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66 similar compounds to monomer 104183

Compile data set for download or QSAR
Wt: 377.4
BDBM41535
Wt: 381.3
BDBM104211
Wt: 395.4
BDBM104213
Wt: 391.4
BDBM104215
Wt: 399.3
BDBM104216
Wt: 363.3
BDBM104217
Wt: 391.4
BDBM104222
Wt: 395.4
BDBM104225
Wt: 395.4
BDBM104226
Wt: 405.4
BDBM104227
Wt: 423.4
BDBM104228
Wt: 395.4
BDBM104229
Wt: 349.3
BDBM104230
Wt: 367.3
BDBM104231
Wt: 407.4
BDBM104232
Displayed 1 to 15 (of 66 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 57 hits for monomerid = 41535,104211,104213,104215,104216,104217,104222,104225,104226,104227,104228,104229,104230,104231,104232   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM104213
PNG
(US8575145, 120 | US8575145, 121 | US8575145, 150 |...)
Show SMILES FC1CCNCCC1Oc1cc(F)cc2ccc(nc12)-c1nnc2ccccn12
Show InChI InChI=1S/C21H19F2N5O/c22-14-11-13-4-5-16(21-27-26-19-3-1-2-10-28(19)21)25-20(13)18(12-14)29-17-7-9-24-8-6-15(17)23/h1-5,10-12,15,17,24H,6-9H2
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n/an/a 30.5n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM-3


(Rattus norvegicus (Rat))
BDBM104215
PNG
(US8575145, 152 | US8575145, 92 | US8575145, 92/122)
Show SMILES Cc1ccn2c(nnc2c1)-c1ccc2cccc(OC3CCNCCC3F)c2n1
Show InChI InChI=1S/C22H22FN5O/c1-14-9-12-28-20(13-14)26-27-22(28)17-6-5-15-3-2-4-19(21(15)25-17)29-18-8-11-24-10-7-16(18)23/h2-6,9,12-13,16,18,24H,7-8,10-11H2,1H3
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n/an/a 23.5n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM41535
PNG
(US8575145, 106 | US8575145, 66)
Show SMILES FC1(COc2cccc3ccc(nc23)-c2nnc3ccccn23)CCNCC1
Show InChI InChI=1S/C21H26N6O5/c1-5-31-18-8-7-15(9-19(18)32-6-2)12-25-13-16(10-22-25)24-20(28)21(3,4)26-14-17(11-23-26)27(29)30/h7-11,13-14H,5-6,12H2,1-4H3,(H,24,28)
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n/an/a 0.5n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM41535
PNG
(US8575145, 106 | US8575145, 66)
Show SMILES FC1(COc2cccc3ccc(nc23)-c2nnc3ccccn23)CCNCC1
Show InChI InChI=1S/C21H26N6O5/c1-5-31-18-8-7-15(9-19(18)32-6-2)12-25-13-16(10-22-25)24-20(28)21(3,4)26-14-17(11-23-26)27(29)30/h7-11,13-14H,5-6,12H2,1-4H3,(H,24,28)
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n/an/a 0.800n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM104211
PNG
(US8575145, 88)
Show SMILES FC1CNCCC1Oc1cc(F)cc2ccc(nc12)-c1nnc2ccccn12
Show InChI InChI=1S/C20H17F2N5O/c21-13-9-12-4-5-15(20-26-25-18-3-1-2-8-27(18)20)24-19(12)17(10-13)28-16-6-7-23-11-14(16)22/h1-5,8-10,14,16,23H,6-7,11H2
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n/an/a 8n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM104213
PNG
(US8575145, 120 | US8575145, 121 | US8575145, 150 |...)
Show SMILES FC1CCNCCC1Oc1cc(F)cc2ccc(nc12)-c1nnc2ccccn12
Show InChI InChI=1S/C21H19F2N5O/c22-14-11-13-4-5-16(21-27-26-19-3-1-2-10-28(19)21)25-20(13)18(12-14)29-17-7-9-24-8-6-15(17)23/h1-5,10-12,15,17,24H,6-9H2
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n/an/a 0.400n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM104213
PNG
(US8575145, 120 | US8575145, 121 | US8575145, 150 |...)
Show SMILES FC1CCNCCC1Oc1cc(F)cc2ccc(nc12)-c1nnc2ccccn12
Show InChI InChI=1S/C21H19F2N5O/c22-14-11-13-4-5-16(21-27-26-19-3-1-2-10-28(19)21)25-20(13)18(12-14)29-17-7-9-24-8-6-15(17)23/h1-5,10-12,15,17,24H,6-9H2
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n/an/a 0.800n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM104215
PNG
(US8575145, 152 | US8575145, 92 | US8575145, 92/122)
Show SMILES Cc1ccn2c(nnc2c1)-c1ccc2cccc(OC3CCNCCC3F)c2n1
Show InChI InChI=1S/C22H22FN5O/c1-14-9-12-28-20(13-14)26-27-22(28)17-6-5-15-3-2-4-19(21(15)25-17)29-18-8-11-24-10-7-16(18)23/h2-6,9,12-13,16,18,24H,7-8,10-11H2,1H3
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n/an/a 1n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM104216
PNG
(US8575145, 93)
Show SMILES Fc1cc(OC2CCNCC2(F)F)c2nc(ccc2c1)-c1nnc2ccccn12
Show InChI InChI=1S/C20H16F3N5O/c21-13-9-12-4-5-14(19-27-26-17-3-1-2-8-28(17)19)25-18(12)15(10-13)29-16-6-7-24-11-20(16,22)23/h1-5,8-10,16,24H,6-7,11H2
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n/an/a 4.40n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM104217
PNG
(US8575145, 125 | US8575145, 126 | US8575145, 127 |...)
Show SMILES FC1CNCCC1Oc1cccc2ccc(nc12)-c1nnc2ccccn12
Show InChI InChI=1S/C20H18FN5O/c21-14-12-22-10-9-16(14)27-17-5-3-4-13-7-8-15(23-19(13)17)20-25-24-18-6-1-2-11-26(18)20/h1-8,11,14,16,22H,9-10,12H2
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n/an/a 19.4n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM104217
PNG
(US8575145, 125 | US8575145, 126 | US8575145, 127 |...)
Show SMILES FC1CNCCC1Oc1cccc2ccc(nc12)-c1nnc2ccccn12
Show InChI InChI=1S/C20H18FN5O/c21-14-12-22-10-9-16(14)27-17-5-3-4-13-7-8-15(23-19(13)17)20-25-24-18-6-1-2-11-26(18)20/h1-8,11,14,16,22H,9-10,12H2
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n/an/a 9.80n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM104217
PNG
(US8575145, 125 | US8575145, 126 | US8575145, 127 |...)
Show SMILES FC1CNCCC1Oc1cccc2ccc(nc12)-c1nnc2ccccn12
Show InChI InChI=1S/C20H18FN5O/c21-14-12-22-10-9-16(14)27-17-5-3-4-13-7-8-15(23-19(13)17)20-25-24-18-6-1-2-11-26(18)20/h1-8,11,14,16,22H,9-10,12H2
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n/an/a 10.8n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM104217
PNG
(US8575145, 125 | US8575145, 126 | US8575145, 127 |...)
Show SMILES FC1CNCCC1Oc1cccc2ccc(nc12)-c1nnc2ccccn12
Show InChI InChI=1S/C20H18FN5O/c21-14-12-22-10-9-16(14)27-17-5-3-4-13-7-8-15(23-19(13)17)20-25-24-18-6-1-2-11-26(18)20/h1-8,11,14,16,22H,9-10,12H2
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n/an/a 49n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM104222
PNG
(US8575145, 130 | US8575145, 99/100)
Show SMILES Cc1ccc2nnc(-c3ccc4cccc(OC5CCNCCC5F)c4n3)n2c1
Show InChI InChI=1S/C22H22FN5O/c1-14-5-8-20-26-27-22(28(20)13-14)17-7-6-15-3-2-4-19(21(15)25-17)29-18-10-12-24-11-9-16(18)23/h2-8,13,16,18,24H,9-12H2,1H3
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n/an/a 17.4n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM104222
PNG
(US8575145, 130 | US8575145, 99/100)
Show SMILES Cc1ccc2nnc(-c3ccc4cccc(OC5CCNCCC5F)c4n3)n2c1
Show InChI InChI=1S/C22H22FN5O/c1-14-5-8-20-26-27-22(28(20)13-14)17-7-6-15-3-2-4-19(21(15)25-17)29-18-10-12-24-11-9-16(18)23/h2-8,13,16,18,24H,9-12H2,1H3
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n/an/a 1.5n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM104225
PNG
(US8575145, 102)
Show SMILES FC1CCNCCC1Oc1cccc2ccc(nc12)-c1nnc2ccc(F)cn12
Show InChI InChI=1S/C21H19F2N5O/c22-14-5-7-19-26-27-21(28(19)12-14)16-6-4-13-2-1-3-18(20(13)25-16)29-17-9-11-24-10-8-15(17)23/h1-7,12,15,17,24H,8-11H2
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n/an/a 4.90n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM104226
PNG
(US8575145, 103)
Show SMILES Fc1ccc2nnc(-c3ccc4cccc(OCC5(F)CCNCC5)c4n3)n2c1
Show InChI InChI=1S/C21H19F2N5O/c22-15-5-7-18-26-27-20(28(18)12-15)16-6-4-14-2-1-3-17(19(14)25-16)29-13-21(23)8-10-24-11-9-21/h1-7,12,24H,8-11,13H2
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n/an/a 1.40n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM104227
PNG
(US8575145, 104)
Show SMILES CCN1CCC(F)(COc2cccc3ccc(nc23)-c2nnc3ccccn23)CC1
Show InChI InChI=1S/C23H24FN5O/c1-2-28-14-11-23(24,12-15-28)16-30-19-7-5-6-17-9-10-18(25-21(17)19)22-27-26-20-8-3-4-13-29(20)22/h3-10,13H,2,11-12,14-16H2,1H3
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n/an/a 3.90n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM104228
PNG
(US8575145, 105)
Show SMILES FCCN1CCC(F)(COc2cccc3ccc(nc23)-c2nnc3ccccn23)CC1
Show InChI InChI=1S/C23H23F2N5O/c24-11-15-29-13-9-23(25,10-14-29)16-31-19-5-3-4-17-7-8-18(26-21(17)19)22-28-27-20-6-1-2-12-30(20)22/h1-8,12H,9-11,13-16H2
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n/an/a 8.70n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM104229
PNG
(US8575145, 106)
Show SMILES Fc1cc(OCC2(F)CCNCC2)c2nc(ccc2c1)-c1nnc2ccccn12
Show InChI InChI=1S/C21H19F2N5O/c22-15-11-14-4-5-16(20-27-26-18-3-1-2-10-28(18)20)25-19(14)17(12-15)29-13-21(23)6-8-24-9-7-21/h1-5,10-12,24H,6-9,13H2
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n/an/a 0.5n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM104230
PNG
(US8575145, 107)
Show SMILES FC1(COc2cccc3ccc(nc23)-c2nnc3ccccn23)CNC1
Show InChI InChI=1S/C19H16FN5O/c20-19(10-21-11-19)12-26-15-5-3-4-13-7-8-14(22-17(13)15)18-24-23-16-6-1-2-9-25(16)18/h1-9,21H,10-12H2
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n/an/a 9.40n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM104231
PNG
(US8575145, 108)
Show SMILES Fc1cc(OCC2(F)CNC2)c2nc(ccc2c1)-c1nnc2ccccn12
Show InChI InChI=1S/C19H15F2N5O/c20-13-7-12-4-5-14(18-25-24-16-3-1-2-6-26(16)18)23-17(12)15(8-13)27-11-19(21)9-22-10-19/h1-8,22H,9-11H2
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n/an/a 7.30n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM104232
PNG
(US8575145, 109)
Show SMILES COc1ccc2nnc(-c3ccc4cccc(OCC5(F)CCNCC5)c4n3)n2c1
Show InChI InChI=1S/C22H22FN5O2/c1-29-16-6-8-19-26-27-21(28(19)13-16)17-7-5-15-3-2-4-18(20(15)25-17)30-14-22(23)9-11-24-12-10-22/h2-8,13,24H,9-12,14H2,1H3
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n/an/a 4.70n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM104213
PNG
(US8575145, 120 | US8575145, 121 | US8575145, 150 |...)
Show SMILES FC1CCNCCC1Oc1cc(F)cc2ccc(nc12)-c1nnc2ccccn12
Show InChI InChI=1S/C21H19F2N5O/c22-14-11-13-4-5-16(21-27-26-19-3-1-2-10-28(19)21)25-20(13)18(12-14)29-17-7-9-24-8-6-15(17)23/h1-5,10-12,15,17,24H,6-9H2
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n/an/a 11n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM41535
PNG
(US8575145, 106 | US8575145, 66)
Show SMILES FC1(COc2cccc3ccc(nc23)-c2nnc3ccccn23)CCNCC1
Show InChI InChI=1S/C21H26N6O5/c1-5-31-18-8-7-15(9-19(18)32-6-2)12-25-13-16(10-22-25)24-20(28)21(3,4)26-14-17(11-23-26)27(29)30/h7-11,13-14H,5-6,12H2,1-4H3,(H,24,28)
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n/an/a 52n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM104211
PNG
(US8575145, 88)
Show SMILES FC1CNCCC1Oc1cc(F)cc2ccc(nc12)-c1nnc2ccccn12
Show InChI InChI=1S/C20H17F2N5O/c21-13-9-12-4-5-15(20-26-25-18-3-1-2-8-27(18)20)24-19(12)17(10-13)28-16-6-7-23-11-14(16)22/h1-5,8-10,14,16,23H,6-7,11H2
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n/an/a 502n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM104213
PNG
(US8575145, 120 | US8575145, 121 | US8575145, 150 |...)
Show SMILES FC1CCNCCC1Oc1cc(F)cc2ccc(nc12)-c1nnc2ccccn12
Show InChI InChI=1S/C21H19F2N5O/c22-14-11-13-4-5-16(21-27-26-19-3-1-2-10-28(19)21)25-20(13)18(12-14)29-17-7-9-24-8-6-15(17)23/h1-5,10-12,15,17,24H,6-9H2
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n/an/a 131n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM104213
PNG
(US8575145, 120 | US8575145, 121 | US8575145, 150 |...)
Show SMILES FC1CCNCCC1Oc1cc(F)cc2ccc(nc12)-c1nnc2ccccn12
Show InChI InChI=1S/C21H19F2N5O/c22-14-11-13-4-5-16(21-27-26-19-3-1-2-10-28(19)21)25-20(13)18(12-14)29-17-7-9-24-8-6-15(17)23/h1-5,10-12,15,17,24H,6-9H2
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n/an/a 39n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM104215
PNG
(US8575145, 152 | US8575145, 92 | US8575145, 92/122)
Show SMILES Cc1ccn2c(nnc2c1)-c1ccc2cccc(OC3CCNCCC3F)c2n1
Show InChI InChI=1S/C22H22FN5O/c1-14-9-12-28-20(13-14)26-27-22(28)17-6-5-15-3-2-4-19(21(15)25-17)29-18-8-11-24-10-7-16(18)23/h2-6,9,12-13,16,18,24H,7-8,10-11H2,1H3
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n/an/a 244n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM104216
PNG
(US8575145, 93)
Show SMILES Fc1cc(OC2CCNCC2(F)F)c2nc(ccc2c1)-c1nnc2ccccn12
Show InChI InChI=1S/C20H16F3N5O/c21-13-9-12-4-5-14(19-27-26-17-3-1-2-8-28(17)19)25-18(12)15(10-13)29-16-6-7-24-11-20(16,22)23/h1-5,8-10,16,24H,6-7,11H2
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n/an/a 506n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM104217
PNG
(US8575145, 125 | US8575145, 126 | US8575145, 127 |...)
Show SMILES FC1CNCCC1Oc1cccc2ccc(nc12)-c1nnc2ccccn12
Show InChI InChI=1S/C20H18FN5O/c21-14-12-22-10-9-16(14)27-17-5-3-4-13-7-8-15(23-19(13)17)20-25-24-18-6-1-2-11-26(18)20/h1-8,11,14,16,22H,9-10,12H2
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n/an/a 1.00E+3n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM104217
PNG
(US8575145, 125 | US8575145, 126 | US8575145, 127 |...)
Show SMILES FC1CNCCC1Oc1cccc2ccc(nc12)-c1nnc2ccccn12
Show InChI InChI=1S/C20H18FN5O/c21-14-12-22-10-9-16(14)27-17-5-3-4-13-7-8-15(23-19(13)17)20-25-24-18-6-1-2-11-26(18)20/h1-8,11,14,16,22H,9-10,12H2
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n/an/a 482n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM104217
PNG
(US8575145, 125 | US8575145, 126 | US8575145, 127 |...)
Show SMILES FC1CNCCC1Oc1cccc2ccc(nc12)-c1nnc2ccccn12
Show InChI InChI=1S/C20H18FN5O/c21-14-12-22-10-9-16(14)27-17-5-3-4-13-7-8-15(23-19(13)17)20-25-24-18-6-1-2-11-26(18)20/h1-8,11,14,16,22H,9-10,12H2
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n/an/a 1.00E+3n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM104217
PNG
(US8575145, 125 | US8575145, 126 | US8575145, 127 |...)
Show SMILES FC1CNCCC1Oc1cccc2ccc(nc12)-c1nnc2ccccn12
Show InChI InChI=1S/C20H18FN5O/c21-14-12-22-10-9-16(14)27-17-5-3-4-13-7-8-15(23-19(13)17)20-25-24-18-6-1-2-11-26(18)20/h1-8,11,14,16,22H,9-10,12H2
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n/an/a 1.00E+3n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM104225
PNG
(US8575145, 102)
Show SMILES FC1CCNCCC1Oc1cccc2ccc(nc12)-c1nnc2ccc(F)cn12
Show InChI InChI=1S/C21H19F2N5O/c22-14-5-7-19-26-27-21(28(19)12-14)16-6-4-13-2-1-3-18(20(13)25-16)29-17-9-11-24-10-8-15(17)23/h1-7,12,15,17,24H,8-11H2
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n/an/a 440n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM104226
PNG
(US8575145, 103)
Show SMILES Fc1ccc2nnc(-c3ccc4cccc(OCC5(F)CCNCC5)c4n3)n2c1
Show InChI InChI=1S/C21H19F2N5O/c22-15-5-7-18-26-27-20(28(18)12-15)16-6-4-14-2-1-3-17(19(14)25-16)29-13-21(23)8-10-24-11-9-21/h1-7,12,24H,8-11,13H2
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n/an/a 65.6n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM104227
PNG
(US8575145, 104)
Show SMILES CCN1CCC(F)(COc2cccc3ccc(nc23)-c2nnc3ccccn23)CC1
Show InChI InChI=1S/C23H24FN5O/c1-2-28-14-11-23(24,12-15-28)16-30-19-7-5-6-17-9-10-18(25-21(17)19)22-27-26-20-8-3-4-13-29(20)22/h3-10,13H,2,11-12,14-16H2,1H3
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n/an/a 191n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM104228
PNG
(US8575145, 105)
Show SMILES FCCN1CCC(F)(COc2cccc3ccc(nc23)-c2nnc3ccccn23)CC1
Show InChI InChI=1S/C23H23F2N5O/c24-11-15-29-13-9-23(25,10-14-29)16-31-19-5-3-4-17-7-8-18(26-21(17)19)22-28-27-20-6-1-2-12-30(20)22/h1-8,12H,9-11,13-16H2
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n/an/a 409n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM104229
PNG
(US8575145, 106)
Show SMILES Fc1cc(OCC2(F)CCNCC2)c2nc(ccc2c1)-c1nnc2ccccn12
Show InChI InChI=1S/C21H19F2N5O/c22-15-11-14-4-5-16(20-27-26-18-3-1-2-10-28(18)20)25-19(14)17(12-15)29-13-21(23)6-8-24-9-7-21/h1-5,10-12,24H,6-9,13H2
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n/an/a 25.4n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM104230
PNG
(US8575145, 107)
Show SMILES FC1(COc2cccc3ccc(nc23)-c2nnc3ccccn23)CNC1
Show InChI InChI=1S/C19H16FN5O/c20-19(10-21-11-19)12-26-15-5-3-4-13-7-8-14(22-17(13)15)18-24-23-16-6-1-2-9-25(16)18/h1-9,21H,10-12H2
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n/an/a 1.00E+3n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM104231
PNG
(US8575145, 108)
Show SMILES Fc1cc(OCC2(F)CNC2)c2nc(ccc2c1)-c1nnc2ccccn12
Show InChI InChI=1S/C19H15F2N5O/c20-13-7-12-4-5-14(18-25-24-16-3-1-2-6-26(16)18)23-17(12)15(8-13)27-11-19(21)9-22-10-19/h1-8,22H,9-11H2
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n/an/a 489n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM104232
PNG
(US8575145, 109)
Show SMILES COc1ccc2nnc(-c3ccc4cccc(OCC5(F)CCNCC5)c4n3)n2c1
Show InChI InChI=1S/C22H22FN5O2/c1-29-16-6-8-19-26-27-21(28(19)13-16)17-7-5-15-3-2-4-18(20(15)25-17)30-14-22(23)9-11-24-12-10-22/h2-8,13,24H,9-12,14H2,1H3
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n/an/a 384n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM104213
PNG
(US8575145, 120 | US8575145, 121 | US8575145, 150 |...)
Show SMILES FC1CCNCCC1Oc1cc(F)cc2ccc(nc12)-c1nnc2ccccn12
Show InChI InChI=1S/C21H19F2N5O/c22-14-11-13-4-5-16(21-27-26-19-3-1-2-10-28(19)21)25-20(13)18(12-14)29-17-7-9-24-8-6-15(17)23/h1-5,10-12,15,17,24H,6-9H2
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n/an/a 959n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM104213
PNG
(US8575145, 120 | US8575145, 121 | US8575145, 150 |...)
Show SMILES FC1CCNCCC1Oc1cc(F)cc2ccc(nc12)-c1nnc2ccccn12
Show InChI InChI=1S/C21H19F2N5O/c22-14-11-13-4-5-16(21-27-26-19-3-1-2-10-28(19)21)25-20(13)18(12-14)29-17-7-9-24-8-6-15(17)23/h1-5,10-12,15,17,24H,6-9H2
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n/an/a 520n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM104215
PNG
(US8575145, 152 | US8575145, 92 | US8575145, 92/122)
Show SMILES Cc1ccn2c(nnc2c1)-c1ccc2cccc(OC3CCNCCC3F)c2n1
Show InChI InChI=1S/C22H22FN5O/c1-14-9-12-28-20(13-14)26-27-22(28)17-6-5-15-3-2-4-19(21(15)25-17)29-18-8-11-24-10-7-16(18)23/h2-6,9,12-13,16,18,24H,7-8,10-11H2,1H3
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n/an/a 1.00E+3n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM104222
PNG
(US8575145, 130 | US8575145, 99/100)
Show SMILES Cc1ccc2nnc(-c3ccc4cccc(OC5CCNCCC5F)c4n3)n2c1
Show InChI InChI=1S/C22H22FN5O/c1-14-5-8-20-26-27-22(28(20)13-14)17-7-6-15-3-2-4-19(21(15)25-17)29-18-10-12-24-11-9-16(18)23/h2-8,13,16,18,24H,9-12H2,1H3
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n/an/a 1.00E+3n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM104222
PNG
(US8575145, 130 | US8575145, 99/100)
Show SMILES Cc1ccc2nnc(-c3ccc4cccc(OC5CCNCCC5F)c4n3)n2c1
Show InChI InChI=1S/C22H22FN5O/c1-14-5-8-20-26-27-22(28(20)13-14)17-7-6-15-3-2-4-19(21(15)25-17)29-18-10-12-24-11-9-16(18)23/h2-8,13,16,18,24H,9-12H2,1H3
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n/an/a 352n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM-3


(Rattus norvegicus (Rat))
BDBM41535
PNG
(US8575145, 106 | US8575145, 66)
Show SMILES FC1(COc2cccc3ccc(nc23)-c2nnc3ccccn23)CCNCC1
Show InChI InChI=1S/C21H26N6O5/c1-5-31-18-8-7-15(9-19(18)32-6-2)12-25-13-16(10-22-25)24-20(28)21(3,4)26-14-17(11-23-26)27(29)30/h7-11,13-14H,5-6,12H2,1-4H3,(H,24,28)
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n/an/a 3n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM-3


(Rattus norvegicus (Rat))
BDBM104211
PNG
(US8575145, 88)
Show SMILES FC1CNCCC1Oc1cc(F)cc2ccc(nc12)-c1nnc2ccccn12
Show InChI InChI=1S/C20H17F2N5O/c21-13-9-12-4-5-15(20-26-25-18-3-1-2-8-27(18)20)24-19(12)17(10-13)28-16-6-7-23-11-14(16)22/h1-5,8-10,14,16,23H,6-7,11H2
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n/an/a 24n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM-3


(Rattus norvegicus (Rat))
BDBM104213
PNG
(US8575145, 120 | US8575145, 121 | US8575145, 150 |...)
Show SMILES FC1CCNCCC1Oc1cc(F)cc2ccc(nc12)-c1nnc2ccccn12
Show InChI InChI=1S/C21H19F2N5O/c22-14-11-13-4-5-16(21-27-26-19-3-1-2-10-28(19)21)25-20(13)18(12-14)29-17-7-9-24-8-6-15(17)23/h1-5,10-12,15,17,24H,6-9H2
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n/an/a 2n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
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