,10-11,13-14H,6-9,12H2,1-3H3,(H2,25,26)(H,27,31)
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n/an/a 23n/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
Preparation of rhACC2. Human ACC2 inhibition was measured using purified recombinant human ACC2 (hrACC2). Briefly, a full length Cytomax clone of ACC...


US Patent US8993586 (2015)


BindingDB Entry DOI: 10.7270/Q2N58K43
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM152907
PNG
(US8993586, 95)
Show SMILES CNc1cc2ccc(cc2cn1)C(=O)N1CCC2(CC1)Cc1cn(nc1C(=O)N2)C(C)(C)C
Show InChI InChI=1S/C25H30N6O2/c1-24(2,3)31-15-19-13-25(28-22(32)21(19)29-31)7-9-30(10-8-25)23(33)17-6-5-16-12-20(26-4)27-14-18(16)11-17/h5-6,11-12,14-15H,7-10,13H2,1-4H3,(H,26,27)(H,28,32)
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n/an/a 9.20n/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
Preparation of rhACC2. Human ACC2 inhibition was measured using purified recombinant human ACC2 (hrACC2). Briefly, a full length Cytomax clone of ACC...


US Patent US8993586 (2015)


BindingDB Entry DOI: 10.7270/Q2N58K43
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM152821
PNG
(US8993586, 100)
Show SMILES CC(C)(C)n1cc2CC3(CCN(CC3)C(=O)c3ccc4ccnc(N)c4c3)NC(=O)c2n1
Show InChI InChI=1S/C24H28N6O2/c1-23(2,3)30-14-17-13-24(27-21(31)19(17)28-30)7-10-29(11-8-24)22(32)16-5-4-15-6-9-26-20(25)18(15)12-16/h4-6,9,12,14H,7-8,10-11,13H2,1-3H3,(H2,25,26)(H,27,31)
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n/an/a 21n/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
Preparation of rhACC2. Human ACC2 inhibition was measured using purified recombinant human ACC2 (hrACC2). Briefly, a full length Cytomax clone of ACC...


US Patent US8993586 (2015)


BindingDB Entry DOI: 10.7270/Q2N58K43
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM152822
PNG
(US8993586, 101)
Show SMILES CC(C)(C)n1cc2CC3(CCN(CC3)C(=O)c3ccc4c(N)nccc4c3)NC(=O)c2n1
Show InChI InChI=1S/C24H28N6O2/c1-23(2,3)30-14-17-13-24(27-21(31)19(17)28-30)7-10-29(11-8-24)22(32)16-4-5-18-15(12-16)6-9-26-20(18)25/h4-6,9,12,14H,7-8,10-11,13H2,1-3H3,(H2,25,26)(H,27,31)
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n/an/a 26n/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
Preparation of rhACC2. Human ACC2 inhibition was measured using purified recombinant human ACC2 (hrACC2). Briefly, a full length Cytomax clone of ACC...


US Patent US8993586 (2015)


BindingDB Entry DOI: 10.7270/Q2N58K43
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM152823
PNG
(US8993586, 103)
Show SMILES CC(C)(C)n1cc2CC3(CCN(CC3)C(=O)c3ccc4ccnc(Cl)c4c3)NC(=O)c2n1
Show InChI InChI=1S/C24H26ClN5O2/c1-23(2,3)30-14-17-13-24(27-21(31)19(17)28-30)7-10-29(11-8-24)22(32)16-5-4-15-6-9-26-20(25)18(15)12-16/h4-6,9,12,14H,7-8,10-11,13H2,1-3H3,(H,27,31)
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n/an/a 8.90n/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
Preparation of rhACC2. Human ACC2 inhibition was measured using purified recombinant human ACC2 (hrACC2). Briefly, a full length Cytomax clone of ACC...


US Patent US8993586 (2015)


BindingDB Entry DOI: 10.7270/Q2N58K43
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Homo sapiens (Human))
BDBM152878
PNG
(US8993586, 58)
Show SMILES CC(C)(C)n1cc2CC3(CCN(CC3)C(=O)c3ccc4nc(N)ccc4c3)NC(=O)c2n1
Show InChI InChI=1S/C24H28N6O2/c1-23(2,3)30-14-17-13-24(27-21(31)20(17)28-30)8-10-29(11-9-24)22(32)16-4-6-18-15(12-16)5-7-19(25)26-18/h4-7,12,14H,8-11,13H2,1-3H3,(H2,25,26)(H,27,31)
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n/an/a 149n/an/an/an/a7.5n/a



Pfizer Inc

US Patent


Assay Description
Preparation of rhACC1. Two liters of SF9 cells, infected with recombinant baculovirus containing full length human ACC1 cDNA, were suspended in ice-c...


US Patent US8993586 (2015)


BindingDB Entry DOI: 10.7270/Q2N58K43
More data for this
Ligand-Target Pair