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42 similar compounds to monomer 50425187

Compile data set for download or QSAR
Wt: 273.3
BDBM50453640
Wt: 299.4
BDBM50053638
Wt: 285.3
BDBM50053641
Wt: 285.3
BDBM50053642
Wt: 285.3
BDBM50053643
Wt: 287.3
BDBM50053644
Wt: 285.3
BDBM50053647
Wt: 273.3
BDBM50053648
Wt: 285.3
BDBM50053650
Wt: 271.3
BDBM50053653
Wt: 287.3
BDBM50053654
Wt: 259.3
BDBM50093781
Wt: 417.2
BDBM50106856
Wt: 319.4
BDBM50106859
Wt: 463.3
BDBM50106860
Displayed 1 to 15 (of 42 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 67 hits for monomerid = 50453640,50053638,50053641,50053642,50053643,50053644,50053647,50053648,50053650,50053653,50053654,50093781,50106856,50106859,50106860   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50106856
PNG
(3-(4-Iodo-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]oct...)
Show SMILES CN1C2CCC1C(C(C2)c1ccc(I)cc1)C(=O)OCCF
Show InChI InChI=1S/C17H21FINO2/c1-20-13-6-7-15(20)16(17(21)22-9-8-18)14(10-13)11-2-4-12(19)5-3-11/h2-5,13-16H,6-10H2,1H3
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0.930n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Displacement of [3H]-CIT from dopamine transporter of rat striatal homogenate


Bioorg Med Chem Lett 14: 5635-9 (2004)


Article DOI: 10.1016/j.bmcl.2004.08.049
BindingDB Entry DOI: 10.7270/Q2RB743J
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50106856
PNG
(3-(4-Iodo-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]oct...)
Show SMILES CN1C2CCC1C(C(C2)c1ccc(I)cc1)C(=O)OCCF
Show InChI InChI=1S/C17H21FINO2/c1-20-13-6-7-15(20)16(17(21)22-9-8-18)14(10-13)11-2-4-12(19)5-3-11/h2-5,13-16H,6-10H2,1H3
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0.930n/an/an/an/an/an/an/an/a



Alcohol and Drug Abuse Research Center

Curated by ChEMBL


Assay Description
Ability to displace [3H]- beta-CIT from Dopamine transporter in rat striatal homogenate


Bioorg Med Chem Lett 11: 3049-53 (2001)


Article DOI: 10.1016/s0960-894x(01)00626-6
BindingDB Entry DOI: 10.7270/Q23N22PN
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50106856
PNG
(3-(4-Iodo-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]oct...)
Show SMILES CN1C2CCC1C(C(C2)c1ccc(I)cc1)C(=O)OCCF
Show InChI InChI=1S/C17H21FINO2/c1-20-13-6-7-15(20)16(17(21)22-9-8-18)14(10-13)11-2-4-12(19)5-3-11/h2-5,13-16H,6-10H2,1H3
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1.70n/an/an/an/an/an/an/an/a



Alcohol and Drug Abuse Research Center

Curated by ChEMBL


Assay Description
Ability to displace [3H]- paroxetine from Serotonin transporter in rat cerebral cortical homogenate


Bioorg Med Chem Lett 11: 3049-53 (2001)


Article DOI: 10.1016/s0960-894x(01)00626-6
BindingDB Entry DOI: 10.7270/Q23N22PN
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50106856
PNG
(3-(4-Iodo-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]oct...)
Show SMILES CN1C2CCC1C(C(C2)c1ccc(I)cc1)C(=O)OCCF
Show InChI InChI=1S/C17H21FINO2/c1-20-13-6-7-15(20)16(17(21)22-9-8-18)14(10-13)11-2-4-12(19)5-3-11/h2-5,13-16H,6-10H2,1H3
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4.02n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Displacement of [3H]-cyanoimiprimine from serotonin transporter of rat cerebral cortical homogenate


Bioorg Med Chem Lett 14: 5635-9 (2004)


Article DOI: 10.1016/j.bmcl.2004.08.049
BindingDB Entry DOI: 10.7270/Q2RB743J
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50093781
PNG
(3-p-Tolyl-8-aza-bicyclo[3.2.1]octane | 3-p-Tolyl-8...)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(C)cc1)N2
Show InChI InChI=1S/C16H21NO2/c1-10-3-5-11(6-4-10)13-9-12-7-8-14(17-12)15(13)16(18)19-2/h3-6,12-15,17H,7-9H2,1-2H3
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4.40n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]nisoxetine from norepinephrine transporter (NET) of rat cerebral cortex


J Med Chem 48: 3852-7 (2005)


Article DOI: 10.1021/jm058164j
BindingDB Entry DOI: 10.7270/Q2M909FV
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50093781
PNG
(3-p-Tolyl-8-aza-bicyclo[3.2.1]octane | 3-p-Tolyl-8...)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(C)cc1)N2
Show InChI InChI=1S/C16H21NO2/c1-10-3-5-11(6-4-10)13-9-12-7-8-14(17-12)15(13)16(18)19-2/h3-6,12-15,17H,7-9H2,1-2H3
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4.40n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of 0.5 nM [3H]nisoxetine binding to Norepinephrine transporter


Bioorg Med Chem Lett 10: 2445-7 (2001)


Article DOI: 10.1016/s0960-894x(00)00480-7
BindingDB Entry DOI: 10.7270/Q2474BCV
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50093781
PNG
(3-p-Tolyl-8-aza-bicyclo[3.2.1]octane | 3-p-Tolyl-8...)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(C)cc1)N2
Show InChI InChI=1S/C16H21NO2/c1-10-3-5-11(6-4-10)13-9-12-7-8-14(17-12)15(13)16(18)19-2/h3-6,12-15,17H,7-9H2,1-2H3
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5.20n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]nisoxetine from norepinephrine transporter (NET) of rat cerebral cortex


J Med Chem 48: 3852-7 (2005)


Article DOI: 10.1021/jm058164j
BindingDB Entry DOI: 10.7270/Q2M909FV
More data for this
Ligand-Target Pair
Monoamine transporters; Norepininephrine & dopamine


(Rattus norvegicus)
BDBM50093781
PNG
(3-p-Tolyl-8-aza-bicyclo[3.2.1]octane | 3-p-Tolyl-8...)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(C)cc1)N2
Show InChI InChI=1S/C16H21NO2/c1-10-3-5-11(6-4-10)13-9-12-7-8-14(17-12)15(13)16(18)19-2/h3-6,12-15,17H,7-9H2,1-2H3
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5.20n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of 0.5 nM [3H]nisoxetine binding toNorepinephrine transporter


Bioorg Med Chem Lett 10: 2445-7 (2001)


Article DOI: 10.1016/s0960-894x(00)00480-7
BindingDB Entry DOI: 10.7270/Q2474BCV
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50106859
PNG
(8-Methyl-3-p-tolyl-8-aza-bicyclo[3.2.1]octane-2-ca...)
Show SMILES CN1C2CCC1C(C(C2)c1ccc(C)cc1)C(=O)OCCCF
Show InChI InChI=1S/C19H26FNO2/c1-13-4-6-14(7-5-13)16-12-15-8-9-17(21(15)2)18(16)19(22)23-11-3-10-20/h4-7,15-18H,3,8-12H2,1-2H3
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7.20n/an/an/an/an/an/an/an/a



Alcohol and Drug Abuse Research Center

Curated by ChEMBL


Assay Description
Ability to displace [3H]- beta-CIT from Dopamine transporter in rat striatal homogenate


Bioorg Med Chem Lett 11: 3049-53 (2001)


Article DOI: 10.1016/s0960-894x(01)00626-6
BindingDB Entry DOI: 10.7270/Q23N22PN
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50106860
PNG
(8-(3-Fluoro-propyl)-3-(4-iodo-phenyl)-8-aza-bicycl...)
Show SMILES FCCCN1C2CCC1C(C(C2)c1ccc(I)cc1)C(=O)OCCF
Show InChI InChI=1S/C19H24F2INO2/c20-8-1-10-23-15-6-7-17(23)18(19(24)25-11-9-21)16(12-15)13-2-4-14(22)5-3-13/h2-5,15-18H,1,6-12H2
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8.70n/an/an/an/an/an/an/an/a



Alcohol and Drug Abuse Research Center

Curated by ChEMBL


Assay Description
Ability to displace [3H]- beta-CIT from Dopamine transporter in rat striatal homogenate


Bioorg Med Chem Lett 11: 3049-53 (2001)


Article DOI: 10.1016/s0960-894x(01)00626-6
BindingDB Entry DOI: 10.7270/Q23N22PN
More data for this
Ligand-Target Pair
Monoamine transporters; serotonin & dopamine


(Rattus norvegicus (rat))
BDBM50093781
PNG
(3-p-Tolyl-8-aza-bicyclo[3.2.1]octane | 3-p-Tolyl-8...)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(C)cc1)N2
Show InChI InChI=1S/C16H21NO2/c1-10-3-5-11(6-4-10)13-9-12-7-8-14(17-12)15(13)16(18)19-2/h3-6,12-15,17H,7-9H2,1-2H3
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12n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of 0.2 nM [3H]paroxetine binding to Serotonin transporter


Bioorg Med Chem Lett 10: 2445-7 (2001)


Article DOI: 10.1016/s0960-894x(00)00480-7
BindingDB Entry DOI: 10.7270/Q2474BCV
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50093781
PNG
(3-p-Tolyl-8-aza-bicyclo[3.2.1]octane | 3-p-Tolyl-8...)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(C)cc1)N2
Show InChI InChI=1S/C16H21NO2/c1-10-3-5-11(6-4-10)13-9-12-7-8-14(17-12)15(13)16(18)19-2/h3-6,12-15,17H,7-9H2,1-2H3
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12n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]paroxetine from serotonin transporter (5-HT) of rat cerebral cortex


J Med Chem 48: 3852-7 (2005)


Article DOI: 10.1021/jm058164j
BindingDB Entry DOI: 10.7270/Q2M909FV
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50106860
PNG
(8-(3-Fluoro-propyl)-3-(4-iodo-phenyl)-8-aza-bicycl...)
Show SMILES FCCCN1C2CCC1C(C(C2)c1ccc(I)cc1)C(=O)OCCF
Show InChI InChI=1S/C19H24F2INO2/c20-8-1-10-23-15-6-7-17(23)18(19(24)25-11-9-21)16(12-15)13-2-4-14(22)5-3-13/h2-5,15-18H,1,6-12H2
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13n/an/an/an/an/an/an/an/a



Alcohol and Drug Abuse Research Center

Curated by ChEMBL


Assay Description
Ability to displace [3H]- paroxetine from Serotonin transporter in rat cerebral cortical homogenate


Bioorg Med Chem Lett 11: 3049-53 (2001)


Article DOI: 10.1016/s0960-894x(01)00626-6
BindingDB Entry DOI: 10.7270/Q23N22PN
More data for this
Ligand-Target Pair
Monoamine transporters; serotonin & dopamine


(Rattus norvegicus (rat))
BDBM50093781
PNG
(3-p-Tolyl-8-aza-bicyclo[3.2.1]octane | 3-p-Tolyl-8...)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(C)cc1)N2
Show InChI InChI=1S/C16H21NO2/c1-10-3-5-11(6-4-10)13-9-12-7-8-14(17-12)15(13)16(18)19-2/h3-6,12-15,17H,7-9H2,1-2H3
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46n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of 0.2 nM [3H]paroxetine binding to Serotonin transporter


Bioorg Med Chem Lett 10: 2445-7 (2001)


Article DOI: 10.1016/s0960-894x(00)00480-7
BindingDB Entry DOI: 10.7270/Q2474BCV
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50093781
PNG
(3-p-Tolyl-8-aza-bicyclo[3.2.1]octane | 3-p-Tolyl-8...)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(C)cc1)N2
Show InChI InChI=1S/C16H21NO2/c1-10-3-5-11(6-4-10)13-9-12-7-8-14(17-12)15(13)16(18)19-2/h3-6,12-15,17H,7-9H2,1-2H3
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46n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]paroxetine from serotonin transporter (5-HT) of rat cerebral cortex


J Med Chem 48: 3852-7 (2005)


Article DOI: 10.1021/jm058164j
BindingDB Entry DOI: 10.7270/Q2M909FV
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50106856
PNG
(3-(4-Iodo-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]oct...)
Show SMILES CN1C2CCC1C(C(C2)c1ccc(I)cc1)C(=O)OCCF
Show InChI InChI=1S/C17H21FINO2/c1-20-13-6-7-15(20)16(17(21)22-9-8-18)14(10-13)11-2-4-12(19)5-3-11/h2-5,13-16H,6-10H2,1H3
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116n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Displacement of [3H]-nisoxetine from norepinephrine transporter of rat cerebral corticex homogenate


Bioorg Med Chem Lett 14: 5635-9 (2004)


Article DOI: 10.1016/j.bmcl.2004.08.049
BindingDB Entry DOI: 10.7270/Q2RB743J
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50106856
PNG
(3-(4-Iodo-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]oct...)
Show SMILES CN1C2CCC1C(C(C2)c1ccc(I)cc1)C(=O)OCCF
Show InChI InChI=1S/C17H21FINO2/c1-20-13-6-7-15(20)16(17(21)22-9-8-18)14(10-13)11-2-4-12(19)5-3-11/h2-5,13-16H,6-10H2,1H3
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173n/an/an/an/an/an/an/an/a



Alcohol and Drug Abuse Research Center

Curated by ChEMBL


Assay Description
Ability to displace [3H]- nisoxetin from Norepinephrine transporter in rat cerebral cortical homogenate


Bioorg Med Chem Lett 11: 3049-53 (2001)


Article DOI: 10.1016/s0960-894x(01)00626-6
BindingDB Entry DOI: 10.7270/Q23N22PN
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50106859
PNG
(8-Methyl-3-p-tolyl-8-aza-bicyclo[3.2.1]octane-2-ca...)
Show SMILES CN1C2CCC1C(C(C2)c1ccc(C)cc1)C(=O)OCCCF
Show InChI InChI=1S/C19H26FNO2/c1-13-4-6-14(7-5-13)16-12-15-8-9-17(21(15)2)18(16)19(22)23-11-3-10-20/h4-7,15-18H,3,8-12H2,1-2H3
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260n/an/an/an/an/an/an/an/a



Alcohol and Drug Abuse Research Center

Curated by ChEMBL


Assay Description
Ability to displace [3H]- nisoxetin from Norepinephrine transporter in rat cerebral cortical homogenate


Bioorg Med Chem Lett 11: 3049-53 (2001)


Article DOI: 10.1016/s0960-894x(01)00626-6
BindingDB Entry DOI: 10.7270/Q23N22PN
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50106859
PNG
(8-Methyl-3-p-tolyl-8-aza-bicyclo[3.2.1]octane-2-ca...)
Show SMILES CN1C2CCC1C(C(C2)c1ccc(C)cc1)C(=O)OCCCF
Show InChI InChI=1S/C19H26FNO2/c1-13-4-6-14(7-5-13)16-12-15-8-9-17(21(15)2)18(16)19(22)23-11-3-10-20/h4-7,15-18H,3,8-12H2,1-2H3
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325n/an/an/an/an/an/an/an/a



Alcohol and Drug Abuse Research Center

Curated by ChEMBL


Assay Description
Ability to displace [3H]- paroxetine from Serotonin transporter in rat cerebral cortical homogenate


Bioorg Med Chem Lett 11: 3049-53 (2001)


Article DOI: 10.1016/s0960-894x(01)00626-6
BindingDB Entry DOI: 10.7270/Q23N22PN
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50106860
PNG
(8-(3-Fluoro-propyl)-3-(4-iodo-phenyl)-8-aza-bicycl...)
Show SMILES FCCCN1C2CCC1C(C(C2)c1ccc(I)cc1)C(=O)OCCF
Show InChI InChI=1S/C19H24F2INO2/c20-8-1-10-23-15-6-7-17(23)18(19(24)25-11-9-21)16(12-15)13-2-4-14(22)5-3-13/h2-5,15-18H,1,6-12H2
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723n/an/an/an/an/an/an/an/a



Alcohol and Drug Abuse Research Center

Curated by ChEMBL


Assay Description
Ability to displace [3H]- nisoxetin from Norepinephrine transporter in rat cerebral cortical homogenate


Bioorg Med Chem Lett 11: 3049-53 (2001)


Article DOI: 10.1016/s0960-894x(01)00626-6
BindingDB Entry DOI: 10.7270/Q23N22PN
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50453640
PNG
(CHEMBL2112860)
Show SMILES CCc1ccc(cc1)[C@H]1C[C@H]2CCC(N2)[C@H]1C(=O)OC
Show InChI InChI=1S/C17H23NO2/c1-3-11-4-6-12(7-5-11)14-10-13-8-9-15(18-13)16(14)17(19)20-2/h4-7,13-16,18H,3,8-10H2,1-2H3/t13-,14-,15?,16+/m1/s1
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n/an/a 50n/an/an/an/an/an/a



National Institute on Drug Abuse

Curated by ChEMBL


Assay Description
Inhibition of [3H]WIN-35428 binding to dopamine (DA) transporter


J Med Chem 37: 1220-3 (1994)


Article DOI: 10.1021/jm00034a021
BindingDB Entry DOI: 10.7270/Q2Z60PQ2
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50453640
PNG
(CHEMBL2112860)
Show SMILES CCc1ccc(cc1)[C@H]1C[C@H]2CCC(N2)[C@H]1C(=O)OC
Show InChI InChI=1S/C17H23NO2/c1-3-11-4-6-12(7-5-11)14-10-13-8-9-15(18-13)16(14)17(19)20-2/h4-7,13-16,18H,3,8-10H2,1-2H3/t13-,14-,15?,16+/m1/s1
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n/an/a 8.10n/an/an/an/an/an/a



National Institute on Drug Abuse

Curated by ChEMBL


Assay Description
Inhibition of [3H]paroxetine binding to 5-hydroxytryptamine (5-HT) transporter


J Med Chem 37: 1220-3 (1994)


Article DOI: 10.1021/jm00034a021
BindingDB Entry DOI: 10.7270/Q2Z60PQ2
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50453640
PNG
(CHEMBL2112860)
Show SMILES CCc1ccc(cc1)[C@H]1C[C@H]2CCC(N2)[C@H]1C(=O)OC
Show InChI InChI=1S/C17H23NO2/c1-3-11-4-6-12(7-5-11)14-10-13-8-9-15(18-13)16(14)17(19)20-2/h4-7,13-16,18H,3,8-10H2,1-2H3/t13-,14-,15?,16+/m1/s1
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n/an/a 122n/an/an/an/an/an/a



National Institute on Drug Abuse

Curated by ChEMBL


Assay Description
Inhibition of [3H]nisoxetine binding to norepinephrine (NE) transporter


J Med Chem 37: 1220-3 (1994)


Article DOI: 10.1021/jm00034a021
BindingDB Entry DOI: 10.7270/Q2Z60PQ2
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50093781
PNG
(3-p-Tolyl-8-aza-bicyclo[3.2.1]octane | 3-p-Tolyl-8...)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(C)cc1)N2
Show InChI InChI=1S/C16H21NO2/c1-10-3-5-11(6-4-10)13-9-12-7-8-14(17-12)15(13)16(18)19-2/h3-6,12-15,17H,7-9H2,1-2H3
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n/an/a 0.840n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Displacement of 0.5 nM [3H]WIN-35248 from Dopamine transporter


Bioorg Med Chem Lett 10: 2445-7 (2001)


Article DOI: 10.1016/s0960-894x(00)00480-7
BindingDB Entry DOI: 10.7270/Q2474BCV
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50093781
PNG
(3-p-Tolyl-8-aza-bicyclo[3.2.1]octane | 3-p-Tolyl-8...)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(C)cc1)N2
Show InChI InChI=1S/C16H21NO2/c1-10-3-5-11(6-4-10)13-9-12-7-8-14(17-12)15(13)16(18)19-2/h3-6,12-15,17H,7-9H2,1-2H3
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n/an/a 500n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of 0.2 nM [3H]paroxetine binding to Serotonin transporter


Bioorg Med Chem Lett 10: 2445-7 (2001)


Article DOI: 10.1016/s0960-894x(00)00480-7
BindingDB Entry DOI: 10.7270/Q2474BCV
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50053638
PNG
(3-(4-Isopropenyl-phenyl)-8-methyl-8-aza-bicyclo[3....)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(cc1)C(C)=C)N2C
Show InChI InChI=1S/C19H25NO2/c1-12(2)13-5-7-14(8-6-13)16-11-15-9-10-17(20(15)3)18(16)19(21)22-4/h5-8,15-18H,1,9-11H2,2-4H3
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n/an/a 14n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]WIN-35428 binding to the dopamine transporter in rat striata.


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50053642
PNG
(3-(4-Allyl-phenyl)-8-aza-bicyclo[3.2.1]octane-2-ca...)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(CC=C)cc1)N2
Show InChI InChI=1S/C18H23NO2/c1-3-4-12-5-7-13(8-6-12)15-11-14-9-10-16(19-14)17(15)18(20)21-2/h3,5-8,14-17,19H,1,4,9-11H2,2H3
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n/an/a 6.20n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]paroxetine binding to serotonin transporter in rat frontal cortex


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50053641
PNG
(3-[((Z)-4-Propenyl)-phenyl]-8-aza-bicyclo[3.2.1]oc...)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(\C=C/C)cc1)N2
Show InChI InChI=1S/C18H23NO2/c1-3-4-12-5-7-13(8-6-12)15-11-14-9-10-16(19-14)17(15)18(20)21-2/h3-8,14-17,19H,9-11H2,1-2H3/b4-3-
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n/an/a 1.20n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]paroxetine binding to serotonin transporter in rat frontal cortex


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50053644
PNG
(3-(4-Isopropyl-phenyl)-8-aza-bicyclo[3.2.1]octane-...)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(cc1)C(C)C)N2
Show InChI InChI=1S/C18H25NO2/c1-11(2)12-4-6-13(7-5-12)15-10-14-8-9-16(19-14)17(15)18(20)21-3/h4-7,11,14-17,19H,8-10H2,1-3H3
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n/an/a 15n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]paroxetine binding to serotonin transporter in rat frontal cortex


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50053643
PNG
(3-[((E)-4-Propenyl)-phenyl]-8-aza-bicyclo[3.2.1]oc...)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(\C=C\C)cc1)N2
Show InChI InChI=1S/C18H23NO2/c1-3-4-12-5-7-13(8-6-12)15-11-14-9-10-16(19-14)17(15)18(20)21-2/h3-8,14-17,19H,9-11H2,1-2H3/b4-3+
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n/an/a 29n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]WIN-35428 binding to the dopamine transporter in rat striata.


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50053647
PNG
(8-Methyl-3-(4-vinyl-phenyl)-8-aza-bicyclo[3.2.1]oc...)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(C=C)cc1)N2C
Show InChI InChI=1S/C18H23NO2/c1-4-12-5-7-13(8-6-12)15-11-14-9-10-16(19(14)2)17(15)18(20)21-3/h4-8,14-17H,1,9-11H2,2-3H3
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n/an/a 1.20n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]WIN-35428 binding to the dopamine transporter in rat striata.


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50053647
PNG
(8-Methyl-3-(4-vinyl-phenyl)-8-aza-bicyclo[3.2.1]oc...)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(C=C)cc1)N2C
Show InChI InChI=1S/C18H23NO2/c1-4-12-5-7-13(8-6-12)15-11-14-9-10-16(19(14)2)17(15)18(20)21-3/h4-8,14-17H,1,9-11H2,2-3H3
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n/an/a 78n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]nisoxetine binding to the norepinephrine transporter in rat midbrain.


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50053648
PNG
((R)-3-(4-Ethyl-phenyl)-8-aza-bicyclo[3.2.1]octane-...)
Show SMILES CCc1ccc(cc1)C1CC2CCC(N2)C1C(=O)OC
Show InChI InChI=1S/C17H23NO2/c1-3-11-4-6-12(7-5-11)14-10-13-8-9-15(18-13)16(14)17(19)20-2/h4-7,13-16,18H,3,8-10H2,1-2H3
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n/an/a 8.10n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]paroxetine binding to serotonin transporter in rat frontal cortex


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50053641
PNG
(3-[((Z)-4-Propenyl)-phenyl]-8-aza-bicyclo[3.2.1]oc...)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(\C=C/C)cc1)N2
Show InChI InChI=1S/C18H23NO2/c1-3-4-12-5-7-13(8-6-12)15-11-14-9-10-16(19-14)17(15)18(20)21-2/h3-8,14-17,19H,9-11H2,1-2H3/b4-3-
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n/an/a 147n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]nisoxetine binding to the norepinephrine transporter in rat midbrain.


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50053648
PNG
((R)-3-(4-Ethyl-phenyl)-8-aza-bicyclo[3.2.1]octane-...)
Show SMILES CCc1ccc(cc1)C1CC2CCC(N2)C1C(=O)OC
Show InChI InChI=1S/C17H23NO2/c1-3-11-4-6-12(7-5-11)14-10-13-8-9-15(18-13)16(14)17(19)20-2/h4-7,13-16,18H,3,8-10H2,1-2H3
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n/an/a 122n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]nisoxetine binding to the norepinephrine transporter in rat midbrain.


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50053650
PNG
(3-(4-Isopropenyl-phenyl)-8-aza-bicyclo[3.2.1]octan...)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(cc1)C(C)=C)N2
Show InChI InChI=1S/C18H23NO2/c1-11(2)12-4-6-13(7-5-12)15-10-14-8-9-16(19-14)17(15)18(20)21-3/h4-7,14-17,19H,1,8-10H2,2-3H3
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n/an/a 144n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]nisoxetine binding to the norepinephrine transporter in rat midbrain.


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50053644
PNG
(3-(4-Isopropyl-phenyl)-8-aza-bicyclo[3.2.1]octane-...)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(cc1)C(C)C)N2
Show InChI InChI=1S/C18H25NO2/c1-11(2)12-4-6-13(7-5-12)15-10-14-8-9-16(19-14)17(15)18(20)21-3/h4-7,11,14-17,19H,8-10H2,1-3H3
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n/an/a 320n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]WIN-35428 binding to the dopamine transporter in rat striata.


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50053653
PNG
(3-(4-Vinyl-phenyl)-8-aza-bicyclo[3.2.1]octane-2-ca...)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(C=C)cc1)N2
Show InChI InChI=1S/C17H21NO2/c1-3-11-4-6-12(7-5-11)14-10-13-8-9-15(18-13)16(14)17(19)20-2/h3-7,13-16,18H,1,8-10H2,2H3
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n/an/a 15n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]nisoxetine binding to the norepinephrine transporter in rat midbrain.


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50053643
PNG
(3-[((E)-4-Propenyl)-phenyl]-8-aza-bicyclo[3.2.1]oc...)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(\C=C\C)cc1)N2
Show InChI InChI=1S/C18H23NO2/c1-3-4-12-5-7-13(8-6-12)15-11-14-9-10-16(19-14)17(15)18(20)21-2/h3-8,14-17,19H,9-11H2,1-2H3/b4-3+
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n/an/a 1.30n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]paroxetine binding to serotonin transporter in rat frontal cortex


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50053638
PNG
(3-(4-Isopropenyl-phenyl)-8-methyl-8-aza-bicyclo[3....)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(cc1)C(C)=C)N2C
Show InChI InChI=1S/C19H25NO2/c1-12(2)13-5-7-14(8-6-13)16-11-15-9-10-17(20(15)3)18(16)19(21)22-4/h5-8,15-18H,1,9-11H2,2-4H3
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n/an/a 3.10n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]paroxetine binding to serotonin transporter in rat frontal cortex


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50053641
PNG
(3-[((Z)-4-Propenyl)-phenyl]-8-aza-bicyclo[3.2.1]oc...)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(\C=C/C)cc1)N2
Show InChI InChI=1S/C18H23NO2/c1-3-4-12-5-7-13(8-6-12)15-11-14-9-10-16(19-14)17(15)18(20)21-2/h3-8,14-17,19H,9-11H2,1-2H3/b4-3-
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n/an/a 32n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]WIN-35428 binding to the dopamine transporter in rat striata.


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50053654
PNG
(3-(4-Propyl-phenyl)-8-aza-bicyclo[3.2.1]octane-2-c...)
Show SMILES CCCc1ccc(cc1)C1CC2CCC(N2)C1C(=O)OC
Show InChI InChI=1S/C18H25NO2/c1-3-4-12-5-7-13(8-6-12)15-11-14-9-10-16(19-14)17(15)18(20)21-2/h5-8,14-17,19H,3-4,9-11H2,1-2H3
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n/an/a 532n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]nisoxetine binding to the norepinephrine transporter in rat midbrain.


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50053638
PNG
(3-(4-Isopropenyl-phenyl)-8-methyl-8-aza-bicyclo[3....)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(cc1)C(C)=C)N2C
Show InChI InChI=1S/C19H25NO2/c1-12(2)13-5-7-14(8-6-13)16-11-15-9-10-17(20(15)3)18(16)19(21)22-4/h5-8,15-18H,1,9-11H2,2-4H3
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n/an/a 1.33E+3n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]nisoxetine binding to the norepinephrine transporter in rat midbrain.


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50053654
PNG
(3-(4-Propyl-phenyl)-8-aza-bicyclo[3.2.1]octane-2-c...)
Show SMILES CCCc1ccc(cc1)C1CC2CCC(N2)C1C(=O)OC
Show InChI InChI=1S/C18H25NO2/c1-3-4-12-5-7-13(8-6-12)15-11-14-9-10-16(19-14)17(15)18(20)21-2/h5-8,14-17,19H,3-4,9-11H2,1-2H3
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n/an/a 212n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]WIN-35428 binding to the dopamine transporter in rat striata.


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50053642
PNG
(3-(4-Allyl-phenyl)-8-aza-bicyclo[3.2.1]octane-2-ca...)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(CC=C)cc1)N2
Show InChI InChI=1S/C18H23NO2/c1-3-4-12-5-7-13(8-6-12)15-11-14-9-10-16(19-14)17(15)18(20)21-2/h3,5-8,14-17,19H,1,4,9-11H2,2H3
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n/an/a 57n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]WIN-35428 binding to the dopamine transporter in rat striata.


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50053653
PNG
(3-(4-Vinyl-phenyl)-8-aza-bicyclo[3.2.1]octane-2-ca...)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(C=C)cc1)N2
Show InChI InChI=1S/C17H21NO2/c1-3-11-4-6-12(7-5-11)14-10-13-8-9-15(18-13)16(14)17(19)20-2/h3-7,13-16,18H,1,8-10H2,2H3
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n/an/a 1.70n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]WIN-35428 binding to the dopamine transporter in rat striata.


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50053650
PNG
(3-(4-Isopropenyl-phenyl)-8-aza-bicyclo[3.2.1]octan...)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(cc1)C(C)=C)N2
Show InChI InChI=1S/C18H23NO2/c1-11(2)12-4-6-13(7-5-12)15-10-14-8-9-16(19-14)17(15)18(20)21-3/h4-7,14-17,19H,1,8-10H2,2-3H3
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n/an/a 23n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]WIN-35428 binding to the dopamine transporter in rat striata.


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50053643
PNG
(3-[((E)-4-Propenyl)-phenyl]-8-aza-bicyclo[3.2.1]oc...)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(\C=C\C)cc1)N2
Show InChI InChI=1S/C18H23NO2/c1-3-4-12-5-7-13(8-6-12)15-11-14-9-10-16(19-14)17(15)18(20)21-2/h3-8,14-17,19H,9-11H2,1-2H3/b4-3+
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n/an/a 54n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]nisoxetine binding to the norepinephrine transporter in rat midbrain.


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50053642
PNG
(3-(4-Allyl-phenyl)-8-aza-bicyclo[3.2.1]octane-2-ca...)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(CC=C)cc1)N2
Show InChI InChI=1S/C18H23NO2/c1-3-4-12-5-7-13(8-6-12)15-11-14-9-10-16(19-14)17(15)18(20)21-2/h3,5-8,14-17,19H,1,4,9-11H2,2H3
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n/an/a 90n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]nisoxetine binding to the norepinephrine transporter in rat midbrain.


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50053653
PNG
(3-(4-Vinyl-phenyl)-8-aza-bicyclo[3.2.1]octane-2-ca...)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(C=C)cc1)N2
Show InChI InChI=1S/C17H21NO2/c1-3-11-4-6-12(7-5-11)14-10-13-8-9-15(18-13)16(14)17(19)20-2/h3-7,13-16,18H,1,8-10H2,2H3
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n/an/a 2.30n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]paroxetine binding to serotonin transporter in rat frontal cortex


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
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