BindingDB logo
myBDB logout

4 similar compounds to monomer 50007305

Compile data set for download or QSAR
Wt: 493.9
BDBM50007252
Wt: 405.4
BDBM50007259
Wt: 456.3
BDBM50007269
Wt: 383.8
BDBM50007282

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50007252,50007259,50007269,50007282   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
HMG-CoA reductase


(Rattus norvegicus (rat))
BDBM50007252
PNG
(CHEMBL100884 | Sodium; 6-{4-chloro-2-cyclopentyl-6...)
Show SMILES OC(COc1c(CCCOc2ccc(F)cc2)cc(Cl)cc1C1CCCC1)C[C@@H](O)CC([O-])=O
Show InChI InChI=1S/C26H32ClFO6/c27-19-12-18(6-3-11-33-23-9-7-20(28)8-10-23)26(24(13-19)17-4-1-2-5-17)34-16-22(30)14-21(29)15-25(31)32/h7-10,12-13,17,21-22,29-30H,1-6,11,14-16H2,(H,31,32)/p-1/t21-,22?/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Hoechst AG

Curated by ChEMBL


Assay Description
In vitro inhibition of HMG-CoA reductase in solubilized rat liver.


J Med Chem 34: 2962-83 (1991)


Article DOI: 10.1021/jm00114a004
BindingDB Entry DOI: 10.7270/Q2C829WX
More data for this
Ligand-Target Pair
HMG-CoA reductase


(Rattus norvegicus (rat))
BDBM50007282
PNG
(CHEMBL101662 | Sodium; 6-(4-chloro-2-cyclohexylmet...)
Show SMILES Cc1cc(Cl)cc(CC2CCCCC2)c1OCC(O)C[C@@H](O)CC([O-])=O
Show InChI InChI=1S/C20H29ClO5/c1-13-7-16(21)9-15(8-14-5-3-2-4-6-14)20(13)26-12-18(23)10-17(22)11-19(24)25/h7,9,14,17-18,22-23H,2-6,8,10-12H2,1H3,(H,24,25)/p-1/t17-,18?/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 75n/an/an/an/an/an/a



Hoechst AG

Curated by ChEMBL


Assay Description
In vitro inhibition of HMG-CoA reductase in solubilized rat liver.


J Med Chem 34: 2962-83 (1991)


Article DOI: 10.1021/jm00114a004
BindingDB Entry DOI: 10.7270/Q2C829WX
More data for this
Ligand-Target Pair
HMG-CoA reductase


(Rattus norvegicus (rat))
BDBM50007269
PNG
(CHEMBL316712 | Sodium; 6-{4-chloro-2-[3-(4-chloro-...)
Show SMILES Cc1cc(Cl)cc(CCCOc2ccc(Cl)cc2)c1OCC(O)C[C@@H](O)CC([O-])=O
Show InChI InChI=1S/C22H26Cl2O6/c1-14-9-17(24)10-15(3-2-8-29-20-6-4-16(23)5-7-20)22(14)30-13-19(26)11-18(25)12-21(27)28/h4-7,9-10,18-19,25-26H,2-3,8,11-13H2,1H3,(H,27,28)/p-1/t18-,19?/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 50n/an/an/an/an/an/a



Hoechst AG

Curated by ChEMBL


Assay Description
In vitro inhibition of HMG-CoA reductase in solubilized rat liver.


J Med Chem 34: 2962-83 (1991)


Article DOI: 10.1021/jm00114a004
BindingDB Entry DOI: 10.7270/Q2C829WX
More data for this
Ligand-Target Pair
HMG-CoA reductase


(Rattus norvegicus (rat))
BDBM50007259
PNG
(CHEMBL316899 | Sodium; 6-{2-[3-(4-fluoro-phenoxy)-...)
Show SMILES Cc1cccc(CCCOc2ccc(F)cc2)c1OCC(O)C[C@@H](O)CC([O-])=O
Show InChI InChI=1S/C22H27FO6/c1-15-4-2-5-16(6-3-11-28-20-9-7-17(23)8-10-20)22(15)29-14-19(25)12-18(24)13-21(26)27/h2,4-5,7-10,18-19,24-25H,3,6,11-14H2,1H3,(H,26,27)/p-1/t18-,19?/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 250n/an/an/an/an/an/a



Hoechst AG

Curated by ChEMBL


Assay Description
In vitro inhibition of HMG-CoA reductase in solubilized rat liver.


J Med Chem 34: 2962-83 (1991)


Article DOI: 10.1021/jm00114a004
BindingDB Entry DOI: 10.7270/Q2C829WX
More data for this
Ligand-Target Pair