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1 similar compounds to monomer 50289267

Compile data set for download or QSAR
Wt: 359.4
BDBM20111

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 20111   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cathepsin L1


(Homo sapiens (Human))
BDBM20111
PNG
(dipeptide-derived nitrile, 32 | tert-butyl N-[(1S)...)
Show SMILES CC(C)(C)OC(=O)N[C@@H](Cc1csc2ccccc12)C(=O)NCC#N
Show InChI InChI=1/C18H21N3O3S/c1-18(2,3)24-17(23)21-14(16(22)20-9-8-19)10-12-11-25-15-7-5-4-6-13(12)15/h4-7,11,14H,9-10H2,1-3H3,(H,20,22)(H,21,23)/t14-/s2
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Article
PubMed
290n/an/an/an/an/an/an/an/a



Rheinische Friedrich-Wilhelms-Universitat Bonn



Assay Description
Enzyme activities were calculated from kinetic measurements performed by fluorimetric detection of the product AMC at the wavelengths for excitation ...


J Med Chem 48: 7688-707 (2005)


Article DOI: 10.1021/jm050686b
BindingDB Entry DOI: 10.7270/Q2GB22BG
More data for this
Ligand-Target Pair
Cathepsin S


(Homo sapiens (Human))
BDBM20111
PNG
(dipeptide-derived nitrile, 32 | tert-butyl N-[(1S)...)
Show SMILES CC(C)(C)OC(=O)N[C@@H](Cc1csc2ccccc12)C(=O)NCC#N
Show InChI InChI=1/C18H21N3O3S/c1-18(2,3)24-17(23)21-14(16(22)20-9-8-19)10-12-11-25-15-7-5-4-6-13(12)15/h4-7,11,14H,9-10H2,1-3H3,(H,20,22)(H,21,23)/t14-/s2
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PubMed
300n/an/an/an/an/an/an/an/a



Rheinische Friedrich-Wilhelms-Universitat Bonn



Assay Description
Enzyme activities were calculated from kinetic measurements performed by fluorimetric detection of the product AMC at the wavelengths for excitation ...


J Med Chem 48: 7688-707 (2005)


Article DOI: 10.1021/jm050686b
BindingDB Entry DOI: 10.7270/Q2GB22BG
More data for this
Ligand-Target Pair
Cathepsin L


(Bos taurus (bovine))
BDBM20111
PNG
(dipeptide-derived nitrile, 32 | tert-butyl N-[(1S)...)
Show SMILES CC(C)(C)OC(=O)N[C@@H](Cc1csc2ccccc12)C(=O)NCC#N
Show InChI InChI=1/C18H21N3O3S/c1-18(2,3)24-17(23)21-14(16(22)20-9-8-19)10-12-11-25-15-7-5-4-6-13(12)15/h4-7,11,14H,9-10H2,1-3H3,(H,20,22)(H,21,23)/t14-/s2
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Article
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320n/an/an/an/an/an/an/an/a



Rheinische Friedrich-Wilhelms-Universitat Bonn



Assay Description
Enzyme activities were calculated from kinetic measurements performed by fluorimetric detection of the product AMC at the wavelengths for excitation ...


J Med Chem 48: 7688-707 (2005)


Article DOI: 10.1021/jm050686b
BindingDB Entry DOI: 10.7270/Q2GB22BG
More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM20111
PNG
(dipeptide-derived nitrile, 32 | tert-butyl N-[(1S)...)
Show SMILES CC(C)(C)OC(=O)N[C@@H](Cc1csc2ccccc12)C(=O)NCC#N
Show InChI InChI=1/C18H21N3O3S/c1-18(2,3)24-17(23)21-14(16(22)20-9-8-19)10-12-11-25-15-7-5-4-6-13(12)15/h4-7,11,14H,9-10H2,1-3H3,(H,20,22)(H,21,23)/t14-/s2
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Article
PubMed
7.40E+3n/an/an/an/an/an/an/an/a



Rheinische Friedrich-Wilhelms-Universitat Bonn



Assay Description
Enzyme activities were calculated from kinetic measurements performed by spectrophotometric detection of the product p-nitroaniline (pNA) at waveleng...


J Med Chem 48: 7688-707 (2005)


Article DOI: 10.1021/jm050686b
BindingDB Entry DOI: 10.7270/Q2GB22BG
More data for this
Ligand-Target Pair
Cathepsin K


(Homo sapiens (Human))
BDBM20111
PNG
(dipeptide-derived nitrile, 32 | tert-butyl N-[(1S)...)
Show SMILES CC(C)(C)OC(=O)N[C@@H](Cc1csc2ccccc12)C(=O)NCC#N
Show InChI InChI=1/C18H21N3O3S/c1-18(2,3)24-17(23)21-14(16(22)20-9-8-19)10-12-11-25-15-7-5-4-6-13(12)15/h4-7,11,14H,9-10H2,1-3H3,(H,20,22)(H,21,23)/t14-/s2
PDB
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Article
PubMed
3.40E+4n/an/an/an/an/an/an/an/a



Rheinische Friedrich-Wilhelms-Universitat Bonn



Assay Description
Enzyme activities were calculated from kinetic measurements performed by fluorimetric detection of the product AMC at the wavelengths for excitation ...


J Med Chem 48: 7688-707 (2005)


Article DOI: 10.1021/jm050686b
BindingDB Entry DOI: 10.7270/Q2GB22BG
More data for this
Ligand-Target Pair