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4 similar compounds to monomer 50007266

Compile data set for download or QSAR
Wt: 431.5
BDBM50007292
Wt: 481.5
BDBM50007306
Wt: 469.4
BDBM50007256
Wt: 389.4
BDBM50007280

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50007292,50007306,50007256,50007280   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
HMG-CoA reductase


(Rattus norvegicus (rat))
BDBM50007256
PNG
(CHEMBL420646 | Sodium; 6-{2-[bis-(4-fluoro-phenyl)...)
Show SMILES Cc1cc(C)c(OCC(O)C[C@@H](O)CC([O-])=O)c(c1)C(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C27H28F2O5/c1-16-11-17(2)27(34-15-23(31)13-22(30)14-25(32)33)24(12-16)26(18-3-7-20(28)8-4-18)19-5-9-21(29)10-6-19/h3-12,22-23,26,30-31H,13-15H2,1-2H3,(H,32,33)/p-1/t22-,23?/m1/s1
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n/an/a 70n/an/an/an/an/an/a



Hoechst AG

Curated by ChEMBL


Assay Description
In vitro inhibition of HMG-CoA reductase in solubilized rat liver.


J Med Chem 34: 2962-83 (1991)


Article DOI: 10.1021/jm00114a004
BindingDB Entry DOI: 10.7270/Q2C829WX
More data for this
Ligand-Target Pair
HMG-CoA reductase


(Rattus norvegicus (rat))
BDBM50007306
PNG
(CHEMBL316938 | Sodium; 6-{2-[(4-fluoro-phenyl)-(4-...)
Show SMILES COc1ccc(cc1)C(c1ccc(F)cc1)c1cc(C)cc(C)c1OCC(O)C[C@@H](O)CC([O-])=O
Show InChI InChI=1S/C28H31FO6/c1-17-12-18(2)28(35-16-23(31)14-22(30)15-26(32)33)25(13-17)27(19-4-8-21(29)9-5-19)20-6-10-24(34-3)11-7-20/h4-13,22-23,27,30-31H,14-16H2,1-3H3,(H,32,33)/p-1/t22-,23?,27?/m1/s1
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n/an/a 100n/an/an/an/an/an/a



Hoechst AG

Curated by ChEMBL


Assay Description
In vitro inhibition of HMG-CoA reductase in solubilized rat liver.


J Med Chem 34: 2962-83 (1991)


Article DOI: 10.1021/jm00114a004
BindingDB Entry DOI: 10.7270/Q2C829WX
More data for this
Ligand-Target Pair
HMG-CoA reductase


(Rattus norvegicus (rat))
BDBM50007292
PNG
(CHEMBL101774 | Sodium; 6-{2-[1-(4-fluoro-phenyl)-3...)
Show SMILES CC(C)CC(c1ccc(F)cc1)c1cc(C)cc(C)c1OCC(O)C[C@@H](O)CC([O-])=O
Show InChI InChI=1S/C25H33FO5/c1-15(2)9-22(18-5-7-19(26)8-6-18)23-11-16(3)10-17(4)25(23)31-14-21(28)12-20(27)13-24(29)30/h5-8,10-11,15,20-22,27-28H,9,12-14H2,1-4H3,(H,29,30)/p-1/t20-,21?,22?/m1/s1
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n/an/a 140n/an/an/an/an/an/a



Hoechst AG

Curated by ChEMBL


Assay Description
In vitro inhibition of HMG-CoA reductase in solubilized rat liver.


J Med Chem 34: 2962-83 (1991)


Article DOI: 10.1021/jm00114a004
BindingDB Entry DOI: 10.7270/Q2C829WX
More data for this
Ligand-Target Pair
HMG-CoA reductase


(Rattus norvegicus (rat))
BDBM50007280
PNG
(CHEMBL100560 | Sodium; 6-{2-[1-(4-fluoro-phenyl)-e...)
Show SMILES CC(c1ccc(F)cc1)c1cc(C)cc(C)c1OCC(O)C[C@@H](O)CC([O-])=O
Show InChI InChI=1S/C22H27FO5/c1-13-8-14(2)22(28-12-19(25)10-18(24)11-21(26)27)20(9-13)15(3)16-4-6-17(23)7-5-16/h4-9,15,18-19,24-25H,10-12H2,1-3H3,(H,26,27)/p-1/t15?,18-,19?/m1/s1
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n/an/a 160n/an/an/an/an/an/a



Hoechst AG

Curated by ChEMBL


Assay Description
In vitro inhibition of HMG-CoA reductase in solubilized rat liver.


J Med Chem 34: 2962-83 (1991)


Article DOI: 10.1021/jm00114a004
BindingDB Entry DOI: 10.7270/Q2C829WX
More data for this
Ligand-Target Pair