BindingDB logo
myBDB logout

9 similar compounds to monomer 50406531

Compile data set for download or QSAR
Wt: 228.2
BDBM22892
Wt: 256.3
BDBM50406527
Wt: 242.3
BDBM50406528
Wt: 242.3
BDBM50406529
Wt: 242.3
BDBM50406530
Wt: 242.3
BDBM50406532
Wt: 256.3
BDBM50406533
Wt: 200.2
BDBM50406534
Wt: 228.2
BDBM50406535

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 22892,50406527,50406528,50406529,50406530,50406532,50406533,50406534,50406535   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine H4 receptor


(Homo sapiens (Human))
BDBM22892
PNG
(DA 4577 | DA-4577 | Mifentidine | N-[4-(1H-imidazo...)
Show SMILES CC(C)NC=Nc1ccc(cc1)-c1c[nH]cn1
Show InChI InChI=1S/C13H16N4/c1-10(2)15-9-16-12-5-3-11(4-6-12)13-7-14-8-17-13/h3-10H,1-2H3,(H,14,17)(H,15,16)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



Vrije Universiteit Amsterdam



Assay Description
Ligand displacement assays were performed on The SK-N-MC/hH4R cell homogenates. Retained radioactivity was determined by liquid scintillation countin...


J Pharmacol Exp Ther 314: 1310-21 (2005)


Article DOI: 10.1124/jpet.105.087965
BindingDB Entry DOI: 10.7270/Q2KD1W6V
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM22892
PNG
(DA 4577 | DA-4577 | Mifentidine | N-[4-(1H-imidazo...)
Show SMILES CC(C)NC=Nc1ccc(cc1)-c1c[nH]cn1
Show InChI InChI=1S/C13H16N4/c1-10(2)15-9-16-12-5-3-11(4-6-12)13-7-14-8-17-13/h3-10H,1-2H3,(H,14,17)(H,15,16)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/a 17n/an/an/a7.4n/a



TBA

Curated by ChEMBL


Assay Description
Antagonistic activity of guinea pig Histamine H2 receptor expressed as pA2 at pH 7.4


J Med Chem 30: 208-11 (1987)


Article DOI: 10.1021/jm00384a036
BindingDB Entry DOI: 10.7270/Q2ZC842P
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406527
PNG
(CHEMBL423660)
Show SMILES CCC(CC)NC=Nc1ccc(cc1)-c1c[nH]cn1
Show InChI InChI=1S/C15H20N4/c1-3-13(4-2)17-11-18-14-7-5-12(6-8-14)15-9-16-10-19-15/h5-11,13H,3-4H2,1-2H3,(H,16,19)(H,17,18)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 31.6n/an/an/an/an/a



Research Laboratories of Istituto De Angeli

Curated by ChEMBL


Assay Description
Histamine H2 receptor antagonism on the right atrium of the guinea pig


J Med Chem 34: 1772-6 (1991)


Article DOI: 10.1021/jm00110a004
BindingDB Entry DOI: 10.7270/Q2W95BCR
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406528
PNG
(CHEMBL362059)
Show SMILES CCCCNC=Nc1ccc(cc1)-c1c[nH]cn1
Show InChI InChI=1S/C14H18N4/c1-2-3-8-15-10-17-13-6-4-12(5-7-13)14-9-16-11-18-14/h4-7,9-11H,2-3,8H2,1H3,(H,15,17)(H,16,18)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 11.2n/an/an/an/an/a



Research Laboratories of Istituto De Angeli

Curated by ChEMBL


Assay Description
Histamine H2 receptor antagonism on the right atrium of the guinea pig


J Med Chem 34: 1772-6 (1991)


Article DOI: 10.1021/jm00110a004
BindingDB Entry DOI: 10.7270/Q2W95BCR
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM22892
PNG
(DA 4577 | DA-4577 | Mifentidine | N-[4-(1H-imidazo...)
Show SMILES CC(C)NC=Nc1ccc(cc1)-c1c[nH]cn1
Show InChI InChI=1S/C13H16N4/c1-10(2)15-9-16-12-5-3-11(4-6-12)13-7-14-8-17-13/h3-10H,1-2H3,(H,14,17)(H,15,16)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/a 45.7n/an/an/a7.0n/a



TBA

Curated by ChEMBL


Assay Description
Antagonistic activity of guinea pig Histamine H2 receptor expressed as pA2 at pH 7.0


J Med Chem 30: 208-11 (1987)


Article DOI: 10.1021/jm00384a036
BindingDB Entry DOI: 10.7270/Q2ZC842P
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406530
PNG
(CHEMBL51541)
Show SMILES CC(C)(C)NC=Nc1ccc(cc1)-c1c[nH]cn1
Show InChI InChI=1S/C14H18N4/c1-14(2,3)18-10-16-12-6-4-11(5-7-12)13-8-15-9-17-13/h4-10H,1-3H3,(H,15,17)(H,16,18)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 11.2n/an/an/an/an/a



Research Laboratories of Istituto De Angeli

Curated by ChEMBL


Assay Description
Histamine H2 receptor antagonism on the right atrium of the guinea pig


J Med Chem 34: 1772-6 (1991)


Article DOI: 10.1021/jm00110a004
BindingDB Entry DOI: 10.7270/Q2W95BCR
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406532
PNG
(CHEMBL298859)
Show SMILES CC(C)CNC=Nc1ccc(cc1)-c1c[nH]cn1
Show InChI InChI=1S/C14H18N4/c1-11(2)7-15-9-17-13-5-3-12(4-6-13)14-8-16-10-18-14/h3-6,8-11H,7H2,1-2H3,(H,15,17)(H,16,18)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 5.25n/an/an/an/an/a



Research Laboratories of Istituto De Angeli

Curated by ChEMBL


Assay Description
Histamine H2 receptor antagonism on the right atrium of the guinea pig


J Med Chem 34: 1772-6 (1991)


Article DOI: 10.1021/jm00110a004
BindingDB Entry DOI: 10.7270/Q2W95BCR
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406533
PNG
(CHEMBL299537)
Show SMILES CCC(C)(C)NC=Nc1ccc(cc1)-c1c[nH]cn1
Show InChI InChI=1S/C15H20N4/c1-4-15(2,3)19-11-17-13-7-5-12(6-8-13)14-9-16-10-18-14/h5-11H,4H2,1-3H3,(H,16,18)(H,17,19)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 7.59n/an/an/an/an/a



Research Laboratories of Istituto De Angeli

Curated by ChEMBL


Assay Description
Histamine H2 receptor antagonism on the right atrium of the guinea pig


J Med Chem 34: 1772-6 (1991)


Article DOI: 10.1021/jm00110a004
BindingDB Entry DOI: 10.7270/Q2W95BCR
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406534
PNG
(CHEMBL50960)
Show SMILES CNC=Nc1ccc(cc1)-c1c[nH]cn1
Show InChI InChI=1S/C11H12N4/c1-12-7-14-10-4-2-9(3-5-10)11-6-13-8-15-11/h2-8H,1H3,(H,12,14)(H,13,15)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 1.20E+3n/an/an/an/an/a



Research Laboratories of Istituto De Angeli

Curated by ChEMBL


Assay Description
Histamine H2 receptor antagonism on the right atrium of the guinea pig


J Med Chem 34: 1772-6 (1991)


Article DOI: 10.1021/jm00110a004
BindingDB Entry DOI: 10.7270/Q2W95BCR
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406535
PNG
(CHEMBL50020)
Show SMILES CC(C)NC=Nc1ccc(cc1)-c1c[nH]cn1
Show InChI InChI=1S/C13H16N4/c1-10(2)15-9-16-12-5-3-11(4-6-12)13-7-14-8-17-13/h3-10H,1-2H3,(H,14,17)(H,15,16)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 28.2n/an/an/an/an/a



Research Laboratories of Istituto De Angeli

Curated by ChEMBL


Assay Description
Histamine H2 receptor antagonism on the right atrium of the guinea pig


J Med Chem 34: 1772-6 (1991)


Article DOI: 10.1021/jm00110a004
BindingDB Entry DOI: 10.7270/Q2W95BCR
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM22892
PNG
(DA 4577 | DA-4577 | Mifentidine | N-[4-(1H-imidazo...)
Show SMILES CC(C)NC=Nc1ccc(cc1)-c1c[nH]cn1
Show InChI InChI=1S/C13H16N4/c1-10(2)15-9-16-12-5-3-11(4-6-12)13-7-14-8-17-13/h3-10H,1-2H3,(H,14,17)(H,15,16)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/a 12n/an/an/a7.8n/a



TBA

Curated by ChEMBL


Assay Description
Antagonistic activity of guinea pig Histamine H2 receptor expressed as pA2 at pH 7.8


J Med Chem 30: 208-11 (1987)


Article DOI: 10.1021/jm00384a036
BindingDB Entry DOI: 10.7270/Q2ZC842P
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406529
PNG
(CHEMBL51540)
Show SMILES CCC(C)NC=Nc1ccc(cc1)-c1c[nH]cn1
Show InChI InChI=1S/C14H18N4/c1-3-11(2)16-10-17-13-6-4-12(5-7-13)14-8-15-9-18-14/h4-11H,3H2,1-2H3,(H,15,18)(H,16,17)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 14.1n/an/an/an/an/a



Research Laboratories of Istituto De Angeli

Curated by ChEMBL


Assay Description
Histamine H2 receptor antagonism on the right atrium of the guinea pig


J Med Chem 34: 1772-6 (1991)


Article DOI: 10.1021/jm00110a004
BindingDB Entry DOI: 10.7270/Q2W95BCR
More data for this
Ligand-Target Pair