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4 similar compounds to monomer 22032

Compile data set for download or QSAR
Wt: 352.8
BDBM50054139
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Wt: 332.4
BDBM50059743
Wt: 352.8
BDBM50229596
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Wt: 386.8
BDBM50011498

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50054139,50059743,50229596,50011498   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50011498
PNG
(CHEMBL3261908)
Show SMILES CN(Cc1ccccc1)C(=O)c1cc2ccccc2c(n1)-c1ccccc1Cl
Show InChI InChI=1S/C24H19ClN2O/c1-27(16-17-9-3-2-4-10-17)24(28)22-15-18-11-5-6-12-19(18)23(26-22)20-13-7-8-14-21(20)25/h2-15H,16H2,1H3
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0.442n/an/an/an/an/an/an/an/a



Universit£ di Salerno

Curated by ChEMBL


Assay Description
Displacement of [3H]PK11195 from TSPO in rat kidney mitochondrial membranes


J Med Chem 57: 2413-28 (2014)


Article DOI: 10.1021/jm401721h
BindingDB Entry DOI: 10.7270/Q2416ZKP
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50054139
PNG
((R)1-(2-Chloro-phenyl)-isoquinoline-3-carboxylic a...)
Show SMILES CC[C@@H](C)N(C)C(=O)c1cc2ccccc2c(n1)-c1ccccc1Cl
Show InChI InChI=1S/C21H21ClN2O/c1-4-14(2)24(3)21(25)19-13-15-9-5-6-10-16(15)20(23-19)17-11-7-8-12-18(17)22/h5-14H,4H2,1-3H3/t14-/m1/s1
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0.700n/an/an/an/an/an/an/an/a



National Institute of Radiological Sciences

Curated by ChEMBL


Assay Description
Displacement of [11C]-PK-11195 from TPSO in Sprague-Dawley rat brain homogenate after 30 mins by gamma counting


J Med Chem 54: 6040-9 (2011)


Article DOI: 10.1021/jm200516a
BindingDB Entry DOI: 10.7270/Q2C53N16
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50229596
PNG
(1-(2-chlorophenyl)-N-methyl-N-[(1S)-1-methylpropyl...)
Show SMILES CC[C@H](C)N(C)C(=O)c1cc2ccccc2c(n1)-c1ccccc1Cl
Show InChI InChI=1S/C21H21ClN2O/c1-4-14(2)24(3)21(25)19-13-15-9-5-6-10-16(15)20(23-19)17-11-7-8-12-18(17)22/h5-14H,4H2,1-3H3/t14-/m0/s1
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0.730n/an/an/an/an/an/an/an/a



National Institute of Mental Health

Curated by ChEMBL


Assay Description
Binding affinity to PBR in Sprague-Dawley rat mitochondrial tissue


J Med Chem 51: 17-30 (2008)


Article DOI: 10.1021/jm0707370
BindingDB Entry DOI: 10.7270/Q2N58M32
More data for this
Ligand-Target Pair
Translocator protein


(Homo sapiens (Human))
BDBM50229596
PNG
(1-(2-chlorophenyl)-N-methyl-N-[(1S)-1-methylpropyl...)
Show SMILES CC[C@H](C)N(C)C(=O)c1cc2ccccc2c(n1)-c1ccccc1Cl
Show InChI InChI=1S/C21H21ClN2O/c1-4-14(2)24(3)21(25)19-13-15-9-5-6-10-16(15)20(23-19)17-11-7-8-12-18(17)22/h5-14H,4H2,1-3H3/t14-/m0/s1
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4.5n/an/an/an/an/an/an/an/a



National Institute of Mental Health

Curated by ChEMBL


Assay Description
Binding affinity to PBR in human mitochondrial tissue


J Med Chem 51: 17-30 (2008)


Article DOI: 10.1021/jm0707370
BindingDB Entry DOI: 10.7270/Q2N58M32
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50229596
PNG
(1-(2-chlorophenyl)-N-methyl-N-[(1S)-1-methylpropyl...)
Show SMILES CC[C@H](C)N(C)C(=O)c1cc2ccccc2c(n1)-c1ccccc1Cl
Show InChI InChI=1S/C21H21ClN2O/c1-4-14(2)24(3)21(25)19-13-15-9-5-6-10-16(15)20(23-19)17-11-7-8-12-18(17)22/h5-14H,4H2,1-3H3/t14-/m0/s1
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n/an/a 19n/an/an/an/an/an/a



Universit£ degli Studi Magna Graecia di Catanzaro

Curated by ChEMBL


Assay Description
Test in vitro, for potential ability to displace [3H]1 from PBR in rat brain cortex


J Med Chem 44: 1134-50 (2001)


Article DOI: 10.1021/jm0009742
BindingDB Entry DOI: 10.7270/Q2G161KM
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50054139
PNG
((R)1-(2-Chloro-phenyl)-isoquinoline-3-carboxylic a...)
Show SMILES CC[C@@H](C)N(C)C(=O)c1cc2ccccc2c(n1)-c1ccccc1Cl
Show InChI InChI=1S/C21H21ClN2O/c1-4-14(2)24(3)21(25)19-13-15-9-5-6-10-16(15)20(23-19)17-11-7-8-12-18(17)22/h5-14H,4H2,1-3H3/t14-/m1/s1
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n/an/a 9n/an/an/an/an/an/a



Universit£ degli Studi Magna Graecia di Catanzaro

Curated by ChEMBL


Assay Description
Test in vitro, for potential ability to displace [3H]1 from PBR in rat brain cortex


J Med Chem 44: 1134-50 (2001)


Article DOI: 10.1021/jm0009742
BindingDB Entry DOI: 10.7270/Q2G161KM
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50059743
PNG
(4-Methyl-1-phenyl-isoquinoline-3-carboxylic acid s...)
Show SMILES CCC(C)N(C)C(=O)c1nc(-c2ccccc2)c2ccccc2c1C
Show InChI InChI=1S/C22H24N2O/c1-5-15(2)24(4)22(25)20-16(3)18-13-9-10-14-19(18)21(23-20)17-11-7-6-8-12-17/h6-15H,5H2,1-4H3
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n/an/a 11n/an/an/an/an/an/a



Universit£ degli Studi Magna Graecia di Catanzaro

Curated by ChEMBL


Assay Description
Test in vitro, for potential ability to displace [3H]1 from PBR in rat brain cortex


J Med Chem 44: 1134-50 (2001)


Article DOI: 10.1021/jm0009742
BindingDB Entry DOI: 10.7270/Q2G161KM
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50059743
PNG
(4-Methyl-1-phenyl-isoquinoline-3-carboxylic acid s...)
Show SMILES CCC(C)N(C)C(=O)c1nc(-c2ccccc2)c2ccccc2c1C
Show InChI InChI=1S/C22H24N2O/c1-5-15(2)24(4)22(25)20-16(3)18-13-9-10-14-19(18)21(23-20)17-11-7-6-8-12-17/h6-15H,5H2,1-4H3
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n/an/a 11n/an/an/an/an/an/a



Universit£ di Siena

Curated by ChEMBL


Assay Description
In vitro binding affinity (pIC50) was tested against peripheral benzodiazepine receptor (PBR) in rat.


J Med Chem 40: 2910-21 (1997)


Article DOI: 10.1021/jm960516m
BindingDB Entry DOI: 10.7270/Q2KW5GQZ
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50059743
PNG
(4-Methyl-1-phenyl-isoquinoline-3-carboxylic acid s...)
Show SMILES CCC(C)N(C)C(=O)c1nc(-c2ccccc2)c2ccccc2c1C
Show InChI InChI=1S/C22H24N2O/c1-5-15(2)24(4)22(25)20-16(3)18-13-9-10-14-19(18)21(23-20)17-11-7-6-8-12-17/h6-15H,5H2,1-4H3
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n/an/a 11n/an/an/an/an/an/a



Universit£ di Siena

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]PK11195 from the peripheral benzodiazepine receptor (PBR) in rat cortex


J Med Chem 40: 2910-21 (1997)


Article DOI: 10.1021/jm960516m
BindingDB Entry DOI: 10.7270/Q2KW5GQZ
More data for this
Ligand-Target Pair