BindingDB logo
myBDB logout

3 similar compounds to monomer 50001979

Compile data set for download or QSAR
Wt: 257.3
BDBM50001962
Wt: 289.4
BDBM50047145
Wt: 201.2
BDBM50056447

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50001962,50047145,50056447   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50047145
PNG
((Recemic)5-Dipropylamino-5,6-dihydro-1H,4H-imidazo...)
Show SMILES CCCN(CCC)[C@@H]1Cc2cccc3[nH]c(=S)n(C1)c23
Show InChI InChI=1S/C16H23N3S/c1-3-8-18(9-4-2)13-10-12-6-5-7-14-15(12)19(11-13)16(20)17-14/h5-7,13H,3-4,8-11H2,1-2H3,(H,17,20)/t13-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.600n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Compound was tested for agonistic activity against D2 receptor from cloned CHO cells, used [3H]U-86170 as radioligand


J Med Chem 36: 1301-15 (1993)


Article DOI: 10.1021/jm00062a001
BindingDB Entry DOI: 10.7270/Q2TD9Z06
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50047145
PNG
((Recemic)5-Dipropylamino-5,6-dihydro-1H,4H-imidazo...)
Show SMILES CCCN(CCC)[C@@H]1Cc2cccc3[nH]c(=S)n(C1)c23
Show InChI InChI=1S/C16H23N3S/c1-3-8-18(9-4-2)13-10-12-6-5-7-14-15(12)19(11-13)16(20)17-14/h5-7,13H,3-4,8-11H2,1-2H3,(H,17,20)/t13-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
39n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Compound was tested for antagonistic activity against D2 receptor from rat striatum, used [3H]raclopride as radioligand


J Med Chem 36: 1301-15 (1993)


Article DOI: 10.1021/jm00062a001
BindingDB Entry DOI: 10.7270/Q2TD9Z06
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM50047145
PNG
((Recemic)5-Dipropylamino-5,6-dihydro-1H,4H-imidazo...)
Show SMILES CCCN(CCC)[C@@H]1Cc2cccc3[nH]c(=S)n(C1)c23
Show InChI InChI=1S/C16H23N3S/c1-3-8-18(9-4-2)13-10-12-6-5-7-14-15(12)19(11-13)16(20)17-14/h5-7,13H,3-4,8-11H2,1-2H3,(H,17,20)/t13-/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
80n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor from bovine hippocampus, used [3H]8-OH-DPAT as radioligand


J Med Chem 36: 1301-15 (1993)


Article DOI: 10.1021/jm00062a001
BindingDB Entry DOI: 10.7270/Q2TD9Z06
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM50001962
PNG
((5,6-Dihydro-4H-imidazo[4,5,1-ij]quinolin-5-yl)-di...)
Show SMILES CCCN(CCC)C1Cc2cccc3ncn(C1)c23
Show InChI InChI=1S/C16H23N3/c1-3-8-18(9-4-2)14-10-13-6-5-7-15-16(13)19(11-14)12-17-15/h5-7,12,14H,3-4,8-11H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
827n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Ability to displace [3H]-DPAT from 5-hydroxytryptamine 1A receptor in homogenates of bovine hippocampus.


J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50001962
PNG
((5,6-Dihydro-4H-imidazo[4,5,1-ij]quinolin-5-yl)-di...)
Show SMILES CCCN(CCC)C1Cc2cccc3ncn(C1)c23
Show InChI InChI=1S/C16H23N3/c1-3-8-18(9-4-2)14-10-13-6-5-7-15-16(13)19(11-14)12-17-15/h5-7,12,14H,3-4,8-11H2,1-2H3
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
>1.00E+3n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Ability to displace [3H]raclopride from dopamine receptor D2 in rat striatal homogenates.


J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50056447
PNG
((R)-5,6-Dihydro-4H-imidazo[4,5,1-ij]quinolin-5-yl-...)
Show SMILES CN(C)[C@@H]1Cc2cccc3ncn(C1)c23
Show InChI InChI=1S/C12H15N3/c1-14(2)10-6-9-4-3-5-11-12(9)15(7-10)8-13-11/h3-5,8,10H,6-7H2,1-2H3/t10-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.28E+3n/an/an/an/an/an/an/an/a



Pharmacia & Upjohn

Curated by ChEMBL


Assay Description
Binding affinity towards Dopamine receptor D2 by displacement of [3H]-U-86,170.


J Med Chem 40: 639-46 (1997)


Article DOI: 10.1021/jm960360q
BindingDB Entry DOI: 10.7270/Q29P30R9
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50056447
PNG
((R)-5,6-Dihydro-4H-imidazo[4,5,1-ij]quinolin-5-yl-...)
Show SMILES CN(C)[C@@H]1Cc2cccc3ncn(C1)c23
Show InChI InChI=1S/C12H15N3/c1-14(2)10-6-9-4-3-5-11-12(9)15(7-10)8-13-11/h3-5,8,10H,6-7H2,1-2H3/t10-/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
2.95E+3n/an/an/an/an/an/an/an/a



Pharmacia & Upjohn

Curated by ChEMBL


Assay Description
Binding affinity towards Dopamine receptor D3 by displacement of [3H]-(+)-7-OH-DPAT.


J Med Chem 40: 639-46 (1997)


Article DOI: 10.1021/jm960360q
BindingDB Entry DOI: 10.7270/Q29P30R9
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM50056447
PNG
((R)-5,6-Dihydro-4H-imidazo[4,5,1-ij]quinolin-5-yl-...)
Show SMILES CN(C)[C@@H]1Cc2cccc3ncn(C1)c23
Show InChI InChI=1S/C12H15N3/c1-14(2)10-6-9-4-3-5-11-12(9)15(7-10)8-13-11/h3-5,8,10H,6-7H2,1-2H3/t10-/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
>3.52E+3n/an/an/an/an/an/an/an/a



Pharmacia & Upjohn

Curated by ChEMBL


Assay Description
Binding affinity towards Serotonin 5-hydroxytryptamine 1A receptor by displacement of [3H]-(+)-8-OH-DPAT.


J Med Chem 40: 639-46 (1997)


Article DOI: 10.1021/jm960360q
BindingDB Entry DOI: 10.7270/Q29P30R9
More data for this
Ligand-Target Pair