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9 similar compounds to monomer 50006222

Compile data set for download or QSAR
Wt: 277.2
BDBM50008288
Wt: 277.2
BDBM50008289
Wt: 233.2
BDBM50006215
Wt: 247.2
BDBM50006223
Wt: 281.2
BDBM50144206
Wt: 297.6
BDBM50336547
Wt: 342.1
BDBM50336548
Wt: 389.1
BDBM50336549
Wt: 281.6
BDBM50018500

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 23 hits for monomerid = 50008288,50008289,50006215,50006223,50144206,50336547,50336548,50336549,50018500   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Adenosylhomocysteinase


(Homo sapiens (Human))
BDBM50006215
PNG
((1'R,2'S,3'R)-9-(2',3'-dihydroxycyclopent-4'-enyl)...)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1C=C[C@@H](O)[C@H]1O
Show InChI InChI=1S/C10H11N5O2/c11-9-7-10(13-3-12-9)15(4-14-7)5-1-2-6(16)8(5)17/h1-6,8,16-17H,(H2,11,12,13)/t5-,6-,8+/m1/s1
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41n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Time course of inactivation of bovine liver S-adenosyl-homocysteine hydrolase


J Med Chem 31: 500-3 (1988)


Article DOI: 10.1021/jm00398a002
BindingDB Entry DOI: 10.7270/Q28P61Q3
More data for this
Ligand-Target Pair
Adenosylhomocysteinase


(Homo sapiens (Human))
BDBM50006215
PNG
((1'R,2'S,3'R)-9-(2',3'-dihydroxycyclopent-4'-enyl)...)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1C=C[C@@H](O)[C@H]1O
Show InChI InChI=1S/C10H11N5O2/c11-9-7-10(13-3-12-9)15(4-14-7)5-1-2-6(16)8(5)17/h1-6,8,16-17H,(H2,11,12,13)/t5-,6-,8+/m1/s1
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49n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against bovine liver S-adenosyl-L-homocysteine hydrolase (AdoHcy).


J Med Chem 35: 1782-91 (1992)


Article DOI: 10.1021/jm00088a013
BindingDB Entry DOI: 10.7270/Q23J3BW0
More data for this
Ligand-Target Pair
Adenosylhomocysteinase


(Mus musculus)
BDBM50008288
PNG
((1S,2R,5R)-5-(6-Amino-purin-9-yl)-3-((R)-1-hydroxy...)
Show SMILES C[C@@H](O)C1=C[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C12H15N5O3/c1-5(18)6-2-7(10(20)9(6)19)17-4-16-8-11(13)14-3-15-12(8)17/h2-5,7,9-10,18-20H,1H3,(H2,13,14,15)/t5-,7-,9-,10+/m1/s1
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86n/an/an/an/an/an/an/an/a



Toyo Jozo Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory effect of the compound against L929 Cell S-adenosyl-L-homocysteine hydrolase


J Med Chem 35: 324-31 (1992)


Article DOI: 10.1021/jm00080a018
BindingDB Entry DOI: 10.7270/Q2RX9B1R
More data for this
Ligand-Target Pair
Adenosylhomocysteinase


(Mus musculus)
BDBM50006223
PNG
(5-(6-Amino-purin-9-yl)-3-methyl-cyclopent-3-ene-1,...)
Show SMILES CC1=C[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C11H13N5O2/c1-5-2-6(9(18)8(5)17)16-4-15-7-10(12)13-3-14-11(7)16/h2-4,6,8-9,17-18H,1H3,(H2,12,13,14)/t6-,8-,9+/m1/s1
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150n/an/an/an/an/an/an/an/a



Toyo Jozo Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory effect of the compound against L929 Cell S-adenosyl-L-homocysteine hydrolase


J Med Chem 35: 324-31 (1992)


Article DOI: 10.1021/jm00080a018
BindingDB Entry DOI: 10.7270/Q2RX9B1R
More data for this
Ligand-Target Pair
Adenosylhomocysteinase


(Homo sapiens (Human))
BDBM50006223
PNG
(5-(6-Amino-purin-9-yl)-3-methyl-cyclopent-3-ene-1,...)
Show SMILES CC1=C[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C11H13N5O2/c1-5-2-6(9(18)8(5)17)16-4-15-7-10(12)13-3-14-11(7)16/h2-4,6,8-9,17-18H,1H3,(H2,12,13,14)/t6-,8-,9+/m1/s1
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9.15E+3n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against bovine liver S-adenosyl-L-homocysteine hydrolase (AdoHcy).


J Med Chem 35: 1782-91 (1992)


Article DOI: 10.1021/jm00088a013
BindingDB Entry DOI: 10.7270/Q23J3BW0
More data for this
Ligand-Target Pair
Adenosylhomocysteinase


(Mus musculus)
BDBM50008289
PNG
((1S,2R,5R)-5-(6-Amino-purin-9-yl)-3-((S)-1-hydroxy...)
Show SMILES C[C@H](O)C1=C[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C12H15N5O3/c1-5(18)6-2-7(10(20)9(6)19)17-4-16-8-11(13)14-3-15-12(8)17/h2-5,7,9-10,18-20H,1H3,(H2,13,14,15)/t5-,7+,9+,10-/m0/s1
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5.57E+4n/an/an/an/an/an/an/an/a



Toyo Jozo Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory effect of the compound against L929 Cell S-adenosyl-L-homocysteine hydrolase


J Med Chem 35: 324-31 (1992)


Article DOI: 10.1021/jm00080a018
BindingDB Entry DOI: 10.7270/Q2RX9B1R
More data for this
Ligand-Target Pair
Adenosylhomocysteinase


(Homo sapiens (Human))
BDBM50144206
PNG
((1S,2R,5S)-5-(6-Amino-purin-9-yl)-4-fluoro-3-hydro...)
Show SMILES Nc1ncnc2n(cnc12)[C@H]1[C@H](O)[C@H](O)C(CO)=C1F
Show InChI InChI=1S/C11H12FN5O3/c12-5-4(1-18)8(19)9(20)7(5)17-3-16-6-10(13)14-2-15-11(6)17/h2-3,7-9,18-20H,1H2,(H2,13,14,15)/t7-,8-,9+/m1/s1
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n/an/a 240n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human placental AdoHcy hydrolase expressed in Escherichia coli BL21 using AdoHcy as substrate preincubated for 10 mins foll...


J Med Chem 58: 5108-20 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00553
BindingDB Entry DOI: 10.7270/Q2T155DR
More data for this
Ligand-Target Pair
Adenosylhomocysteinase


(Homo sapiens (Human))
BDBM50006223
PNG
(5-(6-Amino-purin-9-yl)-3-methyl-cyclopent-3-ene-1,...)
Show SMILES CC1=C[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C11H13N5O2/c1-5-2-6(9(18)8(5)17)16-4-15-7-10(12)13-3-14-11(7)16/h2-4,6,8-9,17-18H,1H3,(H2,12,13,14)/t6-,8-,9+/m1/s1
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n/an/a>10n/an/an/an/an/an/a



Toyo Jozo Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory effect against S-adenosyl-L-homocysteine hydrolase of rabbit erythrocyte.


J Med Chem 35: 324-31 (1992)


Article DOI: 10.1021/jm00080a018
BindingDB Entry DOI: 10.7270/Q2RX9B1R
More data for this
Ligand-Target Pair
Adenosylhomocysteinase


(Homo sapiens (Human))
BDBM50336547
PNG
(5-(6-Aminopurin-9-yl)-4-chloro-3-hydroxymethylcycl...)
Show SMILES Nc1ncnc2n(cnc12)[C@H]1[C@H](O)[C@H](O)C(CO)=C1Cl
Show InChI InChI=1S/C11H12ClN5O3/c12-5-4(1-18)8(19)9(20)7(5)17-3-16-6-10(13)14-2-15-11(6)17/h2-3,7-9,18-20H,1H2,(H2,13,14,15)/t7-,8-,9+/m1/s1
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n/an/a 3.65E+4n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human placental AdoHcy hydrolase expressed in Escherichia coli JM109


J Med Chem 54: 930-8 (2011)


Article DOI: 10.1021/jm1010836
BindingDB Entry DOI: 10.7270/Q2D50N8H
More data for this
Ligand-Target Pair
Adenosylhomocysteinase


(Homo sapiens (Human))
BDBM50336548
PNG
(5-(6-Aminopurin-9-yl)-4-bromo-3-hydroxymethyl-cycl...)
Show SMILES Nc1ncnc2n(cnc12)[C@H]1[C@H](O)[C@H](O)C(CO)=C1Br
Show InChI InChI=1S/C11H12BrN5O3/c12-5-4(1-18)8(19)9(20)7(5)17-3-16-6-10(13)14-2-15-11(6)17/h2-3,7-9,18-20H,1H2,(H2,13,14,15)/t7-,8-,9+/m1/s1
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n/an/a 6.02E+4n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human placental AdoHcy hydrolase expressed in Escherichia coli JM109


J Med Chem 54: 930-8 (2011)


Article DOI: 10.1021/jm1010836
BindingDB Entry DOI: 10.7270/Q2D50N8H
More data for this
Ligand-Target Pair
Adenosylhomocysteinase


(Homo sapiens (Human))
BDBM50336549
PNG
(5-(6-Aminopurin-9-yl)-4-iodo-3-hydroxymethylcyclop...)
Show SMILES Nc1ncnc2n(cnc12)[C@H]1[C@H](O)[C@H](O)C(CO)=C1I
Show InChI InChI=1S/C11H12IN5O3/c12-5-4(1-18)8(19)9(20)7(5)17-3-16-6-10(13)14-2-15-11(6)17/h2-3,7-9,18-20H,1H2,(H2,13,14,15)/t7-,8-,9+/m1/s1
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n/an/a>1.00E+6n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human placental AdoHcy hydrolase expressed in Escherichia coli JM109


J Med Chem 54: 930-8 (2011)


Article DOI: 10.1021/jm1010836
BindingDB Entry DOI: 10.7270/Q2D50N8H
More data for this
Ligand-Target Pair
Adenosylhomocysteinase


(Homo sapiens (Human))
BDBM50006215
PNG
((1'R,2'S,3'R)-9-(2',3'-dihydroxycyclopent-4'-enyl)...)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1C=C[C@@H](O)[C@H]1O
Show InChI InChI=1S/C10H11N5O2/c11-9-7-10(13-3-12-9)15(4-14-7)5-1-2-6(16)8(5)17/h1-6,8,16-17H,(H2,11,12,13)/t5-,6-,8+/m1/s1
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n/an/a 5.83E+3n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human placental AdoHcy hydrolase expressed in Escherichia coli JM109


J Med Chem 54: 930-8 (2011)


Article DOI: 10.1021/jm1010836
BindingDB Entry DOI: 10.7270/Q2D50N8H
More data for this
Ligand-Target Pair
Adenosylhomocysteinase


(Homo sapiens (Human))
BDBM50006215
PNG
((1'R,2'S,3'R)-9-(2',3'-dihydroxycyclopent-4'-enyl)...)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1C=C[C@@H](O)[C@H]1O
Show InChI InChI=1S/C10H11N5O2/c11-9-7-10(13-3-12-9)15(4-14-7)5-1-2-6(16)8(5)17/h1-6,8,16-17H,(H2,11,12,13)/t5-,6-,8+/m1/s1
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n/an/a 8.70E+3n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
In vitro inhibitory activity of the compound against recombinant S-adenosyl-L-homocysteine hydrolase obtained from human placenta


Bioorg Med Chem Lett 14: 2091-3 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.039
BindingDB Entry DOI: 10.7270/Q2DR2TXQ
More data for this
Ligand-Target Pair
Adenosylhomocysteinase


(Homo sapiens (Human))
BDBM50018500
PNG
(CHEMBL419393)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1C=C(CCl)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C11H12ClN5O2/c12-2-5-1-6(9(19)8(5)18)17-4-16-7-10(13)14-3-15-11(7)17/h1,3-4,6,8-9,18-19H,2H2,(H2,13,14,15)/t6-,8-,9+/m1/s1
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n/an/a>10n/an/an/an/an/an/a



Toyo Jozo Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory effect against S-adenosyl-L-homocysteine hydrolase of rabbit erythrocyte.


J Med Chem 35: 324-31 (1992)


Article DOI: 10.1021/jm00080a018
BindingDB Entry DOI: 10.7270/Q2RX9B1R
More data for this
Ligand-Target Pair
Adenosylhomocysteinase


(Homo sapiens (Human))
BDBM50008288
PNG
((1S,2R,5R)-5-(6-Amino-purin-9-yl)-3-((R)-1-hydroxy...)
Show SMILES C[C@@H](O)C1=C[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C12H15N5O3/c1-5(18)6-2-7(10(20)9(6)19)17-4-16-8-11(13)14-3-15-12(8)17/h2-5,7,9-10,18-20H,1H3,(H2,13,14,15)/t5-,7-,9-,10+/m1/s1
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n/an/a 0.200n/an/an/an/an/an/a



Toyo Jozo Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory effect against S-adenosyl-L-homocysteine hydrolase of rabbit erythrocyte.


J Med Chem 35: 324-31 (1992)


Article DOI: 10.1021/jm00080a018
BindingDB Entry DOI: 10.7270/Q2RX9B1R
More data for this
Ligand-Target Pair
Adenosylhomocysteinase


(Homo sapiens (Human))
BDBM50008289
PNG
((1S,2R,5R)-5-(6-Amino-purin-9-yl)-3-((S)-1-hydroxy...)
Show SMILES C[C@H](O)C1=C[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C12H15N5O3/c1-5(18)6-2-7(10(20)9(6)19)17-4-16-8-11(13)14-3-15-12(8)17/h2-5,7,9-10,18-20H,1H3,(H2,13,14,15)/t5-,7+,9+,10-/m0/s1
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n/an/a>10n/an/an/an/an/an/a



Toyo Jozo Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory effect against S-adenosyl-L-homocysteine hydrolase of rabbit erythrocyte.


J Med Chem 35: 324-31 (1992)


Article DOI: 10.1021/jm00080a018
BindingDB Entry DOI: 10.7270/Q2RX9B1R
More data for this
Ligand-Target Pair
Adenosylhomocysteinase


(Homo sapiens (Human))
BDBM50144206
PNG
((1S,2R,5S)-5-(6-Amino-purin-9-yl)-4-fluoro-3-hydro...)
Show SMILES Nc1ncnc2n(cnc12)[C@H]1[C@H](O)[C@H](O)C(CO)=C1F
Show InChI InChI=1S/C11H12FN5O3/c12-5-4(1-18)8(19)9(20)7(5)17-3-16-6-10(13)14-2-15-11(6)17/h2-3,7-9,18-20H,1H2,(H2,13,14,15)/t7-,8-,9+/m1/s1
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n/an/a 480n/an/an/an/an/an/a



Pusan National University

Curated by ChEMBL


Assay Description
Inhibitory activity against enzyme S-adenosylhomocysteine hydrolase of human placenta


Bioorg Med Chem Lett 14: 5641-4 (2004)


Article DOI: 10.1016/j.bmcl.2004.08.047
BindingDB Entry DOI: 10.7270/Q2MP52RP
More data for this
Ligand-Target Pair
Adenosylhomocysteinase


(Homo sapiens (Human))
BDBM50144206
PNG
((1S,2R,5S)-5-(6-Amino-purin-9-yl)-4-fluoro-3-hydro...)
Show SMILES Nc1ncnc2n(cnc12)[C@H]1[C@H](O)[C@H](O)C(CO)=C1F
Show InChI InChI=1S/C11H12FN5O3/c12-5-4(1-18)8(19)9(20)7(5)17-3-16-6-10(13)14-2-15-11(6)17/h2-3,7-9,18-20H,1H2,(H2,13,14,15)/t7-,8-,9+/m1/s1
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n/an/a 470n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
In vitro inhibitory activity of the compound against recombinant S-adenosyl-L-homocysteine hydrolase obtained from human placenta


Bioorg Med Chem Lett 14: 2091-3 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.039
BindingDB Entry DOI: 10.7270/Q2DR2TXQ
More data for this
Ligand-Target Pair
Adenosylhomocysteinase


(Homo sapiens (Human))
BDBM50006215
PNG
((1'R,2'S,3'R)-9-(2',3'-dihydroxycyclopent-4'-enyl)...)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1C=C[C@@H](O)[C@H]1O
Show InChI InChI=1S/C10H11N5O2/c11-9-7-10(13-3-12-9)15(4-14-7)5-1-2-6(16)8(5)17/h1-6,8,16-17H,(H2,11,12,13)/t5-,6-,8+/m1/s1
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PubMed
n/an/a 877n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of AHCY in human SH-SY5Y cells assessed as formation of homocysteine after 48 hrs by HPLC analysis


Bioorg Med Chem Lett 24: 2737-40 (2014)


Article DOI: 10.1016/j.bmcl.2014.04.034
BindingDB Entry DOI: 10.7270/Q2VM4DTT
More data for this
Ligand-Target Pair
Adenosylhomocysteinase


(Homo sapiens (Human))
BDBM50018500
PNG
(CHEMBL419393)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1C=C(CCl)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C11H12ClN5O2/c12-2-5-1-6(9(19)8(5)18)17-4-16-7-10(13)14-3-15-11(7)17/h1,3-4,6,8-9,18-19H,2H2,(H2,13,14,15)/t6-,8-,9+/m1/s1
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Article
PubMed
n/an/a 939n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of AHCY in human SH-SY5Y cells assessed as formation of homocysteine after 48 hrs by HPLC analysis


Bioorg Med Chem Lett 24: 2737-40 (2014)


Article DOI: 10.1016/j.bmcl.2014.04.034
BindingDB Entry DOI: 10.7270/Q2VM4DTT
More data for this
Ligand-Target Pair
Adenosylhomocysteinase


(Homo sapiens (Human))
BDBM50006215
PNG
((1'R,2'S,3'R)-9-(2',3'-dihydroxycyclopent-4'-enyl)...)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1C=C[C@@H](O)[C@H]1O
Show InChI InChI=1S/C10H11N5O2/c11-9-7-10(13-3-12-9)15(4-14-7)5-1-2-6(16)8(5)17/h1-6,8,16-17H,(H2,11,12,13)/t5-,6-,8+/m1/s1
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n/an/a 4.13E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of recombinant human AHCY using SAH as substrate assessed as formation of homocysteine after 10 mins


Bioorg Med Chem Lett 24: 2737-40 (2014)


Article DOI: 10.1016/j.bmcl.2014.04.034
BindingDB Entry DOI: 10.7270/Q2VM4DTT
More data for this
Ligand-Target Pair
Adenosylhomocysteinase


(Homo sapiens (Human))
BDBM50018500
PNG
(CHEMBL419393)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1C=C(CCl)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C11H12ClN5O2/c12-2-5-1-6(9(19)8(5)18)17-4-16-7-10(13)14-3-15-11(7)17/h1,3-4,6,8-9,18-19H,2H2,(H2,13,14,15)/t6-,8-,9+/m1/s1
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n/an/a 195n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of recombinant human AHCY using SAH as substrate assessed as formation of homocysteine after 10 mins


Bioorg Med Chem Lett 24: 2737-40 (2014)


Article DOI: 10.1016/j.bmcl.2014.04.034
BindingDB Entry DOI: 10.7270/Q2VM4DTT
More data for this
Ligand-Target Pair
Adenosylhomocysteinase


(Homo sapiens (Human))
BDBM50144206
PNG
((1S,2R,5S)-5-(6-Amino-purin-9-yl)-4-fluoro-3-hydro...)
Show SMILES Nc1ncnc2n(cnc12)[C@H]1[C@H](O)[C@H](O)C(CO)=C1F
Show InChI InChI=1S/C11H12FN5O3/c12-5-4(1-18)8(19)9(20)7(5)17-3-16-6-10(13)14-2-15-11(6)17/h2-3,7-9,18-20H,1H2,(H2,13,14,15)/t7-,8-,9+/m1/s1
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n/an/a 480n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human placental AdoHcy hydrolase expressed in Escherichia coli JM109


J Med Chem 54: 930-8 (2011)


Article DOI: 10.1021/jm1010836
BindingDB Entry DOI: 10.7270/Q2D50N8H
More data for this
Ligand-Target Pair