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25 similar compounds to monomer 188704

Compile data set for download or QSAR
Wt: 427.4
BDBM188703
Wt: 445.3
BDBM188705
Wt: 387.3
BDBM188706
Wt: 401.3
BDBM188707
Wt: 417.3
BDBM188708
Wt: 413.3
BDBM188709
Wt: 443.4
BDBM188710
Wt: 399.3
BDBM188712
Wt: 431.4
BDBM188713
Wt: 415.4
BDBM188715
Wt: 413.3
BDBM188716
Wt: 457.4
BDBM188717
Wt: 441.4
BDBM188719
Wt: 442.4
BDBM188628
Wt: 415.4
BDBM188720
Displayed 1 to 15 (of 25 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 188703,188705,188706,188707,188708,188709,188710,188712,188713,188715,188716,188717,188719,188628,188720   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM188628
PNG
(US9169246, 166)
Show SMILES CN1CCN(CC1)c1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C22H21F3N6O/c1-29-7-9-30(10-8-29)20-15(3-2-6-26-20)14-4-5-16-18(11-14)31(13-22(23,24)25)21(32)17-12-27-28-19(16)17/h2-6,11-12H,7-10,13H2,1H3,(H,27,28)
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n/an/a 7.24n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...


US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM188720
PNG
(US9169246, 262)
Show SMILES CC(C)N(C)c1ncccc1-c1ccc2c3n[nH]cc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C21H20F3N5O/c1-12(2)28(3)19-14(5-4-8-25-19)13-6-7-15-17(9-13)29(11-21(22,23)24)20(30)16-10-26-27-18(15)16/h4-10,12H,11H2,1-3H3,(H,26,27)
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n/an/a 86n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...


US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM188705
PNG
(US9169246, 247)
Show SMILES OC1CN(CC1O)c1ncccc1-c1ccc2c3n[nH]cc3c(=O)n(CC(F)(F)F)c2c1
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n/an/a 6.41n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...


US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM188706
PNG
(US9169246, 248)
Show SMILES CN(C)c1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C19H16F3N5O/c1-26(2)17-12(4-3-7-23-17)11-5-6-13-15(8-11)27(10-19(20,21)22)18(28)14-9-24-25-16(13)14/h3-9H,10H2,1-2H3,(H,24,25)
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n/an/a 3.87n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...


US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM188707
PNG
(US9169246, 249)
Show SMILES CCN(C)c1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C20H18F3N5O/c1-3-27(2)18-13(5-4-8-24-18)12-6-7-14-16(9-12)28(11-20(21,22)23)19(29)15-10-25-26-17(14)15/h4-10H,3,11H2,1-2H3,(H,25,26)
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n/an/a 4.19n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...


US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM188708
PNG
(US9169246, 250)
Show SMILES CN(CCO)c1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C20H18F3N5O2/c1-27(7-8-29)18-13(3-2-6-24-18)12-4-5-14-16(9-12)28(11-20(21,22)23)19(30)15-10-25-26-17(14)15/h2-6,9-10,29H,7-8,11H2,1H3,(H,25,26)
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n/an/a 4.41n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...


US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM188709
PNG
(US9169246, 251)
Show SMILES FC(F)(F)Cn1c2cc(ccc2c2[nH]ncc2c1=O)-c1cccnc1N1CCCC1
Show InChI InChI=1S/C21H18F3N5O/c22-21(23,24)12-29-17-10-13(5-6-15(17)18-16(20(29)30)11-26-27-18)14-4-3-7-25-19(14)28-8-1-2-9-28/h3-7,10-11H,1-2,8-9,12H2,(H,26,27)
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n/an/a 5.34n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...


US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM188710
PNG
(US9169246, 252)
Show SMILES FC(F)(F)Cn1c2cc(ccc2c2[nH]ncc2c1=O)-c1cccnc1N1CCCOCC1
Show InChI InChI=1S/C22H20F3N5O2/c23-22(24,25)13-30-18-11-14(4-5-16(18)19-17(21(30)31)12-27-28-19)15-3-1-6-26-20(15)29-7-2-9-32-10-8-29/h1,3-6,11-12H,2,7-10,13H2,(H,27,28)
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n/an/a 8.35n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...


US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM188712
PNG
(US9169246, 254)
Show SMILES FC(F)(F)Cn1c2cc(ccc2c2[nH]ncc2c1=O)-c1cccnc1N1CCC1
Show InChI InChI=1S/C20H16F3N5O/c21-20(22,23)11-28-16-9-12(13-3-1-6-24-18(13)27-7-2-8-27)4-5-14(16)17-15(19(28)29)10-25-26-17/h1,3-6,9-10H,2,7-8,11H2,(H,25,26)
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n/an/a 13n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...


US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM188713
PNG
(US9169246, 255)
Show SMILES COCCN(C)c1ncccc1-c1ccc2c3n[nH]cc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C21H20F3N5O2/c1-28(8-9-31-2)19-14(4-3-7-25-19)13-5-6-15-17(10-13)29(12-21(22,23)24)20(30)16-11-26-27-18(15)16/h3-7,10-11H,8-9,12H2,1-2H3,(H,26,27)
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n/an/a 24n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...


US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM188715
PNG
(US9169246, 257)
Show SMILES CCN(CC)c1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C21H20F3N5O/c1-3-28(4-2)19-14(6-5-9-25-19)13-7-8-15-17(10-13)29(12-21(22,23)24)20(30)16-11-26-27-18(15)16/h5-11H,3-4,12H2,1-2H3,(H,26,27)
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n/an/a 31.1n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...


US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM188716
PNG
(US9169246, 258)
Show SMILES FC(F)(F)Cn1c2cc(ccc2c2[nH]ncc2c1=O)-c1cccnc1NC1CCC1
Show InChI InChI=1S/C21H18F3N5O/c22-21(23,24)11-29-17-9-12(6-7-15(17)18-16(20(29)30)10-26-28-18)14-5-2-8-25-19(14)27-13-3-1-4-13/h2,5-10,13H,1,3-4,11H2,(H,25,27)(H,26,28)
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n/an/a 34.5n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...


US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM188717
PNG
(US9169246, 259)
Show SMILES CC1CN(CC(C)O1)c1ncccc1-c1ccc2c3n[nH]cc3c(=O)n(CC(F)(F)F)c2c1
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n/an/a 34.5n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...


US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM188719
PNG
(US9169246, 261)
Show SMILES FC(F)(F)Cn1c2cc(ccc2c2n[nH]cc2c1=O)-c1cccnc1NC1CCCCC1
Show InChI InChI=1S/C23H22F3N5O/c24-23(25,26)13-31-19-11-14(8-9-17(19)20-18(22(31)32)12-28-30-20)16-7-4-10-27-21(16)29-15-5-2-1-3-6-15/h4,7-12,15H,1-3,5-6,13H2,(H,27,29)(H,28,30)
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n/an/a 85.7n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...


US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))
BDBM188703
PNG
(US9169246, 245)
Show SMILES FC(F)(F)Cn1c2cc(ccc2c2[nH]ncc2c1=O)-c1cccnc1N1CCCCC1
Show InChI InChI=1S/C22H20F3N5O/c23-22(24,25)13-30-18-11-14(6-7-16(18)19-17(21(30)31)12-27-28-19)15-5-4-8-26-20(15)29-9-2-1-3-10-29/h4-8,11-12H,1-3,9-10,13H2,(H,27,28)
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n/an/a 82.8n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...


US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair