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1 similar compounds to monomer 50007297

Compile data set for download or QSAR
Wt: 381.2
BDBM50024972

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50024972   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
HMG-CoA reductase


(Rattus norvegicus (rat))
BDBM50024972
PNG
((+) 6-[2-(3,5-Dichloro-4''-fluoro-biphenyl-2-yl)-v...)
Show SMILES O[C@@H]1C[C@H](OC(=O)C1)\C=C\c1c(Cl)cc(Cl)cc1-c1ccc(F)cc1
Show InChI InChI=1S/C19H15Cl2FO3/c20-12-7-17(11-1-3-13(22)4-2-11)16(18(21)8-12)6-5-15-9-14(23)10-19(24)25-15/h1-8,14-15,23H,9-10H2/b6-5+/t14-,15-/m1/s1
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PubMed
n/an/a 24n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of solubilized partially purified rat liver HMG-CoA reductase


J Med Chem 29: 170-81 (1986)


Article DOI: 10.1021/jm00152a002
BindingDB Entry DOI: 10.7270/Q2RV0MQX
More data for this
Ligand-Target Pair
HMG-CoA reductase


(Rattus norvegicus (rat))
BDBM50024972
PNG
((+) 6-[2-(3,5-Dichloro-4''-fluoro-biphenyl-2-yl)-v...)
Show SMILES O[C@@H]1C[C@H](OC(=O)C1)\C=C\c1c(Cl)cc(Cl)cc1-c1ccc(F)cc1
Show InChI InChI=1S/C19H15Cl2FO3/c20-12-7-17(11-1-3-13(22)4-2-11)16(18(21)8-12)6-5-15-9-14(23)10-19(24)25-15/h1-8,14-15,23H,9-10H2/b6-5+/t14-,15-/m1/s1
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MMDB

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Article
PubMed
n/an/a 260n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of solubilized partially purified rat liver HMG-CoA reductase


J Med Chem 29: 170-81 (1986)


Article DOI: 10.1021/jm00152a002
BindingDB Entry DOI: 10.7270/Q2RV0MQX
More data for this
Ligand-Target Pair
HMG-CoA reductase


(Rattus norvegicus (rat))
BDBM50024972
PNG
((+) 6-[2-(3,5-Dichloro-4''-fluoro-biphenyl-2-yl)-v...)
Show SMILES O[C@@H]1C[C@H](OC(=O)C1)\C=C\c1c(Cl)cc(Cl)cc1-c1ccc(F)cc1
Show InChI InChI=1S/C19H15Cl2FO3/c20-12-7-17(11-1-3-13(22)4-2-11)16(18(21)8-12)6-5-15-9-14(23)10-19(24)25-15/h1-8,14-15,23H,9-10H2/b6-5+/t14-,15-/m1/s1
PDB
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Article
PubMed
n/an/a 5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of solubilized partially purified rat liver HMG-CoA reductase


J Med Chem 29: 170-81 (1986)


Article DOI: 10.1021/jm00152a002
BindingDB Entry DOI: 10.7270/Q2RV0MQX
More data for this
Ligand-Target Pair
HMG-CoA reductase


(Rattus norvegicus (rat))
BDBM50024972
PNG
((+) 6-[2-(3,5-Dichloro-4''-fluoro-biphenyl-2-yl)-v...)
Show SMILES O[C@@H]1C[C@H](OC(=O)C1)\C=C\c1c(Cl)cc(Cl)cc1-c1ccc(F)cc1
Show InChI InChI=1S/C19H15Cl2FO3/c20-12-7-17(11-1-3-13(22)4-2-11)16(18(21)8-12)6-5-15-9-14(23)10-19(24)25-15/h1-8,14-15,23H,9-10H2/b6-5+/t14-,15-/m1/s1
PDB
MMDB

Reactome pathway
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UniProtKB/SwissProt

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GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

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Article
PubMed
n/an/a 24n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested in vitro for its ability to inhibit rat liver HMG-CoA reductase


J Med Chem 29: 852-5 (1986)


Article DOI: 10.1021/jm00155a041
BindingDB Entry DOI: 10.7270/Q22F7MFN
More data for this
Ligand-Target Pair