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35 similar compounds to monomer 50001637

Compile data set for download or QSAR
Wt: 417.5
BDBM50001634
Wt: 375.4
BDBM50001635
Wt: 409.9
BDBM50001636
Wt: 395.8
BDBM50001639
Wt: 360.4
BDBM50001640
Wt: 375.4
BDBM50001641
Wt: 390.4
BDBM50001642
Wt: 391.4
BDBM50001643
Wt: 389.4
BDBM50001644
Wt: 393.4
BDBM50001645
Wt: 418.5
BDBM50001646
Wt: 419.4
BDBM50001647
Wt: 404.5
BDBM50001648
Wt: 403.5
BDBM50001650
Wt: 379.4
BDBM50001651
Displayed 1 to 15 (of 35 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 38 hits for monomerid = 50001634,50001635,50001636,50001639,50001640,50001641,50001642,50001643,50001644,50001645,50001646,50001647,50001648,50001650,50001651   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
LTB4R


(Homo sapiens (Human))
BDBM50001635
PNG
(6-(4-Phenyl-6-p-tolyl-pyridin-2-yloxy)-hexanoic ac...)
Show SMILES Cc1ccc(cc1)-c1cc(cc(OCCCCCC(O)=O)n1)-c1ccccc1
Show InChI InChI=1S/C24H25NO3/c1-18-11-13-20(14-12-18)22-16-21(19-8-4-2-5-9-19)17-23(25-22)28-15-7-3-6-10-24(26)27/h2,4-5,8-9,11-14,16-17H,3,6-7,10,15H2,1H3,(H,26,27)
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n/an/a 300n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.


J Med Chem 35: 4315-24 (1992)


Article DOI: 10.1021/jm00101a008
BindingDB Entry DOI: 10.7270/Q2QR4W2W
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))
BDBM50001639
PNG
(6-[4-(2-Chloro-phenyl)-6-phenyl-pyridin-2-yloxy]-h...)
Show SMILES OC(=O)CCCCCOc1cc(cc(n1)-c1ccccc1)-c1ccccc1Cl
Show InChI InChI=1S/C23H22ClNO3/c24-20-12-7-6-11-19(20)18-15-21(17-9-3-1-4-10-17)25-22(16-18)28-14-8-2-5-13-23(26)27/h1,3-4,6-7,9-12,15-16H,2,5,8,13-14H2,(H,26,27)
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n/an/a 200n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.


J Med Chem 35: 4315-24 (1992)


Article DOI: 10.1021/jm00101a008
BindingDB Entry DOI: 10.7270/Q2QR4W2W
More data for this
Ligand-Target Pair
LTB4R


(Homo sapiens (Human))
BDBM50001639
PNG
(6-[4-(2-Chloro-phenyl)-6-phenyl-pyridin-2-yloxy]-h...)
Show SMILES OC(=O)CCCCCOc1cc(cc(n1)-c1ccccc1)-c1ccccc1Cl
Show InChI InChI=1S/C23H22ClNO3/c24-20-12-7-6-11-19(20)18-15-21(17-9-3-1-4-10-17)25-22(16-18)28-14-8-2-5-13-23(26)27/h1,3-4,6-7,9-12,15-16H,2,5,8,13-14H2,(H,26,27)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes


J Med Chem 35: 4315-24 (1992)


Article DOI: 10.1021/jm00101a008
BindingDB Entry DOI: 10.7270/Q2QR4W2W
More data for this
Ligand-Target Pair
LTB4R


(Homo sapiens (Human))
BDBM50001643
PNG
(6-[6-(3-Methoxy-phenyl)-4-phenyl-pyridin-2-yloxy]-...)
Show SMILES COc1cccc(c1)-c1cc(cc(OCCCCCC(O)=O)n1)-c1ccccc1
Show InChI InChI=1S/C24H25NO4/c1-28-21-12-8-11-19(15-21)22-16-20(18-9-4-2-5-10-18)17-23(25-22)29-14-7-3-6-13-24(26)27/h2,4-5,8-12,15-17H,3,6-7,13-14H2,1H3,(H,26,27)
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n/an/a 500n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.


J Med Chem 35: 4315-24 (1992)


Article DOI: 10.1021/jm00101a008
BindingDB Entry DOI: 10.7270/Q2QR4W2W
More data for this
Ligand-Target Pair
LTB4R


(Homo sapiens (Human))
BDBM50001646
PNG
(6-[4-(4-Isopropylamino-phenyl)-6-phenyl-pyridin-2-...)
Show SMILES CC(C)Nc1ccc(cc1)-c1cc(OCCCCCC(O)=O)nc(c1)-c1ccccc1
Show InChI InChI=1S/C26H30N2O3/c1-19(2)27-23-14-12-20(13-15-23)22-17-24(21-9-5-3-6-10-21)28-25(18-22)31-16-8-4-7-11-26(29)30/h3,5-6,9-10,12-15,17-19,27H,4,7-8,11,16H2,1-2H3,(H,29,30)
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n/an/a 22n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.


J Med Chem 35: 4315-24 (1992)


Article DOI: 10.1021/jm00101a008
BindingDB Entry DOI: 10.7270/Q2QR4W2W
More data for this
Ligand-Target Pair
LTB4R


(Homo sapiens (Human))
BDBM50001634
PNG
(8-(4,6-Diphenyl-pyridin-2-yloxy)-2,2-dimethyl-octa...)
Show SMILES CC(C)(CCCCCCOc1cc(cc(n1)-c1ccccc1)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C27H31NO3/c1-27(2,26(29)30)17-11-3-4-12-18-31-25-20-23(21-13-7-5-8-14-21)19-24(28-25)22-15-9-6-10-16-22/h5-10,13-16,19-20H,3-4,11-12,17-18H2,1-2H3,(H,29,30)
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n/an/a 60n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.


J Med Chem 35: 4315-24 (1992)


Article DOI: 10.1021/jm00101a008
BindingDB Entry DOI: 10.7270/Q2QR4W2W
More data for this
Ligand-Target Pair
LTB4R


(Homo sapiens (Human))
BDBM50001650
PNG
(7-(4,6-Diphenyl-pyridin-2-yloxy)-2,2-dimethyl-hept...)
Show SMILES CC(C)(CCCCCOc1cc(cc(n1)-c1ccccc1)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C26H29NO3/c1-26(2,25(28)29)16-10-5-11-17-30-24-19-22(20-12-6-3-7-13-20)18-23(27-24)21-14-8-4-9-15-21/h3-4,6-9,12-15,18-19H,5,10-11,16-17H2,1-2H3,(H,28,29)
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n/an/a 100n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes


J Med Chem 35: 4315-24 (1992)


Article DOI: 10.1021/jm00101a008
BindingDB Entry DOI: 10.7270/Q2QR4W2W
More data for this
Ligand-Target Pair
LTB4R


(Homo sapiens (Human))
BDBM50001645
PNG
(6-[6-(2-Fluoro-phenyl)-4-phenyl-pyridin-2-yloxy]-2...)
Show SMILES CC(CCCCOc1cc(cc(n1)-c1ccccc1F)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C24H24FNO3/c1-17(24(27)28)9-7-8-14-29-23-16-19(18-10-3-2-4-11-18)15-22(26-23)20-12-5-6-13-21(20)25/h2-6,10-13,15-17H,7-9,14H2,1H3,(H,27,28)
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n/an/a 70n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes


J Med Chem 35: 4315-24 (1992)


Article DOI: 10.1021/jm00101a008
BindingDB Entry DOI: 10.7270/Q2QR4W2W
More data for this
Ligand-Target Pair
LTB4R


(Homo sapiens (Human))
BDBM50001647
PNG
(6-(4-Benzo[1,3]dioxol-5-yl-6-phenyl-pyridin-2-ylox...)
Show SMILES CC(CCCCOc1cc(cc(n1)-c1ccccc1)-c1ccc2OCOc2c1)C(O)=O
Show InChI InChI=1S/C25H25NO5/c1-17(25(27)28)7-5-6-12-29-24-15-20(13-21(26-24)18-8-3-2-4-9-18)19-10-11-22-23(14-19)31-16-30-22/h2-4,8-11,13-15,17H,5-7,12,16H2,1H3,(H,27,28)
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n/an/a 6.60n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.


J Med Chem 35: 4315-24 (1992)


Article DOI: 10.1021/jm00101a008
BindingDB Entry DOI: 10.7270/Q2QR4W2W
More data for this
Ligand-Target Pair
LTB4R


(Homo sapiens (Human))
BDBM50001644
PNG
(6-(4,6-Diphenyl-pyridin-2-yloxy)-2,2-dimethyl-hexa...)
Show SMILES CC(C)(CCCCOc1cc(cc(n1)-c1ccccc1)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C25H27NO3/c1-25(2,24(27)28)15-9-10-16-29-23-18-21(19-11-5-3-6-12-19)17-22(26-23)20-13-7-4-8-14-20/h3-8,11-14,17-18H,9-10,15-16H2,1-2H3,(H,27,28)
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n/an/a 160n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes


J Med Chem 35: 4315-24 (1992)


Article DOI: 10.1021/jm00101a008
BindingDB Entry DOI: 10.7270/Q2QR4W2W
More data for this
Ligand-Target Pair
LTB4R


(Homo sapiens (Human))
BDBM50001651
PNG
(6-[4-(2-Fluoro-phenyl)-6-phenyl-pyridin-2-yloxy]-h...)
Show SMILES OC(=O)CCCCCOc1cc(cc(n1)-c1ccccc1)-c1ccccc1F
Show InChI InChI=1S/C23H22FNO3/c24-20-12-7-6-11-19(20)18-15-21(17-9-3-1-4-10-17)25-22(16-18)28-14-8-2-5-13-23(26)27/h1,3-4,6-7,9-12,15-16H,2,5,8,13-14H2,(H,26,27)
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Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.


J Med Chem 35: 4315-24 (1992)


Article DOI: 10.1021/jm00101a008
BindingDB Entry DOI: 10.7270/Q2QR4W2W
More data for this
Ligand-Target Pair
LTB4R


(Homo sapiens (Human))
BDBM50001641
PNG
(6-(4,6-Diphenyl-pyridin-2-yloxy)-2-methyl-hexanoic...)
Show SMILES CC(CCCCOc1cc(cc(n1)-c1ccccc1)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C24H25NO3/c1-18(24(26)27)10-8-9-15-28-23-17-21(19-11-4-2-5-12-19)16-22(25-23)20-13-6-3-7-14-20/h2-7,11-14,16-18H,8-10,15H2,1H3,(H,26,27)
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n/an/a 30n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.


J Med Chem 35: 4315-24 (1992)


Article DOI: 10.1021/jm00101a008
BindingDB Entry DOI: 10.7270/Q2QR4W2W
More data for this
Ligand-Target Pair
LTB4R


(Homo sapiens (Human))
BDBM50001640
PNG
(6-(4,6-Diphenyl-pyridin-2-yloxy)-hexanoic acid ami...)
Show SMILES NC(=O)CCCCCOc1cc(cc(n1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C23H24N2O2/c24-22(26)14-8-3-9-15-27-23-17-20(18-10-4-1-5-11-18)16-21(25-23)19-12-6-2-7-13-19/h1-2,4-7,10-13,16-17H,3,8-9,14-15H2,(H2,24,26)
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n/an/a 160n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.


J Med Chem 35: 4315-24 (1992)


Article DOI: 10.1021/jm00101a008
BindingDB Entry DOI: 10.7270/Q2QR4W2W
More data for this
Ligand-Target Pair
LTB4R


(Homo sapiens (Human))
BDBM50001642
PNG
(6-[4-(4-Amino-phenyl)-6-phenyl-pyridin-2-yloxy]-2-...)
Show SMILES CC(CCCCOc1cc(cc(n1)-c1ccccc1)-c1ccc(N)cc1)C(O)=O
Show InChI InChI=1S/C24H26N2O3/c1-17(24(27)28)7-5-6-14-29-23-16-20(18-10-12-21(25)13-11-18)15-22(26-23)19-8-3-2-4-9-19/h2-4,8-13,15-17H,5-7,14,25H2,1H3,(H,27,28)
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n/an/a 30n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.


J Med Chem 35: 4315-24 (1992)


Article DOI: 10.1021/jm00101a008
BindingDB Entry DOI: 10.7270/Q2QR4W2W
More data for this
Ligand-Target Pair
LTB4R


(Homo sapiens (Human))
BDBM50001648
PNG
(6-[4-(4-Dimethylamino-phenyl)-6-phenyl-pyridin-2-y...)
Show SMILES CN(C)c1ccc(cc1)-c1cc(OCCCCCC(O)=O)nc(c1)-c1ccccc1
Show InChI InChI=1S/C25H28N2O3/c1-27(2)22-14-12-19(13-15-22)21-17-23(20-9-5-3-6-10-20)26-24(18-21)30-16-8-4-7-11-25(28)29/h3,5-6,9-10,12-15,17-18H,4,7-8,11,16H2,1-2H3,(H,28,29)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes


J Med Chem 35: 4315-24 (1992)


Article DOI: 10.1021/jm00101a008
BindingDB Entry DOI: 10.7270/Q2QR4W2W
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))
BDBM50001651
PNG
(6-[4-(2-Fluoro-phenyl)-6-phenyl-pyridin-2-yloxy]-h...)
Show SMILES OC(=O)CCCCCOc1cc(cc(n1)-c1ccccc1)-c1ccccc1F
Show InChI InChI=1S/C23H22FNO3/c24-20-12-7-6-11-19(20)18-15-21(17-9-3-1-4-10-17)25-22(16-18)28-14-8-2-5-13-23(26)27/h1,3-4,6-7,9-12,15-16H,2,5,8,13-14H2,(H,26,27)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.


J Med Chem 35: 4315-24 (1992)


Article DOI: 10.1021/jm00101a008
BindingDB Entry DOI: 10.7270/Q2QR4W2W
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))
BDBM50001640
PNG
(6-(4,6-Diphenyl-pyridin-2-yloxy)-hexanoic acid ami...)
Show SMILES NC(=O)CCCCCOc1cc(cc(n1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C23H24N2O2/c24-22(26)14-8-3-9-15-27-23-17-20(18-10-4-1-5-11-18)16-21(25-23)19-12-6-2-7-13-19/h1-2,4-7,10-13,16-17H,3,8-9,14-15H2,(H2,24,26)
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n/an/a 150n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.


J Med Chem 35: 4315-24 (1992)


Article DOI: 10.1021/jm00101a008
BindingDB Entry DOI: 10.7270/Q2QR4W2W
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))
BDBM50001636
PNG
(6-[4-(3-Chloro-phenyl)-6-phenyl-pyridin-2-yloxy]-2...)
Show SMILES CC(CCCCOc1cc(cc(n1)-c1ccccc1)-c1cccc(Cl)c1)C(O)=O
Show InChI InChI=1S/C24H24ClNO3/c1-17(24(27)28)8-5-6-13-29-23-16-20(19-11-7-12-21(25)14-19)15-22(26-23)18-9-3-2-4-10-18/h2-4,7,9-12,14-17H,5-6,8,13H2,1H3,(H,27,28)
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n/an/a 40n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.


J Med Chem 35: 4315-24 (1992)


Article DOI: 10.1021/jm00101a008
BindingDB Entry DOI: 10.7270/Q2QR4W2W
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))
BDBM50001642
PNG
(6-[4-(4-Amino-phenyl)-6-phenyl-pyridin-2-yloxy]-2-...)
Show SMILES CC(CCCCOc1cc(cc(n1)-c1ccccc1)-c1ccc(N)cc1)C(O)=O
Show InChI InChI=1S/C24H26N2O3/c1-17(24(27)28)7-5-6-14-29-23-16-20(18-10-12-21(25)13-11-18)15-22(26-23)19-8-3-2-4-9-19/h2-4,8-13,15-17H,5-7,14,25H2,1H3,(H,27,28)
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n/an/a 15n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.


J Med Chem 35: 4315-24 (1992)


Article DOI: 10.1021/jm00101a008
BindingDB Entry DOI: 10.7270/Q2QR4W2W
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))
BDBM50001642
PNG
(6-[4-(4-Amino-phenyl)-6-phenyl-pyridin-2-yloxy]-2-...)
Show SMILES CC(CCCCOc1cc(cc(n1)-c1ccccc1)-c1ccc(N)cc1)C(O)=O
Show InChI InChI=1S/C24H26N2O3/c1-17(24(27)28)7-5-6-14-29-23-16-20(18-10-12-21(25)13-11-18)15-22(26-23)19-8-3-2-4-9-19/h2-4,8-13,15-17H,5-7,14,25H2,1H3,(H,27,28)
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n/an/a 5n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.


J Med Chem 35: 4315-24 (1992)


Article DOI: 10.1021/jm00101a008
BindingDB Entry DOI: 10.7270/Q2QR4W2W
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))
BDBM50001647
PNG
(6-(4-Benzo[1,3]dioxol-5-yl-6-phenyl-pyridin-2-ylox...)
Show SMILES CC(CCCCOc1cc(cc(n1)-c1ccccc1)-c1ccc2OCOc2c1)C(O)=O
Show InChI InChI=1S/C25H25NO5/c1-17(25(27)28)7-5-6-12-29-24-15-20(13-21(26-24)18-8-3-2-4-9-18)19-10-11-22-23(14-19)31-16-30-22/h2-4,8-11,13-15,17H,5-7,12,16H2,1H3,(H,27,28)
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n/an/a 4.20n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes


J Med Chem 35: 4315-24 (1992)


Article DOI: 10.1021/jm00101a008
BindingDB Entry DOI: 10.7270/Q2QR4W2W
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))
BDBM50001641
PNG
(6-(4,6-Diphenyl-pyridin-2-yloxy)-2-methyl-hexanoic...)
Show SMILES CC(CCCCOc1cc(cc(n1)-c1ccccc1)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C24H25NO3/c1-18(24(26)27)10-8-9-15-28-23-17-21(19-11-4-2-5-12-19)16-22(25-23)20-13-6-3-7-14-20/h2-7,11-14,16-18H,8-10,15H2,1H3,(H,26,27)
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n/an/a 22n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes


J Med Chem 35: 4315-24 (1992)


Article DOI: 10.1021/jm00101a008
BindingDB Entry DOI: 10.7270/Q2QR4W2W
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))
BDBM50001650
PNG
(7-(4,6-Diphenyl-pyridin-2-yloxy)-2,2-dimethyl-hept...)
Show SMILES CC(C)(CCCCCOc1cc(cc(n1)-c1ccccc1)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C26H29NO3/c1-26(2,25(28)29)16-10-5-11-17-30-24-19-22(20-12-6-3-7-13-20)18-23(27-24)21-14-8-4-9-15-21/h3-4,6-9,12-15,18-19H,5,10-11,16-17H2,1-2H3,(H,28,29)
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n/an/a 50n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.


J Med Chem 35: 4315-24 (1992)


Article DOI: 10.1021/jm00101a008
BindingDB Entry DOI: 10.7270/Q2QR4W2W
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))
BDBM50001641
PNG
(6-(4,6-Diphenyl-pyridin-2-yloxy)-2-methyl-hexanoic...)
Show SMILES CC(CCCCOc1cc(cc(n1)-c1ccccc1)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C24H25NO3/c1-18(24(26)27)10-8-9-15-28-23-17-21(19-11-4-2-5-12-19)16-22(25-23)20-13-6-3-7-14-20/h2-7,11-14,16-18H,8-10,15H2,1H3,(H,26,27)
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n/an/a 4n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.


J Med Chem 35: 4315-24 (1992)


Article DOI: 10.1021/jm00101a008
BindingDB Entry DOI: 10.7270/Q2QR4W2W
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))
BDBM50001647
PNG
(6-(4-Benzo[1,3]dioxol-5-yl-6-phenyl-pyridin-2-ylox...)
Show SMILES CC(CCCCOc1cc(cc(n1)-c1ccccc1)-c1ccc2OCOc2c1)C(O)=O
Show InChI InChI=1S/C25H25NO5/c1-17(25(27)28)7-5-6-12-29-24-15-20(13-21(26-24)18-8-3-2-4-9-18)19-10-11-22-23(14-19)31-16-30-22/h2-4,8-11,13-15,17H,5-7,12,16H2,1H3,(H,27,28)
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n/an/a 120n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.


J Med Chem 35: 4315-24 (1992)


Article DOI: 10.1021/jm00101a008
BindingDB Entry DOI: 10.7270/Q2QR4W2W
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))
BDBM50001636
PNG
(6-[4-(3-Chloro-phenyl)-6-phenyl-pyridin-2-yloxy]-2...)
Show SMILES CC(CCCCOc1cc(cc(n1)-c1ccccc1)-c1cccc(Cl)c1)C(O)=O
Show InChI InChI=1S/C24H24ClNO3/c1-17(24(27)28)8-5-6-13-29-23-16-20(19-11-7-12-21(25)14-19)15-22(26-23)18-9-3-2-4-10-18/h2-4,7,9-12,14-17H,5-6,8,13H2,1H3,(H,27,28)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.


J Med Chem 35: 4315-24 (1992)


Article DOI: 10.1021/jm00101a008
BindingDB Entry DOI: 10.7270/Q2QR4W2W
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))
BDBM50001645
PNG
(6-[6-(2-Fluoro-phenyl)-4-phenyl-pyridin-2-yloxy]-2...)
Show SMILES CC(CCCCOc1cc(cc(n1)-c1ccccc1F)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C24H24FNO3/c1-17(24(27)28)9-7-8-14-29-23-16-19(18-10-3-2-4-11-18)15-22(26-23)20-12-5-6-13-21(20)25/h2-6,10-13,15-17H,7-9,14H2,1H3,(H,27,28)
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n/an/a 4n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.


J Med Chem 35: 4315-24 (1992)


Article DOI: 10.1021/jm00101a008
BindingDB Entry DOI: 10.7270/Q2QR4W2W
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))
BDBM50001648
PNG
(6-[4-(4-Dimethylamino-phenyl)-6-phenyl-pyridin-2-y...)
Show SMILES CN(C)c1ccc(cc1)-c1cc(OCCCCCC(O)=O)nc(c1)-c1ccccc1
Show InChI InChI=1S/C25H28N2O3/c1-27(2)22-14-12-19(13-15-22)21-17-23(20-9-5-3-6-10-20)26-24(18-21)30-16-8-4-7-11-25(28)29/h3,5-6,9-10,12-15,17-18H,4,7-8,11,16H2,1-2H3,(H,28,29)
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n/an/a 110n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.


J Med Chem 35: 4315-24 (1992)


Article DOI: 10.1021/jm00101a008
BindingDB Entry DOI: 10.7270/Q2QR4W2W
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))
BDBM50001644
PNG
(6-(4,6-Diphenyl-pyridin-2-yloxy)-2,2-dimethyl-hexa...)
Show SMILES CC(C)(CCCCOc1cc(cc(n1)-c1ccccc1)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C25H27NO3/c1-25(2,24(27)28)15-9-10-16-29-23-18-21(19-11-5-3-6-12-19)17-22(26-23)20-13-7-4-8-14-20/h3-8,11-14,17-18H,9-10,15-16H2,1-2H3,(H,27,28)
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n/an/a 5n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.


J Med Chem 35: 4315-24 (1992)


Article DOI: 10.1021/jm00101a008
BindingDB Entry DOI: 10.7270/Q2QR4W2W
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))
BDBM50001645
PNG
(6-[6-(2-Fluoro-phenyl)-4-phenyl-pyridin-2-yloxy]-2...)
Show SMILES CC(CCCCOc1cc(cc(n1)-c1ccccc1F)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C24H24FNO3/c1-17(24(27)28)9-7-8-14-29-23-16-19(18-10-3-2-4-11-18)15-22(26-23)20-12-5-6-13-21(20)25/h2-6,10-13,15-17H,7-9,14H2,1H3,(H,27,28)
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n/an/a 18n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.


J Med Chem 35: 4315-24 (1992)


Article DOI: 10.1021/jm00101a008
BindingDB Entry DOI: 10.7270/Q2QR4W2W
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))
BDBM50001644
PNG
(6-(4,6-Diphenyl-pyridin-2-yloxy)-2,2-dimethyl-hexa...)
Show SMILES CC(C)(CCCCOc1cc(cc(n1)-c1ccccc1)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C25H27NO3/c1-25(2,24(27)28)15-9-10-16-29-23-18-21(19-11-5-3-6-12-19)17-22(26-23)20-13-7-4-8-14-20/h3-8,11-14,17-18H,9-10,15-16H2,1-2H3,(H,27,28)
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n/an/a 30n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.


J Med Chem 35: 4315-24 (1992)


Article DOI: 10.1021/jm00101a008
BindingDB Entry DOI: 10.7270/Q2QR4W2W
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))
BDBM50001648
PNG
(6-[4-(4-Dimethylamino-phenyl)-6-phenyl-pyridin-2-y...)
Show SMILES CN(C)c1ccc(cc1)-c1cc(OCCCCCC(O)=O)nc(c1)-c1ccccc1
Show InChI InChI=1S/C25H28N2O3/c1-27(2)22-14-12-19(13-15-22)21-17-23(20-9-5-3-6-10-20)26-24(18-21)30-16-8-4-7-11-25(28)29/h3,5-6,9-10,12-15,17-18H,4,7-8,11,16H2,1-2H3,(H,28,29)
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n/an/a 30n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes


J Med Chem 35: 4315-24 (1992)


Article DOI: 10.1021/jm00101a008
BindingDB Entry DOI: 10.7270/Q2QR4W2W
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))
BDBM50001651
PNG
(6-[4-(2-Fluoro-phenyl)-6-phenyl-pyridin-2-yloxy]-h...)
Show SMILES OC(=O)CCCCCOc1cc(cc(n1)-c1ccccc1)-c1ccccc1F
Show InChI InChI=1S/C23H22FNO3/c24-20-12-7-6-11-19(20)18-15-21(17-9-3-1-4-10-17)25-22(16-18)28-14-8-2-5-13-23(26)27/h1,3-4,6-7,9-12,15-16H,2,5,8,13-14H2,(H,26,27)
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n/an/a 10n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.


J Med Chem 35: 4315-24 (1992)


Article DOI: 10.1021/jm00101a008
BindingDB Entry DOI: 10.7270/Q2QR4W2W
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))
BDBM50001634
PNG
(8-(4,6-Diphenyl-pyridin-2-yloxy)-2,2-dimethyl-octa...)
Show SMILES CC(C)(CCCCCCOc1cc(cc(n1)-c1ccccc1)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C27H31NO3/c1-27(2,26(29)30)17-11-3-4-12-18-31-25-20-23(21-13-7-5-8-14-21)19-24(28-25)22-15-9-6-10-16-22/h5-10,13-16,19-20H,3-4,11-12,17-18H2,1-2H3,(H,29,30)
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n/an/a 22n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.


J Med Chem 35: 4315-24 (1992)


Article DOI: 10.1021/jm00101a008
BindingDB Entry DOI: 10.7270/Q2QR4W2W
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))
BDBM50001650
PNG
(7-(4,6-Diphenyl-pyridin-2-yloxy)-2,2-dimethyl-hept...)
Show SMILES CC(C)(CCCCCOc1cc(cc(n1)-c1ccccc1)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C26H29NO3/c1-26(2,25(28)29)16-10-5-11-17-30-24-19-22(20-12-6-3-7-13-20)18-23(27-24)21-14-8-4-9-15-21/h3-4,6-9,12-15,18-19H,5,10-11,16-17H2,1-2H3,(H,28,29)
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n/an/a 15n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.


J Med Chem 35: 4315-24 (1992)


Article DOI: 10.1021/jm00101a008
BindingDB Entry DOI: 10.7270/Q2QR4W2W
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))
BDBM50001646
PNG
(6-[4-(4-Isopropylamino-phenyl)-6-phenyl-pyridin-2-...)
Show SMILES CC(C)Nc1ccc(cc1)-c1cc(OCCCCCC(O)=O)nc(c1)-c1ccccc1
Show InChI InChI=1S/C26H30N2O3/c1-19(2)27-23-14-12-20(13-15-23)22-17-24(21-9-5-3-6-10-21)28-25(18-22)31-16-8-4-7-11-26(29)30/h3,5-6,9-10,12-15,17-19,27H,4,7-8,11,16H2,1-2H3,(H,29,30)
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n/an/a 300n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes


J Med Chem 35: 4315-24 (1992)


Article DOI: 10.1021/jm00101a008
BindingDB Entry DOI: 10.7270/Q2QR4W2W
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))
BDBM50001634
PNG
(8-(4,6-Diphenyl-pyridin-2-yloxy)-2,2-dimethyl-octa...)
Show SMILES CC(C)(CCCCCCOc1cc(cc(n1)-c1ccccc1)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C27H31NO3/c1-27(2,26(29)30)17-11-3-4-12-18-31-25-20-23(21-13-7-5-8-14-21)19-24(28-25)22-15-9-6-10-16-22/h5-10,13-16,19-20H,3-4,11-12,17-18H2,1-2H3,(H,29,30)
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n/an/a 100n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes


J Med Chem 35: 4315-24 (1992)


Article DOI: 10.1021/jm00101a008
BindingDB Entry DOI: 10.7270/Q2QR4W2W
More data for this
Ligand-Target Pair
LTB4R


(Homo sapiens (Human))
BDBM50001636
PNG
(6-[4-(3-Chloro-phenyl)-6-phenyl-pyridin-2-yloxy]-2...)
Show SMILES CC(CCCCOc1cc(cc(n1)-c1ccccc1)-c1cccc(Cl)c1)C(O)=O
Show InChI InChI=1S/C24H24ClNO3/c1-17(24(27)28)8-5-6-13-29-23-16-20(19-11-7-12-21(25)14-19)15-22(26-23)18-9-3-2-4-10-18/h2-4,7,9-12,14-17H,5-6,8,13H2,1H3,(H,27,28)
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n/an/a 5n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.


J Med Chem 35: 4315-24 (1992)


Article DOI: 10.1021/jm00101a008
BindingDB Entry DOI: 10.7270/Q2QR4W2W
More data for this
Ligand-Target Pair