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14 similar compounds to monomer 50375138

Compile data set for download or QSAR
Wt: 524.6
BDBM27909
Wt: 523.6
BDBM27890
Wt: 537.6
BDBM27891
Wt: 524.6
BDBM27892
Wt: 551.6
BDBM27893
Wt: 567.6
BDBM27894
Wt: 468.5
BDBM50375139
Wt: 454.5
BDBM50375140
Wt: 496.5
BDBM50375141
Wt: 480.5
BDBM50375142
Wt: 397.4
BDBM50375146
Wt: 523.6
BDBM50375151
Wt: 509.6
BDBM50375155
Wt: 510.5
BDBM50375158

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 32 hits for monomerid = 27909,27890,27891,27892,27893,27894,50375139,50375140,50375141,50375142,50375146,50375151,50375155,50375158   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM27890
PNG
(8-(2,3-dihydro-1H-inden-5-yl)-2-({4-[2-(4-methylpi...)
Show SMILES CN1CCN(CCc2ccc(Nc3ncc4c(n3)n(cc(C(N)=O)c4=O)-c3ccc4CCCc4c3)cc2)CC1
Show InChI InChI=1S/C30H33N7O2/c1-35-13-15-36(16-14-35)12-11-20-5-8-23(9-6-20)33-30-32-18-25-27(38)26(28(31)39)19-37(29(25)34-30)24-10-7-21-3-2-4-22(21)17-24/h5-10,17-19H,2-4,11-16H2,1H3,(H2,31,39)(H,32,33,34)
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n/an/a 0.800n/an/an/an/a7.522



Johnson & Johnson Pharmaceutical



Assay Description
FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...


J Med Chem 52: 1081-99 (2009)


Article DOI: 10.1021/jm801406h
BindingDB Entry DOI: 10.7270/Q21834T7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM50375155
PNG
(CHEMBL256893)
Show SMILES CN1CCN(Cc2ccc(Nc3ncc4c(n3)n(cc(C(N)=O)c4=O)-c3ccc4CCCc4c3)cc2)CC1
Show InChI InChI=1S/C29H31N7O2/c1-34-11-13-35(14-12-34)17-19-5-8-22(9-6-19)32-29-31-16-24-26(37)25(27(30)38)18-36(28(24)33-29)23-10-7-20-3-2-4-21(20)15-23/h5-10,15-16,18H,2-4,11-14,17H2,1H3,(H2,30,38)(H,31,32,33)
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of Axl


Bioorg Med Chem Lett 18: 2355-61 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.070
BindingDB Entry DOI: 10.7270/Q26W9BX3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM27892
PNG
(8-(2,3-dihydro-1H-inden-5-yl)-N-methyl-2-({4-[2-(m...)
Show SMILES CNC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(CCN4CCOCC4)cc3)ncc2c1=O
Show InChI InChI=1S/C30H32N6O3/c1-31-29(38)26-19-36(24-10-7-21-3-2-4-22(21)17-24)28-25(27(26)37)18-32-30(34-28)33-23-8-5-20(6-9-23)11-12-35-13-15-39-16-14-35/h5-10,17-19H,2-4,11-16H2,1H3,(H,31,38)(H,32,33,34)
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n/an/a 1.40n/an/an/an/a7.522



Johnson & Johnson Pharmaceutical



Assay Description
FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...


J Med Chem 52: 1081-99 (2009)


Article DOI: 10.1021/jm801406h
BindingDB Entry DOI: 10.7270/Q21834T7
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM27893
PNG
(8-(2,3-dihydro-1H-inden-5-yl)-N-ethyl-2-({4-[2-(4-...)
Show SMILES CCNC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(CCN4CCN(C)CC4)cc3)ncc2c1=O
Show InChI InChI=1S/C32H37N7O2/c1-3-33-31(41)28-21-39(26-12-9-23-5-4-6-24(23)19-26)30-27(29(28)40)20-34-32(36-30)35-25-10-7-22(8-11-25)13-14-38-17-15-37(2)16-18-38/h7-12,19-21H,3-6,13-18H2,1-2H3,(H,33,41)(H,34,35,36)
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n/an/a 3.20n/an/an/an/a7.522



Johnson & Johnson Pharmaceutical



Assay Description
FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...


J Med Chem 52: 1081-99 (2009)


Article DOI: 10.1021/jm801406h
BindingDB Entry DOI: 10.7270/Q21834T7
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM27894
PNG
(8-(2,3-dihydro-1H-inden-5-yl)-N-(2-hydroxyethyl)-2...)
Show SMILES CN1CCN(CCc2ccc(Nc3ncc4c(n3)n(cc(C(=O)NCCO)c4=O)-c3ccc4CCCc4c3)cc2)CC1
Show InChI InChI=1S/C32H37N7O3/c1-37-14-16-38(17-15-37)13-11-22-5-8-25(9-6-22)35-32-34-20-27-29(41)28(31(42)33-12-18-40)21-39(30(27)36-32)26-10-7-23-3-2-4-24(23)19-26/h5-10,19-21,40H,2-4,11-18H2,1H3,(H,33,42)(H,34,35,36)
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n/an/a 0.700n/an/an/an/a7.522



Johnson & Johnson Pharmaceutical



Assay Description
FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...


J Med Chem 52: 1081-99 (2009)


Article DOI: 10.1021/jm801406h
BindingDB Entry DOI: 10.7270/Q21834T7
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM27909
PNG
(8-(2,3-dihydro-1H-inden-5-yl)-N-methoxy-2-{[4-(1-m...)
Show SMILES CONC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(cc3)C3CCN(C)CC3)ncc2c1=O
Show InChI InChI=1S/C30H32N6O3/c1-35-14-12-21(13-15-35)20-6-9-23(10-7-20)32-30-31-17-25-27(37)26(29(38)34-39-2)18-36(28(25)33-30)24-11-8-19-4-3-5-22(19)16-24/h6-11,16-18,21H,3-5,12-15H2,1-2H3,(H,34,38)(H,31,32,33)
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n/an/a 0.400n/an/an/an/a7.522



Johnson & Johnson Pharmaceutical



Assay Description
FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...


J Med Chem 52: 1081-99 (2009)


Article DOI: 10.1021/jm801406h
BindingDB Entry DOI: 10.7270/Q21834T7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM27890
PNG
(8-(2,3-dihydro-1H-inden-5-yl)-2-({4-[2-(4-methylpi...)
Show SMILES CN1CCN(CCc2ccc(Nc3ncc4c(n3)n(cc(C(N)=O)c4=O)-c3ccc4CCCc4c3)cc2)CC1
Show InChI InChI=1S/C30H33N7O2/c1-35-13-15-36(16-14-35)12-11-20-5-8-23(9-6-20)33-30-32-18-25-27(38)26(28(31)39)19-37(29(25)34-30)24-10-7-21-3-2-4-22(21)17-24/h5-10,17-19H,2-4,11-16H2,1H3,(H2,31,39)(H,32,33,34)
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n/an/a 1n/an/an/an/an/a25



Johnson & Johnson Pharmaceutical



Assay Description
FLT-3 was assayed using a fluorescence polarization (FP) competition immunoassay that measured FLT-3 phosphorylation of polyGlu4Tyr. The reaction was...


J Med Chem 52: 1081-99 (2009)


Article DOI: 10.1021/jm801406h
BindingDB Entry DOI: 10.7270/Q21834T7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM27909
PNG
(8-(2,3-dihydro-1H-inden-5-yl)-N-methoxy-2-{[4-(1-m...)
Show SMILES CONC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(cc3)C3CCN(C)CC3)ncc2c1=O
Show InChI InChI=1S/C30H32N6O3/c1-35-14-12-21(13-15-35)20-6-9-23(10-7-20)32-30-31-17-25-27(37)26(29(38)34-39-2)18-36(28(25)33-30)24-11-8-19-4-3-5-22(19)16-24/h6-11,16-18,21H,3-5,12-15H2,1-2H3,(H,34,38)(H,31,32,33)
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n/an/a 6n/an/an/an/an/a25



Johnson & Johnson Pharmaceutical



Assay Description
FLT-3 was assayed using a fluorescence polarization (FP) competition immunoassay that measured FLT-3 phosphorylation of polyGlu4Tyr. The reaction was...


J Med Chem 52: 1081-99 (2009)


Article DOI: 10.1021/jm801406h
BindingDB Entry DOI: 10.7270/Q21834T7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM27890
PNG
(8-(2,3-dihydro-1H-inden-5-yl)-2-({4-[2-(4-methylpi...)
Show SMILES CN1CCN(CCc2ccc(Nc3ncc4c(n3)n(cc(C(N)=O)c4=O)-c3ccc4CCCc4c3)cc2)CC1
Show InChI InChI=1S/C30H33N7O2/c1-35-13-15-36(16-14-35)12-11-20-5-8-23(9-6-20)33-30-32-18-25-27(38)26(28(31)39)19-37(29(25)34-30)24-10-7-21-3-2-4-22(21)17-24/h5-10,17-19H,2-4,11-16H2,1H3,(H2,31,39)(H,32,33,34)
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n/an/a>500n/an/an/an/an/a25



Johnson & Johnson Pharmaceutical



Assay Description
Axl was assayed using a fluorescence polarization (FP) competition immunoassay that measured Axl phosphorylation of polyGlu4Tyr. The reaction was ini...


J Med Chem 52: 1081-99 (2009)


Article DOI: 10.1021/jm801406h
BindingDB Entry DOI: 10.7270/Q21834T7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM27909
PNG
(8-(2,3-dihydro-1H-inden-5-yl)-N-methoxy-2-{[4-(1-m...)
Show SMILES CONC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(cc3)C3CCN(C)CC3)ncc2c1=O
Show InChI InChI=1S/C30H32N6O3/c1-35-14-12-21(13-15-35)20-6-9-23(10-7-20)32-30-31-17-25-27(37)26(29(38)34-39-2)18-36(28(25)33-30)24-11-8-19-4-3-5-22(19)16-24/h6-11,16-18,21H,3-5,12-15H2,1-2H3,(H,34,38)(H,31,32,33)
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n/an/a>1.00E+3n/an/an/an/an/a25



Johnson & Johnson Pharmaceutical



Assay Description
Axl was assayed using a fluorescence polarization (FP) competition immunoassay that measured Axl phosphorylation of polyGlu4Tyr. The reaction was ini...


J Med Chem 52: 1081-99 (2009)


Article DOI: 10.1021/jm801406h
BindingDB Entry DOI: 10.7270/Q21834T7
More data for this
Ligand-Target Pair
Tyrosine Kinase TrkA


(Homo sapiens (Human))
BDBM27890
PNG
(8-(2,3-dihydro-1H-inden-5-yl)-2-({4-[2-(4-methylpi...)
Show SMILES CN1CCN(CCc2ccc(Nc3ncc4c(n3)n(cc(C(N)=O)c4=O)-c3ccc4CCCc4c3)cc2)CC1
Show InChI InChI=1S/C30H33N7O2/c1-35-13-15-36(16-14-35)12-11-20-5-8-23(9-6-20)33-30-32-18-25-27(38)26(28(31)39)19-37(29(25)34-30)24-10-7-21-3-2-4-22(21)17-24/h5-10,17-19H,2-4,11-16H2,1H3,(H2,31,39)(H,32,33,34)
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n/an/a 170n/an/an/an/an/a25



Johnson & Johnson Pharmaceutical



Assay Description
TrkA was assayed using a fluorescence polarization (FP) competition immunoassay that measured TrkA phosphorylation of polyGlu4Tyr. The reaction was i...


J Med Chem 52: 1081-99 (2009)


Article DOI: 10.1021/jm801406h
BindingDB Entry DOI: 10.7270/Q21834T7
More data for this
Ligand-Target Pair
Tyrosine Kinase TrkA


(Homo sapiens (Human))
BDBM27909
PNG
(8-(2,3-dihydro-1H-inden-5-yl)-N-methoxy-2-{[4-(1-m...)
Show SMILES CONC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(cc3)C3CCN(C)CC3)ncc2c1=O
Show InChI InChI=1S/C30H32N6O3/c1-35-14-12-21(13-15-35)20-6-9-23(10-7-20)32-30-31-17-25-27(37)26(29(38)34-39-2)18-36(28(25)33-30)24-11-8-19-4-3-5-22(19)16-24/h6-11,16-18,21H,3-5,12-15H2,1-2H3,(H,34,38)(H,31,32,33)
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n/an/a 500n/an/an/an/an/a25



Johnson & Johnson Pharmaceutical



Assay Description
TrkA was assayed using a fluorescence polarization (FP) competition immunoassay that measured TrkA phosphorylation of polyGlu4Tyr. The reaction was i...


J Med Chem 52: 1081-99 (2009)


Article DOI: 10.1021/jm801406h
BindingDB Entry DOI: 10.7270/Q21834T7
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM27890
PNG
(8-(2,3-dihydro-1H-inden-5-yl)-2-({4-[2-(4-methylpi...)
Show SMILES CN1CCN(CCc2ccc(Nc3ncc4c(n3)n(cc(C(N)=O)c4=O)-c3ccc4CCCc4c3)cc2)CC1
Show InChI InChI=1S/C30H33N7O2/c1-35-13-15-36(16-14-35)12-11-20-5-8-23(9-6-20)33-30-32-18-25-27(38)26(28(31)39)19-37(29(25)34-30)24-10-7-21-3-2-4-22(21)17-24/h5-10,17-19H,2-4,11-16H2,1H3,(H2,31,39)(H,32,33,34)
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n/an/a 20n/an/an/an/an/a25



Johnson & Johnson Pharmaceutical



Assay Description
KIT was assayed using a fluorescence polarization (FP) competition immunoassay that measured KIT phosphorylation of polyGlu4Tyr. The reaction was ini...


J Med Chem 52: 1081-99 (2009)


Article DOI: 10.1021/jm801406h
BindingDB Entry DOI: 10.7270/Q21834T7
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM27909
PNG
(8-(2,3-dihydro-1H-inden-5-yl)-N-methoxy-2-{[4-(1-m...)
Show SMILES CONC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(cc3)C3CCN(C)CC3)ncc2c1=O
Show InChI InChI=1S/C30H32N6O3/c1-35-14-12-21(13-15-35)20-6-9-23(10-7-20)32-30-31-17-25-27(37)26(29(38)34-39-2)18-36(28(25)33-30)24-11-8-19-4-3-5-22(19)16-24/h6-11,16-18,21H,3-5,12-15H2,1-2H3,(H,34,38)(H,31,32,33)
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n/an/a 6n/an/an/an/an/a25



Johnson & Johnson Pharmaceutical



Assay Description
KIT was assayed using a fluorescence polarization (FP) competition immunoassay that measured KIT phosphorylation of polyGlu4Tyr. The reaction was ini...


J Med Chem 52: 1081-99 (2009)


Article DOI: 10.1021/jm801406h
BindingDB Entry DOI: 10.7270/Q21834T7
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (Human))
BDBM27890
PNG
(8-(2,3-dihydro-1H-inden-5-yl)-2-({4-[2-(4-methylpi...)
Show SMILES CN1CCN(CCc2ccc(Nc3ncc4c(n3)n(cc(C(N)=O)c4=O)-c3ccc4CCCc4c3)cc2)CC1
Show InChI InChI=1S/C30H33N7O2/c1-35-13-15-36(16-14-35)12-11-20-5-8-23(9-6-20)33-30-32-18-25-27(38)26(28(31)39)19-37(29(25)34-30)24-10-7-21-3-2-4-22(21)17-24/h5-10,17-19H,2-4,11-16H2,1H3,(H2,31,39)(H,32,33,34)
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n/an/a>4.20E+4n/an/an/an/an/a25



Johnson & Johnson Pharmaceutical



Assay Description
IRKbeta was assayed using a fluorescence polarization (FP) competition immunoassay that measured IRKbeta phosphorylation of polyGlu4Tyr. The reaction...


J Med Chem 52: 1081-99 (2009)


Article DOI: 10.1021/jm801406h
BindingDB Entry DOI: 10.7270/Q21834T7
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (Human))
BDBM27909
PNG
(8-(2,3-dihydro-1H-inden-5-yl)-N-methoxy-2-{[4-(1-m...)
Show SMILES CONC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(cc3)C3CCN(C)CC3)ncc2c1=O
Show InChI InChI=1S/C30H32N6O3/c1-35-14-12-21(13-15-35)20-6-9-23(10-7-20)32-30-31-17-25-27(37)26(29(38)34-39-2)18-36(28(25)33-30)24-11-8-19-4-3-5-22(19)16-24/h6-11,16-18,21H,3-5,12-15H2,1-2H3,(H,34,38)(H,31,32,33)
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n/an/a 3.70E+3n/an/an/an/an/a25



Johnson & Johnson Pharmaceutical



Assay Description
IRKbeta was assayed using a fluorescence polarization (FP) competition immunoassay that measured IRKbeta phosphorylation of polyGlu4Tyr. The reaction...


J Med Chem 52: 1081-99 (2009)


Article DOI: 10.1021/jm801406h
BindingDB Entry DOI: 10.7270/Q21834T7
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50375139
PNG
(CHEMBL256459)
Show SMILES CN(C)CCc1ccc(Nc2ncc3c(n2)n(cc(C(N)=O)c3=O)-c2ccc3CCCc3c2)cc1
Show InChI InChI=1S/C27H28N6O2/c1-32(2)13-12-17-6-9-20(10-7-17)30-27-29-15-22-24(34)23(25(28)35)16-33(26(22)31-27)21-11-8-18-4-3-5-19(18)14-21/h6-11,14-16H,3-5,12-13H2,1-2H3,(H2,28,35)(H,29,30,31)
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n/an/a 3n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of ATP-induced CSF1R autophosphorylation


Bioorg Med Chem Lett 18: 2355-61 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.070
BindingDB Entry DOI: 10.7270/Q26W9BX3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50375140
PNG
(CHEMBL256405)
Show SMILES CN(C)Cc1ccc(Nc2ncc3c(n2)n(cc(C(N)=O)c3=O)-c2ccc3CCCc3c2)cc1
Show InChI InChI=1S/C26H26N6O2/c1-31(2)14-16-6-9-19(10-7-16)29-26-28-13-21-23(33)22(24(27)34)15-32(25(21)30-26)20-11-8-17-4-3-5-18(17)12-20/h6-13,15H,3-5,14H2,1-2H3,(H2,27,34)(H,28,29,30)
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n/an/a 21n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of ATP-induced CSF1R autophosphorylation


Bioorg Med Chem Lett 18: 2355-61 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.070
BindingDB Entry DOI: 10.7270/Q26W9BX3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50375141
PNG
(CHEMBL256406)
Show SMILES NC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(CN4CCOCC4)cc3)ncc2c1=O
Show InChI InChI=1S/C28H28N6O3/c29-26(36)24-17-34(22-9-6-19-2-1-3-20(19)14-22)27-23(25(24)35)15-30-28(32-27)31-21-7-4-18(5-8-21)16-33-10-12-37-13-11-33/h4-9,14-15,17H,1-3,10-13,16H2,(H2,29,36)(H,30,31,32)
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n/an/a 22n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of ATP-induced CSF1R autophosphorylation


Bioorg Med Chem Lett 18: 2355-61 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.070
BindingDB Entry DOI: 10.7270/Q26W9BX3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM27890
PNG
(8-(2,3-dihydro-1H-inden-5-yl)-2-({4-[2-(4-methylpi...)
Show SMILES CN1CCN(CCc2ccc(Nc3ncc4c(n3)n(cc(C(N)=O)c4=O)-c3ccc4CCCc4c3)cc2)CC1
Show InChI InChI=1S/C30H33N7O2/c1-35-13-15-36(16-14-35)12-11-20-5-8-23(9-6-20)33-30-32-18-25-27(38)26(28(31)39)19-37(29(25)34-30)24-10-7-21-3-2-4-22(21)17-24/h5-10,17-19H,2-4,11-16H2,1H3,(H2,31,39)(H,32,33,34)
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n/an/a 8n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of ATP-induced CSF1R autophosphorylation


Bioorg Med Chem Lett 18: 2355-61 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.070
BindingDB Entry DOI: 10.7270/Q26W9BX3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50375142
PNG
(CHEMBL257528)
Show SMILES NC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(cc3)C3CCNCC3)ncc2c1=O
Show InChI InChI=1S/C28H28N6O2/c29-26(36)24-16-34(22-9-6-17-2-1-3-20(17)14-22)27-23(25(24)35)15-31-28(33-27)32-21-7-4-18(5-8-21)19-10-12-30-13-11-19/h4-9,14-16,19,30H,1-3,10-13H2,(H2,29,36)(H,31,32,33)
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n/an/a 8n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of ATP-induced CSF1R autophosphorylation


Bioorg Med Chem Lett 18: 2355-61 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.070
BindingDB Entry DOI: 10.7270/Q26W9BX3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50375146
PNG
(CHEMBL271460)
Show SMILES NC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccccc3)ncc2c1=O
Show InChI InChI=1S/C23H19N5O2/c24-21(30)19-13-28(17-10-9-14-5-4-6-15(14)11-17)22-18(20(19)29)12-25-23(27-22)26-16-7-2-1-3-8-16/h1-3,7-13H,4-6H2,(H2,24,30)(H,25,26,27)
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n/an/a 280n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of ATP-induced CSF1R autophosphorylation


Bioorg Med Chem Lett 18: 2355-61 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.070
BindingDB Entry DOI: 10.7270/Q26W9BX3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50375151
PNG
(CHEMBL255181)
Show SMILES CCNC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(cc3)N3CCN(C)CC3)ncc2c1=O
Show InChI InChI=1S/C30H33N7O2/c1-3-31-29(39)26-19-37(24-10-7-20-5-4-6-21(20)17-24)28-25(27(26)38)18-32-30(34-28)33-22-8-11-23(12-9-22)36-15-13-35(2)14-16-36/h7-12,17-19H,3-6,13-16H2,1-2H3,(H,31,39)(H,32,33,34)
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n/an/a 68n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of ATP-induced CSF1R autophosphorylation


Bioorg Med Chem Lett 18: 2355-61 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.070
BindingDB Entry DOI: 10.7270/Q26W9BX3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50375155
PNG
(CHEMBL256893)
Show SMILES CN1CCN(Cc2ccc(Nc3ncc4c(n3)n(cc(C(N)=O)c4=O)-c3ccc4CCCc4c3)cc2)CC1
Show InChI InChI=1S/C29H31N7O2/c1-34-11-13-35(14-12-34)17-19-5-8-22(9-6-19)32-29-31-16-24-26(37)25(27(30)38)18-36(28(24)33-29)23-10-7-20-3-2-4-21(20)15-23/h5-10,15-16,18H,2-4,11-14,17H2,1H3,(H2,30,38)(H,31,32,33)
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n/an/a 14n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of CSF1R


Bioorg Med Chem Lett 18: 2355-61 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.070
BindingDB Entry DOI: 10.7270/Q26W9BX3
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50375155
PNG
(CHEMBL256893)
Show SMILES CN1CCN(Cc2ccc(Nc3ncc4c(n3)n(cc(C(N)=O)c4=O)-c3ccc4CCCc4c3)cc2)CC1
Show InChI InChI=1S/C29H31N7O2/c1-34-11-13-35(14-12-34)17-19-5-8-22(9-6-19)32-29-31-16-24-26(37)25(27(30)38)18-36(28(24)33-29)23-10-7-20-3-2-4-21(20)15-23/h5-10,15-16,18H,2-4,11-14,17H2,1H3,(H2,30,38)(H,31,32,33)
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n/an/a 1n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of FLT3


Bioorg Med Chem Lett 18: 2355-61 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.070
BindingDB Entry DOI: 10.7270/Q26W9BX3
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50375155
PNG
(CHEMBL256893)
Show SMILES CN1CCN(Cc2ccc(Nc3ncc4c(n3)n(cc(C(N)=O)c4=O)-c3ccc4CCCc4c3)cc2)CC1
Show InChI InChI=1S/C29H31N7O2/c1-34-11-13-35(14-12-34)17-19-5-8-22(9-6-19)32-29-31-16-24-26(37)25(27(30)38)18-36(28(24)33-29)23-10-7-20-3-2-4-21(20)15-23/h5-10,15-16,18H,2-4,11-14,17H2,1H3,(H2,30,38)(H,31,32,33)
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n/an/a 28n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of KIT


Bioorg Med Chem Lett 18: 2355-61 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.070
BindingDB Entry DOI: 10.7270/Q26W9BX3
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50375155
PNG
(CHEMBL256893)
Show SMILES CN1CCN(Cc2ccc(Nc3ncc4c(n3)n(cc(C(N)=O)c4=O)-c3ccc4CCCc4c3)cc2)CC1
Show InChI InChI=1S/C29H31N7O2/c1-34-11-13-35(14-12-34)17-19-5-8-22(9-6-19)32-29-31-16-24-26(37)25(27(30)38)18-36(28(24)33-29)23-10-7-20-3-2-4-21(20)15-23/h5-10,15-16,18H,2-4,11-14,17H2,1H3,(H2,30,38)(H,31,32,33)
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n/an/a>2.00E+3n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 18: 2355-61 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.070
BindingDB Entry DOI: 10.7270/Q26W9BX3
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM50375155
PNG
(CHEMBL256893)
Show SMILES CN1CCN(Cc2ccc(Nc3ncc4c(n3)n(cc(C(N)=O)c4=O)-c3ccc4CCCc4c3)cc2)CC1
Show InChI InChI=1S/C29H31N7O2/c1-34-11-13-35(14-12-34)17-19-5-8-22(9-6-19)32-29-31-16-24-26(37)25(27(30)38)18-36(28(24)33-29)23-10-7-20-3-2-4-21(20)15-23/h5-10,15-16,18H,2-4,11-14,17H2,1H3,(H2,30,38)(H,31,32,33)
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n/an/a 310n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of TrkA


Bioorg Med Chem Lett 18: 2355-61 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.070
BindingDB Entry DOI: 10.7270/Q26W9BX3
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50375155
PNG
(CHEMBL256893)
Show SMILES CN1CCN(Cc2ccc(Nc3ncc4c(n3)n(cc(C(N)=O)c4=O)-c3ccc4CCCc4c3)cc2)CC1
Show InChI InChI=1S/C29H31N7O2/c1-34-11-13-35(14-12-34)17-19-5-8-22(9-6-19)32-29-31-16-24-26(37)25(27(30)38)18-36(28(24)33-29)23-10-7-20-3-2-4-21(20)15-23/h5-10,15-16,18H,2-4,11-14,17H2,1H3,(H2,30,38)(H,31,32,33)
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n/an/a 1.50E+3n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of Src


Bioorg Med Chem Lett 18: 2355-61 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.070
BindingDB Entry DOI: 10.7270/Q26W9BX3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50375158
PNG
(CHEMBL404188)
Show SMILES NC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(CCN4CCOCC4)cc3)ncc2c1=O
Show InChI InChI=1S/C29H30N6O3/c30-27(37)25-18-35(23-9-6-20-2-1-3-21(20)16-23)28-24(26(25)36)17-31-29(33-28)32-22-7-4-19(5-8-22)10-11-34-12-14-38-15-13-34/h4-9,16-18H,1-3,10-15H2,(H2,30,37)(H,31,32,33)
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n/an/a 8n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of ATP-induced CSF1R autophosphorylation


Bioorg Med Chem Lett 18: 2355-61 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.070
BindingDB Entry DOI: 10.7270/Q26W9BX3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50375155
PNG
(CHEMBL256893)
Show SMILES CN1CCN(Cc2ccc(Nc3ncc4c(n3)n(cc(C(N)=O)c4=O)-c3ccc4CCCc4c3)cc2)CC1
Show InChI InChI=1S/C29H31N7O2/c1-34-11-13-35(14-12-34)17-19-5-8-22(9-6-19)32-29-31-16-24-26(37)25(27(30)38)18-36(28(24)33-29)23-10-7-20-3-2-4-21(20)15-23/h5-10,15-16,18H,2-4,11-14,17H2,1H3,(H2,30,38)(H,31,32,33)
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n/an/a 14n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of ATP-induced CSF1R autophosphorylation


Bioorg Med Chem Lett 18: 2355-61 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.070
BindingDB Entry DOI: 10.7270/Q26W9BX3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM27891
PNG
(8-(2,3-dihydro-1H-inden-5-yl)-N-methyl-2-({4-[2-(4...)
Show SMILES CNC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(CCN4CCN(C)CC4)cc3)ncc2c1=O
Show InChI InChI=1S/C31H35N7O2/c1-32-30(40)27-20-38(25-11-8-22-4-3-5-23(22)18-25)29-26(28(27)39)19-33-31(35-29)34-24-9-6-21(7-10-24)12-13-37-16-14-36(2)15-17-37/h6-11,18-20H,3-5,12-17H2,1-2H3,(H,32,40)(H,33,34,35)
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n/an/a 1.20n/an/an/an/a7.522



Johnson & Johnson Pharmaceutical



Assay Description
FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...


J Med Chem 52: 1081-99 (2009)


Article DOI: 10.1021/jm801406h
BindingDB Entry DOI: 10.7270/Q21834T7
More data for this
Ligand-Target Pair