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3 similar compounds to monomer 50006381

Compile data set for download or QSAR
Wt: 366.3
BDBM50006405
Wt: 276.2
BDBM50006360
Wt: 262.2
BDBM50006382

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50006405,50006360,50006382   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006360
PNG
(6'-methoxy-3'-methyl-1'H,2H,5H-spiro[imidazolidine...)
Show SMILES COc1ccc2NC(=O)N(C)C3(NC(=O)NC3=O)c2c1
Show InChI InChI=1S/C12H12N4O4/c1-16-11(19)13-8-4-3-6(20-2)5-7(8)12(16)9(17)14-10(18)15-12/h3-5H,1-2H3,(H,13,19)(H2,14,15,17,18)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4.50E+3n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006405
PNG
(3'-methyl-2,2',5-trioxo-2',3'-dihydro-1'H-spiro[im...)
Show SMILES CN1C(=O)Nc2ccc(OC(=O)c3ccccc3)cc2C11NC(=O)NC1=O
Show InChI InChI=1S/C18H14N4O5/c1-22-17(26)19-13-8-7-11(27-14(23)10-5-3-2-4-6-10)9-12(13)18(22)15(24)20-16(25)21-18/h2-9H,1H3,(H,19,26)(H2,20,21,24,25)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.00E+3n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006382
PNG
(6'-hydroxy-3'-methyl-1'H,2H,5H-spiro[imidazolidine...)
Show SMILES CN1C(=O)Nc2ccc(O)cc2C11NC(=O)NC1=O
Show InChI InChI=1S/C11H10N4O4/c1-15-10(19)12-7-3-2-5(16)4-6(7)11(15)8(17)13-9(18)14-11/h2-4,16H,1H3,(H,12,19)(H2,13,14,17,18)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair