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5 similar compounds to monomer 50042065

Compile data set for download or QSAR
Wt: 325.4
BDBM50042059
Wt: 327.3
BDBM50047883
Wt: 295.3
BDBM50047888
Wt: 325.4
BDBM50047891
Wt: 311.3
BDBM50047893

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50042059,50047883,50047888,50047891,50047893   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50042059
PNG
(4-Hydroxy-2-methyl-quinoline-3-carboxylic acid (8-...)
Show SMILES CN1C2CCC1CC(C2)NC(=O)c1c(C)nc2ccccc2c1O
Show InChI InChI=1S/C19H23N3O2/c1-11-17(18(23)15-5-3-4-6-16(15)20-11)19(24)21-12-9-13-7-8-14(10-12)22(13)2/h3-6,12-14H,7-10H2,1-2H3,(H,20,23)(H,21,24)
PDB

UniProtKB/SwissProt

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Article
PubMed
7.20n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity against radioligand [3H]quipazine labeled 5-hydroxytryptamine 3 receptor sites in neuroblastoma-glioma (NG108-15) cells.


J Med Chem 36: 617-26 (1993)


Article DOI: 10.1021/jm00057a011
BindingDB Entry DOI: 10.7270/Q25B034N
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50047883
PNG
(4-Hydroxy-2-oxo-1,2-dihydro-quinoline-3-carboxylic...)
Show SMILES CN1C2CCC1CC(C2)NC(=O)c1c(O)c2ccccc2[nH]c1=O
Show InChI InChI=1S/C18H21N3O3/c1-21-11-6-7-12(21)9-10(8-11)19-17(23)15-16(22)13-4-2-3-5-14(13)20-18(15)24/h2-5,10-12H,6-9H2,1H3,(H,19,23)(H2,20,22,24)
PDB

UniProtKB/SwissProt

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UniChem

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Article
PubMed
7.60n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity against radioligand [3H]quipazine labeled 5-hydroxytryptamine 3 receptor sites in neuroblastoma-glioma (NG108-15) cells.


J Med Chem 36: 617-26 (1993)


Article DOI: 10.1021/jm00057a011
BindingDB Entry DOI: 10.7270/Q25B034N
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50047893
PNG
(4-Hydroxy-quinoline-3-carboxylic acid (1-aza-bicyc...)
Show SMILES Oc1c(cnc2ccccc12)C(=O)NC1CCN2CCCC1C2
Show InChI InChI=1S/C18H21N3O2/c22-17-13-5-1-2-6-16(13)19-10-14(17)18(23)20-15-7-9-21-8-3-4-12(15)11-21/h1-2,5-6,10,12,15H,3-4,7-9,11H2,(H,19,22)(H,20,23)
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18n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity against radioligand [3H]quipazine labeled 5-hydroxytryptamine 3 receptor sites in neuroblastoma-glioma (NG108-15) cells.


J Med Chem 36: 617-26 (1993)


Article DOI: 10.1021/jm00057a011
BindingDB Entry DOI: 10.7270/Q25B034N
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50047891
PNG
(4-Hydroxy-quinoline-3-carboxylic acid (9-methyl-9-...)
Show SMILES CN1C2CCCC1CC(C2)NC(=O)c1cnc2ccccc2c1O
Show InChI InChI=1S/C19H23N3O2/c1-22-13-5-4-6-14(22)10-12(9-13)21-19(24)16-11-20-17-8-3-2-7-15(17)18(16)23/h2-3,7-8,11-14H,4-6,9-10H2,1H3,(H,20,23)(H,21,24)
PDB

UniProtKB/SwissProt

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Article
PubMed
30n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity against radioligand [3H]quipazine labeled 5-hydroxytryptamine 3 receptor sites in neuroblastoma-glioma (NG108-15) cells.


J Med Chem 36: 617-26 (1993)


Article DOI: 10.1021/jm00057a011
BindingDB Entry DOI: 10.7270/Q25B034N
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50047888
PNG
(CHEMBL347029 | Quinoline-3-carboxylic acid (8-meth...)
Show SMILES CN1C2CCC1CC(C2)NC(=O)c1cnc2ccccc2c1
Show InChI InChI=1S/C18H21N3O/c1-21-15-6-7-16(21)10-14(9-15)20-18(22)13-8-12-4-2-3-5-17(12)19-11-13/h2-5,8,11,14-16H,6-7,9-10H2,1H3,(H,20,22)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
>100n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity against radioligand [3H]quipazine labeled 5-hydroxytryptamine 3 receptor sites in neuroblastoma-glioma (NG108-15) cells.


J Med Chem 36: 617-26 (1993)


Article DOI: 10.1021/jm00057a011
BindingDB Entry DOI: 10.7270/Q25B034N
More data for this
Ligand-Target Pair