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5 similar compounds to monomer 50011933

Compile data set for download or QSAR
Wt: 309.3
BDBM50011934
Wt: 323.3
BDBM50011930
Wt: 464.4
BDBM50177915
Wt: 450.3
BDBM50177950
Wt: 492.4
BDBM50177974

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50011934,50011930,50177915,50177950,50177974   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Arachidonate 15-lipoxygenase, type II


(Rattus norvegicus)
BDBM50011930
PNG
(2-Cyano-3-(3,4-dihydroxy-phenyl)-acrylic acid 3-ph...)
Show SMILES Oc1ccc(\C=C(/C#N)C(=O)OCCCc2ccccc2)cc1O
Show InChI InChI=1S/C19H17NO4/c20-13-16(11-15-8-9-17(21)18(22)12-15)19(23)24-10-4-7-14-5-2-1-3-6-14/h1-3,5-6,8-9,11-12,21-22H,4,7,10H2/b16-11+
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n/an/a 1.40E+3n/an/an/an/an/an/a



Institute for Bio-Medical Research

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against 15-lipoxygenase in rat polymorphonuclear leukocytes


J Med Chem 34: 1503-5 (1991)


Article DOI: 10.1021/jm00108a039
BindingDB Entry DOI: 10.7270/Q22Z14G6
More data for this
Ligand-Target Pair
Arachidonate 12-lipoxygenase


(Rattus norvegicus)
BDBM50011930
PNG
(2-Cyano-3-(3,4-dihydroxy-phenyl)-acrylic acid 3-ph...)
Show SMILES Oc1ccc(\C=C(/C#N)C(=O)OCCCc2ccccc2)cc1O
Show InChI InChI=1S/C19H17NO4/c20-13-16(11-15-8-9-17(21)18(22)12-15)19(23)24-10-4-7-14-5-2-1-3-6-14/h1-3,5-6,8-9,11-12,21-22H,4,7,10H2/b16-11+
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n/an/a 53n/an/an/an/an/an/a



Institute for Bio-Medical Research

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against 12-lipoxygenase in rat platelet rich plasma


J Med Chem 34: 1503-5 (1991)


Article DOI: 10.1021/jm00108a039
BindingDB Entry DOI: 10.7270/Q22Z14G6
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50011930
PNG
(2-Cyano-3-(3,4-dihydroxy-phenyl)-acrylic acid 3-ph...)
Show SMILES Oc1ccc(\C=C(/C#N)C(=O)OCCCc2ccccc2)cc1O
Show InChI InChI=1S/C19H17NO4/c20-13-16(11-15-8-9-17(21)18(22)12-15)19(23)24-10-4-7-14-5-2-1-3-6-14/h1-3,5-6,8-9,11-12,21-22H,4,7,10H2/b16-11+
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n/an/a 160n/an/an/an/an/an/a



Institute for Bio-Medical Research

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against 5-lipoxygenase in rat polymorphonuclear leukocytes


J Med Chem 34: 1503-5 (1991)


Article DOI: 10.1021/jm00108a039
BindingDB Entry DOI: 10.7270/Q22Z14G6
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase, type II


(Rattus norvegicus)
BDBM50011934
PNG
(2-Cyano-3-(3,4-dihydroxy-phenyl)-acrylic acid phen...)
Show SMILES Oc1ccc(\C=C(/C#N)C(=O)OCCc2ccccc2)cc1O
Show InChI InChI=1S/C18H15NO4/c19-12-15(10-14-6-7-16(20)17(21)11-14)18(22)23-9-8-13-4-2-1-3-5-13/h1-7,10-11,20-21H,8-9H2/b15-10+
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n/an/a 430n/an/an/an/an/an/a



Institute for Bio-Medical Research

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against 15-lipoxygenase in rat polymorphonuclear leukocytes


J Med Chem 34: 1503-5 (1991)


Article DOI: 10.1021/jm00108a039
BindingDB Entry DOI: 10.7270/Q22Z14G6
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens (Human))
BDBM50177974
PNG
(2-cyano-3-(3,4-dihydroxyphenyl)acrylic acid 2-[2-c...)
Show SMILES Oc1ccc(\C=C(/C#N)C(=O)OCCCCCCOC(=O)C(=C\c2ccc(O)c(O)c2)\C#N)cc1O
Show InChI InChI=1S/C26H24N2O8/c27-15-19(11-17-5-7-21(29)23(31)13-17)25(33)35-9-3-1-2-4-10-36-26(34)20(16-28)12-18-6-8-22(30)24(32)14-18/h5-8,11-14,29-32H,1-4,9-10H2/b19-11+,20-12+
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n/an/a>1.00E+5n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Arachidonate 12-lipoxygenase


(Rattus norvegicus)
BDBM50011934
PNG
(2-Cyano-3-(3,4-dihydroxy-phenyl)-acrylic acid phen...)
Show SMILES Oc1ccc(\C=C(/C#N)C(=O)OCCc2ccccc2)cc1O
Show InChI InChI=1S/C18H15NO4/c19-12-15(10-14-6-7-16(20)17(21)11-14)18(22)23-9-8-13-4-2-1-3-5-13/h1-7,10-11,20-21H,8-9H2/b15-10+
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n/an/a 51n/an/an/an/an/an/a



Institute for Bio-Medical Research

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against 12-lipoxygenase in rat platelet rich plasma


J Med Chem 34: 1503-5 (1991)


Article DOI: 10.1021/jm00108a039
BindingDB Entry DOI: 10.7270/Q22Z14G6
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens (Human))
BDBM50177915
PNG
(2-cyano-3-(3,4-dihydroxyphenyl)acrylic acid 2-[2-c...)
Show SMILES Oc1ccc(\C=C(/C#N)C(=O)OCCCCOC(=O)C(=C\c2ccc(O)c(O)c2)\C#N)cc1O
Show InChI InChI=1S/C24H20N2O8/c25-13-17(9-15-3-5-19(27)21(29)11-15)23(31)33-7-1-2-8-34-24(32)18(14-26)10-16-4-6-20(28)22(30)12-16/h3-6,9-12,27-30H,1-2,7-8H2/b17-9+,18-10+
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n/an/a 6.10E+4n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens (Human))
BDBM50177950
PNG
(2-cyano-3-(3,4-dihydroxyphenyl)acrylic acid 2-[2-c...)
Show SMILES Oc1ccc(\C=C(/C#N)C(=O)OCCCOC(=O)C(=C\c2ccc(O)c(O)c2)\C#N)cc1O
Show InChI InChI=1S/C23H18N2O8/c24-12-16(8-14-2-4-18(26)20(28)10-14)22(30)32-6-1-7-33-23(31)17(13-25)9-15-3-5-19(27)21(29)11-15/h2-5,8-11,26-29H,1,6-7H2/b16-8+,17-9+
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n/an/a 3.80E+4n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50011934
PNG
(2-Cyano-3-(3,4-dihydroxy-phenyl)-acrylic acid phen...)
Show SMILES Oc1ccc(\C=C(/C#N)C(=O)OCCc2ccccc2)cc1O
Show InChI InChI=1S/C18H15NO4/c19-12-15(10-14-6-7-16(20)17(21)11-14)18(22)23-9-8-13-4-2-1-3-5-13/h1-7,10-11,20-21H,8-9H2/b15-10+
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n/an/a 160n/an/an/an/an/an/a



Institute for Bio-Medical Research

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against 5-lipoxygenase in rat polymorphonuclear leukocytes


J Med Chem 34: 1503-5 (1991)


Article DOI: 10.1021/jm00108a039
BindingDB Entry DOI: 10.7270/Q22Z14G6
More data for this
Ligand-Target Pair