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5 similar compounds to monomer 50010872

Compile data set for download or QSAR
Wt: 261.4
BDBM50010880
Wt: 326.2
BDBM50010887
Wt: 247.3
BDBM50010863
Wt: 326.2
BDBM50010867
Wt: 298.2
BDBM50010876

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50010880,50010887,50010863,50010867,50010876   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50010863
PNG
(1-(2-Dimethylamino-1-phenyl-ethyl)-cyclohexanol (H...)
Show SMILES CN(C)CC(c1ccccc1)C1(O)CCCCC1
Show InChI InChI=1S/C16H25NO/c1-17(2)13-15(14-9-5-3-6-10-14)16(18)11-7-4-8-12-16/h3,5-6,9-10,15,18H,4,7-8,11-13H2,1-2H3
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n/an/a 2.58E+3n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of uptake of tritiated serotonin (5-HT) into rat brain synaptosomes


J Med Chem 33: 2899-905 (1990)


Article DOI: 10.1021/jm00172a035
BindingDB Entry DOI: 10.7270/Q20C4WCM
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50010867
PNG
(1-[1-(3-Bromo-phenyl)-2-dimethylamino-ethyl]-cyclo...)
Show SMILES CN(C)CC(c1cccc(Br)c1)C1(O)CCCCC1
Show InChI InChI=1S/C16H24BrNO/c1-18(2)12-15(13-7-6-8-14(17)11-13)16(19)9-4-3-5-10-16/h6-8,11,15,19H,3-5,9-10,12H2,1-2H3
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n/an/a 110n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of uptake of tritiated norepinephrine (NE) into rat brain synaptosomes


J Med Chem 33: 2899-905 (1990)


Article DOI: 10.1021/jm00172a035
BindingDB Entry DOI: 10.7270/Q20C4WCM
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50010867
PNG
(1-[1-(3-Bromo-phenyl)-2-dimethylamino-ethyl]-cyclo...)
Show SMILES CN(C)CC(c1cccc(Br)c1)C1(O)CCCCC1
Show InChI InChI=1S/C16H24BrNO/c1-18(2)12-15(13-7-6-8-14(17)11-13)16(19)9-4-3-5-10-16/h6-8,11,15,19H,3-5,9-10,12H2,1-2H3
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n/an/a 230n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of uptake of tritiated serotonin (5-HT) into rat brain synaptosomes


J Med Chem 33: 2899-905 (1990)


Article DOI: 10.1021/jm00172a035
BindingDB Entry DOI: 10.7270/Q20C4WCM
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Rattus norvegicus (Rat))
BDBM50010867
PNG
(1-[1-(3-Bromo-phenyl)-2-dimethylamino-ethyl]-cyclo...)
Show SMILES CN(C)CC(c1cccc(Br)c1)C1(O)CCCCC1
Show InChI InChI=1S/C16H24BrNO/c1-18(2)12-15(13-7-6-8-14(17)11-13)16(19)9-4-3-5-10-16/h6-8,11,15,19H,3-5,9-10,12H2,1-2H3
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n/an/a 52n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]imipramine to imipramine receptor in rat brain


J Med Chem 33: 2899-905 (1990)


Article DOI: 10.1021/jm00172a035
BindingDB Entry DOI: 10.7270/Q20C4WCM
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50010876
PNG
(1-[1-(4-Bromo-phenyl)-2-dimethylamino-ethyl]-cyclo...)
Show SMILES CN(C)CC(c1ccc(Br)cc1)C1(O)CCC1
Show InChI InChI=1S/C14H20BrNO/c1-16(2)10-13(14(17)8-3-9-14)11-4-6-12(15)7-5-11/h4-7,13,17H,3,8-10H2,1-2H3
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n/an/a 890n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of uptake of tritiated norepinephrine (NE) into rat brain synaptosomes


J Med Chem 33: 2899-905 (1990)


Article DOI: 10.1021/jm00172a035
BindingDB Entry DOI: 10.7270/Q20C4WCM
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50010880
PNG
(1-(2-Dimethylamino-1-p-tolyl-ethyl)-cyclohexanol (...)
Show SMILES CN(C)CC(c1ccc(C)cc1)C1(O)CCCCC1
Show InChI InChI=1S/C17H27NO/c1-14-7-9-15(10-8-14)16(13-18(2)3)17(19)11-5-4-6-12-17/h7-10,16,19H,4-6,11-13H2,1-3H3
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n/an/a 1.54E+3n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of uptake of tritiated serotonin (5-HT) into rat brain synaptosomes


J Med Chem 33: 2899-905 (1990)


Article DOI: 10.1021/jm00172a035
BindingDB Entry DOI: 10.7270/Q20C4WCM
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50010876
PNG
(1-[1-(4-Bromo-phenyl)-2-dimethylamino-ethyl]-cyclo...)
Show SMILES CN(C)CC(c1ccc(Br)cc1)C1(O)CCC1
Show InChI InChI=1S/C14H20BrNO/c1-16(2)10-13(14(17)8-3-9-14)11-4-6-12(15)7-5-11/h4-7,13,17H,3,8-10H2,1-2H3
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n/an/a 580n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of uptake of tritiated serotonin (5-HT) into rat brain synaptosomes


J Med Chem 33: 2899-905 (1990)


Article DOI: 10.1021/jm00172a035
BindingDB Entry DOI: 10.7270/Q20C4WCM
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Rattus norvegicus (Rat))
BDBM50010880
PNG
(1-(2-Dimethylamino-1-p-tolyl-ethyl)-cyclohexanol (...)
Show SMILES CN(C)CC(c1ccc(C)cc1)C1(O)CCCCC1
Show InChI InChI=1S/C17H27NO/c1-14-7-9-15(10-8-14)16(13-18(2)3)17(19)11-5-4-6-12-17/h7-10,16,19H,4-6,11-13H2,1-3H3
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n/an/a 205n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]imipramine to imipramine receptor in rat brain


J Med Chem 33: 2899-905 (1990)


Article DOI: 10.1021/jm00172a035
BindingDB Entry DOI: 10.7270/Q20C4WCM
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50010863
PNG
(1-(2-Dimethylamino-1-phenyl-ethyl)-cyclohexanol (H...)
Show SMILES CN(C)CC(c1ccccc1)C1(O)CCCCC1
Show InChI InChI=1S/C16H25NO/c1-17(2)13-15(14-9-5-3-6-10-14)16(18)11-7-4-8-12-16/h3,5-6,9-10,15,18H,4,7-8,11-13H2,1-2H3
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n/an/a 1.90E+3n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of uptake of tritiated norepinephrine (NE) into rat brain synaptosomes


J Med Chem 33: 2899-905 (1990)


Article DOI: 10.1021/jm00172a035
BindingDB Entry DOI: 10.7270/Q20C4WCM
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Rattus norvegicus (Rat))
BDBM50010876
PNG
(1-[1-(4-Bromo-phenyl)-2-dimethylamino-ethyl]-cyclo...)
Show SMILES CN(C)CC(c1ccc(Br)cc1)C1(O)CCC1
Show InChI InChI=1S/C14H20BrNO/c1-16(2)10-13(14(17)8-3-9-14)11-4-6-12(15)7-5-11/h4-7,13,17H,3,8-10H2,1-2H3
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PubMed
n/an/a 435n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]imipramine to imipramine receptor in rat brain


J Med Chem 33: 2899-905 (1990)


Article DOI: 10.1021/jm00172a035
BindingDB Entry DOI: 10.7270/Q20C4WCM
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Rattus norvegicus (Rat))
BDBM50010887
PNG
(1-[1-(2-Bromo-phenyl)-2-dimethylamino-ethyl]-cyclo...)
Show SMILES CN(C)CC(c1ccccc1Br)C1(O)CCCCC1
Show InChI InChI=1S/C16H24BrNO/c1-18(2)12-14(13-8-4-5-9-15(13)17)16(19)10-6-3-7-11-16/h4-5,8-9,14,19H,3,6-7,10-12H2,1-2H3
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n/an/a 260n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]imipramine to imipramine receptor in rat brain


J Med Chem 33: 2899-905 (1990)


Article DOI: 10.1021/jm00172a035
BindingDB Entry DOI: 10.7270/Q20C4WCM
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Rattus norvegicus (Rat))
BDBM50010863
PNG
(1-(2-Dimethylamino-1-phenyl-ethyl)-cyclohexanol (H...)
Show SMILES CN(C)CC(c1ccccc1)C1(O)CCCCC1
Show InChI InChI=1S/C16H25NO/c1-17(2)13-15(14-9-5-3-6-10-14)16(18)11-7-4-8-12-16/h3,5-6,9-10,15,18H,4,7-8,11-13H2,1-2H3
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PubMed
n/an/a 300n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]imipramine to imipramine receptor in rat brain


J Med Chem 33: 2899-905 (1990)


Article DOI: 10.1021/jm00172a035
BindingDB Entry DOI: 10.7270/Q20C4WCM
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50010880
PNG
(1-(2-Dimethylamino-1-p-tolyl-ethyl)-cyclohexanol (...)
Show SMILES CN(C)CC(c1ccc(C)cc1)C1(O)CCCCC1
Show InChI InChI=1S/C17H27NO/c1-14-7-9-15(10-8-14)16(13-18(2)3)17(19)11-5-4-6-12-17/h7-10,16,19H,4-6,11-13H2,1-3H3
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n/an/a 530n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of uptake of tritiated norepinephrine (NE) into rat brain synaptosomes


J Med Chem 33: 2899-905 (1990)


Article DOI: 10.1021/jm00172a035
BindingDB Entry DOI: 10.7270/Q20C4WCM
More data for this
Ligand-Target Pair