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20 similar compounds to monomer 50010898

Compile data set for download or QSAR
Wt: 802.0
BDBM50012922
Wt: 830.0
BDBM50012923
Wt: 622.8
BDBM50012924
Wt: 840.0
BDBM50012925
Wt: 817.0
BDBM50012928
Wt: 790.0
BDBM50012929
Wt: 796.9
BDBM50012932
Wt: 710.9
BDBM50012933
Wt: 725.9
BDBM50012936
Wt: 711.9
BDBM50012937
Wt: 712.9
BDBM50012938
Wt: 731.9
BDBM50012939
Wt: 710.9
BDBM50012942
Wt: 752.9
BDBM50012944
Wt: 683.8
BDBM50012945
Displayed 1 to 15 (of 20 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 50012922,50012923,50012924,50012925,50012928,50012929,50012932,50012933,50012936,50012937,50012938,50012939,50012942,50012944,50012945   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Renin


(Homo sapiens (Human))
BDBM50012929
PNG
(2-(3-Aminomethyl-benzylamino)-4-methyl-pentanoic a...)
Show SMILES CC(C)CC(NC(=O)C(CC(C)C)NCc1cccc(CN)c1)C(O)CC(=O)NC(=O)C(Cc1cccnc1)c1nnc2c(CC(C)C)nc(cn12)-c1ccccc1
Show InChI InChI=1S/C45H59N9O4/c1-28(2)18-36(50-45(58)38(20-30(5)6)48-26-32-13-10-12-31(21-32)24-46)40(55)23-41(56)51-44(57)35(22-33-14-11-17-47-25-33)42-52-53-43-37(19-29(3)4)49-39(27-54(42)43)34-15-8-7-9-16-34/h7-17,21,25,27-30,35-36,38,40,48,55H,18-20,22-24,26,46H2,1-6H3,(H,50,58)(H,51,56,57)
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n/an/a 6.80n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Tested in vitro for their ability to inhibit human renin incubated with human angiotensinogen


J Med Chem 33: 2326-34 (1990)


Article DOI: 10.1021/jm00171a005
BindingDB Entry DOI: 10.7270/Q2H13105
More data for this
Ligand-Target Pair
Renin


(Homo sapiens (Human))
BDBM50012937
PNG
(CHEMBL76697 | Less polar Epimer-6-Cyclohexyl-4-hyd...)
Show SMILES CCCc1nc(cn2c(nnc12)C(Cc1cccnc1)C(=O)NC(CC1CCCCC1)C(O)CC(C(C)C)C(=O)NCCN(C)C)-c1cccnc1
Show InChI InChI=1S/C40H57N9O3/c1-6-12-33-38-47-46-37(49(38)26-35(44-33)30-16-11-18-42-25-30)32(21-29-15-10-17-41-24-29)40(52)45-34(22-28-13-8-7-9-14-28)36(50)23-31(27(2)3)39(51)43-19-20-48(4)5/h10-11,15-18,24-28,31-32,34,36,50H,6-9,12-14,19-23H2,1-5H3,(H,43,51)(H,45,52)
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n/an/a 0.300n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human renin


J Med Chem 33: 2335-42 (1990)


Article DOI: 10.1021/jm00171a006
BindingDB Entry DOI: 10.7270/Q2C8288F
More data for this
Ligand-Target Pair
Renin


(Homo sapiens (Human))
BDBM50012924
PNG
(CHEMBL78121 | N-(2-Cyclohexyl-1-cyclohexylmethyl-2...)
Show SMILES CC(C)Cc1nc(cn2c(nnc12)C(Cc1cccnc1)C(=O)N[C@@H](CC1CCCCC1)C(O)C1CCCCC1)-c1ccccc1
Show InChI InChI=1S/C38H50N6O2/c1-26(2)21-33-37-43-42-36(44(37)25-34(40-33)29-16-8-4-9-17-29)31(22-28-15-12-20-39-24-28)38(46)41-32(23-27-13-6-3-7-14-27)35(45)30-18-10-5-11-19-30/h4,8-9,12,15-17,20,24-27,30-32,35,45H,3,5-7,10-11,13-14,18-19,21-23H2,1-2H3,(H,41,46)/t31?,32-,35?/m0/s1
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n/an/a 290n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Tested in vitro for their ability to inhibit human renin incubated with human angiotensinogen


J Med Chem 33: 2326-34 (1990)


Article DOI: 10.1021/jm00171a005
BindingDB Entry DOI: 10.7270/Q2H13105
More data for this
Ligand-Target Pair
Renin


(Homo sapiens (Human))
BDBM50012923
PNG
(2-(3-Aminomethyl-benzylamino)-4-methyl-pentanoic a...)
Show SMILES CC(C)CC(NCc1cccc(CN)c1)C(=O)NC(CC1CCCCC1)C(O)CC(=O)NC(=O)C(Cc1cccnc1)c1nnc2c(CC(C)C)nc(cn12)-c1ccccc1
Show InChI InChI=1S/C48H63N9O4/c1-31(2)21-40-46-56-55-45(57(46)30-42(52-40)37-18-9-6-10-19-37)38(24-36-17-12-20-50-28-36)47(60)54-44(59)26-43(58)39(25-33-13-7-5-8-14-33)53-48(61)41(22-32(3)4)51-29-35-16-11-15-34(23-35)27-49/h6,9-12,15-20,23,28,30-33,38-39,41,43,51,58H,5,7-8,13-14,21-22,24-27,29,49H2,1-4H3,(H,53,61)(H,54,59,60)
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n/an/a 1.70n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Tested in vitro for their ability to inhibit human renin incubated with human angiotensinogen


J Med Chem 33: 2326-34 (1990)


Article DOI: 10.1021/jm00171a005
BindingDB Entry DOI: 10.7270/Q2H13105
More data for this
Ligand-Target Pair
Renin


(Homo sapiens (Human))
BDBM50012928
PNG
(2-(3-Aminomethyl-benzylamino)-4-methyl-pentanoic a...)
Show SMILES CCCc1nc(cn2c(nnc12)C(Cc1cccnc1)C(=O)NC(=O)C[C@H](O)[C@H](CC1CCCCC1)NC(=O)C(CC(C)C)NCc1cccc(CN)c1)-c1cccnc1
Show InChI InChI=1S/C46H60N10O4/c1-4-11-37-44-55-54-43(56(44)29-40(51-37)35-17-10-19-49-28-35)36(22-34-16-9-18-48-26-34)45(59)53-42(58)24-41(57)38(23-31-12-6-5-7-13-31)52-46(60)39(20-30(2)3)50-27-33-15-8-14-32(21-33)25-47/h8-10,14-19,21,26,28-31,36,38-39,41,50,57H,4-7,11-13,20,22-25,27,47H2,1-3H3,(H,52,60)(H,53,58,59)/t36?,38-,39?,41-/m0/s1
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n/an/a 1.60n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Tested in vitro for their ability to inhibit human renin incubated with human angiotensinogen


J Med Chem 33: 2326-34 (1990)


Article DOI: 10.1021/jm00171a005
BindingDB Entry DOI: 10.7270/Q2H13105
More data for this
Ligand-Target Pair
Renin


(Homo sapiens (Human))
BDBM50012932
PNG
(4-(1-{1-Cyclohexylmethyl-2-hydroxy-4-[2-(8-isobuty...)
Show SMILES CC(C)CC(NCCCC(O)=O)C(=O)N[C@@H](CC1CCCCC1)[C@@H](O)CC(=O)NC(=O)C(Cc1cccnc1)c1nnc2c(CC(C)C)nc(cn12)-c1ccccc1
Show InChI InChI=1S/C44H60N8O6/c1-28(2)21-35-42-51-50-41(52(42)27-37(47-35)32-16-9-6-10-17-32)33(23-31-15-11-19-45-26-31)43(57)49-39(54)25-38(53)34(24-30-13-7-5-8-14-30)48-44(58)36(22-29(3)4)46-20-12-18-40(55)56/h6,9-11,15-17,19,26-30,33-34,36,38,46,53H,5,7-8,12-14,18,20-25H2,1-4H3,(H,48,58)(H,55,56)(H,49,54,57)/t33?,34-,36?,38-/m0/s1
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n/an/a 1.90n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Tested in vitro for their ability to inhibit human renin incubated with human angiotensinogen


J Med Chem 33: 2326-34 (1990)


Article DOI: 10.1021/jm00171a005
BindingDB Entry DOI: 10.7270/Q2H13105
More data for this
Ligand-Target Pair
Renin


(Homo sapiens (Human))
BDBM50012933
PNG
(4-Methyl-2-[(pyridin-2-ylmethyl)-amino]-pentanoic ...)
Show SMILES CC(C)CC(NCc1ccccn1)C(=O)NC(CC1CCCCC1)C(O)CC(=O)NC(=O)Cc1nnc2c(CC(C)C)nc(cn12)-c1ccccc1
Show InChI InChI=1S/C40H54N8O4/c1-26(2)19-32-39-47-46-36(48(39)25-34(43-32)29-15-9-6-10-16-29)23-38(51)45-37(50)22-35(49)31(21-28-13-7-5-8-14-28)44-40(52)33(20-27(3)4)42-24-30-17-11-12-18-41-30/h6,9-12,15-18,25-28,31,33,35,42,49H,5,7-8,13-14,19-24H2,1-4H3,(H,44,52)(H,45,50,51)
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n/an/a 63n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Tested in vitro for their ability to inhibit human renin incubated with human angiotensinogen


J Med Chem 33: 2326-34 (1990)


Article DOI: 10.1021/jm00171a005
BindingDB Entry DOI: 10.7270/Q2H13105
More data for this
Ligand-Target Pair
Renin


(Homo sapiens (Human))
BDBM50012922
PNG
(4-Methyl-2-[(pyridin-2-ylmethyl)-amino]-pentanoic ...)
Show SMILES CC(C)CC(NCc1ccccn1)C(=O)NC(CC1CCCCC1)C(O)CC(=O)NC(=O)C(Cc1cccnc1)c1nnc2c(CC(C)C)nc(cn12)-c1ccccc1
Show InChI InChI=1S/C46H59N9O4/c1-30(2)22-38-44-54-53-43(55(44)29-40(50-38)34-17-9-6-10-18-34)36(24-33-16-13-20-47-27-33)45(58)52-42(57)26-41(56)37(25-32-14-7-5-8-15-32)51-46(59)39(23-31(3)4)49-28-35-19-11-12-21-48-35/h6,9-13,16-21,27,29-32,36-37,39,41,49,56H,5,7-8,14-15,22-26,28H2,1-4H3,(H,51,59)(H,52,57,58)
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n/an/a 1n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Tested in vitro for their ability to inhibit human renin incubated with human angiotensinogen


J Med Chem 33: 2326-34 (1990)


Article DOI: 10.1021/jm00171a005
BindingDB Entry DOI: 10.7270/Q2H13105
More data for this
Ligand-Target Pair
Renin


(Homo sapiens (Human))
BDBM50012936
PNG
(6-Cyclohexyl-4-hydroxy-2-isopropyl-5-[2-(8-propyl-...)
Show SMILES CCCc1nc(cn2c(nnc12)C(Cc1cccnc1)C(=O)NC(CC1CCCCC1)C(O)CC(C(C)C)C(=O)N(C)CCN(C)C)-c1cccnc1
Show InChI InChI=1S/C41H59N9O3/c1-7-13-34-39-47-46-38(50(39)27-36(44-34)31-17-12-19-43-26-31)33(22-30-16-11-18-42-25-30)40(52)45-35(23-29-14-9-8-10-15-29)37(51)24-32(28(2)3)41(53)49(6)21-20-48(4)5/h11-12,16-19,25-29,32-33,35,37,51H,7-10,13-15,20-24H2,1-6H3,(H,45,52)
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n/an/a 212n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human renin


J Med Chem 33: 2335-42 (1990)


Article DOI: 10.1021/jm00171a006
BindingDB Entry DOI: 10.7270/Q2C8288F
More data for this
Ligand-Target Pair
Renin


(Homo sapiens (Human))
BDBM50012939
PNG
(6-Cyclohexyl-4-hydroxy-2-isopropyl-5-[2-(8-propyl-...)
Show SMILES CCCc1nc(cn2c(nnc12)C(Cc1cccnc1)C(=O)NC(CC1CCCCC1)C(O)CC(C(C)C)C(=O)NCc1ccccn1)-c1cccnc1
Show InChI InChI=1S/C42H53N9O3/c1-4-12-35-40-50-49-39(51(40)27-37(47-35)31-16-11-19-44-25-31)34(21-30-15-10-18-43-24-30)42(54)48-36(22-29-13-6-5-7-14-29)38(52)23-33(28(2)3)41(53)46-26-32-17-8-9-20-45-32/h8-11,15-20,24-25,27-29,33-34,36,38,52H,4-7,12-14,21-23,26H2,1-3H3,(H,46,53)(H,48,54)
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n/an/a 0.600n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human renin


J Med Chem 33: 2335-42 (1990)


Article DOI: 10.1021/jm00171a006
BindingDB Entry DOI: 10.7270/Q2C8288F
More data for this
Ligand-Target Pair
Renin


(Homo sapiens (Human))
BDBM50012938
PNG
(6-Cyclohexyl-4-hydroxy-2-isopropyl-5-[2-(8-propyl-...)
Show SMILES CCCc1nc(cn2c(nnc12)C(Cc1cccnc1)C(=O)NC(CC1CCCCC1)C(O)CC(C(C)C)C(=O)NCCCCO)-c1cccnc1
Show InChI InChI=1S/C40H56N8O4/c1-4-12-33-38-47-46-37(48(38)26-35(44-33)30-16-11-18-42-25-30)32(21-29-15-10-17-41-24-29)40(52)45-34(22-28-13-6-5-7-14-28)36(50)23-31(27(2)3)39(51)43-19-8-9-20-49/h10-11,15-18,24-28,31-32,34,36,49-50H,4-9,12-14,19-23H2,1-3H3,(H,43,51)(H,45,52)
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n/an/a 0.300n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human renin


J Med Chem 33: 2335-42 (1990)


Article DOI: 10.1021/jm00171a006
BindingDB Entry DOI: 10.7270/Q2C8288F
More data for this
Ligand-Target Pair
Renin


(Homo sapiens (Human))
BDBM50012937
PNG
(CHEMBL76697 | Less polar Epimer-6-Cyclohexyl-4-hyd...)
Show SMILES CCCc1nc(cn2c(nnc12)C(Cc1cccnc1)C(=O)NC(CC1CCCCC1)C(O)CC(C(C)C)C(=O)NCCN(C)C)-c1cccnc1
Show InChI InChI=1S/C40H57N9O3/c1-6-12-33-38-47-46-37(49(38)26-35(44-33)30-16-11-18-42-25-30)32(21-29-15-10-17-41-24-29)40(52)45-34(22-28-13-8-7-9-14-28)36(50)23-31(27(2)3)39(51)43-19-20-48(4)5/h10-11,15-18,24-28,31-32,34,36,50H,6-9,12-14,19-23H2,1-5H3,(H,43,51)(H,45,52)
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n/an/a 8.60n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human renin


J Med Chem 33: 2335-42 (1990)


Article DOI: 10.1021/jm00171a006
BindingDB Entry DOI: 10.7270/Q2C8288F
More data for this
Ligand-Target Pair
Renin


(Homo sapiens (Human))
BDBM50012942
PNG
(6-Cyclohexyl-4-hydroxy-2-isopropyl-5-[2-(8-propyl-...)
Show SMILES CCCCN(C)C(=O)C(CC(O)C(CC1CCCCC1)NC(=O)C(Cc1cccnc1)c1nnc2c(CCC)nc(cn12)-c1cccnc1)C(C)C
Show InChI InChI=1S/C41H58N8O3/c1-6-8-21-48(5)41(52)32(28(3)4)24-37(50)35(23-29-15-10-9-11-16-29)45-40(51)33(22-30-17-12-19-42-25-30)38-46-47-39-34(14-7-2)44-36(27-49(38)39)31-18-13-20-43-26-31/h12-13,17-20,25-29,32-33,35,37,50H,6-11,14-16,21-24H2,1-5H3,(H,45,51)
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n/an/a 41n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human renin


J Med Chem 33: 2335-42 (1990)


Article DOI: 10.1021/jm00171a006
BindingDB Entry DOI: 10.7270/Q2C8288F
More data for this
Ligand-Target Pair
Renin


(Homo sapiens (Human))
BDBM50012944
PNG
(6-Cyclohexyl-4-hydroxy-2-isopropyl-5-[2-(8-propyl-...)
Show SMILES CCCc1nc(cn2c(nnc12)C(Cc1cccnc1)C(=O)NC(CC1CCCCC1)C(O)CC(C(C)C)C(=O)NCCN1CCNCC1)-c1cccnc1
Show InChI InChI=1S/C42H60N10O3/c1-4-10-35-40-50-49-39(52(40)28-37(47-35)32-14-9-16-45-27-32)34(23-31-13-8-15-44-26-31)42(55)48-36(24-30-11-6-5-7-12-30)38(53)25-33(29(2)3)41(54)46-19-22-51-20-17-43-18-21-51/h8-9,13-16,26-30,33-34,36,38,43,53H,4-7,10-12,17-25H2,1-3H3,(H,46,54)(H,48,55)
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n/an/a 0.600n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human renin


J Med Chem 33: 2335-42 (1990)


Article DOI: 10.1021/jm00171a006
BindingDB Entry DOI: 10.7270/Q2C8288F
More data for this
Ligand-Target Pair
Renin


(Homo sapiens (Human))
BDBM50012945
PNG
(6-Cyclohexyl-4-hydroxy-2-isopropyl-5-[2-(8-propyl-...)
Show SMILES CCCc1nc(cn2c(nnc12)C(Cc1cccnc1)C(=O)NC(CC1CCCCC1)C(O)CC(C(C)C)C(=O)NCCN)-c1cccnc1
Show InChI InChI=1S/C38H53N9O3/c1-4-10-31-36-46-45-35(47(36)24-33(43-31)28-14-9-17-41-23-28)30(19-27-13-8-16-40-22-27)38(50)44-32(20-26-11-6-5-7-12-26)34(48)21-29(25(2)3)37(49)42-18-15-39/h8-9,13-14,16-17,22-26,29-30,32,34,48H,4-7,10-12,15,18-21,39H2,1-3H3,(H,42,49)(H,44,50)
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n/an/a 78n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human renin


J Med Chem 33: 2335-42 (1990)


Article DOI: 10.1021/jm00171a006
BindingDB Entry DOI: 10.7270/Q2C8288F
More data for this
Ligand-Target Pair
Renin


(Homo sapiens (Human))
BDBM50012922
PNG
(4-Methyl-2-[(pyridin-2-ylmethyl)-amino]-pentanoic ...)
Show SMILES CC(C)CC(NCc1ccccn1)C(=O)NC(CC1CCCCC1)C(O)CC(=O)NC(=O)C(Cc1cccnc1)c1nnc2c(CC(C)C)nc(cn12)-c1ccccc1
Show InChI InChI=1S/C46H59N9O4/c1-30(2)22-38-44-54-53-43(55(44)29-40(50-38)34-17-9-6-10-18-34)36(24-33-16-13-20-47-27-33)45(58)52-42(57)26-41(56)37(25-32-14-7-5-8-15-32)51-46(59)39(23-31(3)4)49-28-35-19-11-12-21-48-35/h6,9-13,16-21,27,29-32,36-37,39,41,49,56H,5,7-8,14-15,22-26,28H2,1-4H3,(H,51,59)(H,52,57,58)
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n/an/a 640n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Tested in vitro for their ability to inhibit human renin incubated with human angiotensinogen


J Med Chem 33: 2326-34 (1990)


Article DOI: 10.1021/jm00171a005
BindingDB Entry DOI: 10.7270/Q2H13105
More data for this
Ligand-Target Pair
Renin


(Homo sapiens (Human))
BDBM50012923
PNG
(2-(3-Aminomethyl-benzylamino)-4-methyl-pentanoic a...)
Show SMILES CC(C)CC(NCc1cccc(CN)c1)C(=O)NC(CC1CCCCC1)C(O)CC(=O)NC(=O)C(Cc1cccnc1)c1nnc2c(CC(C)C)nc(cn12)-c1ccccc1
Show InChI InChI=1S/C48H63N9O4/c1-31(2)21-40-46-56-55-45(57(46)30-42(52-40)37-18-9-6-10-19-37)38(24-36-17-12-20-50-28-36)47(60)54-44(59)26-43(58)39(25-33-13-7-5-8-14-33)53-48(61)41(22-32(3)4)51-29-35-16-11-15-34(23-35)27-49/h6,9-12,15-20,23,28,30-33,38-39,41,43,51,58H,5,7-8,13-14,21-22,24-27,29,49H2,1-4H3,(H,53,61)(H,54,59,60)
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n/an/a 190n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Tested in vitro for their ability to inhibit human renin incubated with human angiotensinogen


J Med Chem 33: 2326-34 (1990)


Article DOI: 10.1021/jm00171a005
BindingDB Entry DOI: 10.7270/Q2H13105
More data for this
Ligand-Target Pair
Renin


(Homo sapiens (Human))
BDBM50012929
PNG
(2-(3-Aminomethyl-benzylamino)-4-methyl-pentanoic a...)
Show SMILES CC(C)CC(NC(=O)C(CC(C)C)NCc1cccc(CN)c1)C(O)CC(=O)NC(=O)C(Cc1cccnc1)c1nnc2c(CC(C)C)nc(cn12)-c1ccccc1
Show InChI InChI=1S/C45H59N9O4/c1-28(2)18-36(50-45(58)38(20-30(5)6)48-26-32-13-10-12-31(21-32)24-46)40(55)23-41(56)51-44(57)35(22-33-14-11-17-47-25-33)42-52-53-43-37(19-29(3)4)49-39(27-54(42)43)34-15-8-7-9-16-34/h7-17,21,25,27-30,35-36,38,40,48,55H,18-20,22-24,26,46H2,1-6H3,(H,50,58)(H,51,56,57)
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n/an/a 130n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Tested in vitro for their ability to inhibit human renin incubated with human angiotensinogen


J Med Chem 33: 2326-34 (1990)


Article DOI: 10.1021/jm00171a005
BindingDB Entry DOI: 10.7270/Q2H13105
More data for this
Ligand-Target Pair
Renin


(Homo sapiens (Human))
BDBM50012925
PNG
(2-Amino-6-(1-{1-cyclohexylmethyl-2-hydroxy-4-[2-(8...)
Show SMILES CC(C)CC(NCCCC[C@H](N)C(O)=O)C(=O)N[C@@H](CC1CCCCC1)[C@@H](O)CC(=O)NC(=O)C(Cc1cccnc1)c1nnc2c(CC(C)C)nc(cn12)-c1ccccc1
Show InChI InChI=1S/C46H65N9O6/c1-29(2)22-37-43-54-53-42(55(43)28-39(50-37)33-17-9-6-10-18-33)34(24-32-16-13-20-48-27-32)44(58)52-41(57)26-40(56)36(25-31-14-7-5-8-15-31)51-45(59)38(23-30(3)4)49-21-12-11-19-35(47)46(60)61/h6,9-10,13,16-18,20,27-31,34-36,38,40,49,56H,5,7-8,11-12,14-15,19,21-26,47H2,1-4H3,(H,51,59)(H,60,61)(H,52,57,58)/t34?,35-,36-,38?,40-/m0/s1
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n/an/a 3.70n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Tested in vitro for their ability to inhibit human renin incubated with human angiotensinogen


J Med Chem 33: 2326-34 (1990)


Article DOI: 10.1021/jm00171a005
BindingDB Entry DOI: 10.7270/Q2H13105
More data for this
Ligand-Target Pair