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1 similar compounds to monomer 50415165

Compile data set for download or QSAR
Wt: 309.4
BDBM50064172

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50064172   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50064172
PNG
(1-benzylspiro[hexahydropyridine-4,2'-(3',4'-dihydr...)
Show SMILES C(N1CCC2(CC1)CCc1ccccc1S2)c1ccccc1
Show InChI InChI=1S/C20H23NS/c1-2-6-17(7-3-1)16-21-14-12-20(13-15-21)11-10-18-8-4-5-9-19(18)22-20/h1-9H,10-16H2
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.5n/an/an/an/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Compound was tested for its binding affinity towards sigma 1 receptor using [3H]-(+)-pentazocine from guinea pig brain


J Med Chem 41: 1557-60 (1998)


Article DOI: 10.1021/jm970740r
BindingDB Entry DOI: 10.7270/Q2N29W3Q
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50064172
PNG
(1-benzylspiro[hexahydropyridine-4,2'-(3',4'-dihydr...)
Show SMILES C(N1CCC2(CC1)CCc1ccccc1S2)c1ccccc1
Show InChI InChI=1S/C20H23NS/c1-2-6-17(7-3-1)16-21-14-12-20(13-15-21)11-10-18-8-4-5-9-19(18)22-20/h1-9H,10-16H2
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.589n/an/an/an/an/an/an/an/a



Universit£ di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-pentazocine from sigma1 receptor in human Jurkat cell membrane


J Med Chem 53: 1261-9 (2010)


Article DOI: 10.1021/jm901542q
BindingDB Entry DOI: 10.7270/Q28K7B9S
More data for this
Ligand-Target Pair
Alpha adrenergic receptor 1A and 1B


(Rattus norvegicus (rat))
BDBM50064172
PNG
(1-benzylspiro[hexahydropyridine-4,2'-(3',4'-dihydr...)
Show SMILES C(N1CCC2(CC1)CCc1ccccc1S2)c1ccccc1
Show InChI InChI=1S/C20H23NS/c1-2-6-17(7-3-1)16-21-14-12-20(13-15-21)11-10-18-8-4-5-9-19(18)22-20/h1-9H,10-16H2
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PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Compound was tested for its binding affinity towards Alpha-1B adrenergic receptor using [3H]-prazosin from rat liver


J Med Chem 41: 1557-60 (1998)


Article DOI: 10.1021/jm970740r
BindingDB Entry DOI: 10.7270/Q2N29W3Q
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(RAT)
BDBM50064172
PNG
(1-benzylspiro[hexahydropyridine-4,2'-(3',4'-dihydr...)
Show SMILES C(N1CCC2(CC1)CCc1ccccc1S2)c1ccccc1
Show InChI InChI=1S/C20H23NS/c1-2-6-17(7-3-1)16-21-14-12-20(13-15-21)11-10-18-8-4-5-9-19(18)22-20/h1-9H,10-16H2
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Article
PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Compound was tested for its binding affinity towards Muscarinic acetylcholine receptor M3 using [3H]-NMS from rat submaxillary gland


J Med Chem 41: 1557-60 (1998)


Article DOI: 10.1021/jm970740r
BindingDB Entry DOI: 10.7270/Q2N29W3Q
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Rattus norvegicus (Rat))
BDBM50064172
PNG
(1-benzylspiro[hexahydropyridine-4,2'-(3',4'-dihydr...)
Show SMILES C(N1CCC2(CC1)CCc1ccccc1S2)c1ccccc1
Show InChI InChI=1S/C20H23NS/c1-2-6-17(7-3-1)16-21-14-12-20(13-15-21)11-10-18-8-4-5-9-19(18)22-20/h1-9H,10-16H2
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Compound was tested for its binding affinity towards Alpha-1A adrenergic receptor using [3H]-prazosin from rat submaxillary gland


J Med Chem 41: 1557-60 (1998)


Article DOI: 10.1021/jm970740r
BindingDB Entry DOI: 10.7270/Q2N29W3Q
More data for this
Ligand-Target Pair
NMDA receptor subunit 2C (GluN2C)


(Rattus norvegicus (Rat))
BDBM50064172
PNG
(1-benzylspiro[hexahydropyridine-4,2'-(3',4'-dihydr...)
Show SMILES C(N1CCC2(CC1)CCc1ccccc1S2)c1ccccc1
Show InChI InChI=1S/C20H23NS/c1-2-6-17(7-3-1)16-21-14-12-20(13-15-21)11-10-18-8-4-5-9-19(18)22-20/h1-9H,10-16H2
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Compound was tested for its binding affinity towards PCP receptor using [3H]-(+)-NANM in the presence of 5 microM haloperidol from rat brain


J Med Chem 41: 1557-60 (1998)


Article DOI: 10.1021/jm970740r
BindingDB Entry DOI: 10.7270/Q2N29W3Q
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50064172
PNG
(1-benzylspiro[hexahydropyridine-4,2'-(3',4'-dihydr...)
Show SMILES C(N1CCC2(CC1)CCc1ccccc1S2)c1ccccc1
Show InChI InChI=1S/C20H23NS/c1-2-6-17(7-3-1)16-21-14-12-20(13-15-21)11-10-18-8-4-5-9-19(18)22-20/h1-9H,10-16H2
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Article
PubMed
1.04E+4n/an/an/an/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Compound was tested for its binding affinity towards Dopamine receptor D2 using [3H]-spiperone from rat striatum


J Med Chem 41: 1557-60 (1998)


Article DOI: 10.1021/jm970740r
BindingDB Entry DOI: 10.7270/Q2N29W3Q
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50064172
PNG
(1-benzylspiro[hexahydropyridine-4,2'-(3',4'-dihydr...)
Show SMILES C(N1CCC2(CC1)CCc1ccccc1S2)c1ccccc1
Show InChI InChI=1S/C20H23NS/c1-2-6-17(7-3-1)16-21-14-12-20(13-15-21)11-10-18-8-4-5-9-19(18)22-20/h1-9H,10-16H2
PDB

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UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.08E+4n/an/an/an/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Compound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-NMS from rat heart


J Med Chem 41: 1557-60 (1998)


Article DOI: 10.1021/jm970740r
BindingDB Entry DOI: 10.7270/Q2N29W3Q
More data for this
Ligand-Target Pair