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8 similar compounds to monomer 50051897

Compile data set for download or QSAR
Wt: 292.3
BDBM50051903
Wt: 306.3
BDBM50051905
Wt: 320.3
BDBM50051882
Wt: 350.4
BDBM50051886
Wt: 334.4
BDBM50051893
Wt: 374.4
BDBM50051895
Wt: 482.6
BDBM50051896
Wt: 366.4
BDBM50051900

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50051903,50051905,50051882,50051886,50051893,50051895,50051896,50051900   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50051886
PNG
(CHEMBL289465 | [2-(4,5-Diphenyl-1H-imidazol-2-yl)-...)
Show SMILES CC1(CO)COC(OC1)c1nc(c([nH]1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C21H22N2O3/c1-21(12-24)13-25-20(26-14-21)19-22-17(15-8-4-2-5-9-15)18(23-19)16-10-6-3-7-11-16/h2-11,20,24H,12-14H2,1H3,(H,22,23)
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n/an/a 110n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
In vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase 1 from rat liver.


J Med Chem 39: 1423-32 (1996)


Article DOI: 10.1021/jm9505876
BindingDB Entry DOI: 10.7270/Q2TB160C
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)
BDBM50051886
PNG
(CHEMBL289465 | [2-(4,5-Diphenyl-1H-imidazol-2-yl)-...)
Show SMILES CC1(CO)COC(OC1)c1nc(c([nH]1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C21H22N2O3/c1-21(12-24)13-25-20(26-14-21)19-22-17(15-8-4-2-5-9-15)18(23-19)16-10-6-3-7-11-16/h2-11,20,24H,12-14H2,1H3,(H,22,23)
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n/an/a 4.30E+3n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibitory concentration of the compound was evaluated as concentration required to inhibit 50% activity of the rabbit liver Acyl coenzyme A:choleste...


J Med Chem 39: 1423-32 (1996)


Article DOI: 10.1021/jm9505876
BindingDB Entry DOI: 10.7270/Q2TB160C
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)
BDBM50051886
PNG
(CHEMBL289465 | [2-(4,5-Diphenyl-1H-imidazol-2-yl)-...)
Show SMILES CC1(CO)COC(OC1)c1nc(c([nH]1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C21H22N2O3/c1-21(12-24)13-25-20(26-14-21)19-22-17(15-8-4-2-5-9-15)18(23-19)16-10-6-3-7-11-16/h2-11,20,24H,12-14H2,1H3,(H,22,23)
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n/an/a 4.45E+3n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibitory concentration of the compound was evaluated as concentration required to inhibit 50% activity of the rabbit artery Acyl coenzyme A:cholest...


J Med Chem 39: 1423-32 (1996)


Article DOI: 10.1021/jm9505876
BindingDB Entry DOI: 10.7270/Q2TB160C
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)
BDBM50051893
PNG
(2-(5,5-Dimethyl-[1,3]dioxan-2-yl)-4,5-diphenyl-1H-...)
Show SMILES CC1(C)COC(OC1)c1nc(c([nH]1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C21H22N2O2/c1-21(2)13-24-20(25-14-21)19-22-17(15-9-5-3-6-10-15)18(23-19)16-11-7-4-8-12-16/h3-12,20H,13-14H2,1-2H3,(H,22,23)
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n/an/a 3.50E+3n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibitory concentration of the compound was evaluated as concentration required to inhibit 50% activity of the rabbit liver Acyl coenzyme A:choleste...


J Med Chem 39: 1423-32 (1996)


Article DOI: 10.1021/jm9505876
BindingDB Entry DOI: 10.7270/Q2TB160C
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)
BDBM50051893
PNG
(2-(5,5-Dimethyl-[1,3]dioxan-2-yl)-4,5-diphenyl-1H-...)
Show SMILES CC1(C)COC(OC1)c1nc(c([nH]1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C21H22N2O2/c1-21(2)13-24-20(25-14-21)19-22-17(15-9-5-3-6-10-15)18(23-19)16-11-7-4-8-12-16/h3-12,20H,13-14H2,1-2H3,(H,22,23)
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n/an/a 3.70E+3n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibitory concentration of the compound was evaluated as concentration required to inhibit 50% activity of the rabbit artery Acyl coenzyme A:cholest...


J Med Chem 39: 1423-32 (1996)


Article DOI: 10.1021/jm9505876
BindingDB Entry DOI: 10.7270/Q2TB160C
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50051882
PNG
(2-[1,3]Dioxepan-2-yl-4,5-diphenyl-1H-imidazole | C...)
Show SMILES C1CCOC(OC1)c1nc(c([nH]1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C20H20N2O2/c1-3-9-15(10-4-1)17-18(16-11-5-2-6-12-16)22-19(21-17)20-23-13-7-8-14-24-20/h1-6,9-12,20H,7-8,13-14H2,(H,21,22)
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n/an/a 180n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
In vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase 1 from rat liver.


J Med Chem 39: 1423-32 (1996)


Article DOI: 10.1021/jm9505876
BindingDB Entry DOI: 10.7270/Q2TB160C
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50051905
PNG
(2-[1,3]Dioxan-2-yl-4,5-diphenyl-1H-imidazole | CHE...)
Show SMILES C1COC(OC1)c1nc(c([nH]1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C19H18N2O2/c1-3-8-14(9-4-1)16-17(15-10-5-2-6-11-15)21-18(20-16)19-22-12-7-13-23-19/h1-6,8-11,19H,7,12-13H2,(H,20,21)
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n/an/a 100n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
In vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase 1 from rat liver.


J Med Chem 39: 1423-32 (1996)


Article DOI: 10.1021/jm9505876
BindingDB Entry DOI: 10.7270/Q2TB160C
More data for this
Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1)


(Homo sapiens (Human))
BDBM50051893
PNG
(2-(5,5-Dimethyl-[1,3]dioxan-2-yl)-4,5-diphenyl-1H-...)
Show SMILES CC1(C)COC(OC1)c1nc(c([nH]1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C21H22N2O2/c1-21(2)13-24-20(25-14-21)19-22-17(15-9-5-3-6-10-15)18(23-19)16-11-7-4-8-12-16/h3-12,20H,13-14H2,1-2H3,(H,22,23)
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n/an/a 3.50E+3n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibitory concentration of the compound was evaluated as concentration required to inhibit 50% activity of the rabbit liver Acyl coenzyme A:choleste...


J Med Chem 39: 1423-32 (1996)


Article DOI: 10.1021/jm9505876
BindingDB Entry DOI: 10.7270/Q2TB160C
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50051895
PNG
(2-(2,4-Dioxa-spiro[5.5]undec-3-yl)-4,5-diphenyl-1H...)
Show SMILES C1CCC2(CC1)COC(OC2)c1nc(c([nH]1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C24H26N2O2/c1-4-10-18(11-5-1)20-21(19-12-6-2-7-13-19)26-22(25-20)23-27-16-24(17-28-23)14-8-3-9-15-24/h1-2,4-7,10-13,23H,3,8-9,14-17H2,(H,25,26)
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n/an/a 4n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
In vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase 1 from rat liver.


J Med Chem 39: 1423-32 (1996)


Article DOI: 10.1021/jm9505876
BindingDB Entry DOI: 10.7270/Q2TB160C
More data for this
Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1)


(Homo sapiens (Human))
BDBM50051896
PNG
(2-[5-(4-Benzyloxy-butyl)-5-methyl-[1,3]dioxan-2-yl...)
Show SMILES CC1(CCCCOCc2ccccc2)COC(OC1)c1nc(c([nH]1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C31H34N2O3/c1-31(19-11-12-20-34-21-24-13-5-2-6-14-24)22-35-30(36-23-31)29-32-27(25-15-7-3-8-16-25)28(33-29)26-17-9-4-10-18-26/h2-10,13-18,30H,11-12,19-23H2,1H3,(H,32,33)
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n/an/a 300n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibitory concentration of the compound was evaluated as concentration required to inhibit 50% of the activity of human Acyl coenzyme A:cholesterol ...


J Med Chem 39: 1423-32 (1996)


Article DOI: 10.1021/jm9505876
BindingDB Entry DOI: 10.7270/Q2TB160C
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50051903
PNG
(2-[1,3]Dioxolan-2-yl-4,5-diphenyl-1H-imidazole | C...)
Show SMILES C1COC(O1)c1nc(c([nH]1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C18H16N2O2/c1-3-7-13(8-4-1)15-16(14-9-5-2-6-10-14)20-17(19-15)18-21-11-12-22-18/h1-10,18H,11-12H2,(H,19,20)
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n/an/a 4.80E+3n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
In vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase 1 from rat liver.


J Med Chem 39: 1423-32 (1996)


Article DOI: 10.1021/jm9505876
BindingDB Entry DOI: 10.7270/Q2TB160C
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50051893
PNG
(2-(5,5-Dimethyl-[1,3]dioxan-2-yl)-4,5-diphenyl-1H-...)
Show SMILES CC1(C)COC(OC1)c1nc(c([nH]1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C21H22N2O2/c1-21(2)13-24-20(25-14-21)19-22-17(15-9-5-3-6-10-15)18(23-19)16-11-7-4-8-12-16/h3-12,20H,13-14H2,1-2H3,(H,22,23)
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n/an/a 75n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
In vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase 1 from rat liver.


J Med Chem 39: 1423-32 (1996)


Article DOI: 10.1021/jm9505876
BindingDB Entry DOI: 10.7270/Q2TB160C
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50051900
PNG
(CHEMBL34221 | [2-(4,5-Diphenyl-1H-imidazol-2-yl)-5...)
Show SMILES OCC1(CO)COC(OC1)c1nc(c([nH]1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C21H22N2O4/c24-11-21(12-25)13-26-20(27-14-21)19-22-17(15-7-3-1-4-8-15)18(23-19)16-9-5-2-6-10-16/h1-10,20,24-25H,11-14H2,(H,22,23)
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n/an/a 275n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
In vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase 1 from rat liver.


J Med Chem 39: 1423-32 (1996)


Article DOI: 10.1021/jm9505876
BindingDB Entry DOI: 10.7270/Q2TB160C
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50051886
PNG
(CHEMBL289465 | [2-(4,5-Diphenyl-1H-imidazol-2-yl)-...)
Show SMILES CC1(CO)COC(OC1)c1nc(c([nH]1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C21H22N2O3/c1-21(12-24)13-25-20(26-14-21)19-22-17(15-8-4-2-5-9-15)18(23-19)16-10-6-3-7-11-16/h2-11,20,24H,12-14H2,1H3,(H,22,23)
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n/an/a 90n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
In vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase 1 from rat liver.


J Med Chem 39: 1423-32 (1996)


Article DOI: 10.1021/jm9505876
BindingDB Entry DOI: 10.7270/Q2TB160C
More data for this
Ligand-Target Pair