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2 similar compounds to monomer 50368584

Compile data set for download or QSAR
Wt: 287.3
BDBM50001971
Wt: 287.3
BDBM50047150

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50001971,50047150   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50047150
PNG
((Recemic)6-Dipropylamino-6,7-dihydro-1H,5H-pyrido[...)
Show SMILES CCCN(CCC)[C@H]1CN2CC(=O)Nc3cccc(C1)c23
Show InChI InChI=1S/C17H25N3O/c1-3-8-19(9-4-2)14-10-13-6-5-7-15-17(13)20(11-14)12-16(21)18-15/h5-7,14H,3-4,8-12H2,1-2H3,(H,18,21)/t14-/m1/s1
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PubMed
28n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Compound was tested for antagonistic activity against D2 receptor from rat striatum, used [3H]raclopride as radioligand


J Med Chem 36: 1301-15 (1993)


Article DOI: 10.1021/jm00062a001
BindingDB Entry DOI: 10.7270/Q2TD9Z06
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM50001971
PNG
(6-Dipropylamino-1,2,6,7-tetrahydro-5H-pyrido[1,2,3...)
Show SMILES CCCN(CCC)C1CN2C(=O)CNc3cccc(C1)c23
Show InChI InChI=1S/C17H25N3O/c1-3-8-19(9-4-2)14-10-13-6-5-7-15-17(13)20(12-14)16(21)11-18-15/h5-7,14,18H,3-4,8-12H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


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Article
PubMed
49n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Ability to displace [3H]-DPAT from 5-hydroxytryptamine 1A receptor in homogenates of bovine hippocampus.


J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50001971
PNG
(6-Dipropylamino-1,2,6,7-tetrahydro-5H-pyrido[1,2,3...)
Show SMILES CCCN(CCC)C1CN2C(=O)CNc3cccc(C1)c23
Show InChI InChI=1S/C17H25N3O/c1-3-8-19(9-4-2)14-10-13-6-5-7-15-17(13)20(12-14)16(21)11-18-15/h5-7,14,18H,3-4,8-12H2,1-2H3
Reactome pathway
KEGG

GoogleScholar
CHEMBL
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PC sid
UniChem

Patents


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Article
PubMed
80n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Ability to displace [3H]raclopride from dopamine receptor D2 in rat striatal homogenates.


J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM50047150
PNG
((Recemic)6-Dipropylamino-6,7-dihydro-1H,5H-pyrido[...)
Show SMILES CCCN(CCC)[C@H]1CN2CC(=O)Nc3cccc(C1)c23
Show InChI InChI=1S/C17H25N3O/c1-3-8-19(9-4-2)14-10-13-6-5-7-15-17(13)20(11-14)12-16(21)18-15/h5-7,14H,3-4,8-12H2,1-2H3,(H,18,21)/t14-/m1/s1
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
304n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor from bovine hippocampus, used [3H]8-OH-DPAT as radioligand


J Med Chem 36: 1301-15 (1993)


Article DOI: 10.1021/jm00062a001
BindingDB Entry DOI: 10.7270/Q2TD9Z06
More data for this
Ligand-Target Pair