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13 similar compounds to monomer 106632

Compile data set for download or QSAR
Wt: 265.7
BDBM106668
Wt: 279.3
BDBM106623
Wt: 217.2
BDBM106627
Wt: 293.3
BDBM106628
Wt: 307.3
BDBM106631
Wt: 245.3
BDBM106583
Wt: 249.2
BDBM106633
Wt: 267.2
BDBM106634
Wt: 273.3
BDBM106607
Wt: 299.2
BDBM106610
Wt: 307.3
BDBM106611
Wt: 245.3
BDBM50401213
Wt: 253.2
BDBM47083

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 106668,106623,106627,106628,106631,106583,106633,106634,106607,106610,106611,50401213,47083   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM106631
PNG
(US8586617, 192)
Show SMILES CCN(Cc1cnc[nH]1)c1cccc(OCc2ccccc2)c1
Show InChI InChI=1S/C19H21N3O/c1-2-22(13-17-12-20-15-21-17)18-9-6-10-19(11-18)23-14-16-7-4-3-5-8-16/h3-12,15H,2,13-14H2,1H3,(H,20,21)
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US Patent
1 -11.4n/an/an/an/an/an/a4



Hoffmann-La Roche Inc

US Patent


Assay Description
Radioligand binding assay: The radioligand [3H]-rac-2-(1,2,3,4-tetrahydro-1-naphthyl)-2-imidazoline was used at a concentration equal to the calcula...


US Patent US8586617 (2013)


BindingDB Entry DOI: 10.7270/Q2GF0S56
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM106668
PNG
(US8586617, 324)
Show SMILES CCN(Cc1cnc[nH]1)c1ccc(Cl)c(OC)c1
Show InChI InChI=1S/C13H16ClN3O/c1-3-17(8-10-7-15-9-16-10)11-4-5-12(14)13(6-11)18-2/h4-7,9H,3,8H2,1-2H3,(H,15,16)
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2 -11.0n/an/an/an/an/an/a4



Hoffmann-La Roche Inc

US Patent


Assay Description
Radioligand binding assay: The radioligand [3H]-rac-2-(1,2,3,4-tetrahydro-1-naphthyl)-2-imidazoline was used at a concentration equal to the calcula...


US Patent US8586617 (2013)


BindingDB Entry DOI: 10.7270/Q2GF0S56
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM106611
PNG
(US8586617, 123)
Show SMILES CC(C)N(Cc1cnc[nH]1)c1cccc(Oc2ccccc2)c1
Show InChI InChI=1S/C19H21N3O/c1-15(2)22(13-16-12-20-14-21-16)17-7-6-10-19(11-17)23-18-8-4-3-5-9-18/h3-12,14-15H,13H2,1-2H3,(H,20,21)
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2.10 -11.0n/an/an/an/an/an/a4



Hoffmann-La Roche Inc

US Patent


Assay Description
Radioligand binding assay: The radioligand [3H]-rac-2-(1,2,3,4-tetrahydro-1-naphthyl)-2-imidazoline was used at a concentration equal to the calcula...


US Patent US8586617 (2013)


BindingDB Entry DOI: 10.7270/Q2GF0S56
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM106628
PNG
(US8586617, 188)
Show SMILES CCN(Cc1cnc[nH]1)c1cccc(Oc2ccccc2)c1
Show InChI InChI=1S/C18H19N3O/c1-2-21(13-15-12-19-14-20-15)16-7-6-10-18(11-16)22-17-8-4-3-5-9-17/h3-12,14H,2,13H2,1H3,(H,19,20)
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2.40 -10.9n/an/an/an/an/an/a4



Hoffmann-La Roche Inc

US Patent


Assay Description
Radioligand binding assay: The radioligand [3H]-rac-2-(1,2,3,4-tetrahydro-1-naphthyl)-2-imidazoline was used at a concentration equal to the calcula...


US Patent US8586617 (2013)


BindingDB Entry DOI: 10.7270/Q2GF0S56
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM106623
PNG
(US8586617, 175)
Show SMILES CN(Cc1cnc[nH]1)c1cccc(Oc2ccccc2)c1
Show InChI InChI=1S/C17H17N3O/c1-20(12-14-11-18-13-19-14)15-6-5-9-17(10-15)21-16-7-3-2-4-8-16/h2-11,13H,12H2,1H3,(H,18,19)
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3.60 -10.7n/an/an/an/an/an/a4



Hoffmann-La Roche Inc

US Patent


Assay Description
Radioligand binding assay: The radioligand [3H]-rac-2-(1,2,3,4-tetrahydro-1-naphthyl)-2-imidazoline was used at a concentration equal to the calcula...


US Patent US8586617 (2013)


BindingDB Entry DOI: 10.7270/Q2GF0S56
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM106634
PNG
(US8586617, 195)
Show SMILES CCN(Cc1cnc[nH]1)c1cccc(OC(F)F)c1
Show InChI InChI=1S/C13H15F2N3O/c1-2-18(8-10-7-16-9-17-10)11-4-3-5-12(6-11)19-13(14)15/h3-7,9,13H,2,8H2,1H3,(H,16,17)
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4.20 -10.6n/an/an/an/an/an/a4



Hoffmann-La Roche Inc

US Patent


Assay Description
Radioligand binding assay: The radioligand [3H]-rac-2-(1,2,3,4-tetrahydro-1-naphthyl)-2-imidazoline was used at a concentration equal to the calcula...


US Patent US8586617 (2013)


BindingDB Entry DOI: 10.7270/Q2GF0S56
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM106633
PNG
(US8586617, 194)
Show SMILES CCN(Cc1cnc[nH]1)c1ccc(F)c(OC)c1
Show InChI InChI=1S/C13H16FN3O/c1-3-17(8-10-7-15-9-16-10)11-4-5-12(14)13(6-11)18-2/h4-7,9H,3,8H2,1-2H3,(H,15,16)
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4.80 -10.5n/an/an/an/an/an/a4



Hoffmann-La Roche Inc

US Patent


Assay Description
Radioligand binding assay: The radioligand [3H]-rac-2-(1,2,3,4-tetrahydro-1-naphthyl)-2-imidazoline was used at a concentration equal to the calcula...


US Patent US8586617 (2013)


BindingDB Entry DOI: 10.7270/Q2GF0S56
More data for this
Ligand-Target Pair
trace amine-associated receptor 1


(Homo sapiens (Human))
BDBM106583
PNG
(CHEMBL2206381 | US8586617, 25)
Show SMILES COc1cccc(c1)N(Cc1cnc[nH]1)C(C)C
Show InChI InChI=1S/C14H19N3O/c1-11(2)17(9-12-8-15-10-16-12)13-5-4-6-14(7-13)18-3/h4-8,10-11H,9H2,1-3H3,(H,15,16)
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5n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Inc

Curated by ChEMBL


Assay Description
Displacement of (S)-4-(2,4-difluorophenyl-3-tritio) -4,5-dihydro-2-oxazolamine from human TAAR1 receptor expressed in HEK293 cells after 90 mins by b...


Bioorg Med Chem Lett 22: 5244-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.060
BindingDB Entry DOI: 10.7270/Q2W0973B
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM106583
PNG
(CHEMBL2206381 | US8586617, 25)
Show SMILES COc1cccc(c1)N(Cc1cnc[nH]1)C(C)C
Show InChI InChI=1S/C14H19N3O/c1-11(2)17(9-12-8-15-10-16-12)13-5-4-6-14(7-13)18-3/h4-8,10-11H,9H2,1-3H3,(H,15,16)
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5.5 -10.5n/an/an/an/an/an/a4



Hoffmann-La Roche Inc

US Patent


Assay Description
Radioligand binding assay: The radioligand [3H]-rac-2-(1,2,3,4-tetrahydro-1-naphthyl)-2-imidazoline was used at a concentration equal to the calcula...


US Patent US8586617 (2013)


BindingDB Entry DOI: 10.7270/Q2GF0S56
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM106607
PNG
(US8586617, 110)
Show SMILES CC(C)Oc1cccc(c1)N(Cc1cnc[nH]1)C(C)C
Show InChI InChI=1S/C16H23N3O/c1-12(2)19(10-14-9-17-11-18-14)15-6-5-7-16(8-15)20-13(3)4/h5-9,11-13H,10H2,1-4H3,(H,17,18)
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6.70 -10.4n/an/an/an/an/an/a4



Hoffmann-La Roche Inc

US Patent


Assay Description
Radioligand binding assay: The radioligand [3H]-rac-2-(1,2,3,4-tetrahydro-1-naphthyl)-2-imidazoline was used at a concentration equal to the calcula...


US Patent US8586617 (2013)


BindingDB Entry DOI: 10.7270/Q2GF0S56
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM47083
PNG
(US8586617, 189)
Show SMILES CN(Cc1cnc[nH]1)c1cccc(OC(F)F)c1
Show InChI InChI=1S/C12H13F2N3O/c1-17(7-9-6-15-8-16-9)10-3-2-4-11(5-10)18-12(13)14/h2-6,8,12H,7H2,1H3,(H,15,16)
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6.80n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc

US Patent


Assay Description
Radioligand binding assay: The radioligand [3H]-rac-2-(1,2,3,4-tetrahydro-1-naphthyl)-2-imidazoline was used at a concentration equal to the calcula...


US Patent US8586617 (2013)


BindingDB Entry DOI: 10.7270/Q2GF0S56
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM106627
PNG
(US8586617, 186)
Show SMILES COc1cccc(c1)N(C)Cc1cnc[nH]1
Show InChI InChI=1S/C12H15N3O/c1-15(8-10-7-13-9-14-10)11-4-3-5-12(6-11)16-2/h3-7,9H,8H2,1-2H3,(H,13,14)
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8.90 -10.2n/an/an/an/an/an/a4



Hoffmann-La Roche Inc

US Patent


Assay Description
Radioligand binding assay: The radioligand [3H]-rac-2-(1,2,3,4-tetrahydro-1-naphthyl)-2-imidazoline was used at a concentration equal to the calcula...


US Patent US8586617 (2013)


BindingDB Entry DOI: 10.7270/Q2GF0S56
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM106610
PNG
(US8586617, 115)
Show SMILES CC(C)N(Cc1cnc[nH]1)c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C14H16F3N3O/c1-10(2)20(8-11-7-18-9-19-11)12-4-3-5-13(6-12)21-14(15,16)17/h3-7,9-10H,8H2,1-2H3,(H,18,19)
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9 -10.2n/an/an/an/an/an/a4



Hoffmann-La Roche Inc

US Patent


Assay Description
Radioligand binding assay: The radioligand [3H]-rac-2-(1,2,3,4-tetrahydro-1-naphthyl)-2-imidazoline was used at a concentration equal to the calcula...


US Patent US8586617 (2013)


BindingDB Entry DOI: 10.7270/Q2GF0S56
More data for this
Ligand-Target Pair
trace amine-associated receptor 1


(Homo sapiens (Human))
BDBM50401213
PNG
(CHEMBL2206382)
Show SMILES COc1ccc(cc1)N(Cc1cnc[nH]1)C(C)C
Show InChI InChI=1S/C14H19N3O/c1-11(2)17(9-12-8-15-10-16-12)13-4-6-14(18-3)7-5-13/h4-8,10-11H,9H2,1-3H3,(H,15,16)
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80n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Inc

Curated by ChEMBL


Assay Description
Displacement of (S)-4-(2,4-difluorophenyl-3-tritio) -4,5-dihydro-2-oxazolamine from human TAAR1 receptor expressed in HEK293 cells after 90 mins by b...


Bioorg Med Chem Lett 22: 5244-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.060
BindingDB Entry DOI: 10.7270/Q2W0973B
More data for this
Ligand-Target Pair
trace amine-associated receptor 1


(Homo sapiens (Human))
BDBM106583
PNG
(CHEMBL2206381 | US8586617, 25)
Show SMILES COc1cccc(c1)N(Cc1cnc[nH]1)C(C)C
Show InChI InChI=1S/C14H19N3O/c1-11(2)17(9-12-8-15-10-16-12)13-5-4-6-14(7-13)18-3/h4-8,10-11H,9H2,1-3H3,(H,15,16)
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n/an/an/an/a 37n/an/an/an/a



F. Hoffmann-La Roche Inc

Curated by ChEMBL


Assay Description
Agonist activity at human TAAR1 receptor expressed in HEK293 cells after 30 mins


Bioorg Med Chem Lett 22: 5244-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.060
BindingDB Entry DOI: 10.7270/Q2W0973B
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Rattus norvegicus (Rat))
BDBM106583
PNG
(CHEMBL2206381 | US8586617, 25)
Show SMILES COc1cccc(c1)N(Cc1cnc[nH]1)C(C)C
Show InChI InChI=1S/C14H19N3O/c1-11(2)17(9-12-8-15-10-16-12)13-5-4-6-14(7-13)18-3/h4-8,10-11H,9H2,1-3H3,(H,15,16)
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n/an/an/an/a 61n/an/an/an/a



F. Hoffmann-La Roche Inc

Curated by ChEMBL


Assay Description
Agonist activity at rat TAAR1 receptor expressed in HEK293 cells after 30 mins


Bioorg Med Chem Lett 22: 5244-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.060
BindingDB Entry DOI: 10.7270/Q2W0973B
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM106583
PNG
(CHEMBL2206381 | US8586617, 25)
Show SMILES COc1cccc(c1)N(Cc1cnc[nH]1)C(C)C
Show InChI InChI=1S/C14H19N3O/c1-11(2)17(9-12-8-15-10-16-12)13-5-4-6-14(7-13)18-3/h4-8,10-11H,9H2,1-3H3,(H,15,16)
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n/an/an/an/a 72n/an/an/an/a



F. Hoffmann-La Roche Inc

Curated by ChEMBL


Assay Description
Agonist activity at mouse TAAR1 receptor expressed in HEK293 cells after 30 mins


Bioorg Med Chem Lett 22: 5244-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.060
BindingDB Entry DOI: 10.7270/Q2W0973B
More data for this
Ligand-Target Pair