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15 similar compounds to monomer 50006377

Compile data set for download or QSAR
Wt: 325.6
BDBM50006404
Wt: 246.2
BDBM50006399
Wt: 280.6
BDBM50006401
Wt: 294.6
BDBM50006362
Wt: 246.2
BDBM50006364
Wt: 280.6
BDBM50006369
Wt: 315.1
BDBM50006370
Wt: 261.2
BDBM50006371
Wt: 315.1
BDBM50006372
Wt: 246.2
BDBM50006376
Wt: 260.2
BDBM50006378
Wt: 280.6
BDBM50006389
Wt: 260.2
BDBM50006390
Wt: 280.6
BDBM50006391
Wt: 280.6
BDBM50006397

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50006404,50006399,50006401,50006362,50006364,50006369,50006370,50006371,50006372,50006376,50006378,50006389,50006390,50006391,50006397   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006362
PNG
(6'-chloro-3',7'-dimethyl-1'H,2H,5H-spiro[imidazoli...)
Show SMILES CN1C(=O)Nc2cc(C)c(Cl)cc2C11NC(=O)NC1=O
Show InChI InChI=1S/C12H11ClN4O3/c1-5-3-8-6(4-7(5)13)12(17(2)11(20)14-8)9(18)15-10(19)16-12/h3-4H,1-2H3,(H,14,20)(H2,15,16,18,19)
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Article
PubMed
n/an/a 30n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006404
PNG
(6'-chloro-3'-methyl-8'-nitro-1'H,2H,5H-spiro[imida...)
Show SMILES CN1C(=O)Nc2c(cc(Cl)cc2C11NC(=O)NC1=O)[N+]([O-])=O
Show InChI InChI=1S/C11H8ClN5O5/c1-16-10(20)13-7-5(2-4(12)3-6(7)17(21)22)11(16)8(18)14-9(19)15-11/h2-3H,1H3,(H,13,20)(H2,14,15,18,19)
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n/an/a 46n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006369
PNG
((4R)-6'-chloro-3'-methyl-1'H,2H,5H-spiro[imidazoli...)
Show SMILES CN1C(=O)Nc2ccc(Cl)cc2[C@@]11NC(=O)NC1=O
Show InChI InChI=1S/C11H9ClN4O3/c1-16-10(19)13-7-3-2-5(12)4-6(7)11(16)8(17)14-9(18)15-11/h2-4H,1H3,(H,13,19)(H2,14,15,17,18)/t11-/m1/s1
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n/an/a 22n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006370
PNG
(6',7'-dichloro-3'-methyl-1'H,2H,5H-spiro[imidazoli...)
Show SMILES CN1C(=O)Nc2cc(Cl)c(Cl)cc2C11NC(=O)NC1=O
Show InChI InChI=1S/C11H8Cl2N4O3/c1-17-10(20)14-7-3-6(13)5(12)2-4(7)11(17)8(18)15-9(19)16-11/h2-3H,1H3,(H,14,20)(H2,15,16,18,19)
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n/an/a 74n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006371
PNG
(6'-amino-3'-methyl-1'H,2H,5H-spiro[imidazolidine-4...)
Show SMILES CN1C(=O)Nc2ccc(N)cc2C11NC(=O)NC1=O
Show InChI InChI=1S/C11H11N5O3/c1-16-10(19)13-7-3-2-5(12)4-6(7)11(16)8(17)14-9(18)15-11/h2-4H,12H2,1H3,(H,13,19)(H2,14,15,17,18)
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PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006372
PNG
(6',8'-dichloro-3'-methyl-1'H,2H,5H-spiro[imidazoli...)
Show SMILES CN1C(=O)Nc2c(Cl)cc(Cl)cc2C11NC(=O)NC1=O
Show InChI InChI=1S/C11H8Cl2N4O3/c1-17-10(20)14-7-5(2-4(12)3-6(7)13)11(17)8(18)15-9(19)16-11/h2-3H,1H3,(H,14,20)(H2,15,16,18,19)
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PubMed
n/an/a 37n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006378
PNG
(3,3'-dimethyl-1'H,2H,5H-spiro[imidazolidine-4,4'-q...)
Show SMILES CN1C(=O)NC(=O)C11N(C)C(=O)Nc2ccccc12
Show InChI InChI=1S/C12H12N4O3/c1-15-10(18)13-8-6-4-3-5-7(8)12(15)9(17)14-11(19)16(12)2/h3-6H,1-2H3,(H,13,18)(H,14,17,19)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006376
PNG
(3'-methyl-1'H,2H,5H-spiro[imidazolidine-4,4'-quina...)
Show SMILES CN1C(=O)Nc2ccccc2C11NC(=O)NC1=O
Show InChI InChI=1S/C11H10N4O3/c1-15-10(18)12-7-5-3-2-4-6(7)11(15)8(16)13-9(17)14-11/h2-5H,1H3,(H,12,18)(H2,13,14,16,17)
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n/an/a 280n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006390
PNG
(3',7'-dimethyl-1'H,2H,5H-spiro[imidazolidine-4,4'-...)
Show SMILES CN1C(=O)Nc2cc(C)ccc2C11NC(=O)NC1=O
Show InChI InChI=1S/C12H12N4O3/c1-6-3-4-7-8(5-6)13-11(19)16(2)12(7)9(17)14-10(18)15-12/h3-5H,1-2H3,(H,13,19)(H2,14,15,17,18)
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PubMed
n/an/a 220n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006391
PNG
(6'-chloro-3'-methyl-1'H,2H,5H-spiro[imidazolidine-...)
Show SMILES CN1C(=O)Nc2ccc(Cl)cc2C11NC(=O)NC1=O
Show InChI InChI=1S/C11H9ClN4O3/c1-16-10(19)13-7-3-2-5(12)4-6(7)11(16)8(17)14-9(18)15-11/h2-4H,1H3,(H,13,19)(H2,14,15,17,18)
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Article
PubMed
n/an/a 56n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006389
PNG
(7'-chloro-3'-methyl-1'H,2H,5H-spiro[imidazolidine-...)
Show SMILES CN1C(=O)Nc2cc(Cl)ccc2C11NC(=O)NC1=O
Show InChI InChI=1S/C11H9ClN4O3/c1-16-10(19)13-7-4-5(12)2-3-6(7)11(16)8(17)14-9(18)15-11/h2-4H,1H3,(H,13,19)(H2,14,15,17,18)
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Article
PubMed
n/an/a 94n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006397
PNG
((4S)-6'-chloro-3'-methyl-1'H,2H,5H-spiro[imidazoli...)
Show SMILES CN1C(=O)Nc2ccc(Cl)cc2[C@]11NC(=O)NC1=O
Show InChI InChI=1S/C11H9ClN4O3/c1-16-10(19)13-7-3-2-5(12)4-6(7)11(16)8(17)14-9(18)15-11/h2-4H,1H3,(H,13,19)(H2,14,15,17,18)/t11-/m0/s1
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PubMed
n/an/a 770n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006401
PNG
(5'-chloro-3'-methyl-1'H,2H,5H-spiro[imidazolidine-...)
Show SMILES CN1C(=O)Nc2cccc(Cl)c2C11NC(=O)NC1=O
Show InChI InChI=1S/C11H9ClN4O3/c1-16-10(19)13-6-4-2-3-5(12)7(6)11(16)8(17)14-9(18)15-11/h2-4H,1H3,(H,13,19)(H2,14,15,17,18)
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n/an/a 860n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006399
PNG
((4S)-3'-methyl-1'H,2H,5H-spiro[imidazolidine-4,4'-...)
Show SMILES CN1C(=O)Nc2ccccc2[C@]11NC(=O)NC1=O
Show InChI InChI=1S/C11H10N4O3/c1-15-10(18)12-7-5-3-2-4-6(7)11(15)8(16)13-9(17)14-11/h2-5H,1H3,(H,12,18)(H2,13,14,16,17)/t11-/m0/s1
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n/an/a 3.40E+3n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006364
PNG
((4R)-3'-methyl-1'H,2H,5H-spiro[imidazolidine-4,4'-...)
Show SMILES CN1C(=O)Nc2ccccc2[C@@]11NC(=O)NC1=O
Show InChI InChI=1S/C11H10N4O3/c1-15-10(18)12-7-5-3-2-4-6(7)11(15)8(16)13-9(17)14-11/h2-5H,1H3,(H,12,18)(H2,13,14,16,17)/t11-/m1/s1
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PubMed
n/an/a 310n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair