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16 similar compounds to monomer 50011853

Compile data set for download or QSAR
Wt: 455.9
BDBM50000714
Purchase
Wt: 459.0
BDBM50011852
Wt: 473.0
BDBM50011857
Wt: 456.9
BDBM50011860
Wt: 473.0
BDBM50011862
Wt: 460.9
BDBM50011864
Wt: 475.0
BDBM50011866
Wt: 501.0
BDBM50011868
Wt: 471.0
BDBM50011869
Wt: 471.0
BDBM50011871
Wt: 502.0
BDBM50011872
Wt: 503.0
BDBM50011873
Wt: 338.8
BDBM50011876
Wt: 410.9
BDBM50011877
Wt: 485.0
BDBM50011879
Displayed 1 to 15 (of 16 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 28 hits for monomerid = 50000714,50011852,50011857,50011860,50011862,50011864,50011866,50011868,50011869,50011871,50011872,50011873,50011876,50011877,50011879   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet activating factor receptor


(Homo sapiens (Human))
BDBM50000714
PNG
(3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8,9a...)
Show SMILES Cc1nnc2CN=C(c3cc(CCC(=O)N4CCOCC4)sc3-n12)c1ccccc1Cl
Show InChI InChI=1S/C22H22ClN5O2S/c1-14-25-26-19-13-24-21(16-4-2-3-5-18(16)23)17-12-15(31-22(17)28(14)19)6-7-20(29)27-8-10-30-11-9-27/h2-5,12H,6-11,13H2,1H3
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23.2n/an/an/an/an/an/an/an/a



Rhone-Poulenc Sante

Curated by PDSP Ki Database




J Pharmacol Exp Ther 252: 1221-7 (1990)


BindingDB Entry DOI: 10.7270/Q2JW8CC2
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Homo sapiens (Human))
BDBM50000714
PNG
(3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8,9a...)
Show SMILES Cc1nnc2CN=C(c3cc(CCC(=O)N4CCOCC4)sc3-n12)c1ccccc1Cl
Show InChI InChI=1S/C22H22ClN5O2S/c1-14-25-26-19-13-24-21(16-4-2-3-5-18(16)23)17-12-15(31-22(17)28(14)19)6-7-20(29)27-8-10-30-11-9-27/h2-5,12H,6-11,13H2,1H3
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39.6n/an/an/an/an/an/an/an/a



Rhone-Poulenc Sante

Curated by PDSP Ki Database




J Pharmacol Exp Ther 252: 1221-7 (1990)


BindingDB Entry DOI: 10.7270/Q2JW8CC2
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Homo sapiens (Human))
BDBM50000714
PNG
(3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8,9a...)
Show SMILES Cc1nnc2CN=C(c3cc(CCC(=O)N4CCOCC4)sc3-n12)c1ccccc1Cl
Show InChI InChI=1S/C22H22ClN5O2S/c1-14-25-26-19-13-24-21(16-4-2-3-5-18(16)23)17-12-15(31-22(17)28(14)19)6-7-20(29)27-8-10-30-11-9-27/h2-5,12H,6-11,13H2,1H3
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79.3n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by PDSP Ki Database




J Pharmacol Exp Ther 246: 534-41 (1988)


BindingDB Entry DOI: 10.7270/Q2CJ8BZ8
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50000714
PNG
(3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8,9a...)
Show SMILES Cc1nnc2CN=C(c3cc(CCC(=O)N4CCOCC4)sc3-n12)c1ccccc1Cl
Show InChI InChI=1S/C22H22ClN5O2S/c1-14-25-26-19-13-24-21(16-4-2-3-5-18(16)23)17-12-15(31-22(17)28(14)19)6-7-20(29)27-8-10-30-11-9-27/h2-5,12H,6-11,13H2,1H3
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98n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes


J Med Chem 35: 2055-61 (1992)


Article DOI: 10.1021/jm00089a016
BindingDB Entry DOI: 10.7270/Q2NZ86K9
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50000714
PNG
(3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8,9a...)
Show SMILES Cc1nnc2CN=C(c3cc(CCC(=O)N4CCOCC4)sc3-n12)c1ccccc1Cl
Show InChI InChI=1S/C22H22ClN5O2S/c1-14-25-26-19-13-24-21(16-4-2-3-5-18(16)23)17-12-15(31-22(17)28(14)19)6-7-20(29)27-8-10-30-11-9-27/h2-5,12H,6-11,13H2,1H3
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98n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand


J Med Chem 37: 2011-32 (1994)


Article DOI: 10.1021/jm00039a015
BindingDB Entry DOI: 10.7270/Q2GH9JM7
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Homo sapiens (Human))
BDBM50011862
PNG
(2-[2-(4-Butyl-phenyl)-vinyl]-4-(2-chloro-phenyl)-9...)
Show SMILES CCCCc1ccc(\C=C/c2cc3c(s2)-n2c(C)nnc2CN=C3c2ccccc2Cl)cc1
Show InChI InChI=1S/C27H25ClN4S/c1-3-4-7-19-10-12-20(13-11-19)14-15-21-16-23-26(22-8-5-6-9-24(22)28)29-17-25-31-30-18(2)32(25)27(23)33-21/h5-6,8-16H,3-4,7,17H2,1-2H3/b15-14-
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n/an/a 10n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.


J Med Chem 34: 1440-6 (1991)


Article DOI: 10.1021/jm00108a031
BindingDB Entry DOI: 10.7270/Q2BG2MZ9
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Homo sapiens (Human))
BDBM50011866
PNG
(2-[2-(4-Butyl-phenyl)-ethyl]-4-(2-chloro-phenyl)-9...)
Show SMILES CCCCc1ccc(CCc2cc3c(s2)-n2c(C)nnc2CN=C3c2ccccc2Cl)cc1
Show InChI InChI=1S/C27H27ClN4S/c1-3-4-7-19-10-12-20(13-11-19)14-15-21-16-23-26(22-8-5-6-9-24(22)28)29-17-25-31-30-18(2)32(25)27(23)33-21/h5-6,8-13,16H,3-4,7,14-15,17H2,1-2H3
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n/an/a 10n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.


J Med Chem 34: 1440-6 (1991)


Article DOI: 10.1021/jm00108a031
BindingDB Entry DOI: 10.7270/Q2BG2MZ9
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Homo sapiens (Human))
BDBM50011868
PNG
(4-(2-Chloro-phenyl)-2-[2-(4-cyclohexyl-phenyl)-eth...)
Show SMILES Cc1nnc2CN=C(c3cc(CCc4ccc(cc4)C4CCCCC4)sc3-n12)c1ccccc1Cl
Show InChI InChI=1S/C29H29ClN4S/c1-19-32-33-27-18-31-28(24-9-5-6-10-26(24)30)25-17-23(35-29(25)34(19)27)16-13-20-11-14-22(15-12-20)21-7-3-2-4-8-21/h5-6,9-12,14-15,17,21H,2-4,7-8,13,16,18H2,1H3
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n/an/a 35n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.


J Med Chem 34: 1440-6 (1991)


Article DOI: 10.1021/jm00108a031
BindingDB Entry DOI: 10.7270/Q2BG2MZ9
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Homo sapiens (Human))
BDBM50011871
PNG
(4-(2-Chloro-phenyl)-2-(4-isobutyl-phenylethynyl)-9...)
Show SMILES CC(C)Cc1ccc(cc1)C#Cc1cc2c(s1)-n1c(C)nnc1CN=C2c1ccccc1Cl
Show InChI InChI=1S/C27H23ClN4S/c1-17(2)14-20-10-8-19(9-11-20)12-13-21-15-23-26(22-6-4-5-7-24(22)28)29-16-25-31-30-18(3)32(25)27(23)33-21/h4-11,15,17H,14,16H2,1-3H3
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n/an/a 100n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
Compound tested in vitro for Platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets


J Med Chem 34: 1440-6 (1991)


Article DOI: 10.1021/jm00108a031
BindingDB Entry DOI: 10.7270/Q2BG2MZ9
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Homo sapiens (Human))
BDBM50000714
PNG
(3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8,9a...)
Show SMILES Cc1nnc2CN=C(c3cc(CCC(=O)N4CCOCC4)sc3-n12)c1ccccc1Cl
Show InChI InChI=1S/C22H22ClN5O2S/c1-14-25-26-19-13-24-21(16-4-2-3-5-18(16)23)17-12-15(31-22(17)28(14)19)6-7-20(29)27-8-10-30-11-9-27/h2-5,12H,6-11,13H2,1H3
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n/an/a 50n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonistic activity for inhibition of [3H]PAF receptor binding to washed human platelet membranes.


Bioorg Med Chem Lett 2: 597-602 (1992)


Article DOI: 10.1016/S0960-894X(01)81205-1
BindingDB Entry DOI: 10.7270/Q2CF9QK7
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Homo sapiens (Human))
BDBM50011872
PNG
(4-(2-Chloro-phenyl)-9-methyl-2-[2-(5-pyridin-2-yl-...)
Show SMILES Cc1nnc2CN=C(c3cc(CCc4ccc(s4)-c4ccccn4)sc3-n12)c1ccccc1Cl
Show InChI InChI=1S/C26H20ClN5S2/c1-16-30-31-24-15-29-25(19-6-2-3-7-21(19)27)20-14-18(34-26(20)32(16)24)10-9-17-11-12-23(33-17)22-8-4-5-13-28-22/h2-8,11-14H,9-10,15H2,1H3
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n/an/a 8n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.


J Med Chem 34: 1440-6 (1991)


Article DOI: 10.1021/jm00108a031
BindingDB Entry DOI: 10.7270/Q2BG2MZ9
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Homo sapiens (Human))
BDBM50011873
PNG
(4-(2-Chloro-phenyl)-9-methyl-2-[2-(2,2,7-trimethyl...)
Show SMILES Cc1nnc2CN=C(c3cc(CCc4cc5CC(C)(C)Oc5c(C)c4)sc3-n12)c1ccccc1Cl
Show InChI InChI=1S/C28H27ClN4OS/c1-16-11-18(12-19-14-28(3,4)34-26(16)19)9-10-20-13-22-25(21-7-5-6-8-23(21)29)30-15-24-32-31-17(2)33(24)27(22)35-20/h5-8,11-13H,9-10,14-15H2,1-4H3
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n/an/a 400n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.


J Med Chem 34: 1440-6 (1991)


Article DOI: 10.1021/jm00108a031
BindingDB Entry DOI: 10.7270/Q2BG2MZ9
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Homo sapiens (Human))
BDBM50000714
PNG
(3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8,9a...)
Show SMILES Cc1nnc2CN=C(c3cc(CCC(=O)N4CCOCC4)sc3-n12)c1ccccc1Cl
Show InChI InChI=1S/C22H22ClN5O2S/c1-14-25-26-19-13-24-21(16-4-2-3-5-18(16)23)17-12-15(31-22(17)28(14)19)6-7-20(29)27-8-10-30-11-9-27/h2-5,12H,6-11,13H2,1H3
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n/an/a 200n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.


J Med Chem 34: 1440-6 (1991)


Article DOI: 10.1021/jm00108a031
BindingDB Entry DOI: 10.7270/Q2BG2MZ9
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Homo sapiens (Human))
BDBM50011876
PNG
(4-(2-Chloro-phenyl)-2-ethynyl-9-methyl-6H-1-thia-5...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#C)c1ccccc1Cl
Show InChI InChI=1S/C17H11ClN4S/c1-3-11-8-13-16(12-6-4-5-7-14(12)18)19-9-15-21-20-10(2)22(15)17(13)23-11/h1,4-8H,9H2,2H3
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n/an/a 10n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.


J Med Chem 34: 1440-6 (1991)


Article DOI: 10.1021/jm00108a031
BindingDB Entry DOI: 10.7270/Q2BG2MZ9
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Homo sapiens (Human))
BDBM50011877
PNG
(4-(2-Chloro-phenyl)-9-methyl-2-trimethylsilanyleth...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#C[Si](C)(C)C)c1ccccc1Cl
Show InChI InChI=1S/C20H19ClN4SSi/c1-13-23-24-18-12-22-19(15-7-5-6-8-17(15)21)16-11-14(9-10-27(2,3)4)26-20(16)25(13)18/h5-8,11H,12H2,1-4H3
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n/an/a 20n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.


J Med Chem 34: 1440-6 (1991)


Article DOI: 10.1021/jm00108a031
BindingDB Entry DOI: 10.7270/Q2BG2MZ9
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Homo sapiens (Human))
BDBM50011879
PNG
(4-(2-Chloro-phenyl)-2-[2-(4-imidazol-1-yl-phenyl)-...)
Show SMILES Cc1nnc2CN=C(c3cc(CCc4ccc(cc4)-n4ccnc4)sc3-n12)c1ccccc1Cl
Show InChI InChI=1S/C26H21ClN6S/c1-17-30-31-24-15-29-25(21-4-2-3-5-23(21)27)22-14-20(34-26(22)33(17)24)11-8-18-6-9-19(10-7-18)32-13-12-28-16-32/h2-7,9-10,12-14,16H,8,11,15H2,1H3
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n/an/a 100n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.


J Med Chem 34: 1440-6 (1991)


Article DOI: 10.1021/jm00108a031
BindingDB Entry DOI: 10.7270/Q2BG2MZ9
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Homo sapiens (Human))
BDBM50000714
PNG
(3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8,9a...)
Show SMILES Cc1nnc2CN=C(c3cc(CCC(=O)N4CCOCC4)sc3-n12)c1ccccc1Cl
Show InChI InChI=1S/C22H22ClN5O2S/c1-14-25-26-19-13-24-21(16-4-2-3-5-18(16)23)17-12-15(31-22(17)28(14)19)6-7-20(29)27-8-10-30-11-9-27/h2-5,12H,6-11,13H2,1H3
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n/an/a 200n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay


J Med Chem 34: 1209-21 (1991)


Article DOI: 10.1021/jm00107a048
BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Homo sapiens (Human))
BDBM50000714
PNG
(3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8,9a...)
Show SMILES Cc1nnc2CN=C(c3cc(CCC(=O)N4CCOCC4)sc3-n12)c1ccccc1Cl
Show InChI InChI=1S/C22H22ClN5O2S/c1-14-25-26-19-13-24-21(16-4-2-3-5-18(16)23)17-12-15(31-22(17)28(14)19)6-7-20(29)27-8-10-30-11-9-27/h2-5,12H,6-11,13H2,1H3
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n/an/a 200n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PAF binding to dog platelets.


J Med Chem 32: 1820-35 (1989)


Article DOI: 10.1021/jm00128a026
BindingDB Entry DOI: 10.7270/Q2NZ86MR
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50000714
PNG
(3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8,9a...)
Show SMILES Cc1nnc2CN=C(c3cc(CCC(=O)N4CCOCC4)sc3-n12)c1ccccc1Cl
Show InChI InChI=1S/C22H22ClN5O2S/c1-14-25-26-19-13-24-21(16-4-2-3-5-18(16)23)17-12-15(31-22(17)28(14)19)6-7-20(29)27-8-10-30-11-9-27/h2-5,12H,6-11,13H2,1H3
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n/an/a 146n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.


J Med Chem 35: 3115-29 (1992)


Article DOI: 10.1021/jm00095a005
BindingDB Entry DOI: 10.7270/Q28W3DX8
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50000714
PNG
(3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8,9a...)
Show SMILES Cc1nnc2CN=C(c3cc(CCC(=O)N4CCOCC4)sc3-n12)c1ccccc1Cl
Show InChI InChI=1S/C22H22ClN5O2S/c1-14-25-26-19-13-24-21(16-4-2-3-5-18(16)23)17-12-15(31-22(17)28(14)19)6-7-20(29)27-8-10-30-11-9-27/h2-5,12H,6-11,13H2,1H3
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n/an/a 91n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.


J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50000714
PNG
(3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8,9a...)
Show SMILES Cc1nnc2CN=C(c3cc(CCC(=O)N4CCOCC4)sc3-n12)c1ccccc1Cl
Show InChI InChI=1S/C22H22ClN5O2S/c1-14-25-26-19-13-24-21(16-4-2-3-5-18(16)23)17-12-15(31-22(17)28(14)19)6-7-20(29)27-8-10-30-11-9-27/h2-5,12H,6-11,13H2,1H3
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n/an/a 91n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
Inhibition of PAF-induced platelet aggregation


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Homo sapiens (Human))
BDBM50000714
PNG
(3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8,9a...)
Show SMILES Cc1nnc2CN=C(c3cc(CCC(=O)N4CCOCC4)sc3-n12)c1ccccc1Cl
Show InChI InChI=1S/C22H22ClN5O2S/c1-14-25-26-19-13-24-21(16-4-2-3-5-18(16)23)17-12-15(31-22(17)28(14)19)6-7-20(29)27-8-10-30-11-9-27/h2-5,12H,6-11,13H2,1H3
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n/an/a 94n/an/an/an/an/an/a



University of Virginia

Curated by ChEMBL


Assay Description
Displacement of [3H]-PAF from PAF receptor of human platelet membranes


J Med Chem 41: 1970-9 (1998)


Article DOI: 10.1021/jm980046r
BindingDB Entry DOI: 10.7270/Q2PV6JH2
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Homo sapiens (Human))
BDBM50011864
PNG
(4-(2-Chloro-phenyl)-2-[2-(2,3-dihydro-benzofuran-5...)
Show SMILES Cc1nnc2CN=C(c3cc(CCc4ccc5OCCc5c4)sc3-n12)c1ccccc1Cl
Show InChI InChI=1S/C25H21ClN4OS/c1-15-28-29-23-14-27-24(19-4-2-3-5-21(19)26)20-13-18(32-25(20)30(15)23)8-6-16-7-9-22-17(12-16)10-11-31-22/h2-5,7,9,12-13H,6,8,10-11,14H2,1H3
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n/an/a 20n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.


J Med Chem 34: 1440-6 (1991)


Article DOI: 10.1021/jm00108a031
BindingDB Entry DOI: 10.7270/Q2BG2MZ9
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Homo sapiens (Human))
BDBM50011860
PNG
(4-(2-Chloro-phenyl)-2-(2-indan-5-yl-vinyl)-9-methy...)
Show SMILES Cc1nnc2CN=C(c3cc(\C=C/c4ccc5CCCc5c4)sc3-n12)c1ccccc1Cl
Show InChI InChI=1S/C26H21ClN4S/c1-16-29-30-24-15-28-25(21-7-2-3-8-23(21)27)22-14-20(32-26(22)31(16)24)12-10-17-9-11-18-5-4-6-19(18)13-17/h2-3,7-14H,4-6,15H2,1H3/b12-10-
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n/an/a 110n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.


J Med Chem 34: 1440-6 (1991)


Article DOI: 10.1021/jm00108a031
BindingDB Entry DOI: 10.7270/Q2BG2MZ9
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Homo sapiens (Human))
BDBM50011857
PNG
(4-(2-Chloro-phenyl)-2-[2-(4-isobutyl-phenyl)-vinyl...)
Show SMILES CC(C)Cc1ccc(\C=C/c2cc3c(s2)-n2c(C)nnc2CN=C3c2ccccc2Cl)cc1
Show InChI InChI=1S/C27H25ClN4S/c1-17(2)14-20-10-8-19(9-11-20)12-13-21-15-23-26(22-6-4-5-7-24(22)28)29-16-25-31-30-18(3)32(25)27(23)33-21/h4-13,15,17H,14,16H2,1-3H3/b13-12-
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n/an/a 80n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.


J Med Chem 34: 1440-6 (1991)


Article DOI: 10.1021/jm00108a031
BindingDB Entry DOI: 10.7270/Q2BG2MZ9
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Homo sapiens (Human))
BDBM50011852
PNG
(4-(2-Chloro-phenyl)-2-(2-indan-5-yl-ethyl)-9-methy...)
Show SMILES Cc1nnc2CN=C(c3cc(CCc4ccc5CCCc5c4)sc3-n12)c1ccccc1Cl
Show InChI InChI=1S/C26H23ClN4S/c1-16-29-30-24-15-28-25(21-7-2-3-8-23(21)27)22-14-20(32-26(22)31(16)24)12-10-17-9-11-18-5-4-6-19(18)13-17/h2-3,7-9,11,13-14H,4-6,10,12,15H2,1H3
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n/an/a 20n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.


J Med Chem 34: 1440-6 (1991)


Article DOI: 10.1021/jm00108a031
BindingDB Entry DOI: 10.7270/Q2BG2MZ9
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Homo sapiens (Human))
BDBM50000714
PNG
(3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8,9a...)
Show SMILES Cc1nnc2CN=C(c3cc(CCC(=O)N4CCOCC4)sc3-n12)c1ccccc1Cl
Show InChI InChI=1S/C22H22ClN5O2S/c1-14-25-26-19-13-24-21(16-4-2-3-5-18(16)23)17-12-15(31-22(17)28(14)19)6-7-20(29)27-8-10-30-11-9-27/h2-5,12H,6-11,13H2,1H3
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n/an/a 40n/an/an/an/an/an/a



Schering-Plough Corporation

Curated by ChEMBL


Assay Description
Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when ch...


J Med Chem 34: 457-61 (1991)


Article DOI: 10.1021/jm00105a069
BindingDB Entry DOI: 10.7270/Q2BV7FK0
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Homo sapiens (Human))
BDBM50011869
PNG
(2-(4-Butyl-phenylethynyl)-4-(2-chloro-phenyl)-9-me...)
Show SMILES CCCCc1ccc(cc1)C#Cc1cc2c(s1)-n1c(C)nnc1CN=C2c1ccccc1Cl
Show InChI InChI=1S/C27H23ClN4S/c1-3-4-7-19-10-12-20(13-11-19)14-15-21-16-23-26(22-8-5-6-9-24(22)28)29-17-25-31-30-18(2)32(25)27(23)33-21/h5-6,8-13,16H,3-4,7,17H2,1-2H3
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n/an/a 650n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.


J Med Chem 34: 1440-6 (1991)


Article DOI: 10.1021/jm00108a031
BindingDB Entry DOI: 10.7270/Q2BG2MZ9
More data for this
Ligand-Target Pair