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20 similar compounds to monomer 50086322

Compile data set for download or QSAR
Wt: 354.4
BDBM50086315
Wt: 354.4
BDBM50086316
Wt: 381.4
BDBM50086317
Wt: 353.4
BDBM50086318
Wt: 326.4
BDBM50086320
Wt: 284.3
BDBM50086391
Wt: 270.3
BDBM50086392
Wt: 256.3
BDBM50086393
Wt: 311.4
BDBM50086396
Wt: 311.4
BDBM50086397
Wt: 312.3
BDBM50086399
Wt: 310.4
BDBM50086401
Wt: 324.4
BDBM50086323
Wt: 324.4
BDBM50086324
Wt: 354.4
BDBM50086326
Displayed 1 to 15 (of 20 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 30 hits for monomerid = 50086315,50086316,50086317,50086318,50086320,50086391,50086392,50086393,50086396,50086397,50086399,50086401,50086323,50086324,50086326   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1


(Mus musculus)
BDBM50086396
PNG
(CHEMBL3426183)
Show SMILES C1CNCC(C1)Nc1ncnc2ccc(cc12)-c1cncs1
Show InChI InChI=1S/C16H17N5S/c1-2-12(7-17-5-1)21-16-13-6-11(15-8-18-10-22-15)3-4-14(13)19-9-20-16/h3-4,6,8-10,12,17H,1-2,5,7H2,(H,19,20,21)
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n/an/a 296n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysis


J Med Chem 58: 3548-71 (2015)


Article DOI: 10.1021/jm502009h
BindingDB Entry DOI: 10.7270/Q2NV9M00
More data for this
Ligand-Target Pair
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1


(Mus musculus)
BDBM50086391
PNG
(CHEMBL3426049)
Show SMILES CC(C)(C)Nc1ncnc2ccc(cc12)-c1cncs1
Show InChI InChI=1S/C15H16N4S/c1-15(2,3)19-14-11-6-10(13-7-16-9-20-13)4-5-12(11)17-8-18-14/h4-9H,1-3H3,(H,17,18,19)
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n/an/a 66n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysis


J Med Chem 58: 3548-71 (2015)


Article DOI: 10.1021/jm502009h
BindingDB Entry DOI: 10.7270/Q2NV9M00
More data for this
Ligand-Target Pair
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1


(Mus musculus)
BDBM50086399
PNG
(CHEMBL3426096)
Show SMILES C1CC(CCO1)Nc1ncnc2ccc(cc12)-c1cncs1
Show InChI InChI=1S/C16H16N4OS/c1-2-14-13(7-11(1)15-8-17-10-22-15)16(19-9-18-14)20-12-3-5-21-6-4-12/h1-2,7-10,12H,3-6H2,(H,18,19,20)
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n/an/a 51n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysis


J Med Chem 58: 3548-71 (2015)


Article DOI: 10.1021/jm502009h
BindingDB Entry DOI: 10.7270/Q2NV9M00
More data for this
Ligand-Target Pair
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1


(Mus musculus)
BDBM50086401
PNG
(CHEMBL3426094)
Show SMILES C1CCC(CC1)Nc1ncnc2ccc(cc12)-c1cncs1
Show InChI InChI=1S/C17H18N4S/c1-2-4-13(5-3-1)21-17-14-8-12(16-9-18-11-22-16)6-7-15(14)19-10-20-17/h6-11,13H,1-5H2,(H,19,20,21)
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n/an/a 13n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysis


J Med Chem 58: 3548-71 (2015)


Article DOI: 10.1021/jm502009h
BindingDB Entry DOI: 10.7270/Q2NV9M00
More data for this
Ligand-Target Pair
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1


(Mus musculus)
BDBM50086315
PNG
(CHEMBL3426043)
Show SMILES OC(=O)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)-c1cncs1
Show InChI InChI=1S/C18H18N4O2S/c23-18(24)11-1-4-13(5-2-11)22-17-14-7-12(16-8-19-10-25-16)3-6-15(14)20-9-21-17/h3,6-11,13H,1-2,4-5H2,(H,23,24)(H,20,21,22)/t11-,13-
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n/an/a 40n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysis


J Med Chem 58: 3548-71 (2015)


Article DOI: 10.1021/jm502009h
BindingDB Entry DOI: 10.7270/Q2NV9M00
More data for this
Ligand-Target Pair
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1


(Mus musculus)
BDBM50086316
PNG
(CHEMBL3426042)
Show SMILES OC(=O)[C@@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)-c1cncs1
Show InChI InChI=1S/C18H18N4O2S/c23-18(24)11-1-4-13(5-2-11)22-17-14-7-12(16-8-19-10-25-16)3-6-15(14)20-9-21-17/h3,6-11,13H,1-2,4-5H2,(H,23,24)(H,20,21,22)/t11-,13+
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n/an/a 459n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysis


J Med Chem 58: 3548-71 (2015)


Article DOI: 10.1021/jm502009h
BindingDB Entry DOI: 10.7270/Q2NV9M00
More data for this
Ligand-Target Pair
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1


(Mus musculus)
BDBM50086317
PNG
(CHEMBL3426193)
Show SMILES CCNC(=O)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)-c1cncs1
Show InChI InChI=1S/C20H23N5OS/c1-2-22-20(26)13-3-6-15(7-4-13)25-19-16-9-14(18-10-21-12-27-18)5-8-17(16)23-11-24-19/h5,8-13,15H,2-4,6-7H2,1H3,(H,22,26)(H,23,24,25)/t13-,15-
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n/an/a 12n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysis


J Med Chem 58: 3548-71 (2015)


Article DOI: 10.1021/jm502009h
BindingDB Entry DOI: 10.7270/Q2NV9M00
More data for this
Ligand-Target Pair
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1


(Mus musculus)
BDBM50086318
PNG
(CHEMBL3426192)
Show SMILES NC(=O)[C@@H]1CCC[C@H](C1)Nc1ncnc2ccc(cc12)-c1cncs1
Show InChI InChI=1S/C18H19N5OS/c19-17(24)12-2-1-3-13(6-12)23-18-14-7-11(16-8-20-10-25-16)4-5-15(14)21-9-22-18/h4-5,7-10,12-13H,1-3,6H2,(H2,19,24)(H,21,22,23)/t12-,13-/m1/s1
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n/an/a 37n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysis


J Med Chem 58: 3548-71 (2015)


Article DOI: 10.1021/jm502009h
BindingDB Entry DOI: 10.7270/Q2NV9M00
More data for this
Ligand-Target Pair
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1


(Mus musculus)
BDBM50086320
PNG
(CHEMBL3426190)
Show SMILES OC1CCC(CC1)Nc1ncnc2ccc(cc12)-c1cncs1
Show InChI InChI=1S/C17H18N4OS/c22-13-4-2-12(3-5-13)21-17-14-7-11(16-8-18-10-23-16)1-6-15(14)19-9-20-17/h1,6-10,12-13,22H,2-5H2,(H,19,20,21)
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n/an/a 25n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysis


J Med Chem 58: 3548-71 (2015)


Article DOI: 10.1021/jm502009h
BindingDB Entry DOI: 10.7270/Q2NV9M00
More data for this
Ligand-Target Pair
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1


(Mus musculus)
BDBM50086323
PNG
(CHEMBL3426187)
Show SMILES C[C@H]1CCCC[C@@H]1Nc1ncnc2ccc(cc12)-c1cncs1
Show InChI InChI=1S/C18H20N4S/c1-12-4-2-3-5-15(12)22-18-14-8-13(17-9-19-11-23-17)6-7-16(14)20-10-21-18/h6-12,15H,2-5H2,1H3,(H,20,21,22)/t12-,15-/m0/s1
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n/an/a 10n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysis


J Med Chem 58: 3548-71 (2015)


Article DOI: 10.1021/jm502009h
BindingDB Entry DOI: 10.7270/Q2NV9M00
More data for this
Ligand-Target Pair
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1


(Mus musculus)
BDBM50086324
PNG
(CHEMBL3426186)
Show SMILES CC1CCC(CC1)Nc1ncnc2ccc(cc12)-c1cncs1
Show InChI InChI=1S/C18H20N4S/c1-12-2-5-14(6-3-12)22-18-15-8-13(17-9-19-11-23-17)4-7-16(15)20-10-21-18/h4,7-12,14H,2-3,5-6H2,1H3,(H,20,21,22)
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n/an/a 7n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysis


J Med Chem 58: 3548-71 (2015)


Article DOI: 10.1021/jm502009h
BindingDB Entry DOI: 10.7270/Q2NV9M00
More data for this
Ligand-Target Pair
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1


(Mus musculus)
BDBM50086326
PNG
(CHEMBL3426184)
Show SMILES NC(=O)N1CCC(CC1)Nc1ncnc2ccc(cc12)-c1cncs1
Show InChI InChI=1S/C17H18N6OS/c18-17(24)23-5-3-12(4-6-23)22-16-13-7-11(15-8-19-10-25-15)1-2-14(13)20-9-21-16/h1-2,7-10,12H,3-6H2,(H2,18,24)(H,20,21,22)
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n/an/a 34n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysis


J Med Chem 58: 3548-71 (2015)


Article DOI: 10.1021/jm502009h
BindingDB Entry DOI: 10.7270/Q2NV9M00
More data for this
Ligand-Target Pair
Lymphocyte differentiation antigen CD38


(Homo sapiens (Human))
BDBM50086391
PNG
(CHEMBL3426049)
Show SMILES CC(C)(C)Nc1ncnc2ccc(cc12)-c1cncs1
Show InChI InChI=1S/C15H16N4S/c1-15(2,3)19-14-11-6-10(13-7-16-9-20-13)4-5-12(11)17-8-18-14/h4-9H,1-3H3,(H,17,18,19)
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n/an/a 2.30E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human CD38 extracellular domain expressed in Pichia pastoris assessed as NAD hydrolysis by colorimetric-based assay


J Med Chem 58: 3548-71 (2015)


Article DOI: 10.1021/jm502009h
BindingDB Entry DOI: 10.7270/Q2NV9M00
More data for this
Ligand-Target Pair
Lymphocyte differentiation antigen CD38


(Homo sapiens (Human))
BDBM50086392
PNG
(CHEMBL3426048)
Show SMILES CC(C)Nc1ncnc2ccc(cc12)-c1cncs1
Show InChI InChI=1S/C14H14N4S/c1-9(2)18-14-11-5-10(13-6-15-8-19-13)3-4-12(11)16-7-17-14/h3-9H,1-2H3,(H,16,17,18)
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n/an/a 3.35E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human CD38 extracellular domain expressed in Pichia pastoris assessed as NAD hydrolysis by colorimetric-based assay


J Med Chem 58: 3548-71 (2015)


Article DOI: 10.1021/jm502009h
BindingDB Entry DOI: 10.7270/Q2NV9M00
More data for this
Ligand-Target Pair
Lymphocyte differentiation antigen CD38


(Homo sapiens (Human))
BDBM50086393
PNG
(CHEMBL3426047)
Show SMILES CCNc1ncnc2ccc(cc12)-c1cncs1
Show InChI InChI=1S/C13H12N4S/c1-2-15-13-10-5-9(12-6-14-8-18-12)3-4-11(10)16-7-17-13/h3-8H,2H2,1H3,(H,15,16,17)
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n/an/a 1.14E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human CD38 extracellular domain expressed in Pichia pastoris assessed as NAD hydrolysis by colorimetric-based assay


J Med Chem 58: 3548-71 (2015)


Article DOI: 10.1021/jm502009h
BindingDB Entry DOI: 10.7270/Q2NV9M00
More data for this
Ligand-Target Pair
Lymphocyte differentiation antigen CD38


(Homo sapiens (Human))
BDBM50086315
PNG
(CHEMBL3426043)
Show SMILES OC(=O)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)-c1cncs1
Show InChI InChI=1S/C18H18N4O2S/c23-18(24)11-1-4-13(5-2-11)22-17-14-7-12(16-8-19-10-25-16)3-6-15(14)20-9-21-17/h3,6-11,13H,1-2,4-5H2,(H,23,24)(H,20,21,22)/t11-,13-
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n/an/a 498n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human CD38 extracellular domain expressed in Pichia pastoris assessed as NAD hydrolysis by colorimetric-based assay


J Med Chem 58: 3548-71 (2015)


Article DOI: 10.1021/jm502009h
BindingDB Entry DOI: 10.7270/Q2NV9M00
More data for this
Ligand-Target Pair
Lymphocyte differentiation antigen CD38


(Homo sapiens (Human))
BDBM50086316
PNG
(CHEMBL3426042)
Show SMILES OC(=O)[C@@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)-c1cncs1
Show InChI InChI=1S/C18H18N4O2S/c23-18(24)11-1-4-13(5-2-11)22-17-14-7-12(16-8-19-10-25-16)3-6-15(14)20-9-21-17/h3,6-11,13H,1-2,4-5H2,(H,23,24)(H,20,21,22)/t11-,13+
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n/an/a>3.02E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human CD38 extracellular domain expressed in Pichia pastoris assessed as NAD hydrolysis by colorimetric-based assay


J Med Chem 58: 3548-71 (2015)


Article DOI: 10.1021/jm502009h
BindingDB Entry DOI: 10.7270/Q2NV9M00
More data for this
Ligand-Target Pair
Lymphocyte differentiation antigen CD38


(Homo sapiens (Human))
BDBM50086317
PNG
(CHEMBL3426193)
Show SMILES CCNC(=O)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)-c1cncs1
Show InChI InChI=1S/C20H23N5OS/c1-2-22-20(26)13-3-6-15(7-4-13)25-19-16-9-14(18-10-21-12-27-18)5-8-17(16)23-11-24-19/h5,8-13,15H,2-4,6-7H2,1H3,(H,22,26)(H,23,24,25)/t13-,15-
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n/an/a 92n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human CD38 extracellular domain expressed in Pichia pastoris assessed as NAD hydrolysis by colorimetric-based assay


J Med Chem 58: 3548-71 (2015)


Article DOI: 10.1021/jm502009h
BindingDB Entry DOI: 10.7270/Q2NV9M00
More data for this
Ligand-Target Pair
Lymphocyte differentiation antigen CD38


(Homo sapiens (Human))
BDBM50086318
PNG
(CHEMBL3426192)
Show SMILES NC(=O)[C@@H]1CCC[C@H](C1)Nc1ncnc2ccc(cc12)-c1cncs1
Show InChI InChI=1S/C18H19N5OS/c19-17(24)12-2-1-3-13(6-12)23-18-14-7-11(16-8-20-10-25-16)4-5-15(14)21-9-22-18/h4-5,7-10,12-13H,1-3,6H2,(H2,19,24)(H,21,22,23)/t12-,13-/m1/s1
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n/an/a 971n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human CD38 extracellular domain expressed in Pichia pastoris assessed as NAD hydrolysis by colorimetric-based assay


J Med Chem 58: 3548-71 (2015)


Article DOI: 10.1021/jm502009h
BindingDB Entry DOI: 10.7270/Q2NV9M00
More data for this
Ligand-Target Pair
Lymphocyte differentiation antigen CD38


(Homo sapiens (Human))
BDBM50086320
PNG
(CHEMBL3426190)
Show SMILES OC1CCC(CC1)Nc1ncnc2ccc(cc12)-c1cncs1
Show InChI InChI=1S/C17H18N4OS/c22-13-4-2-12(3-5-13)21-17-14-7-11(16-8-18-10-23-16)1-6-15(14)19-9-20-17/h1,6-10,12-13,22H,2-5H2,(H,19,20,21)
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n/an/a 406n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human CD38 extracellular domain expressed in Pichia pastoris assessed as NAD hydrolysis by colorimetric-based assay


J Med Chem 58: 3548-71 (2015)


Article DOI: 10.1021/jm502009h
BindingDB Entry DOI: 10.7270/Q2NV9M00
More data for this
Ligand-Target Pair
Lymphocyte differentiation antigen CD38


(Homo sapiens (Human))
BDBM50086323
PNG
(CHEMBL3426187)
Show SMILES C[C@H]1CCCC[C@@H]1Nc1ncnc2ccc(cc12)-c1cncs1
Show InChI InChI=1S/C18H20N4S/c1-12-4-2-3-5-15(12)22-18-14-8-13(17-9-19-11-23-17)6-7-16(14)20-10-21-18/h6-12,15H,2-5H2,1H3,(H,20,21,22)/t12-,15-/m0/s1
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n/an/a 140n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human CD38 extracellular domain expressed in Pichia pastoris assessed as NAD hydrolysis by colorimetric-based assay


J Med Chem 58: 3548-71 (2015)


Article DOI: 10.1021/jm502009h
BindingDB Entry DOI: 10.7270/Q2NV9M00
More data for this
Ligand-Target Pair
Lymphocyte differentiation antigen CD38


(Homo sapiens (Human))
BDBM50086324
PNG
(CHEMBL3426186)
Show SMILES CC1CCC(CC1)Nc1ncnc2ccc(cc12)-c1cncs1
Show InChI InChI=1S/C18H20N4S/c1-12-2-5-14(6-3-12)22-18-15-8-13(17-9-19-11-23-17)4-7-16(15)20-10-21-18/h4,7-12,14H,2-3,5-6H2,1H3,(H,20,21,22)
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n/an/a 117n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human CD38 extracellular domain expressed in Pichia pastoris assessed as NAD hydrolysis by colorimetric-based assay


J Med Chem 58: 3548-71 (2015)


Article DOI: 10.1021/jm502009h
BindingDB Entry DOI: 10.7270/Q2NV9M00
More data for this
Ligand-Target Pair
Lymphocyte differentiation antigen CD38


(Homo sapiens (Human))
BDBM50086326
PNG
(CHEMBL3426184)
Show SMILES NC(=O)N1CCC(CC1)Nc1ncnc2ccc(cc12)-c1cncs1
Show InChI InChI=1S/C17H18N6OS/c18-17(24)23-5-3-12(4-6-23)22-16-13-7-11(15-8-19-10-25-15)1-2-14(13)20-9-21-16/h1-2,7-10,12H,3-6H2,(H2,18,24)(H,20,21,22)
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n/an/a 149n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human CD38 extracellular domain expressed in Pichia pastoris assessed as NAD hydrolysis by colorimetric-based assay


J Med Chem 58: 3548-71 (2015)


Article DOI: 10.1021/jm502009h
BindingDB Entry DOI: 10.7270/Q2NV9M00
More data for this
Ligand-Target Pair
Lymphocyte differentiation antigen CD38


(Homo sapiens (Human))
BDBM50086396
PNG
(CHEMBL3426183)
Show SMILES C1CNCC(C1)Nc1ncnc2ccc(cc12)-c1cncs1
Show InChI InChI=1S/C16H17N5S/c1-2-12(7-17-5-1)21-16-13-6-11(15-8-18-10-22-15)3-4-14(13)19-9-20-16/h3-4,6,8-10,12,17H,1-2,5,7H2,(H,19,20,21)
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n/an/a>3.02E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human CD38 extracellular domain expressed in Pichia pastoris assessed as NAD hydrolysis by colorimetric-based assay


J Med Chem 58: 3548-71 (2015)


Article DOI: 10.1021/jm502009h
BindingDB Entry DOI: 10.7270/Q2NV9M00
More data for this
Ligand-Target Pair
Lymphocyte differentiation antigen CD38


(Homo sapiens (Human))
BDBM50086397
PNG
(CHEMBL3426182)
Show SMILES C1CC(CCN1)Nc1ncnc2ccc(cc12)-c1cncs1
Show InChI InChI=1S/C16H17N5S/c1-2-14-13(7-11(1)15-8-18-10-22-15)16(20-9-19-14)21-12-3-5-17-6-4-12/h1-2,7-10,12,17H,3-6H2,(H,19,20,21)
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n/an/a>3.02E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human CD38 extracellular domain expressed in Pichia pastoris assessed as NAD hydrolysis by colorimetric-based assay


J Med Chem 58: 3548-71 (2015)


Article DOI: 10.1021/jm502009h
BindingDB Entry DOI: 10.7270/Q2NV9M00
More data for this
Ligand-Target Pair
Lymphocyte differentiation antigen CD38


(Homo sapiens (Human))
BDBM50086399
PNG
(CHEMBL3426096)
Show SMILES C1CC(CCO1)Nc1ncnc2ccc(cc12)-c1cncs1
Show InChI InChI=1S/C16H16N4OS/c1-2-14-13(7-11(1)15-8-17-10-22-15)16(19-9-18-14)20-12-3-5-21-6-4-12/h1-2,7-10,12H,3-6H2,(H,18,19,20)
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n/an/a 1.06E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human CD38 extracellular domain expressed in Pichia pastoris assessed as NAD hydrolysis by colorimetric-based assay


J Med Chem 58: 3548-71 (2015)


Article DOI: 10.1021/jm502009h
BindingDB Entry DOI: 10.7270/Q2NV9M00
More data for this
Ligand-Target Pair
Lymphocyte differentiation antigen CD38


(Homo sapiens (Human))
BDBM50086401
PNG
(CHEMBL3426094)
Show SMILES C1CCC(CC1)Nc1ncnc2ccc(cc12)-c1cncs1
Show InChI InChI=1S/C17H18N4S/c1-2-4-13(5-3-1)21-17-14-8-12(16-9-18-11-22-16)6-7-15(14)19-10-20-17/h6-11,13H,1-5H2,(H,19,20,21)
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n/an/a 132n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human CD38 extracellular domain expressed in Pichia pastoris assessed as NAD hydrolysis by colorimetric-based assay


J Med Chem 58: 3548-71 (2015)


Article DOI: 10.1021/jm502009h
BindingDB Entry DOI: 10.7270/Q2NV9M00
More data for this
Ligand-Target Pair
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1


(Mus musculus)
BDBM50086393
PNG
(CHEMBL3426047)
Show SMILES CCNc1ncnc2ccc(cc12)-c1cncs1
Show InChI InChI=1S/C13H12N4S/c1-2-15-13-10-5-9(12-6-14-8-18-12)3-4-11(10)16-7-17-13/h3-8H,2H2,1H3,(H,15,16,17)
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n/an/a 145n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysis


J Med Chem 58: 3548-71 (2015)


Article DOI: 10.1021/jm502009h
BindingDB Entry DOI: 10.7270/Q2NV9M00
More data for this
Ligand-Target Pair
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1


(Mus musculus)
BDBM50086392
PNG
(CHEMBL3426048)
Show SMILES CC(C)Nc1ncnc2ccc(cc12)-c1cncs1
Show InChI InChI=1S/C14H14N4S/c1-9(2)18-14-11-5-10(13-6-15-8-19-13)3-4-12(11)16-7-17-14/h3-9H,1-2H3,(H,16,17,18)
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n/an/a 75n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysis


J Med Chem 58: 3548-71 (2015)


Article DOI: 10.1021/jm502009h
BindingDB Entry DOI: 10.7270/Q2NV9M00
More data for this
Ligand-Target Pair
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1


(Mus musculus)
BDBM50086397
PNG
(CHEMBL3426182)
Show SMILES C1CC(CCN1)Nc1ncnc2ccc(cc12)-c1cncs1
Show InChI InChI=1S/C16H17N5S/c1-2-14-13(7-11(1)15-8-18-10-22-15)16(20-9-19-14)21-12-3-5-17-6-4-12/h1-2,7-10,12,17H,3-6H2,(H,19,20,21)
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n/an/a 275n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysis


J Med Chem 58: 3548-71 (2015)


Article DOI: 10.1021/jm502009h
BindingDB Entry DOI: 10.7270/Q2NV9M00
More data for this
Ligand-Target Pair