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4 similar compounds to monomer 50007289

Compile data set for download or QSAR
Wt: 489.9
BDBM50007290
Wt: 538.3
BDBM50007298
Wt: 554.3
BDBM50007263
Wt: 517.9
BDBM50007278

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50007290,50007298,50007263,50007278   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
HMG-CoA reductase


(Rattus norvegicus (rat))
BDBM50007263
PNG
(CHEMBL317576 | Sodium; 6-{2,4-dichloro-6-[3-(4-flu...)
Show SMILES OC(COc1c(Cl)cc(Cl)cc1C(CCOc1ccc(F)cc1)c1ccc(F)cc1)C[C@@H](O)CC([O-])=O
Show InChI InChI=1S/C27H26Cl2F2O6/c28-17-11-24(27(25(29)12-17)37-15-21(33)13-20(32)14-26(34)35)23(16-1-3-18(30)4-2-16)9-10-36-22-7-5-19(31)6-8-22/h1-8,11-12,20-21,23,32-33H,9-10,13-15H2,(H,34,35)/p-1/t20-,21?,23?/m1/s1
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n/an/a 150n/an/an/an/an/an/a



Hoechst AG

Curated by ChEMBL


Assay Description
In vitro inhibition of HMG-CoA reductase in solubilized rat liver.


J Med Chem 34: 2962-83 (1991)


Article DOI: 10.1021/jm00114a004
BindingDB Entry DOI: 10.7270/Q2C829WX
More data for this
Ligand-Target Pair
HMG-CoA reductase


(Rattus norvegicus (rat))
BDBM50007298
PNG
(CHEMBL101097 | Sodium; 6-{2-[bis-(4-fluoro-3-methy...)
Show SMILES Cc1cc(ccc1F)C(c1ccc(F)c(C)c1)c1cc(Cl)cc(Cl)c1OCC(O)C[C@@H](O)CC([O-])=O
Show InChI InChI=1S/C27H26Cl2F2O5/c1-14-7-16(3-5-23(14)30)26(17-4-6-24(31)15(2)8-17)21-9-18(28)10-22(29)27(21)36-13-20(33)11-19(32)12-25(34)35/h3-10,19-20,26,32-33H,11-13H2,1-2H3,(H,34,35)/p-1/t19-,20?/m1/s1
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n/an/a 1.00E+3n/an/an/an/an/an/a



Hoechst AG

Curated by ChEMBL


Assay Description
In vitro inhibition of HMG-CoA reductase in solubilized rat liver.


J Med Chem 34: 2962-83 (1991)


Article DOI: 10.1021/jm00114a004
BindingDB Entry DOI: 10.7270/Q2C829WX
More data for this
Ligand-Target Pair
HMG-CoA reductase


(Rattus norvegicus (rat))
BDBM50007290
PNG
(CHEMBL100357 | Sodium; 6-{2-[bis-(4-fluoro-phenyl)...)
Show SMILES Cc1cc(Cl)cc(C(c2ccc(F)cc2)c2ccc(F)cc2)c1OCC(O)C[C@@H](O)CC([O-])=O
Show InChI InChI=1S/C26H25ClF2O5/c1-15-10-18(27)11-23(26(15)34-14-22(31)12-21(30)13-24(32)33)25(16-2-6-19(28)7-3-16)17-4-8-20(29)9-5-17/h2-11,21-22,25,30-31H,12-14H2,1H3,(H,32,33)/p-1/t21-,22?/m1/s1
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n/an/a 70n/an/an/an/an/an/a



Hoechst AG

Curated by ChEMBL


Assay Description
In vitro inhibition of HMG-CoA reductase in solubilized rat liver.


J Med Chem 34: 2962-83 (1991)


Article DOI: 10.1021/jm00114a004
BindingDB Entry DOI: 10.7270/Q2C829WX
More data for this
Ligand-Target Pair
HMG-CoA reductase


(Rattus norvegicus (rat))
BDBM50007278
PNG
(CHEMBL103712 | Sodium; 6-{2-[bis-(4-fluoro-3-methy...)
Show SMILES Cc1cc(Cl)c(OCC(O)C[C@@H](O)CC([O-])=O)c(c1)C(c1ccc(F)c(C)c1)c1ccc(F)c(C)c1
Show InChI InChI=1S/C28H29ClF2O5/c1-15-8-22(28(23(29)9-15)36-14-21(33)12-20(32)13-26(34)35)27(18-4-6-24(30)16(2)10-18)19-5-7-25(31)17(3)11-19/h4-11,20-21,27,32-33H,12-14H2,1-3H3,(H,34,35)/p-1/t20-,21?/m1/s1
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n/an/a 270n/an/an/an/an/an/a



Hoechst AG

Curated by ChEMBL


Assay Description
In vitro inhibition of HMG-CoA reductase in solubilized rat liver.


J Med Chem 34: 2962-83 (1991)


Article DOI: 10.1021/jm00114a004
BindingDB Entry DOI: 10.7270/Q2C829WX
More data for this
Ligand-Target Pair