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2 similar compounds to monomer 25864

Compile data set for download or QSAR
Wt: 262.3
BDBM25863
Wt: 278.3
BDBM50186762
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 25863,50186762   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
17-beta-Hydroxysteroid Dehydrogenase 1 (17-beta-HSD1)


(Homo sapiens (Human))
BDBM25863
PNG
(3-[4-(3-hydroxyphenyl)phenyl]phenol | hydroxypheny...)
Show SMILES Oc1cccc(c1)-c1ccc(cc1)-c1cccc(O)c1
Show InChI InChI=1S/C18H14O2/c19-17-5-1-3-15(11-17)13-7-9-14(10-8-13)16-4-2-6-18(20)12-16/h1-12,19-20H
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Article
PubMed
n/an/a 173n/an/an/an/an/an/a



Saarland University



Assay Description
Tritiated E1 was incubated with 17beta-HSD1, cofactor, and inhibitor. The amount of labeled E2 formed was quantified by HPLC. Detection and quantific...


J Med Chem 51: 6725-39 (2008)


Article DOI: 10.1021/jm8006917
BindingDB Entry DOI: 10.7270/Q2RB72XG
More data for this
Ligand-Target Pair
Estradiol 17-beta-dehydrogenase 2


(Homo sapiens (Human))
BDBM25863
PNG
(3-[4-(3-hydroxyphenyl)phenyl]phenol | hydroxypheny...)
Show SMILES Oc1cccc(c1)-c1ccc(cc1)-c1cccc(O)c1
Show InChI InChI=1S/C18H14O2/c19-17-5-1-3-15(11-17)13-7-9-14(10-8-13)16-4-2-6-18(20)12-16/h1-12,19-20H
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Article
PubMed
n/an/a 2.26E+3n/an/an/an/an/an/a



Saarland University



Assay Description
Tritiated E2 was incubated with 17beta-HSD2, cofactor, and inhibitor. The amount of labeled E1 formed was quantified by HPLC. Detection and quantific...


J Med Chem 51: 6725-39 (2008)


Article DOI: 10.1021/jm8006917
BindingDB Entry DOI: 10.7270/Q2RB72XG
More data for this
Ligand-Target Pair
Bcr-Abl


(Homo sapiens (Human))
BDBM50186762
PNG
(CHEMBL427392 | [1,1':4',1'']Terphenyl-4,3'',5''-tr...)
Show SMILES Oc1ccc(cc1)-c1ccc(cc1)-c1cc(O)cc(O)c1
Show InChI InChI=1S/C18H14O3/c19-16-7-5-13(6-8-16)12-1-3-14(4-2-12)15-9-17(20)11-18(21)10-15/h1-11,19-21H
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Article
PubMed
n/an/a 2.00E+4n/an/an/an/an/an/a



Universit£ di Bologna

Curated by ChEMBL


Assay Description
Antiproliferative activity against human K562 cell line expressing Bcr-Abl


J Med Chem 49: 3012-8 (2006)


Article DOI: 10.1021/jm060253o
BindingDB Entry DOI: 10.7270/Q2R49RKZ
More data for this
Ligand-Target Pair
Estradiol 17-beta-dehydrogenase 2


(Homo sapiens (Human))
BDBM25863
PNG
(3-[4-(3-hydroxyphenyl)phenyl]phenol | hydroxypheny...)
Show SMILES Oc1cccc(c1)-c1ccc(cc1)-c1cccc(O)c1
Show InChI InChI=1S/C18H14O2/c19-17-5-1-3-15(11-17)13-7-9-14(10-8-13)16-4-2-6-18(20)12-16/h1-12,19-20H
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Article
PubMed
n/an/a 2.26E+3n/an/an/an/an/an/a



Saarland University

Curated by ChEMBL


Assay Description
Inhibition of human placental 17betaHSD2 by radiodetection assay


J Med Chem 52: 6724-43 (2009)


Article DOI: 10.1021/jm901195w
BindingDB Entry DOI: 10.7270/Q2CR5TDT
More data for this
Ligand-Target Pair
P-glycoprotein 1


(Homo sapiens (Human))
BDBM50186762
PNG
(CHEMBL427392 | [1,1':4',1'']Terphenyl-4,3'',5''-tr...)
Show SMILES Oc1ccc(cc1)-c1ccc(cc1)-c1cc(O)cc(O)c1
Show InChI InChI=1S/C18H14O3/c19-16-7-5-13(6-8-16)12-1-3-14(4-2-12)15-9-17(20)11-18(21)10-15/h1-11,19-21H
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Article
PubMed
n/an/a 2.30E+4n/an/an/an/an/an/a



Universit£ di Bologna

Curated by ChEMBL


Assay Description
Antiproliferative activity against MDR human HL60R cell line


J Med Chem 49: 3012-8 (2006)


Article DOI: 10.1021/jm060253o
BindingDB Entry DOI: 10.7270/Q2R49RKZ
More data for this
Ligand-Target Pair
Estradiol 17-beta-dehydrogenase 1 (17beta-HSD1)


(Homo sapiens (Human))
BDBM25863
PNG
(3-[4-(3-hydroxyphenyl)phenyl]phenol | hydroxypheny...)
Show SMILES Oc1cccc(c1)-c1ccc(cc1)-c1cccc(O)c1
Show InChI InChI=1S/C18H14O2/c19-17-5-1-3-15(11-17)13-7-9-14(10-8-13)16-4-2-6-18(20)12-16/h1-12,19-20H
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

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PC cid
PC sid
UniChem

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Article
PubMed
n/an/a 173n/an/an/an/an/an/a



Saarland University

Curated by ChEMBL


Assay Description
Inhibition of human placental 17betaHSD1 by radiodetection assay


J Med Chem 52: 6724-43 (2009)


Article DOI: 10.1021/jm901195w
BindingDB Entry DOI: 10.7270/Q2CR5TDT
More data for this
Ligand-Target Pair