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66 molecules are shown

Compile data set for download or QSAR
Wt: 389.4
BDBM104196
Wt: 442.2
BDBM104201
Wt: 403.4
BDBM104203
Wt: 439.4
BDBM104205
Wt: 391.4
BDBM104207
Wt: 421.4
BDBM104208
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 104196,104201,104203,104205,104207,104208   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM104196
PNG
(US8575145, 73)
Show SMILES COC1(COc2cccc3ccc(nc23)-c2nnc3ccccn23)CCNCC1
Show InChI InChI=1S/C22H23N5O2/c1-28-22(10-12-23-13-11-22)15-29-18-6-4-5-16-8-9-17(24-20(16)18)21-26-25-19-7-2-3-14-27(19)21/h2-9,14,23H,10-13,15H2,1H3
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US Patent
n/an/a 0.960n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM104201
PNG
(US8575145, 78)
Show SMILES FC1CNCCC1Oc1cccc2ccc(nc12)-c1nnc2ccc(Br)cn12
Show InChI InChI=1S/C20H17BrFN5O/c21-13-5-7-18-25-26-20(27(18)11-13)15-6-4-12-2-1-3-17(19(12)24-15)28-16-8-9-23-10-14(16)22/h1-7,11,14,16,23H,8-10H2
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n/an/a 8n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM104203
PNG
(US8575145, 80)
Show SMILES FC1CNCCC1Oc1cccc2ccc(nc12)-c1nnc2ccc(cn12)C1CC1
Show InChI InChI=1S/C23H22FN5O/c24-17-12-25-11-10-19(17)30-20-3-1-2-15-6-8-18(26-22(15)20)23-28-27-21-9-7-16(13-29(21)23)14-4-5-14/h1-3,6-9,13-14,17,19,25H,4-5,10-12H2
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n/an/a 2n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM104205
PNG
(US8575145, 82)
Show SMILES FC1CNCCC1Oc1cccc2ccc(nc12)-c1nnc2ccc(cn12)-c1ccccc1
Show InChI InChI=1S/C26H22FN5O/c27-20-15-28-14-13-22(20)33-23-8-4-7-18-9-11-21(29-25(18)23)26-31-30-24-12-10-19(16-32(24)26)17-5-2-1-3-6-17/h1-12,16,20,22,28H,13-15H2
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n/an/a 3n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM104207
PNG
(US8575145, 84)
Show SMILES CN1CCC(F)(COc2cccc3ccc(nc23)-c2nnc3ccccn23)CC1
Show InChI InChI=1S/C22H22FN5O/c1-27-13-10-22(23,11-14-27)15-29-18-6-4-5-16-8-9-17(24-20(16)18)21-26-25-19-7-2-3-12-28(19)21/h2-9,12H,10-11,13-15H2,1H3
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n/an/a 2n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM104208
PNG
(US8575145, 85)
Show SMILES OCCN1CCC(F)(COc2cccc3ccc(nc23)-c2nnc3ccccn23)CC1
Show InChI InChI=1S/C23H24FN5O2/c24-23(9-12-28(13-10-23)14-15-30)16-31-19-5-3-4-17-7-8-18(25-21(17)19)22-27-26-20-6-1-2-11-29(20)22/h1-8,11,30H,9-10,12-16H2
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n/an/a 2n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM-3


(Rattus norvegicus (Rat))
BDBM104196
PNG
(US8575145, 73)
Show SMILES COC1(COc2cccc3ccc(nc23)-c2nnc3ccccn23)CCNCC1
Show InChI InChI=1S/C22H23N5O2/c1-28-22(10-12-23-13-11-22)15-29-18-6-4-5-16-8-9-17(24-20(16)18)21-26-25-19-7-2-3-14-27(19)21/h2-9,14,23H,10-13,15H2,1H3
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n/an/a 5n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM104201
PNG
(US8575145, 78)
Show SMILES FC1CNCCC1Oc1cccc2ccc(nc12)-c1nnc2ccc(Br)cn12
Show InChI InChI=1S/C20H17BrFN5O/c21-13-5-7-18-25-26-20(27(18)11-13)15-6-4-12-2-1-3-17(19(12)24-15)28-16-8-9-23-10-14(16)22/h1-7,11,14,16,23H,8-10H2
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US Patent
n/an/a 1.28E+3n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM104203
PNG
(US8575145, 80)
Show SMILES FC1CNCCC1Oc1cccc2ccc(nc12)-c1nnc2ccc(cn12)C1CC1
Show InChI InChI=1S/C23H22FN5O/c24-17-12-25-11-10-19(17)30-20-3-1-2-15-6-8-18(26-22(15)20)23-28-27-21-9-7-16(13-29(21)23)14-4-5-14/h1-3,6-9,13-14,17,19,25H,4-5,10-12H2
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US Patent
n/an/a 1.16E+3n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM104205
PNG
(US8575145, 82)
Show SMILES FC1CNCCC1Oc1cccc2ccc(nc12)-c1nnc2ccc(cn12)-c1ccccc1
Show InChI InChI=1S/C26H22FN5O/c27-20-15-28-14-13-22(20)33-23-8-4-7-18-9-11-21(29-25(18)23)26-31-30-24-12-10-19(16-32(24)26)17-5-2-1-3-6-17/h1-12,16,20,22,28H,13-15H2
PDB
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US Patent
n/an/a 1.04E+3n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM104207
PNG
(US8575145, 84)
Show SMILES CN1CCC(F)(COc2cccc3ccc(nc23)-c2nnc3ccccn23)CC1
Show InChI InChI=1S/C22H22FN5O/c1-27-13-10-22(23,11-14-27)15-29-18-6-4-5-16-8-9-17(24-20(16)18)21-26-25-19-7-2-3-12-28(19)21/h2-9,12H,10-11,13-15H2,1H3
PDB
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US Patent
n/an/a 73n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM104208
PNG
(US8575145, 85)
Show SMILES OCCN1CCC(F)(COc2cccc3ccc(nc23)-c2nnc3ccccn23)CC1
Show InChI InChI=1S/C23H24FN5O2/c24-23(9-12-28(13-10-23)14-15-30)16-31-19-5-3-4-17-7-8-18(25-21(17)19)22-27-26-20-6-1-2-11-29(20)22/h1-8,11,30H,9-10,12-16H2
PDB
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US Patent
n/an/a 105n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM104196
PNG
(US8575145, 73)
Show SMILES COC1(COc2cccc3ccc(nc23)-c2nnc3ccccn23)CCNCC1
Show InChI InChI=1S/C22H23N5O2/c1-28-22(10-12-23-13-11-22)15-29-18-6-4-5-16-8-9-17(24-20(16)18)21-26-25-19-7-2-3-14-27(19)21/h2-9,14,23H,10-13,15H2,1H3
PDB
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US Patent
n/an/a 79n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair