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24 similar compounds to monomer 27889

Compile data set for download or QSAR
Wt: 510.5
BDBM27906
Wt: 523.6
BDBM27890
Wt: 537.6
BDBM27891
Wt: 551.6
BDBM27893
Wt: 567.6
BDBM27894
Wt: 553.6
BDBM27895
Wt: 461.5
BDBM50375136
Wt: 434.4
BDBM50375137
Wt: 468.5
BDBM50375139
Wt: 454.5
BDBM50375140
Wt: 496.5
BDBM50375141
Wt: 480.5
BDBM50375142
Wt: 511.5
BDBM50375143
Wt: 495.5
BDBM50375144
Wt: 481.5
BDBM50375145
Displayed 1 to 15 (of 24 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 26 hits for monomerid = 27906,27890,27891,27893,27894,27895,50375136,50375137,50375139,50375140,50375141,50375142,50375143,50375144,50375145   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM27890
PNG
(8-(2,3-dihydro-1H-inden-5-yl)-2-({4-[2-(4-methylpi...)
Show SMILES CN1CCN(CCc2ccc(Nc3ncc4c(n3)n(cc(C(N)=O)c4=O)-c3ccc4CCCc4c3)cc2)CC1
Show InChI InChI=1S/C30H33N7O2/c1-35-13-15-36(16-14-35)12-11-20-5-8-23(9-6-20)33-30-32-18-25-27(38)26(28(31)39)19-37(29(25)34-30)24-10-7-21-3-2-4-22(21)17-24/h5-10,17-19H,2-4,11-16H2,1H3,(H2,31,39)(H,32,33,34)
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n/an/a 0.800n/an/an/an/a7.522



Johnson & Johnson Pharmaceutical



Assay Description
FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...


J Med Chem 52: 1081-99 (2009)


Article DOI: 10.1021/jm801406h
BindingDB Entry DOI: 10.7270/Q21834T7
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50375145
PNG
(CHEMBL271461)
Show SMILES NC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(cc3)N3CCNCC3)ncc2c1=O
Show InChI InChI=1S/C27H27N7O2/c28-25(36)23-16-34(21-7-4-17-2-1-3-18(17)14-21)26-22(24(23)35)15-30-27(32-26)31-19-5-8-20(9-6-19)33-12-10-29-11-13-33/h4-9,14-16,29H,1-3,10-13H2,(H2,28,36)(H,30,31,32)
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n/an/a 5n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of ATP-induced CSF1R autophosphorylation


Bioorg Med Chem Lett 18: 2355-61 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.070
BindingDB Entry DOI: 10.7270/Q26W9BX3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM27893
PNG
(8-(2,3-dihydro-1H-inden-5-yl)-N-ethyl-2-({4-[2-(4-...)
Show SMILES CCNC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(CCN4CCN(C)CC4)cc3)ncc2c1=O
Show InChI InChI=1S/C32H37N7O2/c1-3-33-31(41)28-21-39(26-12-9-23-5-4-6-24(23)19-26)30-27(29(28)40)20-34-32(36-30)35-25-10-7-22(8-11-25)13-14-38-17-15-37(2)16-18-38/h7-12,19-21H,3-6,13-18H2,1-2H3,(H,33,41)(H,34,35,36)
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n/an/a 3.20n/an/an/an/a7.522



Johnson & Johnson Pharmaceutical



Assay Description
FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...


J Med Chem 52: 1081-99 (2009)


Article DOI: 10.1021/jm801406h
BindingDB Entry DOI: 10.7270/Q21834T7
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM27894
PNG
(8-(2,3-dihydro-1H-inden-5-yl)-N-(2-hydroxyethyl)-2...)
Show SMILES CN1CCN(CCc2ccc(Nc3ncc4c(n3)n(cc(C(=O)NCCO)c4=O)-c3ccc4CCCc4c3)cc2)CC1
Show InChI InChI=1S/C32H37N7O3/c1-37-14-16-38(17-15-37)13-11-22-5-8-25(9-6-22)35-32-34-20-27-29(41)28(31(42)33-12-18-40)21-39(30(27)36-32)26-10-7-23-3-2-4-24(23)19-26/h5-10,19-21,40H,2-4,11-18H2,1H3,(H,33,42)(H,34,35,36)
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n/an/a 0.700n/an/an/an/a7.522



Johnson & Johnson Pharmaceutical



Assay Description
FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...


J Med Chem 52: 1081-99 (2009)


Article DOI: 10.1021/jm801406h
BindingDB Entry DOI: 10.7270/Q21834T7
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM27895
PNG
(8-(2,3-dihydro-1H-inden-5-yl)-N-methoxy-2-({4-[2-(...)
Show SMILES CONC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(CCN4CCN(C)CC4)cc3)ncc2c1=O
Show InChI InChI=1S/C31H35N7O3/c1-36-14-16-37(17-15-36)13-12-21-6-9-24(10-7-21)33-31-32-19-26-28(39)27(30(40)35-41-2)20-38(29(26)34-31)25-11-8-22-4-3-5-23(22)18-25/h6-11,18-20H,3-5,12-17H2,1-2H3,(H,35,40)(H,32,33,34)
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n/an/a 0.700n/an/an/an/a7.522



Johnson & Johnson Pharmaceutical



Assay Description
FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...


J Med Chem 52: 1081-99 (2009)


Article DOI: 10.1021/jm801406h
BindingDB Entry DOI: 10.7270/Q21834T7
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM27906
PNG
(8-(2,3-dihydro-1H-inden-5-yl)-N-methoxy-5-oxo-2-{[...)
Show SMILES CONC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(cc3)C3CCNCC3)ncc2c1=O
Show InChI InChI=1S/C29H30N6O3/c1-38-34-28(37)25-17-35(23-10-7-18-3-2-4-21(18)15-23)27-24(26(25)36)16-31-29(33-27)32-22-8-5-19(6-9-22)20-11-13-30-14-12-20/h5-10,15-17,20,30H,2-4,11-14H2,1H3,(H,34,37)(H,31,32,33)
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n/an/a 0.5n/an/an/an/a7.522



Johnson & Johnson Pharmaceutical



Assay Description
FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...


J Med Chem 52: 1081-99 (2009)


Article DOI: 10.1021/jm801406h
BindingDB Entry DOI: 10.7270/Q21834T7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM27890
PNG
(8-(2,3-dihydro-1H-inden-5-yl)-2-({4-[2-(4-methylpi...)
Show SMILES CN1CCN(CCc2ccc(Nc3ncc4c(n3)n(cc(C(N)=O)c4=O)-c3ccc4CCCc4c3)cc2)CC1
Show InChI InChI=1S/C30H33N7O2/c1-35-13-15-36(16-14-35)12-11-20-5-8-23(9-6-20)33-30-32-18-25-27(38)26(28(31)39)19-37(29(25)34-30)24-10-7-21-3-2-4-22(21)17-24/h5-10,17-19H,2-4,11-16H2,1H3,(H2,31,39)(H,32,33,34)
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n/an/a 1n/an/an/an/an/a25



Johnson & Johnson Pharmaceutical



Assay Description
FLT-3 was assayed using a fluorescence polarization (FP) competition immunoassay that measured FLT-3 phosphorylation of polyGlu4Tyr. The reaction was...


J Med Chem 52: 1081-99 (2009)


Article DOI: 10.1021/jm801406h
BindingDB Entry DOI: 10.7270/Q21834T7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM27895
PNG
(8-(2,3-dihydro-1H-inden-5-yl)-N-methoxy-2-({4-[2-(...)
Show SMILES CONC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(CCN4CCN(C)CC4)cc3)ncc2c1=O
Show InChI InChI=1S/C31H35N7O3/c1-36-14-16-37(17-15-36)13-12-21-6-9-24(10-7-21)33-31-32-19-26-28(39)27(30(40)35-41-2)20-38(29(26)34-31)25-11-8-22-4-3-5-23(22)18-25/h6-11,18-20H,3-5,12-17H2,1-2H3,(H,35,40)(H,32,33,34)
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n/an/a 36n/an/an/an/an/a25



Johnson & Johnson Pharmaceutical



Assay Description
FLT-3 was assayed using a fluorescence polarization (FP) competition immunoassay that measured FLT-3 phosphorylation of polyGlu4Tyr. The reaction was...


J Med Chem 52: 1081-99 (2009)


Article DOI: 10.1021/jm801406h
BindingDB Entry DOI: 10.7270/Q21834T7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM27890
PNG
(8-(2,3-dihydro-1H-inden-5-yl)-2-({4-[2-(4-methylpi...)
Show SMILES CN1CCN(CCc2ccc(Nc3ncc4c(n3)n(cc(C(N)=O)c4=O)-c3ccc4CCCc4c3)cc2)CC1
Show InChI InChI=1S/C30H33N7O2/c1-35-13-15-36(16-14-35)12-11-20-5-8-23(9-6-20)33-30-32-18-25-27(38)26(28(31)39)19-37(29(25)34-30)24-10-7-21-3-2-4-22(21)17-24/h5-10,17-19H,2-4,11-16H2,1H3,(H2,31,39)(H,32,33,34)
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n/an/a>500n/an/an/an/an/a25



Johnson & Johnson Pharmaceutical



Assay Description
Axl was assayed using a fluorescence polarization (FP) competition immunoassay that measured Axl phosphorylation of polyGlu4Tyr. The reaction was ini...


J Med Chem 52: 1081-99 (2009)


Article DOI: 10.1021/jm801406h
BindingDB Entry DOI: 10.7270/Q21834T7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM27895
PNG
(8-(2,3-dihydro-1H-inden-5-yl)-N-methoxy-2-({4-[2-(...)
Show SMILES CONC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(CCN4CCN(C)CC4)cc3)ncc2c1=O
Show InChI InChI=1S/C31H35N7O3/c1-36-14-16-37(17-15-36)13-12-21-6-9-24(10-7-21)33-31-32-19-26-28(39)27(30(40)35-41-2)20-38(29(26)34-31)25-11-8-22-4-3-5-23(22)18-25/h6-11,18-20H,3-5,12-17H2,1-2H3,(H,35,40)(H,32,33,34)
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n/an/a>500n/an/an/an/an/a25



Johnson & Johnson Pharmaceutical



Assay Description
Axl was assayed using a fluorescence polarization (FP) competition immunoassay that measured Axl phosphorylation of polyGlu4Tyr. The reaction was ini...


J Med Chem 52: 1081-99 (2009)


Article DOI: 10.1021/jm801406h
BindingDB Entry DOI: 10.7270/Q21834T7
More data for this
Ligand-Target Pair
Tyrosine Kinase TrkA


(Homo sapiens (Human))
BDBM27890
PNG
(8-(2,3-dihydro-1H-inden-5-yl)-2-({4-[2-(4-methylpi...)
Show SMILES CN1CCN(CCc2ccc(Nc3ncc4c(n3)n(cc(C(N)=O)c4=O)-c3ccc4CCCc4c3)cc2)CC1
Show InChI InChI=1S/C30H33N7O2/c1-35-13-15-36(16-14-35)12-11-20-5-8-23(9-6-20)33-30-32-18-25-27(38)26(28(31)39)19-37(29(25)34-30)24-10-7-21-3-2-4-22(21)17-24/h5-10,17-19H,2-4,11-16H2,1H3,(H2,31,39)(H,32,33,34)
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n/an/a 170n/an/an/an/an/a25



Johnson & Johnson Pharmaceutical



Assay Description
TrkA was assayed using a fluorescence polarization (FP) competition immunoassay that measured TrkA phosphorylation of polyGlu4Tyr. The reaction was i...


J Med Chem 52: 1081-99 (2009)


Article DOI: 10.1021/jm801406h
BindingDB Entry DOI: 10.7270/Q21834T7
More data for this
Ligand-Target Pair
Tyrosine Kinase TrkA


(Homo sapiens (Human))
BDBM27895
PNG
(8-(2,3-dihydro-1H-inden-5-yl)-N-methoxy-2-({4-[2-(...)
Show SMILES CONC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(CCN4CCN(C)CC4)cc3)ncc2c1=O
Show InChI InChI=1S/C31H35N7O3/c1-36-14-16-37(17-15-36)13-12-21-6-9-24(10-7-21)33-31-32-19-26-28(39)27(30(40)35-41-2)20-38(29(26)34-31)25-11-8-22-4-3-5-23(22)18-25/h6-11,18-20H,3-5,12-17H2,1-2H3,(H,35,40)(H,32,33,34)
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n/an/a>500n/an/an/an/an/a25



Johnson & Johnson Pharmaceutical



Assay Description
TrkA was assayed using a fluorescence polarization (FP) competition immunoassay that measured TrkA phosphorylation of polyGlu4Tyr. The reaction was i...


J Med Chem 52: 1081-99 (2009)


Article DOI: 10.1021/jm801406h
BindingDB Entry DOI: 10.7270/Q21834T7
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM27890
PNG
(8-(2,3-dihydro-1H-inden-5-yl)-2-({4-[2-(4-methylpi...)
Show SMILES CN1CCN(CCc2ccc(Nc3ncc4c(n3)n(cc(C(N)=O)c4=O)-c3ccc4CCCc4c3)cc2)CC1
Show InChI InChI=1S/C30H33N7O2/c1-35-13-15-36(16-14-35)12-11-20-5-8-23(9-6-20)33-30-32-18-25-27(38)26(28(31)39)19-37(29(25)34-30)24-10-7-21-3-2-4-22(21)17-24/h5-10,17-19H,2-4,11-16H2,1H3,(H2,31,39)(H,32,33,34)
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n/an/a 20n/an/an/an/an/a25



Johnson & Johnson Pharmaceutical



Assay Description
KIT was assayed using a fluorescence polarization (FP) competition immunoassay that measured KIT phosphorylation of polyGlu4Tyr. The reaction was ini...


J Med Chem 52: 1081-99 (2009)


Article DOI: 10.1021/jm801406h
BindingDB Entry DOI: 10.7270/Q21834T7
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM27895
PNG
(8-(2,3-dihydro-1H-inden-5-yl)-N-methoxy-2-({4-[2-(...)
Show SMILES CONC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(CCN4CCN(C)CC4)cc3)ncc2c1=O
Show InChI InChI=1S/C31H35N7O3/c1-36-14-16-37(17-15-36)13-12-21-6-9-24(10-7-21)33-31-32-19-26-28(39)27(30(40)35-41-2)20-38(29(26)34-31)25-11-8-22-4-3-5-23(22)18-25/h6-11,18-20H,3-5,12-17H2,1-2H3,(H,35,40)(H,32,33,34)
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n/an/a 6n/an/an/an/an/a25



Johnson & Johnson Pharmaceutical



Assay Description
KIT was assayed using a fluorescence polarization (FP) competition immunoassay that measured KIT phosphorylation of polyGlu4Tyr. The reaction was ini...


J Med Chem 52: 1081-99 (2009)


Article DOI: 10.1021/jm801406h
BindingDB Entry DOI: 10.7270/Q21834T7
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (Human))
BDBM27890
PNG
(8-(2,3-dihydro-1H-inden-5-yl)-2-({4-[2-(4-methylpi...)
Show SMILES CN1CCN(CCc2ccc(Nc3ncc4c(n3)n(cc(C(N)=O)c4=O)-c3ccc4CCCc4c3)cc2)CC1
Show InChI InChI=1S/C30H33N7O2/c1-35-13-15-36(16-14-35)12-11-20-5-8-23(9-6-20)33-30-32-18-25-27(38)26(28(31)39)19-37(29(25)34-30)24-10-7-21-3-2-4-22(21)17-24/h5-10,17-19H,2-4,11-16H2,1H3,(H2,31,39)(H,32,33,34)
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n/an/a>4.20E+4n/an/an/an/an/a25



Johnson & Johnson Pharmaceutical



Assay Description
IRKbeta was assayed using a fluorescence polarization (FP) competition immunoassay that measured IRKbeta phosphorylation of polyGlu4Tyr. The reaction...


J Med Chem 52: 1081-99 (2009)


Article DOI: 10.1021/jm801406h
BindingDB Entry DOI: 10.7270/Q21834T7
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (Human))
BDBM27895
PNG
(8-(2,3-dihydro-1H-inden-5-yl)-N-methoxy-2-({4-[2-(...)
Show SMILES CONC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(CCN4CCN(C)CC4)cc3)ncc2c1=O
Show InChI InChI=1S/C31H35N7O3/c1-36-14-16-37(17-15-36)13-12-21-6-9-24(10-7-21)33-31-32-19-26-28(39)27(30(40)35-41-2)20-38(29(26)34-31)25-11-8-22-4-3-5-23(22)18-25/h6-11,18-20H,3-5,12-17H2,1-2H3,(H,35,40)(H,32,33,34)
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n/an/a 1.98E+4n/an/an/an/an/a25



Johnson & Johnson Pharmaceutical



Assay Description
IRKbeta was assayed using a fluorescence polarization (FP) competition immunoassay that measured IRKbeta phosphorylation of polyGlu4Tyr. The reaction...


J Med Chem 52: 1081-99 (2009)


Article DOI: 10.1021/jm801406h
BindingDB Entry DOI: 10.7270/Q21834T7
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50375136
PNG
(CHEMBL272560)
Show SMILES CN1CCN(CCCNc2ncc3c(n2)n(cc(C(N)=O)c3=O)-c2ccc3CCCc3c2)CC1
Show InChI InChI=1S/C25H31N7O2/c1-30-10-12-31(13-11-30)9-3-8-27-25-28-15-20-22(33)21(23(26)34)16-32(24(20)29-25)19-7-6-17-4-2-5-18(17)14-19/h6-7,14-16H,2-5,8-13H2,1H3,(H2,26,34)(H,27,28,29)
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n/an/a 1.80E+3n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of ATP-induced CSF1R autophosphorylation


Bioorg Med Chem Lett 18: 2355-61 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.070
BindingDB Entry DOI: 10.7270/Q26W9BX3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50375137
PNG
(CHEMBL272773)
Show SMILES NC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(NCCN3CCOCC3)ncc2c1=O
Show InChI InChI=1S/C23H26N6O3/c24-21(31)19-14-29(17-5-4-15-2-1-3-16(15)12-17)22-18(20(19)30)13-26-23(27-22)25-6-7-28-8-10-32-11-9-28/h4-5,12-14H,1-3,6-11H2,(H2,24,31)(H,25,26,27)
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n/an/a 3.30E+3n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of ATP-induced CSF1R autophosphorylation


Bioorg Med Chem Lett 18: 2355-61 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.070
BindingDB Entry DOI: 10.7270/Q26W9BX3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50375139
PNG
(CHEMBL256459)
Show SMILES CN(C)CCc1ccc(Nc2ncc3c(n2)n(cc(C(N)=O)c3=O)-c2ccc3CCCc3c2)cc1
Show InChI InChI=1S/C27H28N6O2/c1-32(2)13-12-17-6-9-20(10-7-17)30-27-29-15-22-24(34)23(25(28)35)16-33(26(22)31-27)21-11-8-18-4-3-5-19(18)14-21/h6-11,14-16H,3-5,12-13H2,1-2H3,(H2,28,35)(H,29,30,31)
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n/an/a 3n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of ATP-induced CSF1R autophosphorylation


Bioorg Med Chem Lett 18: 2355-61 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.070
BindingDB Entry DOI: 10.7270/Q26W9BX3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50375140
PNG
(CHEMBL256405)
Show SMILES CN(C)Cc1ccc(Nc2ncc3c(n2)n(cc(C(N)=O)c3=O)-c2ccc3CCCc3c2)cc1
Show InChI InChI=1S/C26H26N6O2/c1-31(2)14-16-6-9-19(10-7-16)29-26-28-13-21-23(33)22(24(27)34)15-32(25(21)30-26)20-11-8-17-4-3-5-18(17)12-20/h6-13,15H,3-5,14H2,1-2H3,(H2,27,34)(H,28,29,30)
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n/an/a 21n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of ATP-induced CSF1R autophosphorylation


Bioorg Med Chem Lett 18: 2355-61 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.070
BindingDB Entry DOI: 10.7270/Q26W9BX3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50375141
PNG
(CHEMBL256406)
Show SMILES NC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(CN4CCOCC4)cc3)ncc2c1=O
Show InChI InChI=1S/C28H28N6O3/c29-26(36)24-17-34(22-9-6-19-2-1-3-20(19)14-22)27-23(25(24)35)15-30-28(32-27)31-21-7-4-18(5-8-21)16-33-10-12-37-13-11-33/h4-9,14-15,17H,1-3,10-13,16H2,(H2,29,36)(H,30,31,32)
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n/an/a 22n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of ATP-induced CSF1R autophosphorylation


Bioorg Med Chem Lett 18: 2355-61 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.070
BindingDB Entry DOI: 10.7270/Q26W9BX3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM27890
PNG
(8-(2,3-dihydro-1H-inden-5-yl)-2-({4-[2-(4-methylpi...)
Show SMILES CN1CCN(CCc2ccc(Nc3ncc4c(n3)n(cc(C(N)=O)c4=O)-c3ccc4CCCc4c3)cc2)CC1
Show InChI InChI=1S/C30H33N7O2/c1-35-13-15-36(16-14-35)12-11-20-5-8-23(9-6-20)33-30-32-18-25-27(38)26(28(31)39)19-37(29(25)34-30)24-10-7-21-3-2-4-22(21)17-24/h5-10,17-19H,2-4,11-16H2,1H3,(H2,31,39)(H,32,33,34)
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n/an/a 8n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of ATP-induced CSF1R autophosphorylation


Bioorg Med Chem Lett 18: 2355-61 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.070
BindingDB Entry DOI: 10.7270/Q26W9BX3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50375142
PNG
(CHEMBL257528)
Show SMILES NC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(cc3)C3CCNCC3)ncc2c1=O
Show InChI InChI=1S/C28H28N6O2/c29-26(36)24-16-34(22-9-6-17-2-1-3-20(17)14-22)27-23(25(24)35)15-31-28(33-27)32-21-7-4-18(5-8-21)19-10-12-30-13-11-19/h4-9,14-16,19,30H,1-3,10-13H2,(H2,29,36)(H,31,32,33)
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n/an/a 8n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of ATP-induced CSF1R autophosphorylation


Bioorg Med Chem Lett 18: 2355-61 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.070
BindingDB Entry DOI: 10.7270/Q26W9BX3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50375143
PNG
(CHEMBL404909)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(cc(C(N)=O)c3=O)-c2ccc3CCCc3c2)c(O)c1
Show InChI InChI=1S/C28H29N7O3/c1-33-9-11-34(12-10-33)19-7-8-23(24(36)14-19)31-28-30-15-21-25(37)22(26(29)38)16-35(27(21)32-28)20-6-5-17-3-2-4-18(17)13-20/h5-8,13-16,36H,2-4,9-12H2,1H3,(H2,29,38)(H,30,31,32)
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n/an/a 93n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of ATP-induced CSF1R autophosphorylation


Bioorg Med Chem Lett 18: 2355-61 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.070
BindingDB Entry DOI: 10.7270/Q26W9BX3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50375144
PNG
(CHEMBL255584)
Show SMILES CN1CCN(CC1)c1cccc(Nc2ncc3c(n2)n(cc(C(N)=O)c3=O)-c2ccc3CCCc3c2)c1
Show InChI InChI=1S/C28H29N7O2/c1-33-10-12-34(13-11-33)21-7-3-6-20(15-21)31-28-30-16-23-25(36)24(26(29)37)17-35(27(23)32-28)22-9-8-18-4-2-5-19(18)14-22/h3,6-9,14-17H,2,4-5,10-13H2,1H3,(H2,29,37)(H,30,31,32)
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n/an/a 8n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of ATP-induced CSF1R autophosphorylation


Bioorg Med Chem Lett 18: 2355-61 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.070
BindingDB Entry DOI: 10.7270/Q26W9BX3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM27891
PNG
(8-(2,3-dihydro-1H-inden-5-yl)-N-methyl-2-({4-[2-(4...)
Show SMILES CNC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(CCN4CCN(C)CC4)cc3)ncc2c1=O
Show InChI InChI=1S/C31H35N7O2/c1-32-30(40)27-20-38(25-11-8-22-4-3-5-23(22)18-25)29-26(28(27)39)19-33-31(35-29)34-24-9-6-21(7-10-24)12-13-37-16-14-36(2)15-17-37/h6-11,18-20H,3-5,12-17H2,1-2H3,(H,32,40)(H,33,34,35)
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n/an/a 1.20n/an/an/an/a7.522



Johnson & Johnson Pharmaceutical



Assay Description
FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...


J Med Chem 52: 1081-99 (2009)


Article DOI: 10.1021/jm801406h
BindingDB Entry DOI: 10.7270/Q21834T7
More data for this
Ligand-Target Pair