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14 similar compounds to monomer 50009861

Compile data set for download or QSAR
Wt: 380.4
BDBM50009852
Wt: 384.4
BDBM50009854
Purchase
Wt: 366.4
BDBM50009870
Wt: 398.4
BDBM50032565
Purchase
Wt: 434.5
BDBM50032571
Wt: 398.4
BDBM50032595
Wt: 402.4
BDBM50032613
Wt: 398.4
BDBM50032615
Wt: 385.4
BDBM50032618
Wt: 384.4
BDBM50032622
Purchase
Wt: 380.4
BDBM50368233
Wt: 366.4
BDBM50368234
Wt: 380.4
BDBM50368231
Wt: 366.4
BDBM50406487

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 50009852,50009854,50009870,50032565,50032571,50032595,50032613,50032615,50032618,50032622,50368233,50368234,50368231,50406487   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cannabinoid receptor 1


(Rattus norvegicus (rat))
BDBM50032595
PNG
(CHEMBL107106 | [1-(1-Methyl-2-morpholin-4-yl-ethyl...)
Show SMILES CC(CN1CCOCC1)n1cc(C(=O)c2cccc3ccccc23)c2ccccc12
Show InChI InChI=1/C26H26N2O2/c1-19(17-27-13-15-30-16-14-27)28-18-24(22-10-4-5-12-25(22)28)26(29)23-11-6-8-20-7-2-3-9-21(20)23/h2-12,18-19H,13-17H2,1H3
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n/an/a 114n/an/an/an/an/an/a



Sanofi Research Division

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.


J Med Chem 38: 3094-105 (1995)


Article DOI: 10.1021/jm00016a013
BindingDB Entry DOI: 10.7270/Q2DN442Z
More data for this
Ligand-Target Pair
Prostaglandin-H2 D-isomerase


(Mus musculus)
BDBM50406487
PNG
(CHEMBL2092863)
Show SMILES C[C@@H](CN1CCOCC1)n1cc(C(=O)c2ccccc2F)c2ccccc12
Show InChI InChI=1/C22H23FN2O2/c1-16(14-24-10-12-27-13-11-24)25-15-19(17-6-3-5-9-21(17)25)22(26)18-7-2-4-8-20(18)23/h2-9,15-16H,10-14H2,1H3/t16-/s2
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n/an/a 7.90E+4n/an/an/an/an/an/a



Sterling Research Group

Curated by ChEMBL


Assay Description
Concentration required to inhibit 50% activity of prostaglandin synthetase was determined in vitro in mouse brain microsomes


J Med Chem 34: 1099-110 (1991)


Article DOI: 10.1021/jm00107a034
BindingDB Entry DOI: 10.7270/Q24M955S
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))
BDBM50009854
PNG
(CHEMBL13078 | [1-(2-Morpholin-4-yl-ethyl)-1H-indol...)
Show SMILES O=C(c1cn(CCN2CCOCC2)c2ccccc12)c1cccc2ccccc12
Show InChI InChI=1S/C25H24N2O2/c28-25(22-10-5-7-19-6-1-2-8-20(19)22)23-18-27(24-11-4-3-9-21(23)24)13-12-26-14-16-29-17-15-26/h1-11,18H,12-17H2
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n/an/a 7.80n/an/an/an/an/an/a



Sanofi Research Division

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.


J Med Chem 38: 3094-105 (1995)


Article DOI: 10.1021/jm00016a013
BindingDB Entry DOI: 10.7270/Q2DN442Z
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))
BDBM50032613
PNG
(CHEMBL78308 | [5-Fluoro-1-(2-morpholin-4-yl-ethyl)...)
Show SMILES Fc1ccc2n(CCN3CCOCC3)cc(C(=O)c3cccc4ccccc34)c2c1
Show InChI InChI=1S/C25H23FN2O2/c26-19-8-9-24-22(16-19)23(17-28(24)11-10-27-12-14-30-15-13-27)25(29)21-7-3-5-18-4-1-2-6-20(18)21/h1-9,16-17H,10-15H2
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n/an/a 35n/an/an/an/an/an/a



Sanofi Research Division

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.


J Med Chem 38: 3094-105 (1995)


Article DOI: 10.1021/jm00016a013
BindingDB Entry DOI: 10.7270/Q2DN442Z
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))
BDBM50032615
PNG
(CHEMBL82361 | [6-Methyl-1-(2-morpholin-4-yl-ethyl)...)
Show SMILES Cc1ccc2c(cn(CCN3CCOCC3)c2c1)C(=O)c1cccc2ccccc12
Show InChI InChI=1S/C26H26N2O2/c1-19-9-10-22-24(26(29)23-8-4-6-20-5-2-3-7-21(20)23)18-28(25(22)17-19)12-11-27-13-15-30-16-14-27/h2-10,17-18H,11-16H2,1H3
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n/an/a 3.5n/an/an/an/an/an/a



Sanofi Research Division

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.


J Med Chem 38: 3094-105 (1995)


Article DOI: 10.1021/jm00016a013
BindingDB Entry DOI: 10.7270/Q2DN442Z
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))
BDBM50032618
PNG
(CHEMBL78992 | [1-(2-Morpholin-4-yl-ethyl)-1H-indol...)
Show SMILES O=C(c1cn(CCN2CCOCC2)c2ccccc12)c1ccc2ncccc2c1
Show InChI InChI=1S/C24H23N3O2/c28-24(19-7-8-22-18(16-19)4-3-9-25-22)21-17-27(23-6-2-1-5-20(21)23)11-10-26-12-14-29-15-13-26/h1-9,16-17H,10-15H2
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n/an/a 491n/an/an/an/an/an/a



Sanofi Research Division

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.


J Med Chem 38: 3094-105 (1995)


Article DOI: 10.1021/jm00016a013
BindingDB Entry DOI: 10.7270/Q2DN442Z
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))
BDBM50032622
PNG
(CHEMBL307073 | [1-(2-Morpholin-4-yl-ethyl)-1H-indo...)
Show SMILES O=C(c1cn(CCN2CCOCC2)c2ccccc12)c1ccc2ccccc2c1
Show InChI InChI=1S/C25H24N2O2/c28-25(21-10-9-19-5-1-2-6-20(19)17-21)23-18-27(24-8-4-3-7-22(23)24)12-11-26-13-15-29-16-14-26/h1-10,17-18H,11-16H2
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n/an/a 59n/an/an/an/an/an/a



Sanofi Research Division

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.


J Med Chem 38: 3094-105 (1995)


Article DOI: 10.1021/jm00016a013
BindingDB Entry DOI: 10.7270/Q2DN442Z
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))
BDBM50032595
PNG
(CHEMBL107106 | [1-(1-Methyl-2-morpholin-4-yl-ethyl...)
Show SMILES CC(CN1CCOCC1)n1cc(C(=O)c2cccc3ccccc23)c2ccccc12
Show InChI InChI=1/C26H26N2O2/c1-19(17-27-13-15-30-16-14-27)28-18-24(22-10-4-5-12-25(22)28)26(29)23-11-6-8-20-7-2-3-9-21(20)23/h2-12,18-19H,13-17H2,1H3
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n/an/a 114n/an/an/an/an/an/a



Sanofi Research Division

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.


J Med Chem 38: 3094-105 (1995)


Article DOI: 10.1021/jm00016a013
BindingDB Entry DOI: 10.7270/Q2DN442Z
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))
BDBM50032565
PNG
((4-Methyl-naphthalen-1-yl)-[1-(2-morpholin-4-yl-et...)
Show SMILES Cc1ccc(C(=O)c2cn(CCN3CCOCC3)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C26H26N2O2/c1-19-10-11-23(21-7-3-2-6-20(19)21)26(29)24-18-28(25-9-5-4-8-22(24)25)13-12-27-14-16-30-17-15-27/h2-11,18H,12-17H2,1H3
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n/an/a 2.80n/an/an/an/an/an/a



Sanofi Research Division

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.


J Med Chem 38: 3094-105 (1995)


Article DOI: 10.1021/jm00016a013
BindingDB Entry DOI: 10.7270/Q2DN442Z
More data for this
Ligand-Target Pair
Adenylate cyclase type V


(Rattus norvegicus)
BDBM50009854
PNG
(CHEMBL13078 | [1-(2-Morpholin-4-yl-ethyl)-1H-indol...)
Show SMILES O=C(c1cn(CCN2CCOCC2)c2ccccc12)c1cccc2ccccc12
Show InChI InChI=1S/C25H24N2O2/c28-25(22-10-5-7-19-6-1-2-8-20(19)22)23-18-27(24-11-4-3-9-21(23)24)13-12-26-14-16-29-17-15-26/h1-11,18H,12-17H2
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n/an/an/an/a 275n/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition of hormone stimulated Adenylate cyclase activity in N18TG2 membranes.


J Med Chem 39: 1967-74 (1996)


Article DOI: 10.1021/jm950932r
BindingDB Entry DOI: 10.7270/Q27M071B
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))
BDBM50009854
PNG
(CHEMBL13078 | [1-(2-Morpholin-4-yl-ethyl)-1H-indol...)
Show SMILES O=C(c1cn(CCN2CCOCC2)c2ccccc12)c1cccc2ccccc12
Show InChI InChI=1S/C25H24N2O2/c28-25(22-10-5-7-19-6-1-2-8-20(19)22)23-18-27(24-11-4-3-9-21(23)24)13-12-26-14-16-29-17-15-26/h1-11,18H,12-17H2
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n/an/a 46n/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Binding affinity against brain cannabinoid receptor 1 using [3H]-CP-55,940 as radioligand at 0.25 nM concentration


J Med Chem 39: 1967-74 (1996)


Article DOI: 10.1021/jm950932r
BindingDB Entry DOI: 10.7270/Q27M071B
More data for this
Ligand-Target Pair
Cannabinoid receptor


(Rattus norvegicus (Rat)-Rattus norvegicus (rat))
BDBM50009854
PNG
(CHEMBL13078 | [1-(2-Morpholin-4-yl-ethyl)-1H-indol...)
Show SMILES O=C(c1cn(CCN2CCOCC2)c2ccccc12)c1cccc2ccccc12
Show InChI InChI=1S/C25H24N2O2/c28-25(22-10-5-7-19-6-1-2-8-20(19)22)23-18-27(24-11-4-3-9-21(23)24)13-12-26-14-16-29-17-15-26/h1-11,18H,12-17H2
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n/an/a 7.80n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Vascular endothelial growth factor receptor 2 (KDR)


Citation and Details

BindingDB Entry DOI: 10.7270/Q2KD213J
More data for this
Ligand-Target Pair
Prostaglandin-H2 D-isomerase


(Mus musculus)
BDBM50368231
PNG
(CHEMBL337134)
Show SMILES C[C@@H](CN1CCOCC1)n1c(C)c(C(=O)c2ccccc2F)c2ccccc12
Show InChI InChI=1S/C23H25FN2O2/c1-16(15-25-11-13-28-14-12-25)26-17(2)22(19-8-4-6-10-21(19)26)23(27)18-7-3-5-9-20(18)24/h3-10,16H,11-15H2,1-2H3/t16-/m0/s1
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n/an/a 8.00E+3n/an/an/an/an/an/a



Sterling Research Group

Curated by ChEMBL


Assay Description
Concentration required to inhibit 50% activity of prostaglandin synthetase was determined in vitro in mouse brain microsomes


J Med Chem 34: 1099-110 (1991)


Article DOI: 10.1021/jm00107a034
BindingDB Entry DOI: 10.7270/Q24M955S
More data for this
Ligand-Target Pair
Prostaglandin-H2 D-isomerase


(Mus musculus)
BDBM50009854
PNG
(CHEMBL13078 | [1-(2-Morpholin-4-yl-ethyl)-1H-indol...)
Show SMILES O=C(c1cn(CCN2CCOCC2)c2ccccc12)c1cccc2ccccc12
Show InChI InChI=1S/C25H24N2O2/c28-25(22-10-5-7-19-6-1-2-8-20(19)22)23-18-27(24-11-4-3-9-21(23)24)13-12-26-14-16-29-17-15-26/h1-11,18H,12-17H2
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n/an/a 6n/an/an/an/an/an/a



Sterling Research Group

Curated by ChEMBL


Assay Description
Concentration required to inhibit 50% activity of prostaglandin synthetase was determined in vitro in mouse brain microsomes


J Med Chem 34: 1099-110 (1991)


Article DOI: 10.1021/jm00107a034
BindingDB Entry DOI: 10.7270/Q24M955S
More data for this
Ligand-Target Pair
Prostaglandin-H2 D-isomerase


(Mus musculus)
BDBM50368233
PNG
(CHEMBL1907833)
Show SMILES C[C@H](CN1CCOCC1)n1c(C)c(C(=O)c2ccccc2F)c2ccccc12
Show InChI InChI=1/C23H25FN2O2/c1-16(15-25-11-13-28-14-12-25)26-17(2)22(19-8-4-6-10-21(19)26)23(27)18-7-3-5-9-20(18)24/h3-10,16H,11-15H2,1-2H3/t16-/s2
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n/an/a 700n/an/an/an/an/an/a



Sterling Research Group

Curated by ChEMBL


Assay Description
Concentration required to inhibit 50% activity of prostaglandin synthetase was determined in vitro in mouse brain microsomes


J Med Chem 34: 1099-110 (1991)


Article DOI: 10.1021/jm00107a034
BindingDB Entry DOI: 10.7270/Q24M955S
More data for this
Ligand-Target Pair
Prostaglandin-H2 D-isomerase


(Mus musculus)
BDBM50009852
PNG
((2-Fluoro-phenyl)-[2-methyl-1-(1-methyl-2-morpholi...)
Show SMILES CC(CN1CCOCC1)n1c(C)c(C(=O)c2ccccc2F)c2ccccc12
Show InChI InChI=1/C23H25FN2O2/c1-16(15-25-11-13-28-14-12-25)26-17(2)22(19-8-4-6-10-21(19)26)23(27)18-7-3-5-9-20(18)24/h3-10,16H,11-15H2,1-2H3
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n/an/a 700n/an/an/an/an/an/a



Sterling Research Group

Curated by ChEMBL


Assay Description
Concentration required to inhibit 50% activity of prostaglandin synthetase was determined in vitro in mouse brain microsomes


J Med Chem 34: 1099-110 (1991)


Article DOI: 10.1021/jm00107a034
BindingDB Entry DOI: 10.7270/Q24M955S
More data for this
Ligand-Target Pair
Prostaglandin-H2 D-isomerase


(Mus musculus)
BDBM50368234
PNG
(CHEMBL1907835)
Show SMILES C[C@H](CN1CCOCC1)n1cc(C(=O)c2ccccc2F)c2ccccc12
Show InChI InChI=1/C22H23FN2O2/c1-16(14-24-10-12-27-13-11-24)25-15-19(17-6-3-5-9-21(17)25)22(26)18-7-2-4-8-20(18)23/h2-9,15-16H,10-14H2,1H3/t16-/s2
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n/an/a 9.00E+3n/an/an/an/an/an/a



Sterling Research Group

Curated by ChEMBL


Assay Description
Concentration required to inhibit 50% activity of prostaglandin synthetase was determined in vitro in mouse brain microsomes


J Med Chem 34: 1099-110 (1991)


Article DOI: 10.1021/jm00107a034
BindingDB Entry DOI: 10.7270/Q24M955S
More data for this
Ligand-Target Pair
Prostaglandin-H2 D-isomerase


(Mus musculus)
BDBM50009870
PNG
((2-Fluoro-phenyl)-[2-methyl-1-(2-morpholin-4-yl-et...)
Show SMILES Cc1c(C(=O)c2ccccc2F)c2ccccc2n1CCN1CCOCC1
Show InChI InChI=1S/C22H23FN2O2/c1-16-21(22(26)17-6-2-4-8-19(17)23)18-7-3-5-9-20(18)25(16)11-10-24-12-14-27-15-13-24/h2-9H,10-15H2,1H3
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n/an/a 1.80E+4n/an/an/an/an/an/a



Sterling Research Group

Curated by ChEMBL


Assay Description
Concentration required to inhibit 50% activity of prostaglandin synthetase was determined in vitro in mouse brain microsomes


J Med Chem 34: 1099-110 (1991)


Article DOI: 10.1021/jm00107a034
BindingDB Entry DOI: 10.7270/Q24M955S
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))
BDBM50032571
PNG
(Anthracen-9-yl-[1-(2-morpholin-4-yl-ethyl)-1H-indo...)
Show SMILES O=C(c1cn(CCN2CCOCC2)c2ccccc12)c1c2ccccc2cc2ccccc12
Show InChI InChI=1S/C29H26N2O2/c32-29(28-23-9-3-1-7-21(23)19-22-8-2-4-10-24(22)28)26-20-31(27-12-6-5-11-25(26)27)14-13-30-15-17-33-18-16-30/h1-12,19-20H,13-18H2
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n/an/a 2.97E+3n/an/an/an/an/an/a



Sanofi Research Division

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.


J Med Chem 38: 3094-105 (1995)


Article DOI: 10.1021/jm00016a013
BindingDB Entry DOI: 10.7270/Q2DN442Z
More data for this
Ligand-Target Pair