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18 similar compounds to monomer 50011869

Compile data set for download or QSAR
Wt: 444.9
BDBM50011673
Wt: 445.9
BDBM50011627
Wt: 475.0
BDBM50011853
Wt: 454.9
BDBM50011854
Wt: 464.9
BDBM50011855
Wt: 368.8
BDBM50011858
Purchase
Wt: 498.0
BDBM50011861
Wt: 473.0
BDBM50011862
Wt: 451.9
BDBM50011865
Wt: 475.0
BDBM50011866
Wt: 499.0
BDBM50011867
Wt: 471.0
BDBM50011871
Wt: 497.0
BDBM50011874
Wt: 338.8
BDBM50011876
Wt: 410.9
BDBM50011877
Displayed 1 to 15 (of 18 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50011673,50011627,50011853,50011854,50011855,50011858,50011861,50011862,50011865,50011866,50011867,50011871,50011874,50011876,50011877   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet activating factor receptor


(Homo sapiens (Human))
BDBM50011853
PNG
(4-(2-Chloro-phenyl)-2-[2-(4-isobutyl-phenyl)-ethyl...)
Show SMILES CC(C)Cc1ccc(CCc2cc3c(s2)-n2c(C)nnc2CN=C3c2ccccc2Cl)cc1
Show InChI InChI=1S/C27H27ClN4S/c1-17(2)14-20-10-8-19(9-11-20)12-13-21-15-23-26(22-6-4-5-7-24(22)28)29-16-25-31-30-18(3)32(25)27(23)33-21/h4-11,15,17H,12-14,16H2,1-3H3
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n/an/a 30n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.


J Med Chem 34: 1440-6 (1991)


Article DOI: 10.1021/jm00108a031
BindingDB Entry DOI: 10.7270/Q2BG2MZ9
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Homo sapiens (Human))
BDBM50011673
PNG
(4-(2-Chloro-phenyl)-9-methyl-2-(3-phenoxy-prop-1-y...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCOc1ccccc1)c1ccccc1Cl
Show InChI InChI=1S/C24H17ClN4OS/c1-16-27-28-22-15-26-23(19-11-5-6-12-21(19)25)20-14-18(31-24(20)29(16)22)10-7-13-30-17-8-3-2-4-9-17/h2-6,8-9,11-12,14H,13,15H2,1H3
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n/an/a 3n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay


J Med Chem 34: 1209-21 (1991)


Article DOI: 10.1021/jm00107a048
BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Homo sapiens (Human))
BDBM50011855
PNG
(4-(2-Chloro-phenyl)-9-methyl-2-naphthalen-1-ylethy...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#Cc1cccc2ccccc12)c1ccccc1Cl
Show InChI InChI=1S/C27H17ClN4S/c1-17-30-31-25-16-29-26(22-11-4-5-12-24(22)28)23-15-20(33-27(23)32(17)25)14-13-19-9-6-8-18-7-2-3-10-21(18)19/h2-12,15H,16H2,1H3
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n/an/a 150n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
Compound tested in vitro for Platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets


J Med Chem 34: 1440-6 (1991)


Article DOI: 10.1021/jm00108a031
BindingDB Entry DOI: 10.7270/Q2BG2MZ9
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Homo sapiens (Human))
BDBM50011858
PNG
(3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8,9a...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCO)c1ccccc1Cl
Show InChI InChI=1S/C18H13ClN4OS/c1-11-21-22-16-10-20-17(13-6-2-3-7-15(13)19)14-9-12(5-4-8-24)25-18(14)23(11)16/h2-3,6-7,9,24H,8,10H2,1H3
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n/an/a 180n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.


J Med Chem 34: 1440-6 (1991)


Article DOI: 10.1021/jm00108a031
BindingDB Entry DOI: 10.7270/Q2BG2MZ9
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Homo sapiens (Human))
BDBM50011861
PNG
(4-(2-Chloro-phenyl)-9-methyl-2-(5-pyridin-2-yl-thi...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#Cc1ccc(s1)-c1ccccn1)c1ccccc1Cl
Show InChI InChI=1S/C26H16ClN5S2/c1-16-30-31-24-15-29-25(19-6-2-3-7-21(19)27)20-14-18(34-26(20)32(16)24)10-9-17-11-12-23(33-17)22-8-4-5-13-28-22/h2-8,11-14H,15H2,1H3
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n/an/a 60n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.


J Med Chem 34: 1440-6 (1991)


Article DOI: 10.1021/jm00108a031
BindingDB Entry DOI: 10.7270/Q2BG2MZ9
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Homo sapiens (Human))
BDBM50011862
PNG
(2-[2-(4-Butyl-phenyl)-vinyl]-4-(2-chloro-phenyl)-9...)
Show SMILES CCCCc1ccc(\C=C/c2cc3c(s2)-n2c(C)nnc2CN=C3c2ccccc2Cl)cc1
Show InChI InChI=1S/C27H25ClN4S/c1-3-4-7-19-10-12-20(13-11-19)14-15-21-16-23-26(22-8-5-6-9-24(22)28)29-17-25-31-30-18(2)32(25)27(23)33-21/h5-6,8-16H,3-4,7,17H2,1-2H3/b15-14-
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Roche Research Center

Curated by ChEMBL


Assay Description
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.


J Med Chem 34: 1440-6 (1991)


Article DOI: 10.1021/jm00108a031
BindingDB Entry DOI: 10.7270/Q2BG2MZ9
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Homo sapiens (Human))
BDBM50011865
PNG
(3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8,9a...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CC(=O)N1CCOCC1)c1ccccc1Cl
Show InChI InChI=1S/C22H18ClN5O2S/c1-14-25-26-19-13-24-21(16-4-2-3-5-18(16)23)17-12-15(31-22(17)28(14)19)6-7-20(29)27-8-10-30-11-9-27/h2-5,12H,8-11,13H2,1H3
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n/an/a 260n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
Compound tested in vitro for Platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets


J Med Chem 34: 1440-6 (1991)


Article DOI: 10.1021/jm00108a031
BindingDB Entry DOI: 10.7270/Q2BG2MZ9
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Homo sapiens (Human))
BDBM50011866
PNG
(2-[2-(4-Butyl-phenyl)-ethyl]-4-(2-chloro-phenyl)-9...)
Show SMILES CCCCc1ccc(CCc2cc3c(s2)-n2c(C)nnc2CN=C3c2ccccc2Cl)cc1
Show InChI InChI=1S/C27H27ClN4S/c1-3-4-7-19-10-12-20(13-11-19)14-15-21-16-23-26(22-8-5-6-9-24(22)28)29-17-25-31-30-18(2)32(25)27(23)33-21/h5-6,8-13,16H,3-4,7,14-15,17H2,1-2H3
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Roche Research Center

Curated by ChEMBL


Assay Description
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.


J Med Chem 34: 1440-6 (1991)


Article DOI: 10.1021/jm00108a031
BindingDB Entry DOI: 10.7270/Q2BG2MZ9
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Homo sapiens (Human))
BDBM50011867
PNG
(4-(2-Chloro-phenyl)-9-methyl-2-(2,2,7-trimethyl-2,...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#Cc1cc2CC(C)(C)Oc2c(C)c1)c1ccccc1Cl
Show InChI InChI=1S/C28H23ClN4OS/c1-16-11-18(12-19-14-28(3,4)34-26(16)19)9-10-20-13-22-25(21-7-5-6-8-23(21)29)30-15-24-32-31-17(2)33(24)27(22)35-20/h5-8,11-13H,14-15H2,1-4H3
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n/an/a 400n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.


J Med Chem 34: 1440-6 (1991)


Article DOI: 10.1021/jm00108a031
BindingDB Entry DOI: 10.7270/Q2BG2MZ9
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Homo sapiens (Human))
BDBM50011871
PNG
(4-(2-Chloro-phenyl)-2-(4-isobutyl-phenylethynyl)-9...)
Show SMILES CC(C)Cc1ccc(cc1)C#Cc1cc2c(s1)-n1c(C)nnc1CN=C2c1ccccc1Cl
Show InChI InChI=1S/C27H23ClN4S/c1-17(2)14-20-10-8-19(9-11-20)12-13-21-15-23-26(22-6-4-5-7-24(22)28)29-16-25-31-30-18(3)32(25)27(23)33-21/h4-11,15,17H,14,16H2,1-3H3
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Roche Research Center

Curated by ChEMBL


Assay Description
Compound tested in vitro for Platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets


J Med Chem 34: 1440-6 (1991)


Article DOI: 10.1021/jm00108a031
BindingDB Entry DOI: 10.7270/Q2BG2MZ9
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Homo sapiens (Human))
BDBM50011874
PNG
(4-(2-Chloro-phenyl)-2-(4-cyclohexyl-phenylethynyl)...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#Cc1ccc(cc1)C1CCCCC1)c1ccccc1Cl
Show InChI InChI=1S/C29H25ClN4S/c1-19-32-33-27-18-31-28(24-9-5-6-10-26(24)30)25-17-23(35-29(25)34(19)27)16-13-20-11-14-22(15-12-20)21-7-3-2-4-8-21/h5-6,9-12,14-15,17,21H,2-4,7-8,18H2,1H3
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Roche Research Center

Curated by ChEMBL


Assay Description
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.


J Med Chem 34: 1440-6 (1991)


Article DOI: 10.1021/jm00108a031
BindingDB Entry DOI: 10.7270/Q2BG2MZ9
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Homo sapiens (Human))
BDBM50011876
PNG
(4-(2-Chloro-phenyl)-2-ethynyl-9-methyl-6H-1-thia-5...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#C)c1ccccc1Cl
Show InChI InChI=1S/C17H11ClN4S/c1-3-11-8-13-16(12-6-4-5-7-14(12)18)19-9-15-21-20-10(2)22(15)17(13)23-11/h1,4-8H,9H2,2H3
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Roche Research Center

Curated by ChEMBL


Assay Description
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.


J Med Chem 34: 1440-6 (1991)


Article DOI: 10.1021/jm00108a031
BindingDB Entry DOI: 10.7270/Q2BG2MZ9
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Homo sapiens (Human))
BDBM50011877
PNG
(4-(2-Chloro-phenyl)-9-methyl-2-trimethylsilanyleth...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#C[Si](C)(C)C)c1ccccc1Cl
Show InChI InChI=1S/C20H19ClN4SSi/c1-13-23-24-18-12-22-19(15-7-5-6-8-17(15)21)16-11-14(9-10-27(2,3)4)26-20(16)25(13)18/h5-8,11H,12H2,1-4H3
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n/an/a 20n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.


J Med Chem 34: 1440-6 (1991)


Article DOI: 10.1021/jm00108a031
BindingDB Entry DOI: 10.7270/Q2BG2MZ9
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Homo sapiens (Human))
BDBM50011627
PNG
(4-(2-Chloro-phenyl)-9-methyl-2-[3-(pyridin-3-yloxy...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCOc1cccnc1)c1ccccc1Cl
Show InChI InChI=1S/C23H16ClN5OS/c1-15-27-28-21-14-26-22(18-8-2-3-9-20(18)24)19-12-17(31-23(19)29(15)21)7-5-11-30-16-6-4-10-25-13-16/h2-4,6,8-10,12-13H,11,14H2,1H3
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n/an/a 4n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay


J Med Chem 34: 1209-21 (1991)


Article DOI: 10.1021/jm00107a048
BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Homo sapiens (Human))
BDBM50011854
PNG
(4-(2-Chloro-phenyl)-2-indan-5-ylethynyl-9-methyl-6...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#Cc1ccc2CCCc2c1)c1ccccc1Cl
Show InChI InChI=1S/C26H19ClN4S/c1-16-29-30-24-15-28-25(21-7-2-3-8-23(21)27)22-14-20(32-26(22)31(16)24)12-10-17-9-11-18-5-4-6-19(18)13-17/h2-3,7-9,11,13-14H,4-6,15H2,1H3
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Roche Research Center

Curated by ChEMBL


Assay Description
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.


J Med Chem 34: 1440-6 (1991)


Article DOI: 10.1021/jm00108a031
BindingDB Entry DOI: 10.7270/Q2BG2MZ9
More data for this
Ligand-Target Pair