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1 similar compounds to monomer 50017458

Compile data set for download or QSAR
Wt: 176.2
BDBM50001903
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50001903   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50001903
PNG
(1-o-Tolyl-piperazine | CHEMBL9746)
Show SMILES Cc1ccccc1N1CCNCC1
Show InChI InChI=1S/C11H16N2/c1-10-4-2-3-5-11(10)13-8-6-12-7-9-13/h2-5,12H,6-9H2,1H3
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PubMed
27n/an/an/an/an/an/an/an/a



McNeil Pharmaceutical and Janssen Research Foundation Worldwide

Curated by ChEMBL


Assay Description
Binding affinity at rat 5-hydroxytryptamine 1A receptor by [3H]-WB-4101 displacement.


J Med Chem 32: 1052-6 (1989)


Article DOI: 10.1021/jm00125a020
BindingDB Entry DOI: 10.7270/Q2HD7TNH
More data for this
Ligand-Target Pair
Serotonin 1B/1D receptor


(Rattus norvegicus (Rat))
BDBM50001903
PNG
(1-o-Tolyl-piperazine | CHEMBL9746)
Show SMILES Cc1ccccc1N1CCNCC1
Show InChI InChI=1S/C11H16N2/c1-10-4-2-3-5-11(10)13-8-6-12-7-9-13/h2-5,12H,6-9H2,1H3
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PubMed
45n/an/an/an/an/an/an/an/a



McNeil Pharmaceutical and Janssen Research Foundation Worldwide

Curated by ChEMBL


Assay Description
Binding affinity at rat 5-hydroxytryptamine 1B receptor by [3H]-5-HT displacement.


J Med Chem 32: 1052-6 (1989)


Article DOI: 10.1021/jm00125a020
BindingDB Entry DOI: 10.7270/Q2HD7TNH
More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(RAT-Rattus norvegicus (rat)-Rattus norvegicus (Rat...)
BDBM50001903
PNG
(1-o-Tolyl-piperazine | CHEMBL9746)
Show SMILES Cc1ccccc1N1CCNCC1
Show InChI InChI=1S/C11H16N2/c1-10-4-2-3-5-11(10)13-8-6-12-7-9-13/h2-5,12H,6-9H2,1H3
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62n/an/an/an/an/an/an/an/a



McNeil Pharmaceutical and Janssen Research Foundation Worldwide

Curated by ChEMBL


Assay Description
Binding affinity determined in radioreceptor binding assay by using [3H]5-HT radioligand against 5-hydroxytryptamine 1 receptor


J Med Chem 32: 1052-6 (1989)


Article DOI: 10.1021/jm00125a020
BindingDB Entry DOI: 10.7270/Q2HD7TNH
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50001903
PNG
(1-o-Tolyl-piperazine | CHEMBL9746)
Show SMILES Cc1ccccc1N1CCNCC1
Show InChI InChI=1S/C11H16N2/c1-10-4-2-3-5-11(10)13-8-6-12-7-9-13/h2-5,12H,6-9H2,1H3
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108n/an/an/an/an/an/an/an/a



McNeil Pharmaceutical and Janssen Research Foundation Worldwide

Curated by ChEMBL


Assay Description
Binding affinity against rat Alpha-1 adrenergic receptor.


J Med Chem 32: 1052-6 (1989)


Article DOI: 10.1021/jm00125a020
BindingDB Entry DOI: 10.7270/Q2HD7TNH
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50001903
PNG
(1-o-Tolyl-piperazine | CHEMBL9746)
Show SMILES Cc1ccccc1N1CCNCC1
Show InChI InChI=1S/C11H16N2/c1-10-4-2-3-5-11(10)13-8-6-12-7-9-13/h2-5,12H,6-9H2,1H3
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558n/an/an/an/an/an/an/an/a



McNeil Pharmaceutical and Janssen Research Foundation Worldwide

Curated by ChEMBL


Assay Description
Binding affinity determined in radioreceptor binding assay by using [3H]ketanserin radioligand against 5-hydroxytryptamine 2 receptor


J Med Chem 32: 1052-6 (1989)


Article DOI: 10.1021/jm00125a020
BindingDB Entry DOI: 10.7270/Q2HD7TNH
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM50001903
PNG
(1-o-Tolyl-piperazine | CHEMBL9746)
Show SMILES Cc1ccccc1N1CCNCC1
Show InChI InChI=1S/C11H16N2/c1-10-4-2-3-5-11(10)13-8-6-12-7-9-13/h2-5,12H,6-9H2,1H3
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>1.00E+3n/an/an/an/an/an/an/an/a



McNeil Pharmaceutical and Janssen Research Foundation Worldwide

Curated by ChEMBL


Assay Description
Binding affinity at rat Dopamine receptor D1 by [3H]-SCH-23,390 displacement.


J Med Chem 32: 1052-6 (1989)


Article DOI: 10.1021/jm00125a020
BindingDB Entry DOI: 10.7270/Q2HD7TNH
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50001903
PNG
(1-o-Tolyl-piperazine | CHEMBL9746)
Show SMILES Cc1ccccc1N1CCNCC1
Show InChI InChI=1S/C11H16N2/c1-10-4-2-3-5-11(10)13-8-6-12-7-9-13/h2-5,12H,6-9H2,1H3
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>1.00E+3n/an/an/an/an/an/an/an/a



McNeil Pharmaceutical and Janssen Research Foundation Worldwide

Curated by ChEMBL


Assay Description
Binding affinity against rat Dopamine receptor D2.


J Med Chem 32: 1052-6 (1989)


Article DOI: 10.1021/jm00125a020
BindingDB Entry DOI: 10.7270/Q2HD7TNH
More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(Homo sapiens (Human))
BDBM50001903
PNG
(1-o-Tolyl-piperazine | CHEMBL9746)
Show SMILES Cc1ccccc1N1CCNCC1
Show InChI InChI=1S/C11H16N2/c1-10-4-2-3-5-11(10)13-8-6-12-7-9-13/h2-5,12H,6-9H2,1H3
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n/an/a 1.40E+4n/an/an/an/an/an/a



Berlex Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for Beta-1 adrenergic receptor by displacing [3H]dihydroalprenolol, in partially purified membrane fractions from canine ventricular...


J Med Chem 35: 743-50 (1992)


Article DOI: 10.1021/jm00082a016
BindingDB Entry DOI: 10.7270/Q2319TT0
More data for this
Ligand-Target Pair
Beta-2 adrenergic receptor


(Canis familiaris)
BDBM50001903
PNG
(1-o-Tolyl-piperazine | CHEMBL9746)
Show SMILES Cc1ccccc1N1CCNCC1
Show InChI InChI=1S/C11H16N2/c1-10-4-2-3-5-11(10)13-8-6-12-7-9-13/h2-5,12H,6-9H2,1H3
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n/an/a 2.90E+4n/an/an/an/an/an/a



Berlex Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards Beta-2 adrenergic receptor by displacing [3H]dihydroalprenolol, in partially purified membrane fractions from canine lung ti...


J Med Chem 35: 743-50 (1992)


Article DOI: 10.1021/jm00082a016
BindingDB Entry DOI: 10.7270/Q2319TT0
More data for this
Ligand-Target Pair