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28 similar compounds to monomer 50006388

Compile data set for download or QSAR
Wt: 304.2
BDBM50006363
Wt: 302.3
BDBM50006366
Wt: 322.3
BDBM50006368
Wt: 288.3
BDBM50006373
Wt: 232.1
BDBM50006398
Wt: 246.2
BDBM50006399
Wt: 260.2
BDBM50006400
Wt: 274.2
BDBM50006402
Wt: 325.1
BDBM50006403
Wt: 260.2
BDBM50006356
Wt: 264.2
BDBM50006358
Wt: 264.2
BDBM50006361
Wt: 246.2
BDBM50006364
Wt: 280.6
BDBM50006369
Wt: 261.2
BDBM50006371
Displayed 1 to 15 (of 28 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50006363,50006366,50006368,50006373,50006398,50006399,50006400,50006402,50006403,50006356,50006358,50006361,50006364,50006369,50006371   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006356
PNG
(3',5'-dimethyl-1'H,2H,5H-spiro[imidazolidine-4,4'-...)
Show SMILES CN1C(=O)Nc2cccc(C)c2C11NC(=O)NC1=O
Show InChI InChI=1S/C12H12N4O3/c1-6-4-3-5-7-8(6)12(16(2)11(19)13-7)9(17)14-10(18)15-12/h3-5H,1-2H3,(H,13,19)(H2,14,15,17,18)
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n/an/a 400n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006403
PNG
(6'-bromo-3'-methyl-1'H,2H,5H-spiro[imidazolidine-4...)
Show SMILES CN1C(=O)Nc2ccc(Br)cc2C11NC(=O)NC1=O
Show InChI InChI=1S/C11H9BrN4O3/c1-16-10(19)13-7-3-2-5(12)4-6(7)11(16)8(17)14-9(18)15-11/h2-4H,1H3,(H,13,19)(H2,14,15,17,18)
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n/an/a 52n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006361
PNG
(6'-fluoro-3'-methyl-1'H,2H,5H-spiro[imidazolidine-...)
Show SMILES CN1C(=O)Nc2ccc(F)cc2C11NC(=O)NC1=O
Show InChI InChI=1S/C11H9FN4O3/c1-16-10(19)13-7-3-2-5(12)4-6(7)11(16)8(17)14-9(18)15-11/h2-4H,1H3,(H,13,19)(H2,14,15,17,18)
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n/an/a 100n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006363
PNG
((3'-methyl-2,2',5-trioxo-2',3'-dihydro-1H,1'H-spir...)
Show SMILES CN1C(=O)Nc2ccccc2C11NC(=O)N(CC(O)=O)C1=O
Show InChI InChI=1S/C13H12N4O5/c1-16-11(21)14-8-5-3-2-4-7(8)13(16)10(20)17(6-9(18)19)12(22)15-13/h2-5H,6H2,1H3,(H,14,21)(H,15,22)(H,18,19)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006366
PNG
(1'-isobutyl-3'-methyl-1'H,2H,5H-spiro[imidazolidin...)
Show SMILES CC(C)CN1C(=O)N(C)C2(NC(=O)NC2=O)c2ccccc12
Show InChI InChI=1S/C15H18N4O3/c1-9(2)8-19-11-7-5-4-6-10(11)15(18(3)14(19)22)12(20)16-13(21)17-15/h4-7,9H,8H2,1-3H3,(H2,16,17,20,21)
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n/an/a 390n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006364
PNG
((4R)-3'-methyl-1'H,2H,5H-spiro[imidazolidine-4,4'-...)
Show SMILES CN1C(=O)Nc2ccccc2[C@@]11NC(=O)NC1=O
Show InChI InChI=1S/C11H10N4O3/c1-15-10(18)12-7-5-3-2-4-6(7)11(15)8(16)13-9(17)14-11/h2-5H,1H3,(H,12,18)(H2,13,14,16,17)/t11-/m1/s1
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n/an/a 310n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006369
PNG
((4R)-6'-chloro-3'-methyl-1'H,2H,5H-spiro[imidazoli...)
Show SMILES CN1C(=O)Nc2ccc(Cl)cc2[C@@]11NC(=O)NC1=O
Show InChI InChI=1S/C11H9ClN4O3/c1-16-10(19)13-7-3-2-5(12)4-6(7)11(16)8(17)14-9(18)15-11/h2-4H,1H3,(H,13,19)(H2,14,15,17,18)/t11-/m1/s1
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n/an/a 22n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006368
PNG
(3'-benzyl-1'H,2H,5H-spiro[imidazolidine-4,4'-quina...)
Show SMILES O=C1NC(=O)C2(N1)N(Cc1ccccc1)C(=O)Nc1ccccc21
Show InChI InChI=1S/C17H14N4O3/c22-14-17(20-15(23)19-14)12-8-4-5-9-13(12)18-16(24)21(17)10-11-6-2-1-3-7-11/h1-9H,10H2,(H,18,24)(H2,19,20,22,23)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006371
PNG
(6'-amino-3'-methyl-1'H,2H,5H-spiro[imidazolidine-4...)
Show SMILES CN1C(=O)Nc2ccc(N)cc2C11NC(=O)NC1=O
Show InChI InChI=1S/C11H11N5O3/c1-16-10(19)13-7-3-2-5(12)4-6(7)11(16)8(17)14-9(18)15-11/h2-4H,12H2,1H3,(H,13,19)(H2,14,15,17,18)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006373
PNG
(3'-butyl-1'H,2H,5H-spiro[imidazolidine-4,4'-quinaz...)
Show SMILES CCCCN1C(=O)Nc2ccccc2C11NC(=O)NC1=O
Show InChI InChI=1S/C14H16N4O3/c1-2-3-8-18-13(21)15-10-7-5-4-6-9(10)14(18)11(19)16-12(20)17-14/h4-7H,2-3,8H2,1H3,(H,15,21)(H2,16,17,19,20)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006398
PNG
(1'H,2H,5H-spiro[imidazolidine-4,4'-quinazoline]-2,...)
Show SMILES O=C1NC(=O)C2(N1)NC(=O)Nc1ccccc21
Show InChI InChI=1S/C10H8N4O3/c15-7-10(14-9(17)12-7)5-3-1-2-4-6(5)11-8(16)13-10/h1-4H,(H2,11,13,16)(H2,12,14,15,17)
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n/an/a 1.40E+3n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006400
PNG
(1,3'-dimethyl-1'H,2H,5H-spiro[imidazolidine-4,4'-q...)
Show SMILES CN1C(=O)NC2(N(C)C(=O)Nc3ccccc23)C1=O
Show InChI InChI=1S/C12H12N4O3/c1-15-9(17)12(14-11(15)19)7-5-3-4-6-8(7)13-10(18)16(12)2/h3-6H,1-2H3,(H,13,18)(H,14,19)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006399
PNG
((4S)-3'-methyl-1'H,2H,5H-spiro[imidazolidine-4,4'-...)
Show SMILES CN1C(=O)Nc2ccccc2[C@]11NC(=O)NC1=O
Show InChI InChI=1S/C11H10N4O3/c1-15-10(18)12-7-5-3-2-4-6(7)11(15)8(16)13-9(17)14-11/h2-5H,1H3,(H,12,18)(H2,13,14,16,17)/t11-/m0/s1
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n/an/a 3.40E+3n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006402
PNG
(1,3,3'-trimethyl-1'H,2H,5H-spiro[imidazolidine-4,4...)
Show SMILES CN1C(=O)N(C)C2(N(C)C(=O)Nc3ccccc23)C1=O
Show InChI InChI=1S/C13H14N4O3/c1-15-10(18)13(17(3)12(15)20)8-6-4-5-7-9(8)14-11(19)16(13)2/h4-7H,1-3H3,(H,14,19)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006358
PNG
(8'-fluoro-3'-methyl-1'H,2H,5H-spiro[imidazolidine-...)
Show SMILES CN1C(=O)Nc2c(F)cccc2C11NC(=O)NC1=O
Show InChI InChI=1S/C11H9FN4O3/c1-16-10(19)13-7-5(3-2-4-6(7)12)11(16)8(17)14-9(18)15-11/h2-4H,1H3,(H,13,19)(H2,14,15,17,18)
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n/an/a 42n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair