BindingDB logo
myBDB logout

35 similar compounds to monomer 50368067

Compile data set for download or QSAR
Wt: 368.4
BDBM50008783
Wt: 338.4
BDBM50008784
Wt: 352.4
BDBM50008785
Wt: 354.4
BDBM50008786
Wt: 334.4
BDBM50008787
Wt: 350.4
BDBM50008788
Wt: 350.4
BDBM50010655
Wt: 308.3
BDBM50010724
Wt: 368.4
BDBM50453046
Wt: 338.4
BDBM50453047
Wt: 306.3
BDBM50026557
Wt: 292.3
BDBM50026562
Wt: 320.4
BDBM50026563
Wt: 320.4
BDBM50026565
Wt: 334.4
BDBM50026569
Displayed 1 to 15 (of 35 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 25 hits for monomerid = 50008783,50008784,50008785,50008786,50008787,50008788,50010655,50010724,50453046,50453047,50026557,50026562,50026563,50026565,50026569   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50008785
PNG
(CHEMBL42953 | N-(1-Ethyl-pyrrolidin-2-ylmethyl)-5-...)
Show SMILES CCN1CCC[C@H]1CNC(=O)c1cc(CCCF)cc(OC)c1OC
Show InChI InChI=1S/C19H29FN2O3/c1-4-22-10-6-8-15(22)13-21-19(23)16-11-14(7-5-9-20)12-17(24-2)18(16)25-3/h11-12,15H,4-10,13H2,1-3H3,(H,21,23)/t15-/m0/s1
Reactome pathway
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.0200n/an/an/an/an/an/an/an/a



University of Pennsylvania

Curated by ChEMBL


Assay Description
Inhibition constant against dopamine receptor D2 in rat


J Med Chem 36: 221-8 (1993)


Article DOI: 10.1021/jm00054a005
BindingDB Entry DOI: 10.7270/Q2TT4Q10
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50008786
PNG
(CHEMBL43506 | N-(1-Ethyl-pyrrolidin-2-ylmethyl)-3-...)
Show SMILES CCN1CCC[C@H]1CNC(=O)c1c(O)c(CCF)cc(OC)c1OC
Show InChI InChI=1S/C18H27FN2O4/c1-4-21-9-5-6-13(21)11-20-18(23)15-16(22)12(7-8-19)10-14(24-2)17(15)25-3/h10,13,22H,4-9,11H2,1-3H3,(H,20,23)/t13-/m0/s1
Reactome pathway
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.240n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Displacement of [3H]- spiperone from dopamine receptor D2 of striatal membranes without sodium chloride


J Med Chem 34: 1612-24 (1991)


Article DOI: 10.1021/jm00109a013
BindingDB Entry DOI: 10.7270/Q2GH9GXF
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50008783
PNG
(CHEMBL42448 | N-(1-Ethyl-pyrrolidin-2-ylmethyl)-3-...)
Show SMILES CCN1CCC[C@H]1CNC(=O)c1c(O)c(CCCF)cc(OC)c1OC
Show InChI InChI=1S/C19H29FN2O4/c1-4-22-10-6-8-14(22)12-21-19(24)16-17(23)13(7-5-9-20)11-15(25-2)18(16)26-3/h11,14,23H,4-10,12H2,1-3H3,(H,21,24)/t14-/m0/s1
Reactome pathway
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.25n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Compound was evaluated for binding affinity towards dopamine receptor D2 in striatal membranes, using [3H]- spiperone as radioligand in the presence ...


J Med Chem 34: 1612-24 (1991)


Article DOI: 10.1021/jm00109a013
BindingDB Entry DOI: 10.7270/Q2GH9GXF
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50010724
PNG
(CHEMBL305916 | N-(1-Ethyl-pyrrolidin-2-ylmethyl)-6...)
Show SMILES CCN1CCC[C@H]1CNC(=O)c1c(O)ccc(OC)c1OC
Show InChI InChI=1S/C16H24N2O4/c1-4-18-9-5-6-11(18)10-17-16(20)14-12(19)7-8-13(21-2)15(14)22-3/h7-8,11,19H,4-6,9-10H2,1-3H3,(H,17,20)/t11-/m0/s1
Reactome pathway
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
0.75n/an/an/an/an/an/an/an/a



Astra Research Centre AB

Curated by ChEMBL


Assay Description
Inhibition of [3H]spiperone binding to rat striatal membrane Dopamine receptor D2


J Med Chem 33: 1155-63 (1990)


Article DOI: 10.1021/jm00166a012
BindingDB Entry DOI: 10.7270/Q24X58DR
More data for this
Ligand-Target Pair
Dopamine D2 receptor and Serotonin 2a receptor (D2 and 5HT2a)


(Rattus norvegicus (rat))
BDBM50008786
PNG
(CHEMBL43506 | N-(1-Ethyl-pyrrolidin-2-ylmethyl)-3-...)
Show SMILES CCN1CCC[C@H]1CNC(=O)c1c(O)c(CCF)cc(OC)c1OC
Show InChI InChI=1S/C18H27FN2O4/c1-4-21-9-5-6-13(21)11-20-18(23)15-16(22)12(7-8-19)10-14(24-2)17(15)25-3/h10,13,22H,4-9,11H2,1-3H3,(H,20,23)/t13-/m0/s1
Reactome pathway
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.770n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Compound was evaluated for binding affinity towards dopamine receptor D2 in striatal membranes, using [3H]- spiperone as radioligand in the presence ...


J Med Chem 34: 1612-24 (1991)


Article DOI: 10.1021/jm00109a013
BindingDB Entry DOI: 10.7270/Q2GH9GXF
More data for this
Ligand-Target Pair
Dopamine D2 receptor and Serotonin 2a receptor (D2 and 5HT2a)


(Rattus norvegicus (rat))
BDBM50008783
PNG
(CHEMBL42448 | N-(1-Ethyl-pyrrolidin-2-ylmethyl)-3-...)
Show SMILES CCN1CCC[C@H]1CNC(=O)c1c(O)c(CCCF)cc(OC)c1OC
Show InChI InChI=1S/C19H29FN2O4/c1-4-22-10-6-8-14(22)12-21-19(24)16-17(23)13(7-5-9-20)11-15(25-2)18(16)26-3/h11,14,23H,4-10,12H2,1-3H3,(H,21,24)/t14-/m0/s1
Reactome pathway
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.800n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Displacement of [3H]- spiperone from dopamine receptor D2 of striatal membranes without sodium chloride


J Med Chem 34: 1612-24 (1991)


Article DOI: 10.1021/jm00109a013
BindingDB Entry DOI: 10.7270/Q2GH9GXF
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50008785
PNG
(CHEMBL42953 | N-(1-Ethyl-pyrrolidin-2-ylmethyl)-5-...)
Show SMILES CCN1CCC[C@H]1CNC(=O)c1cc(CCCF)cc(OC)c1OC
Show InChI InChI=1S/C19H29FN2O3/c1-4-22-10-6-8-15(22)13-21-19(23)16-11-14(7-5-9-20)12-17(24-2)18(16)25-3/h11-12,15H,4-10,13H2,1-3H3,(H,21,23)/t15-/m0/s1
Reactome pathway
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.20n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Compound was evaluated for binding affinity towards dopamine receptor D2 in striatal membranes, using [3H]- spiperone as radioligand in the presence ...


J Med Chem 34: 1612-24 (1991)


Article DOI: 10.1021/jm00109a013
BindingDB Entry DOI: 10.7270/Q2GH9GXF
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50008788
PNG
(CHEMBL42260 | N-(1-Ethyl-pyrrolidin-2-ylmethyl)-2-...)
Show SMILES CCCc1cc(OC)c(OC)c(C(=O)NC[C@@H]2CCCN2CC)c1O
Show InChI InChI=1S/C19H30N2O4/c1-5-8-13-11-15(24-3)18(25-4)16(17(13)22)19(23)20-12-14-9-7-10-21(14)6-2/h11,14,22H,5-10,12H2,1-4H3,(H,20,23)/t14-/m0/s1
Reactome pathway
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.30n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Displacement of [3H]- spiperone from dopamine receptor D2 of striatal membranes without sodium chloride


J Med Chem 34: 1612-24 (1991)


Article DOI: 10.1021/jm00109a013
BindingDB Entry DOI: 10.7270/Q2GH9GXF
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50008784
PNG
(CHEMBL288704 | N-(1-Ethyl-pyrrolidin-2-ylmethyl)-5...)
Show SMILES CCN1CCC[C@H]1CNC(=O)c1cc(CCF)cc(OC)c1OC
Show InChI InChI=1S/C18H27FN2O3/c1-4-21-9-5-6-14(21)12-20-18(22)15-10-13(7-8-19)11-16(23-2)17(15)24-3/h10-11,14H,4-9,12H2,1-3H3,(H,20,22)/t14-/m0/s1
Reactome pathway
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.40n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Compound was evaluated for binding affinity towards dopamine receptor D2 in striatal membranes, using [3H]- spiperone as radioligand in the presence ...


J Med Chem 34: 1612-24 (1991)


Article DOI: 10.1021/jm00109a013
BindingDB Entry DOI: 10.7270/Q2GH9GXF
More data for this
Ligand-Target Pair
Dopamine D2 receptor and Serotonin 2a receptor (D2 and 5HT2a)


(Rattus norvegicus (rat))
BDBM50008785
PNG
(CHEMBL42953 | N-(1-Ethyl-pyrrolidin-2-ylmethyl)-5-...)
Show SMILES CCN1CCC[C@H]1CNC(=O)c1cc(CCCF)cc(OC)c1OC
Show InChI InChI=1S/C19H29FN2O3/c1-4-22-10-6-8-15(22)13-21-19(23)16-11-14(7-5-9-20)12-17(24-2)18(16)25-3/h11-12,15H,4-10,13H2,1-3H3,(H,21,23)/t15-/m0/s1
Reactome pathway
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
4.40n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Compound was evaluated for binding affinity towards dopamine receptor D2 in striatal membranes, using [3H]- spiperone as radioligand in the presence ...


J Med Chem 34: 1612-24 (1991)


Article DOI: 10.1021/jm00109a013
BindingDB Entry DOI: 10.7270/Q2GH9GXF
More data for this
Ligand-Target Pair
Dopamine D2 receptor and Serotonin 2a receptor (D2 and 5HT2a)


(Rattus norvegicus (rat))
BDBM50008784
PNG
(CHEMBL288704 | N-(1-Ethyl-pyrrolidin-2-ylmethyl)-5...)
Show SMILES CCN1CCC[C@H]1CNC(=O)c1cc(CCF)cc(OC)c1OC
Show InChI InChI=1S/C18H27FN2O3/c1-4-21-9-5-6-14(21)12-20-18(22)15-10-13(7-8-19)11-16(23-2)17(15)24-3/h10-11,14H,4-9,12H2,1-3H3,(H,20,22)/t14-/m0/s1
Reactome pathway
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
5.30n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Displacement of [3H]- spiperone from dopamine receptor D2 of striatal membranes without sodium chloride


J Med Chem 34: 1612-24 (1991)


Article DOI: 10.1021/jm00109a013
BindingDB Entry DOI: 10.7270/Q2GH9GXF
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50008787
PNG
(CHEMBL43552 | N-(1-Ethyl-pyrrolidin-2-ylmethyl)-2,...)
Show SMILES CCCc1cc(OC)c(OC)c(c1)C(=O)NC[C@@H]1CCCN1CC
Show InChI InChI=1S/C19H30N2O3/c1-5-8-14-11-16(18(24-4)17(12-14)23-3)19(22)20-13-15-9-7-10-21(15)6-2/h11-12,15H,5-10,13H2,1-4H3,(H,20,22)/t15-/m0/s1
Reactome pathway
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
7n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Displacement of [3H]- spiperone from dopamine receptor D2 of striatal membranes without sodium chloride


J Med Chem 34: 1612-24 (1991)


Article DOI: 10.1021/jm00109a013
BindingDB Entry DOI: 10.7270/Q2GH9GXF
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50008786
PNG
(CHEMBL43506 | N-(1-Ethyl-pyrrolidin-2-ylmethyl)-3-...)
Show SMILES CCN1CCC[C@H]1CNC(=O)c1c(O)c(CCF)cc(OC)c1OC
Show InChI InChI=1S/C18H27FN2O4/c1-4-21-9-5-6-13(21)11-20-18(23)15-16(22)12(7-8-19)10-14(24-2)17(15)25-3/h10,13,22H,4-9,11H2,1-3H3,(H,20,23)/t13-/m0/s1
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
9.5n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
binding affinity towards alpha-2 adrenergic receptor, using [3H]- atipamezole as radioligand from rat frontal cortex membranes


J Med Chem 34: 1612-24 (1991)


Article DOI: 10.1021/jm00109a013
BindingDB Entry DOI: 10.7270/Q2GH9GXF
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50008783
PNG
(CHEMBL42448 | N-(1-Ethyl-pyrrolidin-2-ylmethyl)-3-...)
Show SMILES CCN1CCC[C@H]1CNC(=O)c1c(O)c(CCCF)cc(OC)c1OC
Show InChI InChI=1S/C19H29FN2O4/c1-4-22-10-6-8-14(22)12-21-19(24)16-17(23)13(7-5-9-20)11-15(25-2)18(16)26-3/h11,14,23H,4-10,12H2,1-3H3,(H,21,24)/t14-/m0/s1
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
11n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Compound was evaluated for binding affinity towards dopamine receptor D2 in striatal membranes, using [3H]- spiperone as radioligand in the presence ...


J Med Chem 34: 1612-24 (1991)


Article DOI: 10.1021/jm00109a013
BindingDB Entry DOI: 10.7270/Q2GH9GXF
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50453046
PNG
(CHEMBL2114461)
Show SMILES CCN1CCC[C@@H]1CNC(=O)c1c(O)c(CCCF)cc(OC)c1OC
Show InChI InChI=1S/C19H29FN2O4/c1-4-22-10-6-8-14(22)12-21-19(24)16-17(23)13(7-5-9-20)11-15(25-2)18(16)26-3/h11,14,23H,4-10,12H2,1-3H3,(H,21,24)/t14-/m1/s1
Reactome pathway
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Displacement of [3H]- spiperone from dopamine receptor D2 of striatal membranes without sodium chloride


J Med Chem 34: 1612-24 (1991)


Article DOI: 10.1021/jm00109a013
BindingDB Entry DOI: 10.7270/Q2GH9GXF
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50453047
PNG
(CHEMBL2114460)
Show SMILES CCN1CCC[C@@H]1CNC(=O)c1cc(CCF)cc(OC)c1OC
Show InChI InChI=1S/C18H27FN2O3/c1-4-21-9-5-6-14(21)12-20-18(22)15-10-13(7-8-19)11-16(23-2)17(15)24-3/h10-11,14H,4-9,12H2,1-3H3,(H,20,22)/t14-/m1/s1
Reactome pathway
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Displacement of [3H]- spiperone from dopamine receptor D2 of striatal membranes without sodium chloride


J Med Chem 34: 1612-24 (1991)


Article DOI: 10.1021/jm00109a013
BindingDB Entry DOI: 10.7270/Q2GH9GXF
More data for this
Ligand-Target Pair
Dopamine D2 receptor and Serotonin 2a receptor (D2 and 5HT2a)


(Rattus norvegicus (rat))
BDBM50010724
PNG
(CHEMBL305916 | N-(1-Ethyl-pyrrolidin-2-ylmethyl)-6...)
Show SMILES CCN1CCC[C@H]1CNC(=O)c1c(O)ccc(OC)c1OC
Show InChI InChI=1S/C16H24N2O4/c1-4-18-9-5-6-11(18)10-17-16(20)14-12(19)7-8-13(21-2)15(14)22-3/h7-8,11,19H,4-6,9-10H2,1-3H3,(H,17,20)/t11-/m0/s1
Reactome pathway
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 8.80n/an/an/an/an/an/a



Astra Research Centre AB

Curated by ChEMBL


Assay Description
In vitro ability to inhibit the binding of [3H]spiperone to dopamine receptor D2 in rat striatal membranes.


J Med Chem 33: 1155-63 (1990)


Article DOI: 10.1021/jm00166a012
BindingDB Entry DOI: 10.7270/Q24X58DR
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50026557
PNG
(3-Ethyl-N-(1-ethyl-pyrrolidin-2-ylmethyl)-6-hydrox...)
Show SMILES CCN1CCC[C@H]1CNC(=O)c1c(O)ccc(CC)c1OC
Show InChI InChI=1S/C17H26N2O3/c1-4-12-8-9-14(20)15(16(12)22-3)17(21)18-11-13-7-6-10-19(13)5-2/h8-9,13,20H,4-7,10-11H2,1-3H3,(H,18,21)/t13-/m0/s1
Reactome pathway
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 123n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity at Dopamine receptor D2 in rat by displacing [3H]- spiperone from rat striatal membrane


J Med Chem 28: 1263-9 (1985)


Article DOI: 10.1021/jm00147a025
BindingDB Entry DOI: 10.7270/Q2QZ2BHD
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50026562
PNG
(CHEMBL23228 | N-(1-Ethyl-pyrrolidin-2-ylmethyl)-2-...)
Show SMILES CCN1CCC[C@H]1CNC(=O)c1c(O)c(C)ccc1OC
Show InChI InChI=1S/C16H24N2O3/c1-4-18-9-5-6-12(18)10-17-16(20)14-13(21-3)8-7-11(2)15(14)19/h7-8,12,19H,4-6,9-10H2,1-3H3,(H,17,20)/t12-/m0/s1
Reactome pathway
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 19n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity at Dopamine receptor D2 in rat by displacing [3H]- spiperone from rat striatal membrane


J Med Chem 28: 1263-9 (1985)


Article DOI: 10.1021/jm00147a025
BindingDB Entry DOI: 10.7270/Q2QZ2BHD
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50026563
PNG
(CHEMBL22472 | N-(1-Ethyl-pyrrolidin-2-ylmethyl)-2-...)
Show SMILES CCCc1ccc(OC)c(C(=O)NC[C@@H]2CCCN2CC)c1O
Show InChI InChI=1S/C18H28N2O3/c1-4-7-13-9-10-15(23-3)16(17(13)21)18(22)19-12-14-8-6-11-20(14)5-2/h9-10,14,21H,4-8,11-12H2,1-3H3,(H,19,22)/t14-/m0/s1
Reactome pathway
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4.80n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity at Dopamine receptor D2 in rat by displacing [3H]- spiperone from rat striatal membrane


J Med Chem 28: 1263-9 (1985)


Article DOI: 10.1021/jm00147a025
BindingDB Entry DOI: 10.7270/Q2QZ2BHD
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50010724
PNG
(CHEMBL305916 | N-(1-Ethyl-pyrrolidin-2-ylmethyl)-6...)
Show SMILES CCN1CCC[C@H]1CNC(=O)c1c(O)ccc(OC)c1OC
Show InChI InChI=1S/C16H24N2O4/c1-4-18-9-5-6-11(18)10-17-16(20)14-12(19)7-8-13(21-2)15(14)22-3/h7-8,11,19H,4-6,9-10H2,1-3H3,(H,17,20)/t11-/m0/s1
Reactome pathway
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 8.80n/an/an/an/an/an/a



Astra Research Centre AB

Curated by ChEMBL


Assay Description
The affinity for the Dopamine receptor D2 was assessed by the inhibition of [3H]-spiperone binding in rat striatal membranes in vitro.


J Med Chem 33: 2305-9 (1990)


Article DOI: 10.1021/jm00170a040
BindingDB Entry DOI: 10.7270/Q29P30MH
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50026569
PNG
(3-Butyl-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2-hydrox...)
Show SMILES CCCCc1ccc(OC)c(C(=O)NC[C@@H]2CCCN2CC)c1O
Show InChI InChI=1S/C19H30N2O3/c1-4-6-8-14-10-11-16(24-3)17(18(14)22)19(23)20-13-15-9-7-12-21(15)5-2/h10-11,15,22H,4-9,12-13H2,1-3H3,(H,20,23)/t15-/m0/s1
Reactome pathway
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 26n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity at Dopamine receptor D2 in rat by displacing [3H]- spiperone from rat striatal membrane


J Med Chem 28: 1263-9 (1985)


Article DOI: 10.1021/jm00147a025
BindingDB Entry DOI: 10.7270/Q2QZ2BHD
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50010655
PNG
((S)-3-Ethyl-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2,5,...)
Show SMILES CCN1CCCC1CNC(=O)c1c(OC)c(CC)cc(OC)c1OC
Show InChI InChI=1S/C19H30N2O4/c1-6-13-11-15(23-3)18(25-5)16(17(13)24-4)19(22)20-12-14-9-8-10-21(14)7-2/h11,14H,6-10,12H2,1-5H3,(H,20,22)
Reactome pathway
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 820n/an/an/an/an/an/a



Astra Research Centre AB

Curated by ChEMBL


Assay Description
In vitro ability to inhibit the binding of [3H]spiperone to dopamine receptor D2 in rat striatal membranes.


J Med Chem 33: 1155-63 (1990)


Article DOI: 10.1021/jm00166a012
BindingDB Entry DOI: 10.7270/Q24X58DR
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50026565
PNG
(3-Ethyl-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2,6-dime...)
Show SMILES CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(CC)c1OC
Show InChI InChI=1S/C18H28N2O3/c1-5-13-9-10-15(22-3)16(17(13)23-4)18(21)19-12-14-8-7-11-20(14)6-2/h9-10,14H,5-8,11-12H2,1-4H3,(H,19,21)/t14-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.29n/an/an/an/an/an/a



University of Mazandaran

Curated by ChEMBL


Assay Description
Antagonist activity at dopamine D2 receptor


Eur J Med Chem 45: 4856-62 (2010)


Article DOI: 10.1016/j.ejmech.2010.07.056
BindingDB Entry DOI: 10.7270/Q2833T8S
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50026565
PNG
(3-Ethyl-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2,6-dime...)
Show SMILES CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(CC)c1OC
Show InChI InChI=1S/C18H28N2O3/c1-5-13-9-10-15(22-3)16(17(13)23-4)18(21)19-12-14-8-7-11-20(14)6-2/h9-10,14H,5-8,11-12H2,1-4H3,(H,19,21)/t14-/m0/s1
Reactome pathway
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 921n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity at Dopamine receptor D2 in rat by displacing [3H]- spiperone from rat striatal membrane


J Med Chem 28: 1263-9 (1985)


Article DOI: 10.1021/jm00147a025
BindingDB Entry DOI: 10.7270/Q2QZ2BHD
More data for this
Ligand-Target Pair