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22 similar compounds to monomer 50007523

Compile data set for download or QSAR
Wt: 433.3
BDBM50007508
Wt: 354.4
BDBM50007516
Wt: 371.2
BDBM50007522
Purchase
Wt: 278.3
BDBM50012964
Purchase
Wt: 357.2
BDBM50010727
Wt: 373.2
BDBM50010719
Wt: 308.3
BDBM50010724
Wt: 292.3
BDBM50010726
Purchase
Wt: 371.2
BDBM50452879
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Wt: 292.3
BDBM50026566
Purchase
Wt: 324.3
BDBM50040078
Wt: 398.4
BDBM50168513
Wt: 308.3
BDBM50368068
Wt: 294.3
BDBM50368071
Wt: 357.2
BDBM50417328
Displayed 1 to 15 (of 22 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 28 hits for monomerid = 50007508,50007516,50007522,50012964,50010727,50010719,50010724,50010726,50452879,50026566,50040078,50168513,50368068,50368071,50417328   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50007522
PNG
(5-Bromo-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2,3-dime...)
Show SMILES CCN1CCC[C@H]1CNC(=O)c1cc(Br)cc(OC)c1OC
Show InChI InChI=1S/C16H23BrN2O3/c1-4-19-7-5-6-12(19)10-18-16(20)13-8-11(17)9-14(21-2)15(13)22-3/h8-9,12H,4-7,10H2,1-3H3,(H,18,20)/t12-/m0/s1
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0.00300n/an/an/an/an/an/an/an/a



Institutet

Curated by ChEMBL


Assay Description
Binding affinity to dopamine D2 receptor (unknown origin)


Bioorg Med Chem 16: 6467-73 (2008)


Article DOI: 10.1016/j.bmc.2008.05.039
BindingDB Entry DOI: 10.7270/Q2QN66JM
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50007522
PNG
(5-Bromo-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2,3-dime...)
Show SMILES CCN1CCC[C@H]1CNC(=O)c1cc(Br)cc(OC)c1OC
Show InChI InChI=1S/C16H23BrN2O3/c1-4-19-7-5-6-12(19)10-18-16(20)13-8-11(17)9-14(21-2)15(13)22-3/h8-9,12H,4-7,10H2,1-3H3,(H,18,20)/t12-/m0/s1
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0.0180n/an/an/an/an/an/an/an/a



Astra Research Centre AB

Curated by ChEMBL


Assay Description
Inhibition of [3H]raclopride binding to rat striatal dopamine receptor D2


J Med Chem 34: 948-55 (1991)


Article DOI: 10.1021/jm00107a012
BindingDB Entry DOI: 10.7270/Q2GT5NS9
More data for this
Ligand-Target Pair
Dopamine D2 receptor and Serotonin 2a receptor (D2 and 5HT2a)


(Rattus norvegicus (rat))
BDBM50007508
PNG
((R) N-(1-Benzyl-pyrrolidin-2-ylmethyl)-5-bromo-2,3...)
Show SMILES COc1cc(Br)cc(C(=O)NC[C@H]2CCCN2Cc2ccccc2)c1OC
Show InChI InChI=1S/C21H25BrN2O3/c1-26-19-12-16(22)11-18(20(19)27-2)21(25)23-13-17-9-6-10-24(17)14-15-7-4-3-5-8-15/h3-5,7-8,11-12,17H,6,9-10,13-14H2,1-2H3,(H,23,25)/t17-/m1/s1
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0.0240n/an/an/an/an/an/an/an/a



Astra Research Centre AB

Curated by ChEMBL


Assay Description
Inhibition of [3H]raclopride binding to rat striatal dopamine receptor D2


J Med Chem 34: 948-55 (1991)


Article DOI: 10.1021/jm00107a012
BindingDB Entry DOI: 10.7270/Q2GT5NS9
More data for this
Ligand-Target Pair
Dopamine D2 receptor and Serotonin 2a receptor (D2 and 5HT2a)


(Rattus norvegicus (rat))
BDBM50007522
PNG
(5-Bromo-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2,3-dime...)
Show SMILES CCN1CCC[C@H]1CNC(=O)c1cc(Br)cc(OC)c1OC
Show InChI InChI=1S/C16H23BrN2O3/c1-4-19-7-5-6-12(19)10-18-16(20)13-8-11(17)9-14(21-2)15(13)22-3/h8-9,12H,4-7,10H2,1-3H3,(H,18,20)/t12-/m0/s1
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0.200n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Compound was evaluated for binding affinity towards dopamine receptor D2 in striatal membranes, using [3H]- spiperone as radioligand in the presence ...


J Med Chem 34: 1612-24 (1991)


Article DOI: 10.1021/jm00109a013
BindingDB Entry DOI: 10.7270/Q2GH9GXF
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50007522
PNG
(5-Bromo-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2,3-dime...)
Show SMILES CCN1CCC[C@H]1CNC(=O)c1cc(Br)cc(OC)c1OC
Show InChI InChI=1S/C16H23BrN2O3/c1-4-19-7-5-6-12(19)10-18-16(20)13-8-11(17)9-14(21-2)15(13)22-3/h8-9,12H,4-7,10H2,1-3H3,(H,18,20)/t12-/m0/s1
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0.220n/an/an/an/an/an/an/an/a



Institutet

Curated by ChEMBL


Assay Description
Binding affinity to dopamine D3 receptor (unknown origin)


Bioorg Med Chem 16: 6467-73 (2008)


Article DOI: 10.1016/j.bmc.2008.05.039
BindingDB Entry DOI: 10.7270/Q2QN66JM
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50010724
PNG
(CHEMBL305916 | N-(1-Ethyl-pyrrolidin-2-ylmethyl)-6...)
Show SMILES CCN1CCC[C@H]1CNC(=O)c1c(O)ccc(OC)c1OC
Show InChI InChI=1S/C16H24N2O4/c1-4-18-9-5-6-11(18)10-17-16(20)14-12(19)7-8-13(21-2)15(14)22-3/h7-8,11,19H,4-6,9-10H2,1-3H3,(H,17,20)/t11-/m0/s1
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0.75n/an/an/an/an/an/an/an/a



Astra Research Centre AB

Curated by ChEMBL


Assay Description
Inhibition of [3H]spiperone binding to rat striatal membrane Dopamine receptor D2


J Med Chem 33: 1155-63 (1990)


Article DOI: 10.1021/jm00166a012
BindingDB Entry DOI: 10.7270/Q24X58DR
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50007522
PNG
(5-Bromo-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2,3-dime...)
Show SMILES CCN1CCC[C@H]1CNC(=O)c1cc(Br)cc(OC)c1OC
Show InChI InChI=1S/C16H23BrN2O3/c1-4-19-7-5-6-12(19)10-18-16(20)13-8-11(17)9-14(21-2)15(13)22-3/h8-9,12H,4-7,10H2,1-3H3,(H,18,20)/t12-/m0/s1
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0.760n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Displacement of [3H]- spiperone from dopamine receptor D2 of striatal membranes without sodium chloride


J Med Chem 34: 1612-24 (1991)


Article DOI: 10.1021/jm00109a013
BindingDB Entry DOI: 10.7270/Q2GH9GXF
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50040078
PNG
(CHEMBL305844 | N-(1-Ethyl-pyrrolidin-2-ylmethyl)-2...)
Show SMILES CCN1CCC[C@@H]1CNC(=O)c1cccc(OC)c1OCCF
Show InChI InChI=1S/C17H25FN2O3/c1-3-20-10-5-6-13(20)12-19-17(21)14-7-4-8-15(22-2)16(14)23-11-9-18/h4,7-8,13H,3,5-6,9-12H2,1-2H3,(H,19,21)/t13-/m1/s1
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13n/an/an/an/an/an/an/an/a



University of Pennsylvania

Curated by ChEMBL


Assay Description
Inhibition constant against dopamine receptor D2 in rat


J Med Chem 36: 221-8 (1993)


Article DOI: 10.1021/jm00054a005
BindingDB Entry DOI: 10.7270/Q2TT4Q10
More data for this
Ligand-Target Pair
Dopamine D2 receptor and Serotonin 2a receptor (D2 and 5HT2a)


(Rattus norvegicus (rat))
BDBM50012964
PNG
(3,5-Dichloro-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2-h...)
Show SMILES CCN1CCC[C@H]1CNC(=O)c1c(O)cccc1OC
Show InChI InChI=1S/C15H22N2O3/c1-3-17-9-5-6-11(17)10-16-15(19)14-12(18)7-4-8-13(14)20-2/h4,7-8,11,18H,3,5-6,9-10H2,1-2H3,(H,16,19)/t11-/m0/s1
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31n/an/an/an/an/an/an/an/a



University of Pennsylvania

Curated by ChEMBL


Assay Description
Inhibitory constant against binding of [125I]- IBZM to rat striatal membrane


J Med Chem 31: 1039-43 (1988)


Article DOI: 10.1021/jm00400a027
BindingDB Entry DOI: 10.7270/Q2C24X1V
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50007508
PNG
((R) N-(1-Benzyl-pyrrolidin-2-ylmethyl)-5-bromo-2,3...)
Show SMILES COc1cc(Br)cc(C(=O)NC[C@H]2CCCN2Cc2ccccc2)c1OC
Show InChI InChI=1S/C21H25BrN2O3/c1-26-19-12-16(22)11-18(20(19)27-2)21(25)23-13-17-9-6-10-24(17)14-15-7-4-3-5-8-15/h3-5,7-8,11-12,17H,6,9-10,13-14H2,1-2H3,(H,23,25)/t17-/m1/s1
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n/an/a 1.40n/an/an/an/an/an/a



Astra Research Centre AB

Curated by ChEMBL


Assay Description
Inhibition of [3H]spiperone binding to rat striatal dopamine receptor D2 was determined in vitro


J Med Chem 34: 948-55 (1991)


Article DOI: 10.1021/jm00107a012
BindingDB Entry DOI: 10.7270/Q2GT5NS9
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50007516
PNG
((R) N-(1-Benzyl-pyrrolidin-2-ylmethyl)-2,3-dimetho...)
Show SMILES COc1cccc(C(=O)NC[C@H]2CCCN2Cc2ccccc2)c1OC
Show InChI InChI=1S/C21H26N2O3/c1-25-19-12-6-11-18(20(19)26-2)21(24)22-14-17-10-7-13-23(17)15-16-8-4-3-5-9-16/h3-6,8-9,11-12,17H,7,10,13-15H2,1-2H3,(H,22,24)/t17-/m1/s1
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n/an/a 21n/an/an/an/an/an/a



Astra Research Centre AB

Curated by ChEMBL


Assay Description
Inhibition of [3H]spiperone binding to rat striatal dopamine receptor D2 was determined in vitro


J Med Chem 34: 948-55 (1991)


Article DOI: 10.1021/jm00107a012
BindingDB Entry DOI: 10.7270/Q2GT5NS9
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50012964
PNG
(3,5-Dichloro-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2-h...)
Show SMILES CCN1CCC[C@H]1CNC(=O)c1c(O)cccc1OC
Show InChI InChI=1S/C15H22N2O3/c1-3-17-9-5-6-11(17)10-16-15(19)14-12(18)7-4-8-13(14)20-2/h4,7-8,11,18H,3,5-6,9-10H2,1-2H3,(H,16,19)/t11-/m0/s1
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n/an/an/a 31n/an/an/an/an/a



University of Pennsylvania

Curated by ChEMBL


Assay Description
Evaluated in vivo for the affinity towards Dopamine receptor D2 of rat striatal tissue


J Med Chem 33: 171-8 (1990)


Article DOI: 10.1021/jm00163a029
BindingDB Entry DOI: 10.7270/Q2280860
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50368068
PNG
(CHEMBL1907696)
Show SMILES CCN1CCC[C@H]1CNC(=O)c1c(O)c(OC)ccc1OC
Show InChI InChI=1S/C16H24N2O4/c1-4-18-9-5-6-11(18)10-17-16(20)14-12(21-2)7-8-13(22-3)15(14)19/h7-8,11,19H,4-6,9-10H2,1-3H3,(H,17,20)/t11-/m0/s1
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n/an/a 205n/an/an/an/an/an/a



Astra Research Centre AB

Curated by ChEMBL


Assay Description
In vitro ability to inhibit the binding of [3H]spiperone to dopamine receptor D2 in rat striatal membranes.


J Med Chem 33: 1155-63 (1990)


Article DOI: 10.1021/jm00166a012
BindingDB Entry DOI: 10.7270/Q24X58DR
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50368071
PNG
(CHEMBL1907691)
Show SMILES CCN1CCC[C@H]1CNC(=O)c1c(O)ccc(O)c1OC
Show InChI InChI=1S/C15H22N2O4/c1-3-17-8-4-5-10(17)9-16-15(20)13-11(18)6-7-12(19)14(13)21-2/h6-7,10,18-19H,3-5,8-9H2,1-2H3,(H,16,20)/t10-/m0/s1
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n/an/a 56n/an/an/an/an/an/a



Astra Research Centre AB

Curated by ChEMBL


Assay Description
In vitro ability to inhibit the binding of [3H]spiperone to dopamine receptor D2 in rat striatal membranes.


J Med Chem 33: 1155-63 (1990)


Article DOI: 10.1021/jm00166a012
BindingDB Entry DOI: 10.7270/Q24X58DR
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50012964
PNG
(3,5-Dichloro-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2-h...)
Show SMILES CCN1CCC[C@H]1CNC(=O)c1c(O)cccc1OC
Show InChI InChI=1S/C15H22N2O3/c1-3-17-9-5-6-11(17)10-16-15(19)14-12(18)7-4-8-13(14)20-2/h4,7-8,11,18H,3,5-6,9-10H2,1-2H3,(H,16,19)/t11-/m0/s1
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n/an/an/a 31n/an/an/an/an/a



University of Pennsylvania

Curated by ChEMBL


Assay Description
Affinity constant of compound was evaluated in rat striatum tissue preparation.


J Med Chem 31: 1039-43 (1988)


Article DOI: 10.1021/jm00400a027
BindingDB Entry DOI: 10.7270/Q2C24X1V
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50417328
PNG
(CHEMBL1276459)
Show SMILES CCN1CCC[C@H]1CNC(=O)c1cc(Br)cc(O)c1OC
Show InChI InChI=1S/C15H21BrN2O3/c1-3-18-6-4-5-11(18)9-17-15(20)12-7-10(16)8-13(19)14(12)21-2/h7-8,11,19H,3-6,9H2,1-2H3,(H,17,20)/t11-/m0/s1
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n/an/a 8.32n/an/an/an/an/an/a



University of Mazandaran

Curated by ChEMBL


Assay Description
Antagonist activity at dopamine D2 receptor


Eur J Med Chem 45: 4856-62 (2010)


Article DOI: 10.1016/j.ejmech.2010.07.056
BindingDB Entry DOI: 10.7270/Q2833T8S
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50026566
PNG
(CHEMBL282024 | N-(1-Ethyl-pyrrolidin-2-ylmethyl)-2...)
Show SMILES CCN1CCC[C@H]1CNC(=O)c1c(OC)cccc1OC
Show InChI InChI=1S/C16H24N2O3/c1-4-18-10-6-7-12(18)11-17-16(19)15-13(20-2)8-5-9-14(15)21-3/h5,8-9,12H,4,6-7,10-11H2,1-3H3,(H,17,19)/t12-/m0/s1
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n/an/a 52.5n/an/an/an/an/an/a



University of Mazandaran

Curated by ChEMBL


Assay Description
Antagonist activity at dopamine D2 receptor


Eur J Med Chem 45: 4856-62 (2010)


Article DOI: 10.1016/j.ejmech.2010.07.056
BindingDB Entry DOI: 10.7270/Q2833T8S
More data for this
Ligand-Target Pair
Dopamine D2 receptor and Serotonin 2a receptor (D2 and 5HT2a)


(Rattus norvegicus (rat))
BDBM50010724
PNG
(CHEMBL305916 | N-(1-Ethyl-pyrrolidin-2-ylmethyl)-6...)
Show SMILES CCN1CCC[C@H]1CNC(=O)c1c(O)ccc(OC)c1OC
Show InChI InChI=1S/C16H24N2O4/c1-4-18-9-5-6-11(18)10-17-16(20)14-12(19)7-8-13(21-2)15(14)22-3/h7-8,11,19H,4-6,9-10H2,1-3H3,(H,17,20)/t11-/m0/s1
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n/an/a 8.80n/an/an/an/an/an/a



Astra Research Centre AB

Curated by ChEMBL


Assay Description
In vitro ability to inhibit the binding of [3H]spiperone to dopamine receptor D2 in rat striatal membranes.


J Med Chem 33: 1155-63 (1990)


Article DOI: 10.1021/jm00166a012
BindingDB Entry DOI: 10.7270/Q24X58DR
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50026566
PNG
(CHEMBL282024 | N-(1-Ethyl-pyrrolidin-2-ylmethyl)-2...)
Show SMILES CCN1CCC[C@H]1CNC(=O)c1c(OC)cccc1OC
Show InChI InChI=1S/C16H24N2O3/c1-4-18-10-6-7-12(18)11-17-16(19)15-13(20-2)8-5-9-14(15)21-3/h5,8-9,12H,4,6-7,10-11H2,1-3H3,(H,17,19)/t12-/m0/s1
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n/an/a 1.53E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity at Dopamine receptor D2 in rat by displacing [3H]- spiperone from rat striatal membrane


J Med Chem 28: 1263-9 (1985)


Article DOI: 10.1021/jm00147a025
BindingDB Entry DOI: 10.7270/Q2QZ2BHD
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50012964
PNG
(3,5-Dichloro-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2-h...)
Show SMILES CCN1CCC[C@H]1CNC(=O)c1c(O)cccc1OC
Show InChI InChI=1S/C15H22N2O3/c1-3-17-9-5-6-11(17)10-16-15(19)14-12(18)7-4-8-13(14)20-2/h4,7-8,11,18H,3,5-6,9-10H2,1-2H3,(H,16,19)/t11-/m0/s1
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n/an/a 315n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity at Dopamine receptor D2 in rat by displacing [3H]- spiperone from rat striatal membrane


J Med Chem 28: 1263-9 (1985)


Article DOI: 10.1021/jm00147a025
BindingDB Entry DOI: 10.7270/Q2QZ2BHD
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 1


(Mus musculus)
BDBM50168513
PNG
(CHEMBL434156 | N-(1-Benzo[1,3]dioxol-5-ylmethyl-pi...)
Show SMILES COc1ccc(OC)c(c1)C(=O)NC1CCCN(Cc2ccc3OCOc3c2)C1
Show InChI InChI=1S/C22H26N2O5/c1-26-17-6-8-19(27-2)18(11-17)22(25)23-16-4-3-9-24(13-16)12-15-5-7-20-21(10-15)29-14-28-20/h5-8,10-11,16H,3-4,9,12-14H2,1-2H3,(H,23,25)
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n/an/a 1.56E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibitory concentration required for binding affinity against mouse MCHr1 competing human neuronal IMR32 cells receptor in a radiometric binding ass...


Bioorg Med Chem Lett 15: 3412-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.023
BindingDB Entry DOI: 10.7270/Q26D5SHR
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50452879
PNG
(CHEMBL2114141)
Show SMILES CCN1CCC[C@@H]1CNC(=O)c1cc(Br)cc(OC)c1OC
Show InChI InChI=1S/C16H23BrN2O3/c1-4-19-7-5-6-12(19)10-18-16(20)13-8-11(17)9-14(21-2)15(13)22-3/h8-9,12H,4-7,10H2,1-3H3,(H,18,20)/t12-/m1/s1
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n/an/a 145n/an/an/an/an/an/a



Astra Research Centre AB

Curated by ChEMBL


Assay Description
The affinity for the Dopamine receptor D2 was assessed by the inhibition of [3H]-spiperone binding in rat striatal membranes in vitro.


J Med Chem 33: 2305-9 (1990)


Article DOI: 10.1021/jm00170a040
BindingDB Entry DOI: 10.7270/Q29P30MH
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50007522
PNG
(5-Bromo-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2,3-dime...)
Show SMILES CCN1CCC[C@H]1CNC(=O)c1cc(Br)cc(OC)c1OC
Show InChI InChI=1S/C16H23BrN2O3/c1-4-19-7-5-6-12(19)10-18-16(20)13-8-11(17)9-14(21-2)15(13)22-3/h8-9,12H,4-7,10H2,1-3H3,(H,18,20)/t12-/m0/s1
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n/an/a 1.20n/an/an/an/an/an/a



Astra Research Centre AB

Curated by ChEMBL


Assay Description
The affinity for the Dopamine receptor D2 was assessed by the inhibition of [3H]-spiperone binding in rat striatal membranes in vitro.


J Med Chem 33: 2305-9 (1990)


Article DOI: 10.1021/jm00170a040
BindingDB Entry DOI: 10.7270/Q29P30MH
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50010726
PNG
(CHEMBL75887 | N-(1-Ethyl-pyrrolidin-2-ylmethyl)-2,...)
Show SMILES CCN1CCCC1CNC(=O)c1cccc(OC)c1OC
Show InChI InChI=1S/C16H24N2O3/c1-4-18-10-6-7-12(18)11-17-16(19)13-8-5-9-14(20-2)15(13)21-3/h5,8-9,12H,4,6-7,10-11H2,1-3H3,(H,17,19)
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n/an/a 52n/an/an/an/an/an/a



Astra Research Centre AB

Curated by ChEMBL


Assay Description
The affinity for the Dopamine receptor D2 was assessed by the inhibition of [3H]-spiperone binding in rat striatal membranes in vitro.


J Med Chem 33: 2305-9 (1990)


Article DOI: 10.1021/jm00170a040
BindingDB Entry DOI: 10.7270/Q29P30MH
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50010727
PNG
(5-Bromo-N-(1-ethyl-pyrrolidin-2-ylmethyl)-3-hydrox...)
Show SMILES CCN1CCCC1CNC(=O)c1cc(Br)cc(O)c1OC
Show InChI InChI=1S/C15H21BrN2O3/c1-3-18-6-4-5-11(18)9-17-15(20)12-7-10(16)8-13(19)14(12)21-2/h7-8,11,19H,3-6,9H2,1-2H3,(H,17,20)
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n/an/a 10n/an/an/an/an/an/a



Astra Research Centre AB

Curated by ChEMBL


Assay Description
The affinity for the Dopamine receptor D2 was assessed by the inhibition of [3H]-spiperone binding in rat striatal membranes in vitro.


J Med Chem 33: 2305-9 (1990)


Article DOI: 10.1021/jm00170a040
BindingDB Entry DOI: 10.7270/Q29P30MH
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50010724
PNG
(CHEMBL305916 | N-(1-Ethyl-pyrrolidin-2-ylmethyl)-6...)
Show SMILES CCN1CCC[C@H]1CNC(=O)c1c(O)ccc(OC)c1OC
Show InChI InChI=1S/C16H24N2O4/c1-4-18-9-5-6-11(18)10-17-16(20)14-12(19)7-8-13(21-2)15(14)22-3/h7-8,11,19H,4-6,9-10H2,1-3H3,(H,17,20)/t11-/m0/s1
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n/an/a 8.80n/an/an/an/an/an/a



Astra Research Centre AB

Curated by ChEMBL


Assay Description
The affinity for the Dopamine receptor D2 was assessed by the inhibition of [3H]-spiperone binding in rat striatal membranes in vitro.


J Med Chem 33: 2305-9 (1990)


Article DOI: 10.1021/jm00170a040
BindingDB Entry DOI: 10.7270/Q29P30MH
More data for this
Ligand-Target Pair
Dopamine D2 receptor and Serotonin 2a receptor (D2 and 5HT2a)


(Rattus norvegicus (rat))
BDBM50007522
PNG
(5-Bromo-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2,3-dime...)
Show SMILES CCN1CCC[C@H]1CNC(=O)c1cc(Br)cc(OC)c1OC
Show InChI InChI=1S/C16H23BrN2O3/c1-4-19-7-5-6-12(19)10-18-16(20)13-8-11(17)9-14(21-2)15(13)22-3/h8-9,12H,4-7,10H2,1-3H3,(H,18,20)/t12-/m0/s1
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n/an/a 1.20n/an/an/an/an/an/a



Astra Research Centre AB

Curated by ChEMBL


Assay Description
Inhibition of [3H]spiperone binding to rat striatal dopamine receptor D2 was determined in vitro


J Med Chem 34: 948-55 (1991)


Article DOI: 10.1021/jm00107a012
BindingDB Entry DOI: 10.7270/Q2GT5NS9
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50010719
PNG
(3-Bromo-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2,5-dihy...)
Show SMILES CCN1CCC[C@H]1CNC(=O)c1c(O)c(Br)cc(O)c1OC
Show InChI InChI=1S/C15H21BrN2O4/c1-3-18-6-4-5-9(18)8-17-15(21)12-13(20)10(16)7-11(19)14(12)22-2/h7,9,19-20H,3-6,8H2,1-2H3,(H,17,21)/t9-/m0/s1
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n/an/a 1.90n/an/an/an/an/an/a



Astra Research Centre AB

Curated by ChEMBL


Assay Description
The affinity for the Dopamine receptor D2 was assessed by the inhibition of [3H]-spiperone binding in rat striatal membranes in vitro.


J Med Chem 33: 2305-9 (1990)


Article DOI: 10.1021/jm00170a040
BindingDB Entry DOI: 10.7270/Q29P30MH
More data for this
Ligand-Target Pair