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17 similar compounds to monomer 187631

Compile data set for download or QSAR
Wt: 401.4
BDBM187612
Wt: 399.4
BDBM187473
Wt: 416.4
BDBM187613
Wt: 460.5
BDBM187614
Wt: 400.4
BDBM187438
Wt: 442.4
BDBM187439
Wt: 398.4
BDBM187440
Wt: 430.4
BDBM187441
Wt: 382.4
BDBM187443
Wt: 415.4
BDBM187632
Wt: 487.5
BDBM187633
Wt: 459.5
BDBM187634
Wt: 485.5
BDBM187635
Wt: 485.5
BDBM187636
Wt: 418.4
BDBM187524
Displayed 1 to 15 (of 17 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 187612,187473,187613,187614,187438,187439,187440,187441,187443,187632,187633,187634,187635,187636,187524   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM187438
PNG
(US9169252, 39)
Show SMILES CC(C)Nc1cc(ncc1C(=O)NC[C@@H](F)C(C)(C)O)-n1ccc2cncnc12
Show InChI InChI=1S/C20H25FN6O2/c1-12(2)26-15-7-17(27-6-5-13-8-22-11-25-18(13)27)23-9-14(15)19(28)24-10-16(21)20(3,4)29/h5-9,11-12,16,29H,10H2,1-4H3,(H,23,26)(H,24,28)/t16-/m1/s1
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n/an/a 1.10n/an/an/an/a7.2n/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 L prepared from 15 L additions of enzyme and substrates (fluores...


US Patent US9169252 (2015)


BindingDB Entry DOI: 10.7270/Q2MP5235
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM187636
PNG
(US9169252, 190)
Show SMILES CC(C)Nc1cc(ncc1C(=O)NC[C@@H](F)C(C)(C)O)-n1ccc2cnc(nc12)N1CC[C@@H](O)C1
Show InChI InChI=1S/C24H32FN7O3/c1-14(2)29-18-9-20(26-11-17(18)22(34)27-12-19(25)24(3,4)35)32-8-5-15-10-28-23(30-21(15)32)31-7-6-16(33)13-31/h5,8-11,14,16,19,33,35H,6-7,12-13H2,1-4H3,(H,26,29)(H,27,34)/t16-,19-/m1/s1
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n/an/a 4.70n/an/an/an/a7.2n/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 L prepared from 15 L additions of enzyme and substrates (fluores...


US Patent US9169252 (2015)


BindingDB Entry DOI: 10.7270/Q2MP5235
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM187440
PNG
(US9169252, 41)
Show SMILES CC(C)(O)[C@H](F)CNC(=O)c1cnc(cc1NC1CC1)-n1ccc2cncnc12
Show InChI InChI=1S/C20H23FN6O2/c1-20(2,29)16(21)10-24-19(28)14-9-23-17(7-15(14)26-13-3-4-13)27-6-5-12-8-22-11-25-18(12)27/h5-9,11,13,16,29H,3-4,10H2,1-2H3,(H,23,26)(H,24,28)/t16-/m1/s1
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n/an/a 1.90n/an/an/an/a7.2n/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 L prepared from 15 L additions of enzyme and substrates (fluores...


US Patent US9169252 (2015)


BindingDB Entry DOI: 10.7270/Q2MP5235
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM187441
PNG
(US9169252, 42)
Show SMILES CC(C)(O)CNc1cc(ncc1C(=O)NC[C@@H](F)C(C)(C)O)-n1ccc2cncnc12
Show InChI InChI=1S/C21H27FN6O3/c1-20(2,30)11-26-15-7-17(28-6-5-13-8-23-12-27-18(13)28)24-9-14(15)19(29)25-10-16(22)21(3,4)31/h5-9,12,16,30-31H,10-11H2,1-4H3,(H,24,26)(H,25,29)/t16-/m1/s1
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n/an/a 13.6n/an/an/an/a7.2n/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 L prepared from 15 L additions of enzyme and substrates (fluores...


US Patent US9169252 (2015)


BindingDB Entry DOI: 10.7270/Q2MP5235
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM187443
PNG
(US9169252, 44)
Show SMILES CC(C)Nc1cc(ncc1C(=O)NCCC(C)(C)O)-n1ccc2cncnc12
Show InChI InChI=1S/C20H26N6O2/c1-13(2)25-16-9-17(26-8-5-14-10-21-12-24-18(14)26)23-11-15(16)19(27)22-7-6-20(3,4)28/h5,8-13,28H,6-7H2,1-4H3,(H,22,27)(H,23,25)
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n/an/a 4.20n/an/an/an/a7.2n/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 L prepared from 15 L additions of enzyme and substrates (fluores...


US Patent US9169252 (2015)


BindingDB Entry DOI: 10.7270/Q2MP5235
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM187473
PNG
(US9169252, 74)
Show SMILES CC(C)Nc1cc(ncc1C(=O)NC[C@@H](F)C(C)(C)O)-n1ccc2cccnc12
Show InChI InChI=1S/C21H26FN5O2/c1-13(2)26-16-10-18(27-9-7-14-6-5-8-23-19(14)27)24-11-15(16)20(28)25-12-17(22)21(3,4)29/h5-11,13,17,29H,12H2,1-4H3,(H,24,26)(H,25,28)/t17-/m1/s1
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n/an/a 4.30n/an/an/an/a7.2n/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 L prepared from 15 L additions of enzyme and substrates (fluores...


US Patent US9169252 (2015)


BindingDB Entry DOI: 10.7270/Q2MP5235
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM187524
PNG
(US9169252, 113)
Show SMILES CC(CF)Nc1cc(ncc1C(=O)NC[C@@H](F)C(C)(C)O)-n1ccc2cncnc12
Show InChI InChI=1S/C20H24F2N6O2/c1-12(7-21)27-15-6-17(28-5-4-13-8-23-11-26-18(13)28)24-9-14(15)19(29)25-10-16(22)20(2,3)30/h4-6,8-9,11-12,16,30H,7,10H2,1-3H3,(H,24,27)(H,25,29)/t12?,16-/m1/s1
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n/an/a 1.90n/an/an/an/a7.2n/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 L prepared from 15 L additions of enzyme and substrates (fluores...


US Patent US9169252 (2015)


BindingDB Entry DOI: 10.7270/Q2MP5235
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM187612
PNG
(US9169252, 170)
Show SMILES CC(C)Nc1cc(ncc1C(=O)NC[C@@H](F)C(C)(C)O)-n1cnc2cncnc12
Show InChI InChI=1S/C19H24FN7O2/c1-11(2)26-13-5-16(27-10-25-14-7-21-9-24-17(14)27)22-6-12(13)18(28)23-8-15(20)19(3,4)29/h5-7,9-11,15,29H,8H2,1-4H3,(H,22,26)(H,23,28)/t15-/m1/s1
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n/an/a 15.1n/an/an/an/a7.2n/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 L prepared from 15 L additions of enzyme and substrates (fluores...


US Patent US9169252 (2015)


BindingDB Entry DOI: 10.7270/Q2MP5235
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM187613
PNG
(US9169252, 171)
Show SMILES CC(C)Nc1cc(ncc1C(=O)NC[C@@H](F)C(C)(C)O)-n1cnc2cnc(N)nc12
Show InChI InChI=1S/C19H25FN8O2/c1-10(2)26-12-5-15(28-9-25-13-7-24-18(21)27-16(13)28)22-6-11(12)17(29)23-8-14(20)19(3,4)30/h5-7,9-10,14,30H,8H2,1-4H3,(H,22,26)(H,23,29)(H2,21,24,27)/t14-/m1/s1
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n/an/a 3.70n/an/an/an/a7.2n/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 L prepared from 15 L additions of enzyme and substrates (fluores...


US Patent US9169252 (2015)


BindingDB Entry DOI: 10.7270/Q2MP5235
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM187614
PNG
(US9169252, 172)
Show SMILES CC(C)Nc1cc(ncc1C(=O)NC[C@@H](F)C(C)(C)O)-n1cnc2cnc(NCCO)nc12
Show InChI InChI=1S/C21H29FN8O3/c1-12(2)28-14-7-17(24-8-13(14)19(32)25-10-16(22)21(3,4)33)30-11-27-15-9-26-20(23-5-6-31)29-18(15)30/h7-9,11-12,16,31,33H,5-6,10H2,1-4H3,(H,24,28)(H,25,32)(H,23,26,29)/t16-/m1/s1
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n/an/a 2.5n/an/an/an/a7.2n/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 L prepared from 15 L additions of enzyme and substrates (fluores...


US Patent US9169252 (2015)


BindingDB Entry DOI: 10.7270/Q2MP5235
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM187632
PNG
(US9169252, 186)
Show SMILES CC(C)Nc1cc(ncc1C(=O)NC[C@@H](F)C(C)(C)O)-n1ccc2cnc(N)nc12
Show InChI InChI=1S/C20H26FN7O2/c1-11(2)26-14-7-16(28-6-5-12-8-25-19(22)27-17(12)28)23-9-13(14)18(29)24-10-15(21)20(3,4)30/h5-9,11,15,30H,10H2,1-4H3,(H,23,26)(H,24,29)(H2,22,25,27)/t15-/m1/s1
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n/an/a 1.30n/an/an/an/a7.2n/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 L prepared from 15 L additions of enzyme and substrates (fluores...


US Patent US9169252 (2015)


BindingDB Entry DOI: 10.7270/Q2MP5235
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM187633
PNG
(US9169252, 187)
Show SMILES CC(C)Nc1cc(ncc1C(=O)NC[C@@H](F)C(C)(C)O)-n1ccc2cnc(NCC(C)(C)O)nc12
Show InChI InChI=1S/C24H34FN7O3/c1-14(2)30-17-9-19(26-11-16(17)21(33)27-12-18(25)24(5,6)35)32-8-7-15-10-28-22(31-20(15)32)29-13-23(3,4)34/h7-11,14,18,34-35H,12-13H2,1-6H3,(H,26,30)(H,27,33)(H,28,29,31)/t18-/m1/s1
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n/an/a 1.90n/an/an/an/a7.2n/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 L prepared from 15 L additions of enzyme and substrates (fluores...


US Patent US9169252 (2015)


BindingDB Entry DOI: 10.7270/Q2MP5235
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM187634
PNG
(US9169252, 188)
Show SMILES CC(C)Nc1cc(ncc1C(=O)NC[C@@H](F)C(C)(C)O)-n1ccc2cnc(NCCO)nc12
Show InChI InChI=1S/C22H30FN7O3/c1-13(2)28-16-9-18(25-11-15(16)20(32)26-12-17(23)22(3,4)33)30-7-5-14-10-27-21(24-6-8-31)29-19(14)30/h5,7,9-11,13,17,31,33H,6,8,12H2,1-4H3,(H,25,28)(H,26,32)(H,24,27,29)/t17-/m1/s1
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n/an/a 1.70n/an/an/an/a7.2n/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 L prepared from 15 L additions of enzyme and substrates (fluores...


US Patent US9169252 (2015)


BindingDB Entry DOI: 10.7270/Q2MP5235
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM187635
PNG
(US9169252, 189)
Show SMILES CC(C)Nc1cc(ncc1C(=O)NC[C@@H](F)C(C)(C)O)-n1ccc2cnc(nc12)N1CC[C@H](O)C1
Show InChI InChI=1S/C24H32FN7O3/c1-14(2)29-18-9-20(26-11-17(18)22(34)27-12-19(25)24(3,4)35)32-8-5-15-10-28-23(30-21(15)32)31-7-6-16(33)13-31/h5,8-11,14,16,19,33,35H,6-7,12-13H2,1-4H3,(H,26,29)(H,27,34)/t16-,19+/m0/s1
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n/an/a 4.80n/an/an/an/a7.2n/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 L prepared from 15 L additions of enzyme and substrates (fluores...


US Patent US9169252 (2015)


BindingDB Entry DOI: 10.7270/Q2MP5235
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM187439
PNG
(US9169252, 40)
Show SMILES CC(C)(O)[C@H](F)CNC(=O)c1cnc(cc1NC1CCOCC1)-n1ccc2cncnc12
Show InChI InChI=1S/C22H27FN6O3/c1-22(2,31)18(23)12-26-21(30)16-11-25-19(9-17(16)28-15-4-7-32-8-5-15)29-6-3-14-10-24-13-27-20(14)29/h3,6,9-11,13,15,18,31H,4-5,7-8,12H2,1-2H3,(H,25,28)(H,26,30)/t18-/m1/s1
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n/an/a 2n/an/an/an/a7.2n/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 L prepared from 15 L additions of enzyme and substrates (fluores...


US Patent US9169252 (2015)


BindingDB Entry DOI: 10.7270/Q2MP5235
More data for this
Ligand-Target Pair