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9 similar compounds to monomer 50353887

Compile data set for download or QSAR
Wt: 368.4
BDBM155153
Wt: 366.4
BDBM50353882
Wt: 394.4
BDBM50353885
Wt: 380.4
BDBM50353886
Wt: 406.5
BDBM50353888
Wt: 364.4
BDBM50353889
Wt: 378.4
BDBM50353890
Wt: 392.5
BDBM50353891
Wt: 392.5
BDBM50353893

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 155153,50353882,50353885,50353886,50353888,50353889,50353890,50353891,50353893   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50353882
PNG
(CHEMBL1829078 | US9006187, 23)
Show SMILES Cc1sc(cc1Cc1ccc(O)cc1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C18H22O6S/c1-9-11(6-10-2-4-12(20)5-3-10)7-14(25-9)18-17(23)16(22)15(21)13(8-19)24-18/h2-5,7,13,15-23H,6,8H2,1H3/t13-,15-,16+,17-,18+/m1/s1
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US Patent
n/an/a 50.2n/an/an/an/a7.437



Green Cross Corporation

US Patent


Assay Description
For sodium-dependent glucose transport assay, cells expressing hSGLT2 were seeded into a 96-well culture plate at a density of 5x104 cells/well in RP...


US Patent US9006187 (2015)


BindingDB Entry DOI: 10.7270/Q29K490H
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50353893
PNG
(CHEMBL1829090 | US9006187, 34)
Show SMILES CCc1ccc(Cc2sc([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)c(C)c2C)cc1
Show InChI InChI=1S/C21H28O5S/c1-4-13-5-7-14(8-6-13)9-16-11(2)12(3)21(27-16)20-19(25)18(24)17(23)15(10-22)26-20/h5-8,15,17-20,22-25H,4,9-10H2,1-3H3/t15-,17-,18+,19-,20-/m1/s1
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n/an/a 29.3n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation counting


Bioorg Med Chem 19: 5813-32 (2011)


Article DOI: 10.1016/j.bmc.2011.08.014
BindingDB Entry DOI: 10.7270/Q2FB53BQ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50353890
PNG
(CHEMBL1829086 | US9006187, 25)
Show SMILES CCc1ccc(Cc2sc(cc2C)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C20H26O5S/c1-3-12-4-6-13(7-5-12)9-15-11(2)8-16(26-15)20-19(24)18(23)17(22)14(10-21)25-20/h4-8,14,17-24H,3,9-10H2,1-2H3/t14-,17-,18+,19-,20+/m1/s1
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n/an/a 24.8n/an/an/an/a7.437



Green Cross Corporation

US Patent


Assay Description
For sodium-dependent glucose transport assay, cells expressing hSGLT2 were seeded into a 96-well culture plate at a density of 5x104 cells/well in RP...


US Patent US9006187 (2015)


BindingDB Entry DOI: 10.7270/Q29K490H
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50353889
PNG
(CHEMBL1829085 | US9006187, 26)
Show SMILES Cc1cc(sc1Cc1ccc(C)cc1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C19H24O5S/c1-10-3-5-12(6-4-10)8-14-11(2)7-15(25-14)19-18(23)17(22)16(21)13(9-20)24-19/h3-7,13,16-23H,8-9H2,1-2H3/t13-,16-,17+,18-,19+/m1/s1
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n/an/a 69.6n/an/an/an/a7.437



Green Cross Corporation

US Patent


Assay Description
For sodium-dependent glucose transport assay, cells expressing hSGLT2 were seeded into a 96-well culture plate at a density of 5x104 cells/well in RP...


US Patent US9006187 (2015)


BindingDB Entry DOI: 10.7270/Q29K490H
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50353888
PNG
(CHEMBL1829084 | US9006187, 27)
Show SMILES Cc1cc(sc1Cc1ccc(cc1)C(C)(C)C)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C22H30O5S/c1-12-9-17(21-20(26)19(25)18(24)15(11-23)27-21)28-16(12)10-13-5-7-14(8-6-13)22(2,3)4/h5-9,15,18-21,23-26H,10-11H2,1-4H3/t15-,18-,19+,20-,21+/m1/s1
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n/an/a 88.3n/an/an/an/a7.437



Green Cross Corporation

US Patent


Assay Description
For sodium-dependent glucose transport assay, cells expressing hSGLT2 were seeded into a 96-well culture plate at a density of 5x104 cells/well in RP...


US Patent US9006187 (2015)


BindingDB Entry DOI: 10.7270/Q29K490H
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM155153
PNG
(US9006187, 29)
Show SMILES Cc1cc(sc1Cc1ccc(F)cc1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C18H21FO5S/c1-9-6-14(18-17(23)16(22)15(21)12(8-20)24-18)25-13(9)7-10-2-4-11(19)5-3-10/h2-6,12,15-18,20-23H,7-8H2,1H3/t12-,15-,16+,17-,18+/m1/s1
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n/an/a>1.00E+4n/an/an/an/a7.437



Green Cross Corporation

US Patent


Assay Description
For sodium-dependent glucose transport assay, cells expressing hSGLT2 were seeded into a 96-well culture plate at a density of 5x104 cells/well in RP...


US Patent US9006187 (2015)


BindingDB Entry DOI: 10.7270/Q29K490H
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50353886
PNG
(CHEMBL1829082 | US9006187, 30)
Show SMILES COc1ccc(Cc2sc(cc2C)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C19H24O6S/c1-10-7-15(19-18(23)17(22)16(21)13(9-20)25-19)26-14(10)8-11-3-5-12(24-2)6-4-11/h3-7,13,16-23H,8-9H2,1-2H3/t13-,16-,17+,18-,19+/m1/s1
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n/an/a 68.9n/an/an/an/a7.437



Green Cross Corporation

US Patent


Assay Description
For sodium-dependent glucose transport assay, cells expressing hSGLT2 were seeded into a 96-well culture plate at a density of 5x104 cells/well in RP...


US Patent US9006187 (2015)


BindingDB Entry DOI: 10.7270/Q29K490H
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50353885
PNG
(CHEMBL1829081 | US9006187, 31)
Show SMILES CCOc1ccc(Cc2sc(cc2C)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C20H26O6S/c1-3-25-13-6-4-12(5-7-13)9-15-11(2)8-16(27-15)20-19(24)18(23)17(22)14(10-21)26-20/h4-8,14,17-24H,3,9-10H2,1-2H3/t14-,17-,18+,19-,20+/m1/s1
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n/an/a 71.4n/an/an/an/a7.437



Green Cross Corporation

US Patent


Assay Description
For sodium-dependent glucose transport assay, cells expressing hSGLT2 were seeded into a 96-well culture plate at a density of 5x104 cells/well in RP...


US Patent US9006187 (2015)


BindingDB Entry DOI: 10.7270/Q29K490H
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50353893
PNG
(CHEMBL1829090 | US9006187, 34)
Show SMILES CCc1ccc(Cc2sc([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)c(C)c2C)cc1
Show InChI InChI=1S/C21H28O5S/c1-4-13-5-7-14(8-6-13)9-16-11(2)12(3)21(27-16)20-19(25)18(24)17(23)15(10-22)26-20/h5-8,15,17-20,22-25H,4,9-10H2,1-3H3/t15-,17-,18+,19-,20-/m1/s1
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n/an/a 29.3n/an/an/an/a7.437



Green Cross Corporation

US Patent


Assay Description
For sodium-dependent glucose transport assay, cells expressing hSGLT2 were seeded into a 96-well culture plate at a density of 5x104 cells/well in RP...


US Patent US9006187 (2015)


BindingDB Entry DOI: 10.7270/Q29K490H
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50353882
PNG
(CHEMBL1829078 | US9006187, 23)
Show SMILES Cc1sc(cc1Cc1ccc(O)cc1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C18H22O6S/c1-9-11(6-10-2-4-12(20)5-3-10)7-14(25-9)18-17(23)16(22)15(21)13(8-19)24-18/h2-5,7,13,15-23H,6,8H2,1H3/t13-,15-,16+,17-,18+/m1/s1
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n/an/a 50.2n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation counting


Bioorg Med Chem 19: 5813-32 (2011)


Article DOI: 10.1016/j.bmc.2011.08.014
BindingDB Entry DOI: 10.7270/Q2FB53BQ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50353885
PNG
(CHEMBL1829081 | US9006187, 31)
Show SMILES CCOc1ccc(Cc2sc(cc2C)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C20H26O6S/c1-3-25-13-6-4-12(5-7-13)9-15-11(2)8-16(27-15)20-19(24)18(23)17(22)14(10-21)26-20/h4-8,14,17-24H,3,9-10H2,1-2H3/t14-,17-,18+,19-,20+/m1/s1
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n/an/a 71.4n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation counting


Bioorg Med Chem 19: 5813-32 (2011)


Article DOI: 10.1016/j.bmc.2011.08.014
BindingDB Entry DOI: 10.7270/Q2FB53BQ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50353886
PNG
(CHEMBL1829082 | US9006187, 30)
Show SMILES COc1ccc(Cc2sc(cc2C)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C19H24O6S/c1-10-7-15(19-18(23)17(22)16(21)13(9-20)25-19)26-14(10)8-11-3-5-12(24-2)6-4-11/h3-7,13,16-23H,8-9H2,1-2H3/t13-,16-,17+,18-,19+/m1/s1
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n/an/a 68.9n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation counting


Bioorg Med Chem 19: 5813-32 (2011)


Article DOI: 10.1016/j.bmc.2011.08.014
BindingDB Entry DOI: 10.7270/Q2FB53BQ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50353888
PNG
(CHEMBL1829084 | US9006187, 27)
Show SMILES Cc1cc(sc1Cc1ccc(cc1)C(C)(C)C)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C22H30O5S/c1-12-9-17(21-20(26)19(25)18(24)15(11-23)27-21)28-16(12)10-13-5-7-14(8-6-13)22(2,3)4/h5-9,15,18-21,23-26H,10-11H2,1-4H3/t15-,18-,19+,20-,21+/m1/s1
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n/an/a 88.3n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation counting


Bioorg Med Chem 19: 5813-32 (2011)


Article DOI: 10.1016/j.bmc.2011.08.014
BindingDB Entry DOI: 10.7270/Q2FB53BQ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50353889
PNG
(CHEMBL1829085 | US9006187, 26)
Show SMILES Cc1cc(sc1Cc1ccc(C)cc1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C19H24O5S/c1-10-3-5-12(6-4-10)8-14-11(2)7-15(25-14)19-18(23)17(22)16(21)13(9-20)24-19/h3-7,13,16-23H,8-9H2,1-2H3/t13-,16-,17+,18-,19+/m1/s1
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n/an/a 69.6n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation counting


Bioorg Med Chem 19: 5813-32 (2011)


Article DOI: 10.1016/j.bmc.2011.08.014
BindingDB Entry DOI: 10.7270/Q2FB53BQ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50353890
PNG
(CHEMBL1829086 | US9006187, 25)
Show SMILES CCc1ccc(Cc2sc(cc2C)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C20H26O5S/c1-3-12-4-6-13(7-5-12)9-15-11(2)8-16(26-15)20-19(24)18(23)17(22)14(10-21)25-20/h4-8,14,17-24H,3,9-10H2,1-2H3/t14-,17-,18+,19-,20+/m1/s1
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n/an/a 24.8n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation counting


Bioorg Med Chem 19: 5813-32 (2011)


Article DOI: 10.1016/j.bmc.2011.08.014
BindingDB Entry DOI: 10.7270/Q2FB53BQ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50353891
PNG
(CHEMBL1829087 | US9006187, 24)
Show SMILES CCCc1ccc(Cc2sc(cc2C)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C21H28O5S/c1-3-4-13-5-7-14(8-6-13)10-16-12(2)9-17(27-16)21-20(25)19(24)18(23)15(11-22)26-21/h5-9,15,18-25H,3-4,10-11H2,1-2H3/t15-,18-,19+,20-,21+/m1/s1
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n/an/a 59.8n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation counting


Bioorg Med Chem 19: 5813-32 (2011)


Article DOI: 10.1016/j.bmc.2011.08.014
BindingDB Entry DOI: 10.7270/Q2FB53BQ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50353891
PNG
(CHEMBL1829087 | US9006187, 24)
Show SMILES CCCc1ccc(Cc2sc(cc2C)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C21H28O5S/c1-3-4-13-5-7-14(8-6-13)10-16-12(2)9-17(27-16)21-20(25)19(24)18(23)15(11-22)26-21/h5-9,15,18-25H,3-4,10-11H2,1-2H3/t15-,18-,19+,20-,21+/m1/s1
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n/an/a 59.8n/an/an/an/a7.437



Green Cross Corporation

US Patent


Assay Description
For sodium-dependent glucose transport assay, cells expressing hSGLT2 were seeded into a 96-well culture plate at a density of 5x104 cells/well in RP...


US Patent US9006187 (2015)


BindingDB Entry DOI: 10.7270/Q29K490H
More data for this
Ligand-Target Pair