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32 similar compounds to monomer 50366689

Compile data set for download or QSAR
Wt: 3370.8
BDBM21940
Wt: 2225.4
BDBM50094056
Wt: 1725.8
BDBM50094057
Wt: 1213.3
BDBM50094058
Wt: 3467.9
BDBM50121927
Wt: 3244.6
BDBM50163757
Wt: 3286.7
BDBM50267949
Wt: 3483.0
BDBM50267950
Wt: 3420.9
BDBM50267261
Wt: 3449.7
BDBM50267262
Wt: 3371.8
BDBM50267263
Wt: 3369.8
BDBM50267264
Wt: 1711.8
BDBM50267265
Wt: 1905.0
BDBM50270974
Wt: 1905.0
BDBM50270982
Displayed 1 to 15 (of 32 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 25 hits for monomerid = 21940,50094056,50094057,50094058,50121927,50163757,50267949,50267950,50267261,50267262,50267263,50267264,50267265,50270974,50270982   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Ghrelin receptor


(Homo sapiens (Human))
BDBM21940
PNG
(Ghrelin)
Show SMILES CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(O)=O
Show InChI InChI=1S/C149H249N47O42/c1-9-10-11-12-16-45-118(209)238-78-106(191-135(225)103(75-197)171-115(204)73-154)137(227)187-101(71-84-32-14-13-15-33-84)133(223)186-100(70-81(4)5)132(222)190-105(77-199)144(234)194-66-29-42-108(194)139(229)180-95(51-57-117(207)208)128(218)188-102(72-85-74-165-79-169-85)134(224)179-92(47-53-112(156)201)126(216)175-90(39-26-63-167-148(161)162)130(220)192-119(82(6)7)141(231)181-93(48-54-113(157)202)127(217)177-91(46-52-111(155)200)125(215)174-89(38-25-62-166-147(159)160)122(212)173-87(35-18-22-59-151)121(211)178-94(50-56-116(205)206)129(219)189-104(76-198)136(226)176-88(36-19-23-60-152)123(213)182-96(37-20-24-61-153)142(232)196-68-31-44-110(196)145(235)195-67-30-41-107(195)138(228)170-83(8)120(210)172-86(34-17-21-58-150)124(214)185-99(69-80(2)3)131(221)183-97(49-55-114(158)203)143(233)193-65-28-43-109(193)140(230)184-98(146(236)237)40-27-64-168-149(163)164/h13-15,32-33,74,79-83,86-110,119,197-199H,9-12,16-31,34-73,75-78,150-154H2,1-8H3,(H2,155,200)(H2,156,201)(H2,157,202)(H2,158,203)(H,165,169)(H,170,228)(H,171,204)(H,172,210)(H,173,212)(H,174,215)(H,175,216)(H,176,226)(H,177,217)(H,178,211)(H,179,224)(H,180,229)(H,181,231)(H,182,213)(H,183,221)(H,184,230)(H,185,214)(H,186,223)(H,187,227)(H,188,218)(H,189,219)(H,190,222)(H,191,225)(H,192,220)(H,205,206)(H,207,208)(H,236,237)(H4,159,160,166)(H4,161,162,167)(H4,163,164,168)/t83-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,119-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 1.40n/an/a7.222



Bristol-Myers Squibb Pharmaceutical Research Institute



Assay Description
The functional FLIPR assay was developed from H4 glioma cells in which expression of the endogenous human GHS receptor was enhanced by RAGE-activatio...


J Med Chem 50: 5890-3 (2007)


Article DOI: 10.1021/jm7010595
BindingDB Entry DOI: 10.7270/Q24J0CCV
More data for this
Ligand-Target Pair
Ghrelin receptor


(Homo sapiens (Human))
BDBM50163757
PNG
((4S)-4-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)CN)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(O)=O
Show InChI InChI=1S/C141H235N47O41/c1-73(2)62-92(123(213)175-90(42-48-107(150)196)135(225)185-58-22-37-102(185)132(222)176-91(138(228)229)34-21-57-160-141(155)156)177-116(206)79(28-11-15-51-142)164-112(202)76(7)162-130(220)100-35-24-60-187(100)137(227)103-38-25-61-188(103)134(224)89(31-14-18-54-145)174-115(205)81(30-13-17-53-144)168-128(218)97(69-190)181-121(211)87(43-49-109(198)199)170-113(203)80(29-12-16-52-143)165-114(204)82(32-19-55-158-139(151)152)166-117(207)84(39-45-104(147)193)169-119(209)86(41-47-106(149)195)173-133(223)111(75(5)6)184-122(212)83(33-20-56-159-140(153)154)167-118(208)85(40-46-105(148)194)171-126(216)95(65-78-67-157-72-161-78)180-120(210)88(44-50-110(200)201)172-131(221)101-36-23-59-186(101)136(226)99(71-192)183-124(214)93(63-74(3)4)178-125(215)94(64-77-26-9-8-10-27-77)179-129(219)98(70-191)182-127(217)96(68-189)163-108(197)66-146/h8-10,26-27,67,72-76,79-103,111,189-192H,11-25,28-66,68-71,142-146H2,1-7H3,(H2,147,193)(H2,148,194)(H2,149,195)(H2,150,196)(H,157,161)(H,162,220)(H,163,197)(H,164,202)(H,165,204)(H,166,207)(H,167,208)(H,168,218)(H,169,209)(H,170,203)(H,171,216)(H,172,221)(H,173,223)(H,174,205)(H,175,213)(H,176,222)(H,177,206)(H,178,215)(H,179,219)(H,180,210)(H,181,211)(H,182,217)(H,183,214)(H,184,212)(H,198,199)(H,200,201)(H,228,229)(H4,151,152,158)(H4,153,154,159)(H4,155,156,160)/t76-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,111-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+7n/an/an/an/an/an/a



University of Western Ontario

Curated by ChEMBL


Assay Description
Displacement of [35S]MK-0677 from human growth hormone secretagogue receptor


J Med Chem 52: 2196-203 (2009)


Article DOI: 10.1021/jm8014519
BindingDB Entry DOI: 10.7270/Q2X63NWQ
More data for this
Ligand-Target Pair
Ghrelin receptor


(Homo sapiens (Human))
BDBM50094058
PNG
(CHEMBL263544 | GSS(heptyl carbonyl)FLSPEHQ-NH2)
Show SMILES CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(N)=O
Show InChI InChI=1S/C55H84N14O17/c1-4-5-6-7-11-16-46(76)86-29-41(68-52(82)39(27-70)61-44(73)25-56)53(83)65-37(23-32-13-9-8-10-14-32)50(80)64-36(22-31(2)3)49(79)67-40(28-71)55(85)69-21-12-15-42(69)54(84)63-35(18-20-45(74)75)48(78)66-38(24-33-26-59-30-60-33)51(81)62-34(47(58)77)17-19-43(57)72/h8-10,13-14,26,30-31,34-42,70-71H,4-7,11-12,15-25,27-29,56H2,1-3H3,(H2,57,72)(H2,58,77)(H,59,60)(H,61,73)(H,62,81)(H,63,84)(H,64,80)(H,65,83)(H,66,78)(H,67,79)(H,68,82)(H,74,75)/t34-,35-,36-,37-,38-,39-,40-,41-,42+/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 7.10n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]-MK-0677 as a radiolabeled liga...


J Med Chem 43: 4370-6 (2000)


Article DOI: 10.1021/jm0001727
BindingDB Entry DOI: 10.7270/Q2T72GP0
More data for this
Ligand-Target Pair
Ghrelin receptor


(Homo sapiens (Human))
BDBM50094056
PNG
(CHEMBL412799 | GSS(heptyl carbonyl)FLSPEHQRVQQRKES...)
Show SMILES CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(N)=O
Show InChI InChI=1S/C96H157N31O30/c1-6-7-8-9-13-25-76(139)157-48-68(125-90(152)66(46-129)111-73(134)43-98)91(153)121-63(41-52-19-11-10-12-20-52)88(150)120-62(40-50(2)3)87(149)124-67(47-130)94(156)127-39-18-24-69(127)92(154)118-61(30-35-75(137)138)84(146)122-64(42-53-44-107-49-110-53)89(151)117-58(27-32-71(100)132)82(144)114-56(23-17-38-109-96(105)106)86(148)126-77(51(4)5)93(155)119-59(28-33-72(101)133)83(145)115-57(26-31-70(99)131)81(143)113-55(22-16-37-108-95(103)104)80(142)112-54(21-14-15-36-97)79(141)116-60(29-34-74(135)136)85(147)123-65(45-128)78(102)140/h10-12,19-20,44,49-51,54-69,77,128-130H,6-9,13-18,21-43,45-48,97-98H2,1-5H3,(H2,99,131)(H2,100,132)(H2,101,133)(H2,102,140)(H,107,110)(H,111,134)(H,112,142)(H,113,143)(H,114,144)(H,115,145)(H,116,141)(H,117,151)(H,118,154)(H,119,155)(H,120,150)(H,121,153)(H,122,146)(H,123,147)(H,124,149)(H,125,152)(H,126,148)(H,135,136)(H,137,138)(H4,103,104,108)(H4,105,106,109)/t54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69+,77-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.770n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]-MK-0677 as a radiolabeled liga...


J Med Chem 43: 4370-6 (2000)


Article DOI: 10.1021/jm0001727
BindingDB Entry DOI: 10.7270/Q2T72GP0
More data for this
Ligand-Target Pair
IgG receptor FcRn large subunit p51


(Homo sapiens (Human))
BDBM50270982
PNG
((2S)-1-{2-[(2S)-2-[(2S)-2-{[(2S)-1-[(2S)-2-[(2S)-2...)
Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCC(N)=O)[C@@H](C)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N1CCC[C@H]1C(O)=O
Show InChI InChI=1S/C87H125N25O24/c1-47(2)35-58(80(129)109-63(38-51-23-25-53(114)26-24-51)85(134)112-34-13-21-64(112)83(132)105-57(28-30-72(121)122)78(127)108-62(40-67(91)116)76(125)99-45-71(120)111-33-14-22-65(111)86(135)136)101-69(118)43-96-68(117)42-97-75(124)59(36-49-15-6-4-7-16-49)106-82(131)61(39-52-41-94-46-100-52)102-70(119)44-98-84(133)73(48(3)113)110-79(128)55(19-10-11-31-88)104-81(130)60(37-50-17-8-5-9-18-50)107-77(126)56(20-12-32-95-87(92)93)103-74(123)54(89)27-29-66(90)115/h4-9,15-18,23-26,41,46-48,54-65,73,113-114H,10-14,19-22,27-40,42-45,88-89H2,1-3H3,(H2,90,115)(H2,91,116)(H,94,100)(H,96,117)(H,97,124)(H,98,133)(H,99,125)(H,101,118)(H,102,119)(H,103,123)(H,104,130)(H,105,132)(H,106,131)(H,107,126)(H,108,127)(H,109,129)(H,110,128)(H,121,122)(H,135,136)(H4,92,93,95)/t48-,54+,55+,56+,57+,58+,59+,60+,61+,62+,63+,64+,65+,73+/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.30E+4n/an/an/an/an/an/a



Syntonix Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human IgG binding to soluble human FcRn by ELISA


Bioorg Med Chem 16: 6394-405 (2008)


Article DOI: 10.1016/j.bmc.2008.05.004
BindingDB Entry DOI: 10.7270/Q2QV3M9C
More data for this
Ligand-Target Pair
IgG receptor FcRn large subunit p51


(Homo sapiens (Human))
BDBM50270974
PNG
((2S)-1-{2-[(2S)-2-[(2S)-6-amino-2-{[(2S)-1-[(2S)-2...)
Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCC(N)=O)[C@@H](C)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N1CCC[C@H]1C(O)=O
Show InChI InChI=1S/C87H125N25O24/c1-47(2)35-58(80(129)109-63(38-51-23-25-53(114)26-24-51)85(134)112-34-13-21-64(112)83(132)105-55(19-10-11-31-88)77(126)108-62(40-67(91)116)76(125)99-45-71(120)111-33-14-22-65(111)86(135)136)101-69(118)43-96-68(117)42-97-75(124)59(36-49-15-6-4-7-16-49)106-82(131)61(39-52-41-94-46-100-52)102-70(119)44-98-84(133)73(48(3)113)110-79(128)57(28-30-72(121)122)104-81(130)60(37-50-17-8-5-9-18-50)107-78(127)56(20-12-32-95-87(92)93)103-74(123)54(89)27-29-66(90)115/h4-9,15-18,23-26,41,46-48,54-65,73,113-114H,10-14,19-22,27-40,42-45,88-89H2,1-3H3,(H2,90,115)(H2,91,116)(H,94,100)(H,96,117)(H,97,124)(H,98,133)(H,99,125)(H,101,118)(H,102,119)(H,103,123)(H,104,130)(H,105,132)(H,106,131)(H,107,127)(H,108,126)(H,109,129)(H,110,128)(H,121,122)(H,135,136)(H4,92,93,95)/t48-,54+,55+,56+,57+,58+,59+,60+,61+,62+,63+,64+,65+,73+/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.00E+5n/an/an/an/an/an/a



Syntonix Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human IgG binding to soluble human FcRn by ELISA


Bioorg Med Chem 16: 6394-405 (2008)


Article DOI: 10.1016/j.bmc.2008.05.004
BindingDB Entry DOI: 10.7270/Q2QV3M9C
More data for this
Ligand-Target Pair
IgG receptor FcRn large subunit p51


(Homo sapiens (Human))
BDBM50270982
PNG
((2S)-1-{2-[(2S)-2-[(2S)-2-{[(2S)-1-[(2S)-2-[(2S)-2...)
Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCC(N)=O)[C@@H](C)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N1CCC[C@H]1C(O)=O
Show InChI InChI=1S/C87H125N25O24/c1-47(2)35-58(80(129)109-63(38-51-23-25-53(114)26-24-51)85(134)112-34-13-21-64(112)83(132)105-57(28-30-72(121)122)78(127)108-62(40-67(91)116)76(125)99-45-71(120)111-33-14-22-65(111)86(135)136)101-69(118)43-96-68(117)42-97-75(124)59(36-49-15-6-4-7-16-49)106-82(131)61(39-52-41-94-46-100-52)102-70(119)44-98-84(133)73(48(3)113)110-79(128)55(19-10-11-31-88)104-81(130)60(37-50-17-8-5-9-18-50)107-77(126)56(20-12-32-95-87(92)93)103-74(123)54(89)27-29-66(90)115/h4-9,15-18,23-26,41,46-48,54-65,73,113-114H,10-14,19-22,27-40,42-45,88-89H2,1-3H3,(H2,90,115)(H2,91,116)(H,94,100)(H,96,117)(H,97,124)(H,98,133)(H,99,125)(H,101,118)(H,102,119)(H,103,123)(H,104,130)(H,105,132)(H,106,131)(H,107,126)(H,108,127)(H,109,129)(H,110,128)(H,121,122)(H,135,136)(H4,92,93,95)/t48-,54+,55+,56+,57+,58+,59+,60+,61+,62+,63+,64+,65+,73+/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 1.20E+3n/an/an/a6.0n/a



Syntonix Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human FcRn at pH 6 by surface plasmon resonance assay


Bioorg Med Chem 16: 6394-405 (2008)


Article DOI: 10.1016/j.bmc.2008.05.004
BindingDB Entry DOI: 10.7270/Q2QV3M9C
More data for this
Ligand-Target Pair
IgG receptor FcRn large subunit p51


(Homo sapiens (Human))
BDBM50270974
PNG
((2S)-1-{2-[(2S)-2-[(2S)-6-amino-2-{[(2S)-1-[(2S)-2...)
Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCC(N)=O)[C@@H](C)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N1CCC[C@H]1C(O)=O
Show InChI InChI=1S/C87H125N25O24/c1-47(2)35-58(80(129)109-63(38-51-23-25-53(114)26-24-51)85(134)112-34-13-21-64(112)83(132)105-55(19-10-11-31-88)77(126)108-62(40-67(91)116)76(125)99-45-71(120)111-33-14-22-65(111)86(135)136)101-69(118)43-96-68(117)42-97-75(124)59(36-49-15-6-4-7-16-49)106-82(131)61(39-52-41-94-46-100-52)102-70(119)44-98-84(133)73(48(3)113)110-79(128)57(28-30-72(121)122)104-81(130)60(37-50-17-8-5-9-18-50)107-78(127)56(20-12-32-95-87(92)93)103-74(123)54(89)27-29-66(90)115/h4-9,15-18,23-26,41,46-48,54-65,73,113-114H,10-14,19-22,27-40,42-45,88-89H2,1-3H3,(H2,90,115)(H2,91,116)(H,94,100)(H,96,117)(H,97,124)(H,98,133)(H,99,125)(H,101,118)(H,102,119)(H,103,123)(H,104,130)(H,105,132)(H,106,131)(H,107,127)(H,108,126)(H,109,129)(H,110,128)(H,121,122)(H,135,136)(H4,92,93,95)/t48-,54+,55+,56+,57+,58+,59+,60+,61+,62+,63+,64+,65+,73+/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 2.70E+4n/an/an/a6.0n/a



Syntonix Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human FcRn at pH 6 by surface plasmon resonance assay


Bioorg Med Chem 16: 6394-405 (2008)


Article DOI: 10.1016/j.bmc.2008.05.004
BindingDB Entry DOI: 10.7270/Q2QV3M9C
More data for this
Ligand-Target Pair
Ghrelin receptor


(Homo sapiens (Human))
BDBM50121927
PNG
(CHEMBL437713 | Glu-Ser-OctSer-phe-Leu-Ser-Pro-Glu-...)
Show SMILES CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(O)=O
Show InChI InChI=1S/C154H256N48O43/c1-9-10-11-12-16-47-122(215)245-81-109(196-139(231)106(78-203)176-119(210)76-159)141(233)192-104(74-87-33-14-13-15-34-87)137(229)191-103(73-84(4)5)136(228)195-108(80-205)148(240)199-68-29-43-111(199)143(235)185-98(53-59-121(213)214)132(224)193-105(75-88-77-170-82-174-88)138(230)184-95(49-55-116(161)207)130(222)180-93(40-26-65-172-153(166)167)134(226)197-123(85(6)7)145(237)186-96(50-56-117(162)208)131(223)182-94(48-54-115(160)206)129(221)179-92(39-25-64-171-152(164)165)126(218)178-90(36-18-22-61-156)125(217)183-97(52-58-120(211)212)133(225)194-107(79-204)140(232)181-91(37-19-23-62-157)127(219)187-99(38-20-24-63-158)146(238)201-70-31-45-113(201)150(242)202-71-32-46-114(202)149(241)200-69-30-42-110(200)142(234)175-86(8)124(216)177-89(35-17-21-60-155)128(220)190-102(72-83(2)3)135(227)188-100(51-57-118(163)209)147(239)198-67-28-44-112(198)144(236)189-101(151(243)244)41-27-66-173-154(168)169/h13-15,33-34,77,82-86,89-114,123,203-205H,9-12,16-32,35-76,78-81,155-159H2,1-8H3,(H2,160,206)(H2,161,207)(H2,162,208)(H2,163,209)(H,170,174)(H,175,234)(H,176,210)(H,177,216)(H,178,218)(H,179,221)(H,180,222)(H,181,232)(H,182,223)(H,183,217)(H,184,230)(H,185,235)(H,186,237)(H,187,219)(H,188,227)(H,189,236)(H,190,220)(H,191,229)(H,192,233)(H,193,224)(H,194,225)(H,195,228)(H,196,231)(H,197,226)(H,211,212)(H,213,214)(H,243,244)(H4,164,165,171)(H4,166,167,172)(H4,168,169,173)/t86-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,123-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.710n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Ability to displace [125I]ghrelin from cloned human Growth hormone secretagogue receptor type I (GSH1a) expressed in COS-7 cells


J Med Chem 45: 5609-16 (2002)


Article DOI: 10.1021/jm020424z
BindingDB Entry DOI: 10.7270/Q270825W
More data for this
Ligand-Target Pair
Ghrelin receptor


(Homo sapiens (Human))
BDBM50267949
PNG
((4S)-4-{[(2S)-1-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-3-(a...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](COC(C)=O)NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(O)=O
Show InChI InChI=1S/C143H237N47O42/c1-74(2)63-94(125(215)177-92(43-49-109(152)198)137(227)187-59-23-38-104(187)134(224)178-93(140(230)231)35-22-58-162-143(157)158)179-118(208)81(29-12-16-52-144)166-114(204)77(7)164-132(222)102-36-25-61-189(102)139(229)105-39-26-62-190(105)136(226)91(32-15-19-55-147)176-117(207)83(31-14-18-54-146)170-130(220)99(70-192)183-123(213)89(44-50-111(200)201)172-115(205)82(30-13-17-53-145)167-116(206)84(33-20-56-160-141(153)154)168-119(209)86(40-46-106(149)195)171-121(211)88(42-48-108(151)197)175-135(225)113(76(5)6)186-124(214)85(34-21-57-161-142(155)156)169-120(210)87(41-47-107(150)196)173-128(218)97(66-80-68-159-73-163-80)182-122(212)90(45-51-112(202)203)174-133(223)103-37-24-60-188(103)138(228)100(71-193)184-126(216)95(64-75(3)4)180-127(217)96(65-79-27-10-9-11-28-79)181-131(221)101(72-232-78(8)194)185-129(219)98(69-191)165-110(199)67-148/h9-11,27-28,68,73-77,81-105,113,191-193H,12-26,29-67,69-72,144-148H2,1-8H3,(H2,149,195)(H2,150,196)(H2,151,197)(H2,152,198)(H,159,163)(H,164,222)(H,165,199)(H,166,204)(H,167,206)(H,168,209)(H,169,210)(H,170,220)(H,171,211)(H,172,205)(H,173,218)(H,174,223)(H,175,225)(H,176,207)(H,177,215)(H,178,224)(H,179,208)(H,180,217)(H,181,221)(H,182,212)(H,183,213)(H,184,216)(H,185,219)(H,186,214)(H,200,201)(H,202,203)(H,230,231)(H4,153,154,160)(H4,155,156,161)(H4,157,158,162)/t77-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,113-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>2.00E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]-MK-0677 as a radiolabeled liga...


J Med Chem 43: 4370-6 (2000)


Article DOI: 10.1021/jm0001727
BindingDB Entry DOI: 10.7270/Q2T72GP0
More data for this
Ligand-Target Pair
Ghrelin receptor


(Homo sapiens (Human))
BDBM21940
PNG
(Ghrelin)
Show SMILES CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(O)=O
Show InChI InChI=1S/C149H249N47O42/c1-9-10-11-12-16-45-118(209)238-78-106(191-135(225)103(75-197)171-115(204)73-154)137(227)187-101(71-84-32-14-13-15-33-84)133(223)186-100(70-81(4)5)132(222)190-105(77-199)144(234)194-66-29-42-108(194)139(229)180-95(51-57-117(207)208)128(218)188-102(72-85-74-165-79-169-85)134(224)179-92(47-53-112(156)201)126(216)175-90(39-26-63-167-148(161)162)130(220)192-119(82(6)7)141(231)181-93(48-54-113(157)202)127(217)177-91(46-52-111(155)200)125(215)174-89(38-25-62-166-147(159)160)122(212)173-87(35-18-22-59-151)121(211)178-94(50-56-116(205)206)129(219)189-104(76-198)136(226)176-88(36-19-23-60-152)123(213)182-96(37-20-24-61-153)142(232)196-68-31-44-110(196)145(235)195-67-30-41-107(195)138(228)170-83(8)120(210)172-86(34-17-21-58-150)124(214)185-99(69-80(2)3)131(221)183-97(49-55-114(158)203)143(233)193-65-28-43-109(193)140(230)184-98(146(236)237)40-27-64-168-149(163)164/h13-15,32-33,74,79-83,86-110,119,197-199H,9-12,16-31,34-73,75-78,150-154H2,1-8H3,(H2,155,200)(H2,156,201)(H2,157,202)(H2,158,203)(H,165,169)(H,170,228)(H,171,204)(H,172,210)(H,173,212)(H,174,215)(H,175,216)(H,176,226)(H,177,217)(H,178,211)(H,179,224)(H,180,229)(H,181,231)(H,182,213)(H,183,221)(H,184,230)(H,185,214)(H,186,223)(H,187,227)(H,188,218)(H,189,219)(H,190,222)(H,191,225)(H,192,220)(H,205,206)(H,207,208)(H,236,237)(H4,159,160,166)(H4,161,162,167)(H4,163,164,168)/t83-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,119-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.25n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]-MK-0677 as a radiolabeled liga...


J Med Chem 43: 4370-6 (2000)


Article DOI: 10.1021/jm0001727
BindingDB Entry DOI: 10.7270/Q2T72GP0
More data for this
Ligand-Target Pair
Ghrelin receptor


(Homo sapiens (Human))
BDBM50267263
PNG
((4S)-4-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](COC(=O)CCCCCCN)NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(O)=O
Show InChI InChI=1S/C148H248N48O42/c1-79(2)68-98(130(221)183-96(47-53-113(158)203)142(233)193-64-26-41-108(193)139(230)184-97(145(236)237)38-25-63-168-148(163)164)185-123(214)85(32-14-19-57-150)172-119(210)82(7)170-137(228)106-39-28-66-195(106)144(235)109-42-29-67-196(109)141(232)95(35-17-22-60-153)182-122(213)87(34-16-21-59-152)176-135(226)103(75-198)189-128(219)93(48-54-115(205)206)178-120(211)86(33-15-20-58-151)173-121(212)88(36-23-61-166-146(159)160)174-124(215)90(44-50-110(155)200)177-126(217)92(46-52-112(157)202)181-140(231)118(81(5)6)192-129(220)89(37-24-62-167-147(161)162)175-125(216)91(45-51-111(156)201)179-133(224)101(71-84-73-165-78-169-84)188-127(218)94(49-55-116(207)208)180-138(229)107-40-27-65-194(107)143(234)104(76-199)190-131(222)99(69-80(3)4)186-132(223)100(70-83-30-11-10-12-31-83)187-136(227)105(77-238-117(209)43-13-8-9-18-56-149)191-134(225)102(74-197)171-114(204)72-154/h10-12,30-31,73,78-82,85-109,118,197-199H,8-9,13-29,32-72,74-77,149-154H2,1-7H3,(H2,155,200)(H2,156,201)(H2,157,202)(H2,158,203)(H,165,169)(H,170,228)(H,171,204)(H,172,210)(H,173,212)(H,174,215)(H,175,216)(H,176,226)(H,177,217)(H,178,211)(H,179,224)(H,180,229)(H,181,231)(H,182,213)(H,183,221)(H,184,230)(H,185,214)(H,186,223)(H,187,227)(H,188,218)(H,189,219)(H,190,222)(H,191,225)(H,192,220)(H,205,206)(H,207,208)(H,236,237)(H4,159,160,166)(H4,161,162,167)(H4,163,164,168)/t82-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,118-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>2.00E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]-MK-0677 as a radiolabeled liga...


J Med Chem 43: 4370-6 (2000)


Article DOI: 10.1021/jm0001727
BindingDB Entry DOI: 10.7270/Q2T72GP0
More data for this
Ligand-Target Pair
Ghrelin receptor


(Homo sapiens (Human))
BDBM50267262
PNG
((4S)-4-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](COC(=O)CCCCCCCBr)NC(=O)[C@H](CO)NC(=O)CN)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(O)=O
Show InChI InChI=1S/C149H248BrN47O42/c1-80(2)69-99(131(222)184-97(48-54-114(159)204)143(234)194-65-27-42-109(194)140(231)185-98(146(237)238)39-26-64-169-149(164)165)186-124(215)86(33-15-20-58-151)173-120(211)83(7)171-138(229)107-40-29-67-196(107)145(236)110-43-30-68-197(110)142(233)96(36-18-23-61-154)183-123(214)88(35-17-22-60-153)177-136(227)104(76-199)190-129(220)94(49-55-116(206)207)179-121(212)87(34-16-21-59-152)174-122(213)89(37-24-62-167-147(160)161)175-125(216)91(45-51-111(156)201)178-127(218)93(47-53-113(158)203)182-141(232)119(82(5)6)193-130(221)90(38-25-63-168-148(162)163)176-126(217)92(46-52-112(157)202)180-134(225)102(72-85-74-166-79-170-85)189-128(219)95(50-56-117(208)209)181-139(230)108-41-28-66-195(108)144(235)105(77-200)191-132(223)100(70-81(3)4)187-133(224)101(71-84-31-12-11-13-32-84)188-137(228)106(192-135(226)103(75-198)172-115(205)73-155)78-239-118(210)44-14-9-8-10-19-57-150/h11-13,31-32,74,79-83,86-110,119,198-200H,8-10,14-30,33-73,75-78,151-155H2,1-7H3,(H2,156,201)(H2,157,202)(H2,158,203)(H2,159,204)(H,166,170)(H,171,229)(H,172,205)(H,173,211)(H,174,213)(H,175,216)(H,176,217)(H,177,227)(H,178,218)(H,179,212)(H,180,225)(H,181,230)(H,182,232)(H,183,214)(H,184,222)(H,185,231)(H,186,215)(H,187,224)(H,188,228)(H,189,219)(H,190,220)(H,191,223)(H,192,226)(H,193,221)(H,206,207)(H,208,209)(H,237,238)(H4,160,161,167)(H4,162,163,168)(H4,164,165,169)/t83-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,119-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.0800n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]-MK-0677 as a radiolabeled liga...


J Med Chem 43: 4370-6 (2000)


Article DOI: 10.1021/jm0001727
BindingDB Entry DOI: 10.7270/Q2T72GP0
More data for this
Ligand-Target Pair
Ghrelin receptor


(Homo sapiens (Human))
BDBM50267950
PNG
((4S)-4-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-...)
Show SMILES CCCCCCCCCCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(O)=O
Show InChI InChI=1S/C157H265N47O42/c1-9-10-11-12-13-14-15-16-17-18-19-20-24-53-126(217)246-86-114(199-143(233)111(83-205)179-123(212)81-162)145(235)195-109(79-92-40-22-21-23-41-92)141(231)194-108(78-89(4)5)140(230)198-113(85-207)152(242)202-74-37-50-116(202)147(237)188-103(59-65-125(215)216)136(226)196-110(80-93-82-173-87-177-93)142(232)187-100(55-61-120(164)209)134(224)183-98(47-34-71-175-156(169)170)138(228)200-127(90(6)7)149(239)189-101(56-62-121(165)210)135(225)185-99(54-60-119(163)208)133(223)182-97(46-33-70-174-155(167)168)130(220)181-95(43-26-30-67-159)129(219)186-102(58-64-124(213)214)137(227)197-112(84-206)144(234)184-96(44-27-31-68-160)131(221)190-104(45-28-32-69-161)150(240)204-76-39-52-118(204)153(243)203-75-38-49-115(203)146(236)178-91(8)128(218)180-94(42-25-29-66-158)132(222)193-107(77-88(2)3)139(229)191-105(57-63-122(166)211)151(241)201-73-36-51-117(201)148(238)192-106(154(244)245)48-35-72-176-157(171)172/h21-23,40-41,82,87-91,94-118,127,205-207H,9-20,24-39,42-81,83-86,158-162H2,1-8H3,(H2,163,208)(H2,164,209)(H2,165,210)(H2,166,211)(H,173,177)(H,178,236)(H,179,212)(H,180,218)(H,181,220)(H,182,223)(H,183,224)(H,184,234)(H,185,225)(H,186,219)(H,187,232)(H,188,237)(H,189,239)(H,190,221)(H,191,229)(H,192,238)(H,193,222)(H,194,231)(H,195,235)(H,196,226)(H,197,227)(H,198,230)(H,199,233)(H,200,228)(H,213,214)(H,215,216)(H,244,245)(H4,167,168,174)(H4,169,170,175)(H4,171,172,176)/t91-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,127-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.870n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]-MK-0677 as a radiolabeled liga...


J Med Chem 43: 4370-6 (2000)


Article DOI: 10.1021/jm0001727
BindingDB Entry DOI: 10.7270/Q2T72GP0
More data for this
Ligand-Target Pair
Ghrelin receptor


(Homo sapiens (Human))
BDBM50267261
PNG
((4S)-4-{[(2S)-1-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-3-{[...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](COC(=O)CC12CC3CC(CC(C3)C1)C2)NC(=O)[C@H](CO)NC(=O)CN)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(O)=O
Show InChI InChI=1S/C153H251N47O42/c1-80(2)62-102(134(225)187-100(42-48-117(162)207)146(237)197-58-22-37-112(197)143(234)188-101(149(240)241)34-21-57-172-152(167)168)189-127(218)89(28-11-15-51-154)176-123(214)83(7)174-141(232)110-35-24-60-199(110)148(239)113-38-25-61-200(113)145(236)99(31-14-18-54-157)186-126(217)91(30-13-17-53-156)180-139(230)107(76-202)193-132(223)97(43-49-119(209)210)182-124(215)90(29-12-16-52-155)177-125(216)92(32-19-55-170-150(163)164)178-128(219)94(39-45-114(159)204)181-130(221)96(41-47-116(161)206)185-144(235)122(82(5)6)196-133(224)93(33-20-56-171-151(165)166)179-129(220)95(40-46-115(160)205)183-137(228)105(68-88-74-169-79-173-88)192-131(222)98(44-50-120(211)212)184-142(233)111-36-23-59-198(111)147(238)108(77-203)194-135(226)103(63-81(3)4)190-136(227)104(67-84-26-9-8-10-27-84)191-140(231)109(195-138(229)106(75-201)175-118(208)73-158)78-242-121(213)72-153-69-85-64-86(70-153)66-87(65-85)71-153/h8-10,26-27,74,79-83,85-87,89-113,122,201-203H,11-25,28-73,75-78,154-158H2,1-7H3,(H2,159,204)(H2,160,205)(H2,161,206)(H2,162,207)(H,169,173)(H,174,232)(H,175,208)(H,176,214)(H,177,216)(H,178,219)(H,179,220)(H,180,230)(H,181,221)(H,182,215)(H,183,228)(H,184,233)(H,185,235)(H,186,217)(H,187,225)(H,188,234)(H,189,218)(H,190,227)(H,191,231)(H,192,222)(H,193,223)(H,194,226)(H,195,229)(H,196,224)(H,209,210)(H,211,212)(H,240,241)(H4,163,164,170)(H4,165,166,171)(H4,167,168,172)/t83-,85?,86?,87?,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,122-,153?/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.120n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]-MK-0677 as a radiolabeled liga...


J Med Chem 43: 4370-6 (2000)


Article DOI: 10.1021/jm0001727
BindingDB Entry DOI: 10.7270/Q2T72GP0
More data for this
Ligand-Target Pair
Ghrelin receptor


(Homo sapiens (Human))
BDBM50267264
PNG
((4S)-4-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-...)
Show SMILES CCCCCCCC(=O)NC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(O)=O
Show InChI InChI=1S/C149H250N48O41/c1-9-10-11-12-16-45-115(205)169-75-103(190-136(227)104(76-198)172-116(206)73-154)135(226)188-101(71-84-32-14-13-15-33-84)133(224)187-100(70-81(4)5)132(223)192-106(78-200)144(235)195-66-29-42-108(195)139(230)181-95(51-57-118(209)210)128(219)189-102(72-85-74-165-79-170-85)134(225)180-92(47-53-112(156)202)126(217)176-90(39-26-63-167-148(161)162)130(221)193-119(82(6)7)141(232)182-93(48-54-113(157)203)127(218)178-91(46-52-111(155)201)125(216)175-89(38-25-62-166-147(159)160)122(213)174-87(35-18-22-59-151)121(212)179-94(50-56-117(207)208)129(220)191-105(77-199)137(228)177-88(36-19-23-60-152)123(214)183-96(37-20-24-61-153)142(233)197-68-31-44-110(197)145(236)196-67-30-41-107(196)138(229)171-83(8)120(211)173-86(34-17-21-58-150)124(215)186-99(69-80(2)3)131(222)184-97(49-55-114(158)204)143(234)194-65-28-43-109(194)140(231)185-98(146(237)238)40-27-64-168-149(163)164/h13-15,32-33,74,79-83,86-110,119,198-200H,9-12,16-31,34-73,75-78,150-154H2,1-8H3,(H2,155,201)(H2,156,202)(H2,157,203)(H2,158,204)(H,165,170)(H,169,205)(H,171,229)(H,172,206)(H,173,211)(H,174,213)(H,175,216)(H,176,217)(H,177,228)(H,178,218)(H,179,212)(H,180,225)(H,181,230)(H,182,232)(H,183,214)(H,184,222)(H,185,231)(H,186,215)(H,187,224)(H,188,226)(H,189,219)(H,190,227)(H,191,220)(H,192,223)(H,193,221)(H,207,208)(H,209,210)(H,237,238)(H4,159,160,166)(H4,161,162,167)(H4,163,164,168)/t83-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,119-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.420n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]-MK-0677 as a radiolabeled liga...


J Med Chem 43: 4370-6 (2000)


Article DOI: 10.1021/jm0001727
BindingDB Entry DOI: 10.7270/Q2T72GP0
More data for this
Ligand-Target Pair
Ghrelin receptor


(Homo sapiens (Human))
BDBM50163757
PNG
((4S)-4-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)CN)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(O)=O
Show InChI InChI=1S/C141H235N47O41/c1-73(2)62-92(123(213)175-90(42-48-107(150)196)135(225)185-58-22-37-102(185)132(222)176-91(138(228)229)34-21-57-160-141(155)156)177-116(206)79(28-11-15-51-142)164-112(202)76(7)162-130(220)100-35-24-60-187(100)137(227)103-38-25-61-188(103)134(224)89(31-14-18-54-145)174-115(205)81(30-13-17-53-144)168-128(218)97(69-190)181-121(211)87(43-49-109(198)199)170-113(203)80(29-12-16-52-143)165-114(204)82(32-19-55-158-139(151)152)166-117(207)84(39-45-104(147)193)169-119(209)86(41-47-106(149)195)173-133(223)111(75(5)6)184-122(212)83(33-20-56-159-140(153)154)167-118(208)85(40-46-105(148)194)171-126(216)95(65-78-67-157-72-161-78)180-120(210)88(44-50-110(200)201)172-131(221)101-36-23-59-186(101)136(226)99(71-192)183-124(214)93(63-74(3)4)178-125(215)94(64-77-26-9-8-10-27-77)179-129(219)98(70-191)182-127(217)96(68-189)163-108(197)66-146/h8-10,26-27,67,72-76,79-103,111,189-192H,11-25,28-66,68-71,142-146H2,1-7H3,(H2,147,193)(H2,148,194)(H2,149,195)(H2,150,196)(H,157,161)(H,162,220)(H,163,197)(H,164,202)(H,165,204)(H,166,207)(H,167,208)(H,168,218)(H,169,209)(H,170,203)(H,171,216)(H,172,221)(H,173,223)(H,174,205)(H,175,213)(H,176,222)(H,177,206)(H,178,215)(H,179,219)(H,180,210)(H,181,211)(H,182,217)(H,183,214)(H,184,212)(H,198,199)(H,200,201)(H,228,229)(H4,151,152,158)(H4,153,154,159)(H4,155,156,160)/t76-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,111-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]-MK-0677 as a radiolabeled liga...


J Med Chem 43: 4370-6 (2000)


Article DOI: 10.1021/jm0001727
BindingDB Entry DOI: 10.7270/Q2T72GP0
More data for this
Ligand-Target Pair
Ghrelin receptor


(Homo sapiens (Human))
BDBM50267265
PNG
((4S)-4-{[(2S)-1-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(...)
Show SMILES CCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(O)=O
Show InChI InChI=1S/C75H118N22O24/c1-6-7-8-12-19-60(106)121-37-53(95-69(114)51(35-98)85-58(103)33-76)70(115)92-49(31-41-15-10-9-11-16-41)67(112)91-48(30-39(2)3)66(111)94-52(36-99)73(118)97-29-14-18-54(97)71(116)88-46(23-27-59(104)105)64(109)93-50(32-42-34-82-38-84-42)68(113)87-44(20-24-55(77)100)62(107)86-43(17-13-28-83-75(80)81)65(110)96-61(40(4)5)72(117)89-45(21-25-56(78)101)63(108)90-47(74(119)120)22-26-57(79)102/h9-11,15-16,34,38-40,43-54,61,98-99H,6-8,12-14,17-33,35-37,76H2,1-5H3,(H2,77,100)(H2,78,101)(H2,79,102)(H,82,84)(H,85,103)(H,86,107)(H,87,113)(H,88,116)(H,89,117)(H,90,108)(H,91,112)(H,92,115)(H,93,109)(H,94,111)(H,95,114)(H,96,110)(H,104,105)(H,119,120)(H4,80,81,83)/t43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,61-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 9.60E+3n/an/an/an/an/an/a



University of Western Ontario

Curated by ChEMBL


Assay Description
Displacement of [35S]MK-0677 from human growth hormone secretagogue receptor


J Med Chem 52: 2196-203 (2009)


Article DOI: 10.1021/jm8014519
BindingDB Entry DOI: 10.7270/Q2X63NWQ
More data for this
Ligand-Target Pair
Ghrelin receptor


(Homo sapiens (Human))
BDBM50267264
PNG
((4S)-4-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-...)
Show SMILES CCCCCCCC(=O)NC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(O)=O
Show InChI InChI=1S/C149H250N48O41/c1-9-10-11-12-16-45-115(205)169-75-103(190-136(227)104(76-198)172-116(206)73-154)135(226)188-101(71-84-32-14-13-15-33-84)133(224)187-100(70-81(4)5)132(223)192-106(78-200)144(235)195-66-29-42-108(195)139(230)181-95(51-57-118(209)210)128(219)189-102(72-85-74-165-79-170-85)134(225)180-92(47-53-112(156)202)126(217)176-90(39-26-63-167-148(161)162)130(221)193-119(82(6)7)141(232)182-93(48-54-113(157)203)127(218)178-91(46-52-111(155)201)125(216)175-89(38-25-62-166-147(159)160)122(213)174-87(35-18-22-59-151)121(212)179-94(50-56-117(207)208)129(220)191-105(77-199)137(228)177-88(36-19-23-60-152)123(214)183-96(37-20-24-61-153)142(233)197-68-31-44-110(197)145(236)196-67-30-41-107(196)138(229)171-83(8)120(211)173-86(34-17-21-58-150)124(215)186-99(69-80(2)3)131(222)184-97(49-55-114(158)204)143(234)194-65-28-43-109(194)140(231)185-98(146(237)238)40-27-64-168-149(163)164/h13-15,32-33,74,79-83,86-110,119,198-200H,9-12,16-31,34-73,75-78,150-154H2,1-8H3,(H2,155,201)(H2,156,202)(H2,157,203)(H2,158,204)(H,165,170)(H,169,205)(H,171,229)(H,172,206)(H,173,211)(H,174,213)(H,175,216)(H,176,217)(H,177,228)(H,178,218)(H,179,212)(H,180,225)(H,181,230)(H,182,232)(H,183,214)(H,184,222)(H,185,231)(H,186,215)(H,187,224)(H,188,226)(H,189,219)(H,190,227)(H,191,220)(H,192,223)(H,193,221)(H,207,208)(H,209,210)(H,237,238)(H4,159,160,166)(H4,161,162,167)(H4,163,164,168)/t83-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,119-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 420n/an/an/an/an/an/a



University of Western Ontario

Curated by ChEMBL


Assay Description
Displacement of [35S]MK-0677 from human growth hormone secretagogue receptor


J Med Chem 52: 2196-203 (2009)


Article DOI: 10.1021/jm8014519
BindingDB Entry DOI: 10.7270/Q2X63NWQ
More data for this
Ligand-Target Pair
Ghrelin receptor


(Homo sapiens (Human))
BDBM50267263
PNG
((4S)-4-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](COC(=O)CCCCCCN)NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(O)=O
Show InChI InChI=1S/C148H248N48O42/c1-79(2)68-98(130(221)183-96(47-53-113(158)203)142(233)193-64-26-41-108(193)139(230)184-97(145(236)237)38-25-63-168-148(163)164)185-123(214)85(32-14-19-57-150)172-119(210)82(7)170-137(228)106-39-28-66-195(106)144(235)109-42-29-67-196(109)141(232)95(35-17-22-60-153)182-122(213)87(34-16-21-59-152)176-135(226)103(75-198)189-128(219)93(48-54-115(205)206)178-120(211)86(33-15-20-58-151)173-121(212)88(36-23-61-166-146(159)160)174-124(215)90(44-50-110(155)200)177-126(217)92(46-52-112(157)202)181-140(231)118(81(5)6)192-129(220)89(37-24-62-167-147(161)162)175-125(216)91(45-51-111(156)201)179-133(224)101(71-84-73-165-78-169-84)188-127(218)94(49-55-116(207)208)180-138(229)107-40-27-65-194(107)143(234)104(76-199)190-131(222)99(69-80(3)4)186-132(223)100(70-83-30-11-10-12-31-83)187-136(227)105(77-238-117(209)43-13-8-9-18-56-149)191-134(225)102(74-197)171-114(204)72-154/h10-12,30-31,73,78-82,85-109,118,197-199H,8-9,13-29,32-72,74-77,149-154H2,1-7H3,(H2,155,200)(H2,156,201)(H2,157,202)(H2,158,203)(H,165,169)(H,170,228)(H,171,204)(H,172,210)(H,173,212)(H,174,215)(H,175,216)(H,176,226)(H,177,217)(H,178,211)(H,179,224)(H,180,229)(H,181,231)(H,182,213)(H,183,221)(H,184,230)(H,185,214)(H,186,223)(H,187,227)(H,188,218)(H,189,219)(H,190,222)(H,191,225)(H,192,220)(H,205,206)(H,207,208)(H,236,237)(H4,159,160,166)(H4,161,162,167)(H4,163,164,168)/t82-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,118-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>2.00E+6n/an/an/an/an/an/a



University of Western Ontario

Curated by ChEMBL


Assay Description
Displacement of [35S]MK-0677 from human growth hormone secretagogue receptor


J Med Chem 52: 2196-203 (2009)


Article DOI: 10.1021/jm8014519
BindingDB Entry DOI: 10.7270/Q2X63NWQ
More data for this
Ligand-Target Pair
Ghrelin receptor


(Homo sapiens (Human))
BDBM50267262
PNG
((4S)-4-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](COC(=O)CCCCCCCBr)NC(=O)[C@H](CO)NC(=O)CN)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(O)=O
Show InChI InChI=1S/C149H248BrN47O42/c1-80(2)69-99(131(222)184-97(48-54-114(159)204)143(234)194-65-27-42-109(194)140(231)185-98(146(237)238)39-26-64-169-149(164)165)186-124(215)86(33-15-20-58-151)173-120(211)83(7)171-138(229)107-40-29-67-196(107)145(236)110-43-30-68-197(110)142(233)96(36-18-23-61-154)183-123(214)88(35-17-22-60-153)177-136(227)104(76-199)190-129(220)94(49-55-116(206)207)179-121(212)87(34-16-21-59-152)174-122(213)89(37-24-62-167-147(160)161)175-125(216)91(45-51-111(156)201)178-127(218)93(47-53-113(158)203)182-141(232)119(82(5)6)193-130(221)90(38-25-63-168-148(162)163)176-126(217)92(46-52-112(157)202)180-134(225)102(72-85-74-166-79-170-85)189-128(219)95(50-56-117(208)209)181-139(230)108-41-28-66-195(108)144(235)105(77-200)191-132(223)100(70-81(3)4)187-133(224)101(71-84-31-12-11-13-32-84)188-137(228)106(192-135(226)103(75-198)172-115(205)73-155)78-239-118(210)44-14-9-8-10-19-57-150/h11-13,31-32,74,79-83,86-110,119,198-200H,8-10,14-30,33-73,75-78,151-155H2,1-7H3,(H2,156,201)(H2,157,202)(H2,158,203)(H2,159,204)(H,166,170)(H,171,229)(H,172,205)(H,173,211)(H,174,213)(H,175,216)(H,176,217)(H,177,227)(H,178,218)(H,179,212)(H,180,225)(H,181,230)(H,182,232)(H,183,214)(H,184,222)(H,185,231)(H,186,215)(H,187,224)(H,188,228)(H,189,219)(H,190,220)(H,191,223)(H,192,226)(H,193,221)(H,206,207)(H,208,209)(H,237,238)(H4,160,161,167)(H4,162,163,168)(H4,164,165,169)/t83-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,119-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 80n/an/an/an/an/an/a



University of Western Ontario

Curated by ChEMBL


Assay Description
Displacement of [35S]MK-0677 from human growth hormone secretagogue receptor


J Med Chem 52: 2196-203 (2009)


Article DOI: 10.1021/jm8014519
BindingDB Entry DOI: 10.7270/Q2X63NWQ
More data for this
Ligand-Target Pair
Ghrelin receptor


(Homo sapiens (Human))
BDBM50267261
PNG
((4S)-4-{[(2S)-1-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-3-{[...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](COC(=O)CC12CC3CC(CC(C3)C1)C2)NC(=O)[C@H](CO)NC(=O)CN)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(O)=O
Show InChI InChI=1S/C153H251N47O42/c1-80(2)62-102(134(225)187-100(42-48-117(162)207)146(237)197-58-22-37-112(197)143(234)188-101(149(240)241)34-21-57-172-152(167)168)189-127(218)89(28-11-15-51-154)176-123(214)83(7)174-141(232)110-35-24-60-199(110)148(239)113-38-25-61-200(113)145(236)99(31-14-18-54-157)186-126(217)91(30-13-17-53-156)180-139(230)107(76-202)193-132(223)97(43-49-119(209)210)182-124(215)90(29-12-16-52-155)177-125(216)92(32-19-55-170-150(163)164)178-128(219)94(39-45-114(159)204)181-130(221)96(41-47-116(161)206)185-144(235)122(82(5)6)196-133(224)93(33-20-56-171-151(165)166)179-129(220)95(40-46-115(160)205)183-137(228)105(68-88-74-169-79-173-88)192-131(222)98(44-50-120(211)212)184-142(233)111-36-23-59-198(111)147(238)108(77-203)194-135(226)103(63-81(3)4)190-136(227)104(67-84-26-9-8-10-27-84)191-140(231)109(195-138(229)106(75-201)175-118(208)73-158)78-242-121(213)72-153-69-85-64-86(70-153)66-87(65-85)71-153/h8-10,26-27,74,79-83,85-87,89-113,122,201-203H,11-25,28-73,75-78,154-158H2,1-7H3,(H2,159,204)(H2,160,205)(H2,161,206)(H2,162,207)(H,169,173)(H,174,232)(H,175,208)(H,176,214)(H,177,216)(H,178,219)(H,179,220)(H,180,230)(H,181,221)(H,182,215)(H,183,228)(H,184,233)(H,185,235)(H,186,217)(H,187,225)(H,188,234)(H,189,218)(H,190,227)(H,191,231)(H,192,222)(H,193,223)(H,194,226)(H,195,229)(H,196,224)(H,209,210)(H,211,212)(H,240,241)(H4,163,164,170)(H4,165,166,171)(H4,167,168,172)/t83-,85?,86?,87?,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,122-,153?/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 120n/an/an/an/an/an/a



University of Western Ontario

Curated by ChEMBL


Assay Description
Displacement of [35S]MK-0677 from human growth hormone secretagogue receptor


J Med Chem 52: 2196-203 (2009)


Article DOI: 10.1021/jm8014519
BindingDB Entry DOI: 10.7270/Q2X63NWQ
More data for this
Ligand-Target Pair
Ghrelin receptor


(Homo sapiens (Human))
BDBM50267950
PNG
((4S)-4-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-...)
Show SMILES CCCCCCCCCCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(O)=O
Show InChI InChI=1S/C157H265N47O42/c1-9-10-11-12-13-14-15-16-17-18-19-20-24-53-126(217)246-86-114(199-143(233)111(83-205)179-123(212)81-162)145(235)195-109(79-92-40-22-21-23-41-92)141(231)194-108(78-89(4)5)140(230)198-113(85-207)152(242)202-74-37-50-116(202)147(237)188-103(59-65-125(215)216)136(226)196-110(80-93-82-173-87-177-93)142(232)187-100(55-61-120(164)209)134(224)183-98(47-34-71-175-156(169)170)138(228)200-127(90(6)7)149(239)189-101(56-62-121(165)210)135(225)185-99(54-60-119(163)208)133(223)182-97(46-33-70-174-155(167)168)130(220)181-95(43-26-30-67-159)129(219)186-102(58-64-124(213)214)137(227)197-112(84-206)144(234)184-96(44-27-31-68-160)131(221)190-104(45-28-32-69-161)150(240)204-76-39-52-118(204)153(243)203-75-38-49-115(203)146(236)178-91(8)128(218)180-94(42-25-29-66-158)132(222)193-107(77-88(2)3)139(229)191-105(57-63-122(166)211)151(241)201-73-36-51-117(201)148(238)192-106(154(244)245)48-35-72-176-157(171)172/h21-23,40-41,82,87-91,94-118,127,205-207H,9-20,24-39,42-81,83-86,158-162H2,1-8H3,(H2,163,208)(H2,164,209)(H2,165,210)(H2,166,211)(H,173,177)(H,178,236)(H,179,212)(H,180,218)(H,181,220)(H,182,223)(H,183,224)(H,184,234)(H,185,225)(H,186,219)(H,187,232)(H,188,237)(H,189,239)(H,190,221)(H,191,229)(H,192,238)(H,193,222)(H,194,231)(H,195,235)(H,196,226)(H,197,227)(H,198,230)(H,199,233)(H,200,228)(H,213,214)(H,215,216)(H,244,245)(H4,167,168,174)(H4,169,170,175)(H4,171,172,176)/t91-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,127-/m0/s1
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Article
PubMed
n/an/a 870n/an/an/an/an/an/a



University of Western Ontario

Curated by ChEMBL


Assay Description
Displacement of [35S]MK-0677 from human growth hormone secretagogue receptor


J Med Chem 52: 2196-203 (2009)


Article DOI: 10.1021/jm8014519
BindingDB Entry DOI: 10.7270/Q2X63NWQ
More data for this
Ligand-Target Pair
Ghrelin receptor


(Homo sapiens (Human))
BDBM50267949
PNG
((4S)-4-{[(2S)-1-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-3-(a...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](COC(C)=O)NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(O)=O
Show InChI InChI=1S/C143H237N47O42/c1-74(2)63-94(125(215)177-92(43-49-109(152)198)137(227)187-59-23-38-104(187)134(224)178-93(140(230)231)35-22-58-162-143(157)158)179-118(208)81(29-12-16-52-144)166-114(204)77(7)164-132(222)102-36-25-61-189(102)139(229)105-39-26-62-190(105)136(226)91(32-15-19-55-147)176-117(207)83(31-14-18-54-146)170-130(220)99(70-192)183-123(213)89(44-50-111(200)201)172-115(205)82(30-13-17-53-145)167-116(206)84(33-20-56-160-141(153)154)168-119(209)86(40-46-106(149)195)171-121(211)88(42-48-108(151)197)175-135(225)113(76(5)6)186-124(214)85(34-21-57-161-142(155)156)169-120(210)87(41-47-107(150)196)173-128(218)97(66-80-68-159-73-163-80)182-122(212)90(45-51-112(202)203)174-133(223)103-37-24-60-188(103)138(228)100(71-193)184-126(216)95(64-75(3)4)180-127(217)96(65-79-27-10-9-11-28-79)181-131(221)101(72-232-78(8)194)185-129(219)98(69-191)165-110(199)67-148/h9-11,27-28,68,73-77,81-105,113,191-193H,12-26,29-67,69-72,144-148H2,1-8H3,(H2,149,195)(H2,150,196)(H2,151,197)(H2,152,198)(H,159,163)(H,164,222)(H,165,199)(H,166,204)(H,167,206)(H,168,209)(H,169,210)(H,170,220)(H,171,211)(H,172,205)(H,173,218)(H,174,223)(H,175,225)(H,176,207)(H,177,215)(H,178,224)(H,179,208)(H,180,217)(H,181,221)(H,182,212)(H,183,213)(H,184,216)(H,185,219)(H,186,214)(H,200,201)(H,202,203)(H,230,231)(H4,153,154,160)(H4,155,156,161)(H4,157,158,162)/t77-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,113-/m0/s1
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PubMed
n/an/a>2.00E+6n/an/an/an/an/an/a



University of Western Ontario

Curated by ChEMBL


Assay Description
Displacement of [35S]MK-0677 from human growth hormone secretagogue receptor


J Med Chem 52: 2196-203 (2009)


Article DOI: 10.1021/jm8014519
BindingDB Entry DOI: 10.7270/Q2X63NWQ
More data for this
Ligand-Target Pair
Ghrelin receptor


(Homo sapiens (Human))
BDBM50094057
PNG
(CHEMBL410108 | GSS(heptyl carbonyl)FLSPEHQRVQQ)
Show SMILES CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(O)=O
Show InChI InChI=1S/C76H120N22O24/c1-6-7-8-9-13-20-61(107)122-38-54(96-70(115)52(36-99)86-59(104)34-77)71(116)93-50(32-42-16-11-10-12-17-42)68(113)92-49(31-40(2)3)67(112)95-53(37-100)74(119)98-30-15-19-55(98)72(117)89-47(24-28-60(105)106)65(110)94-51(33-43-35-83-39-85-43)69(114)88-45(21-25-56(78)101)63(108)87-44(18-14-29-84-76(81)82)66(111)97-62(41(4)5)73(118)90-46(22-26-57(79)102)64(109)91-48(75(120)121)23-27-58(80)103/h10-12,16-17,35,39-41,44-55,62,99-100H,6-9,13-15,18-34,36-38,77H2,1-5H3,(H2,78,101)(H2,79,102)(H2,80,103)(H,83,85)(H,86,104)(H,87,108)(H,88,114)(H,89,117)(H,90,118)(H,91,109)(H,92,113)(H,93,116)(H,94,110)(H,95,112)(H,96,115)(H,97,111)(H,105,106)(H,120,121)(H4,81,82,84)/t44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55+,62-/m0/s1
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n/an/a 9.60n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]-MK-0677 as a radiolabeled liga...


J Med Chem 43: 4370-6 (2000)


Article DOI: 10.1021/jm0001727
BindingDB Entry DOI: 10.7270/Q2T72GP0
More data for this
Ligand-Target Pair