BindingDB logo
myBDB logout

3 similar compounds to monomer 50008072

Compile data set for download or QSAR
Wt: 180.2
BDBM50008073
Wt: 208.2
BDBM50008075
Purchase
Wt: 194.2
BDBM50008080

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50008073,50008075,50008080   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50008073
PNG
(4-(3-Methyl-3H-imidazol-4-ylmethyl)-dihydro-furan-...)
Show SMILES Cn1cncc1C[C@H]1COC(=O)C1
Show InChI InChI=1S/C9H12N2O2/c1-11-6-10-4-8(11)2-7-3-9(12)13-5-7/h4,6-7H,2-3,5H2,1H3/t7-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.00E+4n/an/an/an/an/an/a



Sandoz Pharma Ltd.

Curated by ChEMBL


Assay Description
Ability to displace [3H]-pirenzepine (pir) from muscarinic acetylcholine receptor M1 in rat cortical tissue.


J Med Chem 35: 15-27 (1992)


Article DOI: 10.1021/jm00079a002
BindingDB Entry DOI: 10.7270/Q29022RV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50008080
PNG
(5-(4-Ethyl-tetrahydro-furan-3-ylmethyl)-1-methyl-1...)
Show SMILES CC[C@@H]1COC[C@@H]1Cc1cncn1C
Show InChI InChI=1S/C11H18N2O/c1-3-9-6-14-7-10(9)4-11-5-12-8-13(11)2/h5,8-10H,3-4,6-7H2,1-2H3/t9-,10+/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.80E+3n/an/an/an/an/an/a



Sandoz Pharma Ltd.

Curated by ChEMBL


Assay Description
Ability to displace [3H]-pirenzepine (pir) from muscarinic acetylcholine receptor M1 in rat cortical tissue.


J Med Chem 35: 15-27 (1992)


Article DOI: 10.1021/jm00079a002
BindingDB Entry DOI: 10.7270/Q29022RV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50008073
PNG
(4-(3-Methyl-3H-imidazol-4-ylmethyl)-dihydro-furan-...)
Show SMILES Cn1cncc1C[C@H]1COC(=O)C1
Show InChI InChI=1S/C9H12N2O2/c1-11-6-10-4-8(11)2-7-3-9(12)13-5-7/h4,6-7H,2-3,5H2,1H3/t7-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.89E+3n/an/an/an/an/an/a



Sandoz Pharma Ltd.

Curated by ChEMBL


Assay Description
Ability to displace [3H]cis--2-methyl-5-((dimethylamino)methyl)-1,3-di oxolane from muscarinic acetylcholine receptor in rat cortical tissue.


J Med Chem 35: 15-27 (1992)


Article DOI: 10.1021/jm00079a002
BindingDB Entry DOI: 10.7270/Q29022RV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50008080
PNG
(5-(4-Ethyl-tetrahydro-furan-3-ylmethyl)-1-methyl-1...)
Show SMILES CC[C@@H]1COC[C@@H]1Cc1cncn1C
Show InChI InChI=1S/C11H18N2O/c1-3-9-6-14-7-10(9)4-11-5-12-8-13(11)2/h5,8-10H,3-4,6-7H2,1-2H3/t9-,10+/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 445n/an/an/an/an/an/a



Sandoz Pharma Ltd.

Curated by ChEMBL


Assay Description
Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)


J Med Chem 35: 15-27 (1992)


Article DOI: 10.1021/jm00079a002
BindingDB Entry DOI: 10.7270/Q29022RV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50008075
PNG
((+)-isopilocarpine | (3R,4R)-3-ethyl-4-[(1-methyl-...)
Show SMILES CC[C@@H]1[C@@H](Cc2cncn2C)COC1=O
Show InChI InChI=1S/C11H16N2O2/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2/h5,7-8,10H,3-4,6H2,1-2H3/t8-,10+/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 430n/an/an/an/an/an/a



Sandoz Pharma Ltd.

Curated by ChEMBL


Assay Description
Ability to displace [3H]cis--2-methyl-5-((dimethylamino)methyl)-1,3-di oxolane from muscarinic acetylcholine receptor in rat cortical tissue.


J Med Chem 35: 15-27 (1992)


Article DOI: 10.1021/jm00079a002
BindingDB Entry DOI: 10.7270/Q29022RV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50008075
PNG
((+)-isopilocarpine | (3R,4R)-3-ethyl-4-[(1-methyl-...)
Show SMILES CC[C@@H]1[C@@H](Cc2cncn2C)COC1=O
Show InChI InChI=1S/C11H16N2O2/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2/h5,7-8,10H,3-4,6H2,1-2H3/t8-,10+/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 1.80E+3n/an/an/an/an/an/a



Sandoz Pharma Ltd.

Curated by ChEMBL


Assay Description
Ability to displace [3H]-pirenzepine (pir) from muscarinic acetylcholine receptor M1 in rat cortical tissue.


J Med Chem 35: 15-27 (1992)


Article DOI: 10.1021/jm00079a002
BindingDB Entry DOI: 10.7270/Q29022RV
More data for this
Ligand-Target Pair